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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Onecut1_Cux2
Z-value: 1.84
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Transcription factors associated with Onecut1_Cux2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Onecut1 | mm39_v1_chr9_+_74769166_74769203 | 0.88 | 3.7e-24 | Click! |
| Cux2 | mm39_v1_chr5_-_122188165_122188221 | 0.31 | 8.7e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Onecut1_Cux2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 27.6 | 82.8 | GO:0097037 | heme export(GO:0097037) |
| 3.2 | 47.3 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 2.5 | 41.7 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 4.8 | 38.2 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 1.5 | 32.7 | GO:0046415 | urate metabolic process(GO:0046415) |
| 6.5 | 32.5 | GO:0070837 | dehydroascorbic acid transport(GO:0070837) |
| 4.6 | 27.4 | GO:0009992 | cellular water homeostasis(GO:0009992) |
| 1.7 | 22.7 | GO:0097421 | smooth muscle cell-matrix adhesion(GO:0061302) liver regeneration(GO:0097421) |
| 0.4 | 17.8 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 3.4 | 17.1 | GO:0048807 | female genitalia morphogenesis(GO:0048807) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 92.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 27.6 | 82.8 | GO:0061474 | phagolysosome membrane(GO:0061474) |
| 0.3 | 44.4 | GO:0031526 | brush border membrane(GO:0031526) |
| 4.6 | 41.7 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.2 | 38.2 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 33.1 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 31.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 27.9 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 3.2 | 22.7 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 0.4 | 11.2 | GO:0005922 | connexon complex(GO:0005922) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 82.8 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 2.8 | 57.0 | GO:0001848 | complement binding(GO:0001848) |
| 11.8 | 47.3 | GO:0019862 | IgA binding(GO:0019862) |
| 4.8 | 38.2 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 6.5 | 32.5 | GO:0055056 | dehydroascorbic acid transporter activity(GO:0033300) D-glucose transmembrane transporter activity(GO:0055056) |
| 0.1 | 30.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 3.9 | 27.4 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
| 1.7 | 22.7 | GO:0016661 | oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661) |
| 0.8 | 22.7 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 5.7 | 17.1 | GO:0034632 | retinol transporter activity(GO:0034632) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 169.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.7 | 53.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.5 | 38.2 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.3 | 19.9 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.7 | 17.9 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 8.3 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 6.9 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 6.0 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.1 | 4.2 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 3.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 99.9 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 1.8 | 41.7 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 4.8 | 38.2 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 1.9 | 32.5 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 1.3 | 30.0 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.2 | 17.9 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 14.9 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.5 | 11.2 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.3 | 10.9 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.3 | 10.6 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |