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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Pax6

Z-value: 0.70

Motif logo

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Transcription factors associated with Pax6

Gene Symbol Gene ID Gene Info
Pax6
ENSMUSG00000027168.22 Pax6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax6mm39_v1_chr2_+_105499280_1054992970.181.4e-01Click!

Activity profile of Pax6 motif

Sorted Z-values of Pax6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax6

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr7_-_86425016 5.07 ENSMUST00000107271.10
Folh1
folate hydrolase 1
chr7_-_86425147 4.30 ENSMUST00000001824.7
Folh1
folate hydrolase 1
chr11_+_72326337 4.25 ENSMUST00000076443.10
Ggt6
gamma-glutamyltransferase 6
chr15_-_101759212 3.89 ENSMUST00000023790.5
Krt1
keratin 1
chrX_+_102465616 3.65 ENSMUST00000182089.2
Gm26992
predicted gene, 26992
chr1_+_106866678 3.58 ENSMUST00000112724.3
Serpinb12
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12
chr4_-_59915035 3.21 ENSMUST00000030081.2
Slc46a2
solute carrier family 46, member 2
chr11_+_72326358 3.17 ENSMUST00000108499.2
Ggt6
gamma-glutamyltransferase 6
chr11_+_72326391 3.15 ENSMUST00000100903.3
Ggt6
gamma-glutamyltransferase 6
chr13_-_110416637 2.80 ENSMUST00000167824.3
ENSMUST00000224180.2
Rab3c
RAB3C, member RAS oncogene family
chr4_+_85123654 2.79 ENSMUST00000030212.15
ENSMUST00000107189.8
ENSMUST00000107184.8
Sh3gl2
SH3-domain GRB2-like 2
chr3_-_98471301 2.72 ENSMUST00000058728.10
Gm10681
predicted gene 10681
chr11_-_121410152 2.69 ENSMUST00000092298.6
Zfp750
zinc finger protein 750
chr10_+_75409282 2.53 ENSMUST00000006508.10
Ggt1
gamma-glutamyltransferase 1
chr3_-_98660781 2.48 ENSMUST00000094050.11
ENSMUST00000090743.13
Hsd3b3
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3
chr5_+_110248276 2.42 ENSMUST00000141066.8
Plcxd1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr15_+_6329278 2.23 ENSMUST00000159046.2
ENSMUST00000161040.8
Dab2
disabled 2, mitogen-responsive phosphoprotein
chr5_-_74838461 2.21 ENSMUST00000117525.8
ENSMUST00000113531.9
ENSMUST00000039744.13
ENSMUST00000121690.8
Lnx1
ligand of numb-protein X 1
chr6_-_144994327 2.20 ENSMUST00000204138.3
Bcat1
branched chain aminotransferase 1, cytosolic
chr5_-_86893645 2.18 ENSMUST00000161306.2
Tmprss11e
transmembrane protease, serine 11e
chr3_-_98364359 2.09 ENSMUST00000188356.3
ENSMUST00000167753.8
Gm4450
predicted gene 4450
chr7_-_101518217 2.08 ENSMUST00000123321.8
Folr1
folate receptor 1 (adult)
chr15_+_6329263 2.03 ENSMUST00000078019.13
Dab2
disabled 2, mitogen-responsive phosphoprotein
chr6_-_144994534 1.91 ENSMUST00000032402.12
Bcat1
branched chain aminotransferase 1, cytosolic
chr4_+_85123358 1.86 ENSMUST00000107188.10
Sh3gl2
SH3-domain GRB2-like 2
chr7_-_101517874 1.85 ENSMUST00000150184.2
Folr1
folate receptor 1 (adult)
chr11_+_69016722 1.85 ENSMUST00000021268.9
Aloxe3
arachidonate lipoxygenase 3
chrX_+_36059274 1.80 ENSMUST00000016463.4
Slc25a5
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5
chrX_+_16485937 1.79 ENSMUST00000026013.6
Maoa
monoamine oxidase A
chr9_+_15150341 1.72 ENSMUST00000034413.8
Vstm5
V-set and transmembrane domain containing 5
chr17_-_57366795 1.51 ENSMUST00000040280.14
Slc25a23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr9_-_54554483 1.44 ENSMUST00000128163.8
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr12_-_11200306 1.43 ENSMUST00000055673.2
Kcns3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr16_+_34605282 1.38 ENSMUST00000023538.9
Mylk
myosin, light polypeptide kinase
chr1_-_120047868 1.37 ENSMUST00000112648.8
Dbi
diazepam binding inhibitor
chr3_-_89152320 1.31 ENSMUST00000107464.8
ENSMUST00000090924.13
Trim46
tripartite motif-containing 46
chr13_-_110417421 1.30 ENSMUST00000223922.2
Rab3c
RAB3C, member RAS oncogene family
chr6_+_83119368 1.25 ENSMUST00000130622.8
ENSMUST00000129316.2
Rtkn
rhotekin
chr19_-_57107330 1.24 ENSMUST00000111526.8
Ablim1
actin-binding LIM protein 1
chr17_+_25585255 1.04 ENSMUST00000234477.2
Tpsb2
tryptase beta 2
chr13_-_25121568 0.95 ENSMUST00000037615.7
Aldh5a1
aldhehyde dehydrogenase family 5, subfamily A1
chr7_+_12631727 0.95 ENSMUST00000055528.11
ENSMUST00000117189.2
ENSMUST00000120809.2
ENSMUST00000119989.3
Zscan22
zinc finger and SCAN domain containing 22
chr10_-_127025851 0.93 ENSMUST00000222006.2
ENSMUST00000019611.15
ENSMUST00000219245.2
Arhgef25
Rho guanine nucleotide exchange factor (GEF) 25
chr2_+_119857961 0.93 ENSMUST00000044675.5
ENSMUST00000129685.8
ENSMUST00000156805.2
Jmjd7
Gm28042
jumonji domain containing 7
predicted gene, 28042
chr19_-_57107413 0.91 ENSMUST00000111528.8
ENSMUST00000111529.8
ENSMUST00000104902.9
Ablim1
actin-binding LIM protein 1
chr9_-_22218934 0.87 ENSMUST00000086278.7
ENSMUST00000215202.2
Zfp810
zinc finger protein 810
chr13_-_4573312 0.86 ENSMUST00000221564.2
ENSMUST00000078239.5
ENSMUST00000080361.13
Akr1c20
aldo-keto reductase family 1, member C20
chr2_-_117173190 0.85 ENSMUST00000173541.8
ENSMUST00000172901.8
ENSMUST00000173252.2
Rasgrp1
RAS guanyl releasing protein 1
chr10_+_94386714 0.81 ENSMUST00000148910.3
ENSMUST00000117460.8
Tmcc3
transmembrane and coiled coil domains 3
chr9_+_50686647 0.75 ENSMUST00000159576.2
Alg9
asparagine-linked glycosylation 9 (alpha 1,2 mannosyltransferase)
chr4_-_140787852 0.71 ENSMUST00000144196.2
ENSMUST00000097816.9
Crocc
ciliary rootlet coiled-coil, rootletin
chr1_+_155916655 0.70 ENSMUST00000065648.15
ENSMUST00000097526.3
Tor1aip2
torsin A interacting protein 2
chr11_-_6150411 0.69 ENSMUST00000066496.10
Nudcd3
NudC domain containing 3
chr2_-_117173312 0.69 ENSMUST00000178884.8
Rasgrp1
RAS guanyl releasing protein 1
chr5_+_87148697 0.68 ENSMUST00000031186.9
Ugt2b35
UDP glucuronosyltransferase 2 family, polypeptide B35
chr15_+_95698574 0.67 ENSMUST00000226793.2
Ano6
anoctamin 6
chr11_+_67857268 0.66 ENSMUST00000021286.11
ENSMUST00000108675.2
Stx8
syntaxin 8
chr10_-_17898977 0.64 ENSMUST00000020002.9
Abracl
ABRA C-terminal like
chr1_+_21310803 0.62 ENSMUST00000027067.15
Gsta3
glutathione S-transferase, alpha 3
chr2_-_75812311 0.60 ENSMUST00000099994.5
Ttc30a1
tetratricopeptide repeat domain 30A1
chr6_-_122833109 0.59 ENSMUST00000042081.9
C3ar1
complement component 3a receptor 1
chr5_+_124045552 0.58 ENSMUST00000166233.2
Denr
density-regulated protein
chr6_-_124718316 0.57 ENSMUST00000004389.6
Grcc10
gene rich cluster, C10 gene
chr7_+_5054514 0.55 ENSMUST00000069324.7
Zfp580
zinc finger protein 580
chr5_-_38637624 0.54 ENSMUST00000067886.12
Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
chr1_+_21310821 0.51 ENSMUST00000121676.8
ENSMUST00000124990.3
Gsta3
glutathione S-transferase, alpha 3
chr5_+_142615292 0.50 ENSMUST00000036872.16
ENSMUST00000110778.2
Wipi2
WD repeat domain, phosphoinositide interacting 2
chr16_-_52272828 0.49 ENSMUST00000170035.8
ENSMUST00000164728.8
ENSMUST00000168071.2
Alcam
activated leukocyte cell adhesion molecule
chr4_+_155575792 0.49 ENSMUST00000165335.8
ENSMUST00000105616.10
ENSMUST00000030940.14
Gnb1
guanine nucleotide binding protein (G protein), beta 1
chr7_+_25760922 0.49 ENSMUST00000005669.9
Cyp2b13
cytochrome P450, family 2, subfamily b, polypeptide 13
chr6_-_88021999 0.42 ENSMUST00000113598.8
Rab7
RAB7, member RAS oncogene family
chr6_+_29468067 0.42 ENSMUST00000143101.4
ENSMUST00000149646.3
Atp6v1f
ATPase, H+ transporting, lysosomal V1 subunit F
chr9_+_105520154 0.42 ENSMUST00000190358.2
ENSMUST00000191268.7
ENSMUST00000065778.13
ENSMUST00000188784.2
Pik3r4
phosphoinositide-3-kinase regulatory subunit 4
chr19_+_34560922 0.41 ENSMUST00000102825.4
Ifit3
interferon-induced protein with tetratricopeptide repeats 3
chr13_-_24098981 0.41 ENSMUST00000110407.4
Slc17a4
solute carrier family 17 (sodium phosphate), member 4
chr14_-_103583785 0.39 ENSMUST00000160758.8
Mycbp2
MYC binding protein 2, E3 ubiquitin protein ligase
chr8_-_47866869 0.38 ENSMUST00000211882.2
Stox2
storkhead box 2
chr13_+_63963054 0.35 ENSMUST00000021926.13
ENSMUST00000067821.13
ENSMUST00000144763.2
ENSMUST00000021925.14
ENSMUST00000238465.2
Ercc6l2
excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2
chr1_+_59802543 0.35 ENSMUST00000087435.7
Bmpr2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
chr16_+_20317544 0.35 ENSMUST00000003320.14
Eif2b5
eukaryotic translation initiation factor 2B, subunit 5 epsilon
chr4_-_123507494 0.34 ENSMUST00000238866.2
Macf1
microtubule-actin crosslinking factor 1
chr5_-_38637474 0.33 ENSMUST00000143758.8
ENSMUST00000156272.8
Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
chr8_-_27718522 0.32 ENSMUST00000117565.2
Adrb3
adrenergic receptor, beta 3
chr12_+_76593799 0.32 ENSMUST00000218380.2
ENSMUST00000219751.2
Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr7_+_86444235 0.30 ENSMUST00000233099.2
ENSMUST00000164996.2
Vmn2r77
vomeronasal 2, receptor 77
chr2_-_105734829 0.26 ENSMUST00000122965.8
Elp4
elongator acetyltransferase complex subunit 4
chr13_-_24098951 0.25 ENSMUST00000021769.16
Slc17a4
solute carrier family 17 (sodium phosphate), member 4
chr10_-_126866658 0.25 ENSMUST00000120547.2
ENSMUST00000152054.8
Tsfm
Ts translation elongation factor, mitochondrial
chr18_-_80133177 0.25 ENSMUST00000178391.2
Gm21886
predicted gene, 21886
chr1_+_155916629 0.25 ENSMUST00000060404.5
Tor1aip2
torsin A interacting protein 2
chr7_-_85956319 0.24 ENSMUST00000055690.3
Olfr309
olfactory receptor 309
chr15_-_35938155 0.24 ENSMUST00000156915.3
Cox6c
cytochrome c oxidase subunit 6C
chr2_-_131987008 0.23 ENSMUST00000028815.15
Slc23a2
solute carrier family 23 (nucleobase transporters), member 2
chr11_+_78219241 0.23 ENSMUST00000048073.9
Pigs
phosphatidylinositol glycan anchor biosynthesis, class S
chr11_-_72097821 0.22 ENSMUST00000204457.3
Gm43951
predicted gene, 43951
chr11_+_60590584 0.21 ENSMUST00000108719.4
Llgl1
LLGL1 scribble cell polarity complex component
chr1_-_192812509 0.21 ENSMUST00000085555.7
Utp25
UTP25 small subunit processome component
chr11_+_60590498 0.21 ENSMUST00000052346.10
Llgl1
LLGL1 scribble cell polarity complex component
chr1_-_138547403 0.19 ENSMUST00000027642.5
ENSMUST00000186017.7
Nek7
NIMA (never in mitosis gene a)-related expressed kinase 7
chr5_-_134668152 0.17 ENSMUST00000036125.10
ENSMUST00000202622.4
Eif4h
eukaryotic translation initiation factor 4H
chr9_+_64086553 0.16 ENSMUST00000034965.8
Snapc5
small nuclear RNA activating complex, polypeptide 5
chr10_+_80192293 0.15 ENSMUST00000039836.15
ENSMUST00000105351.2
Plk5
polo like kinase 5
chr1_+_173877941 0.14 ENSMUST00000062665.4
Olfr432
olfactory receptor 432
chr2_-_33777874 0.14 ENSMUST00000041555.10
Mvb12b
multivesicular body subunit 12B
chr9_-_117701613 0.13 ENSMUST00000239475.2
Rbms3
RNA binding motif, single stranded interacting protein
chr13_+_73775001 0.10 ENSMUST00000022104.9
Tert
telomerase reverse transcriptase
chr7_+_75259778 0.07 ENSMUST00000207923.2
Akap13
A kinase (PRKA) anchor protein 13
chr16_+_3702604 0.03 ENSMUST00000115860.8
Naa60
N(alpha)-acetyltransferase 60, NatF catalytic subunit
chr11_+_102159558 0.03 ENSMUST00000036467.5
Asb16
ankyrin repeat and SOCS box-containing 16
chr4_+_148123554 0.02 ENSMUST00000141283.8
Mthfr
methylenetetrahydrofolate reductase
chr6_+_56933451 0.02 ENSMUST00000096612.4
Vmn1r4
vomeronasal 1 receptor 4
chr1_+_63215976 0.01 ENSMUST00000129339.8
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr5_+_124045238 0.01 ENSMUST00000023869.15
Denr
density-regulated protein
chr16_+_3702523 0.01 ENSMUST00000176625.8
ENSMUST00000186375.8
Naa60
N(alpha)-acetyltransferase 60, NatF catalytic subunit
chr15_-_35938328 0.01 ENSMUST00000014457.15
Cox6c
cytochrome c oxidase subunit 6C

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 13.1 GO:0006751 glutathione catabolic process(GO:0006751)
0.7 4.3 GO:0035026 leading edge cell differentiation(GO:0035026)
0.5 4.1 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.5 4.7 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.4 3.9 GO:0061713 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231)
0.4 1.5 GO:0097274 urea homeostasis(GO:0097274)
0.4 1.1 GO:1901377 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377)
0.4 1.8 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.3 3.9 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.3 1.4 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.3 1.4 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.3 1.8 GO:0042420 dopamine catabolic process(GO:0042420)
0.2 9.4 GO:0006760 folic acid-containing compound metabolic process(GO:0006760)
0.2 0.7 GO:0002543 activation of blood coagulation via clotting cascade(GO:0002543) phosphatidylserine exposure on blood platelet(GO:0097045)
0.2 1.8 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.2 0.6 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.2 0.9 GO:0006538 glutamate catabolic process(GO:0006538)
0.1 0.5 GO:0061739 protein lipidation involved in autophagosome assembly(GO:0061739)
0.1 0.7 GO:0032053 ciliary basal body organization(GO:0032053) positive regulation of protein localization to cilium(GO:1903566)
0.1 0.3 GO:2000137 regulation of lung blood pressure(GO:0014916) negative regulation of cell proliferation involved in heart morphogenesis(GO:2000137) cell proliferation involved in heart valve development(GO:2000793)
0.1 0.6 GO:0036343 psychomotor behavior(GO:0036343)
0.1 0.4 GO:1903542 negative regulation of exosomal secretion(GO:1903542)
0.1 1.5 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.1 0.6 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.6 GO:0002430 complement receptor mediated signaling pathway(GO:0002430) tolerance induction dependent upon immune response(GO:0002461)
0.1 0.3 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.1 0.2 GO:0015882 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
0.1 1.3 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 1.3 GO:0070233 negative regulation of T cell apoptotic process(GO:0070233)
0.0 0.9 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.4 GO:0030242 pexophagy(GO:0030242)
0.0 0.2 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.4 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.0 0.1 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.0 4.0 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 0.4 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.5 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 0.5 GO:0007603 phototransduction, visible light(GO:0007603)
0.0 1.4 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 0.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.3 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.4 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
0.0 0.4 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.5 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.1 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0 3.3 GO:0006694 steroid biosynthetic process(GO:0006694)
0.0 0.7 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.0 3.6 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 0.2 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 1.5 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.5 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.6 GO:0032757 positive regulation of interleukin-8 production(GO:0032757)
0.0 0.4 GO:0090662 ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 0.3 GO:0014002 astrocyte development(GO:0014002)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.3 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.4 1.8 GO:0071817 MMXD complex(GO:0071817)
0.3 1.3 GO:1990769 proximal neuron projection(GO:1990769)
0.2 0.6 GO:0070992 translation initiation complex(GO:0070992)
0.1 3.9 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 3.9 GO:0045095 keratin filament(GO:0045095)
0.1 0.4 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 0.9 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.3 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 1.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.4 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.2 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.4 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.7 GO:0035253 ciliary rootlet(GO:0035253)
0.0 2.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.5 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 3.5 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 4.1 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.6 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.5 GO:0042101 T cell receptor complex(GO:0042101)
0.0 5.5 GO:0005769 early endosome(GO:0005769)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 13.1 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.6 3.9 GO:0030280 structural constituent of epidermis(GO:0030280)
0.5 4.1 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.4 9.4 GO:0016805 dipeptidase activity(GO:0016805)
0.4 3.9 GO:0051870 methotrexate binding(GO:0051870)
0.4 2.5 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.3 1.4 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.3 3.3 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.2 4.3 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.2 1.8 GO:0008131 primary amine oxidase activity(GO:0008131)
0.2 0.7 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.2 1.2 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.2 1.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 4.1 GO:0031489 myosin V binding(GO:0031489)
0.1 1.5 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 1.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 0.3 GO:0004939 beta-adrenergic receptor activity(GO:0004939) beta-3 adrenergic receptor binding(GO:0031699)
0.1 0.2 GO:0008520 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.1 0.6 GO:0004875 complement receptor activity(GO:0004875)
0.1 2.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.9 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.7 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.7 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.3 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.3 GO:0098821 BMP binding(GO:0036122) BMP receptor activity(GO:0098821)
0.0 0.5 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 0.2 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.9 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 0.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.5 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.8 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.9 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.2 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 1.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 2.4 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 2.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.9 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.5 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 3.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.4 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 2.2 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.4 GO:0005249 voltage-gated potassium channel activity(GO:0005249)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.7 PID RHOA PATHWAY RhoA signaling pathway
0.0 4.3 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.3 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.5 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.5 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 4.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.4 PID AURORA B PATHWAY Aurora B signaling
0.0 3.9 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.2 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.9 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 3.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.2 4.7 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.2 4.1 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.8 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 3.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 0.5 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 2.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 0.9 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 0.9 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.8 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 1.5 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 1.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.7 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP