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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Obox6_Obox5
Z-value: 1.37
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Transcription factors associated with Obox6_Obox5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Obox5 | mm39_v1_chr7_+_15484056_15484056 | -0.02 | 8.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Obox6_Obox5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 31.3 | GO:0015747 | urate transport(GO:0015747) |
| 6.4 | 25.6 | GO:0046356 | acetyl-CoA catabolic process(GO:0046356) |
| 0.6 | 18.4 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 0.0 | 17.9 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 3.4 | 13.5 | GO:0072021 | ascending thin limb development(GO:0072021) thick ascending limb development(GO:0072023) metanephric ascending thin limb development(GO:0072218) metanephric thick ascending limb development(GO:0072233) |
| 1.3 | 11.7 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 2.9 | 11.6 | GO:0051344 | negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344) regulation of aminoacyl-tRNA ligase activity(GO:1903630) |
| 0.4 | 9.5 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.1 | 9.1 | GO:0060395 | SMAD protein signal transduction(GO:0060395) |
| 1.8 | 9.0 | GO:0006566 | threonine metabolic process(GO:0006566) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 40.2 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.1 | 31.3 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 30.1 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 29.2 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.1 | 22.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 22.2 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 20.7 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 17.0 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.1 | 15.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 15.2 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 40.8 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 1.9 | 32.4 | GO:1901702 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 4.1 | 20.5 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
| 0.0 | 18.8 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.6 | 18.4 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 2.8 | 17.1 | GO:0047023 | androsterone dehydrogenase activity(GO:0047023) |
| 1.1 | 13.5 | GO:0019864 | IgG binding(GO:0019864) |
| 0.2 | 12.9 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 1.8 | 12.6 | GO:0050051 | alkane 1-monooxygenase activity(GO:0018685) leukotriene-B4 20-monooxygenase activity(GO:0050051) |
| 0.1 | 11.4 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.3 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.4 | 7.4 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 7.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 6.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 4.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 4.3 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.1 | 3.7 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 3.6 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 3.5 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 2.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 26.0 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.3 | 12.2 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.5 | 11.4 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.1 | 10.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.5 | 8.6 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.4 | 8.3 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.3 | 6.9 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.2 | 6.4 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.4 | 6.0 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.2 | 5.8 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |