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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Pax8

Z-value: 0.58

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Transcription factors associated with Pax8

Gene Symbol Gene ID Gene Info
Pax8
ENSMUSG00000026976.16 Pax8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax8mm39_v1_chr2_-_24365607_24365619-0.397.7e-04Click!

Activity profile of Pax8 motif

Sorted Z-values of Pax8 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax8

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr13_-_25454058 9.50 ENSMUST00000057866.13
Nrsn1
neurensin 1
chr2_-_25471703 5.44 ENSMUST00000114217.3
ENSMUST00000191602.2
Ajm1
apical junction component 1
chr9_-_108474757 4.82 ENSMUST00000193621.2
ENSMUST00000006853.11
P4htm
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr10_+_112151245 4.22 ENSMUST00000218445.2
Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
chr1_+_149975782 3.21 ENSMUST00000035065.9
Ptgs2
prostaglandin-endoperoxide synthase 2
chr14_+_60615128 3.14 ENSMUST00000022561.9
Amer2
APC membrane recruitment 2
chr11_+_78389913 2.97 ENSMUST00000017488.5
Vtn
vitronectin
chr9_+_32027335 2.64 ENSMUST00000174641.8
Arhgap32
Rho GTPase activating protein 32
chr18_-_66993567 2.58 ENSMUST00000057942.4
Mc4r
melanocortin 4 receptor
chr2_-_73605387 2.55 ENSMUST00000166199.9
Chn1
chimerin 1
chrX_-_7439082 2.54 ENSMUST00000132788.2
Ppp1r3f
protein phosphatase 1, regulatory subunit 3F
chr11_+_24030663 2.52 ENSMUST00000118955.2
Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chr11_-_69692542 2.12 ENSMUST00000011285.11
ENSMUST00000102585.2
Fgf11
fibroblast growth factor 11
chr18_-_60743169 2.05 ENSMUST00000115318.4
Synpo
synaptopodin
chr19_+_46064302 1.96 ENSMUST00000165017.2
ENSMUST00000223741.2
ENSMUST00000225780.2
Nolc1
nucleolar and coiled-body phosphoprotein 1
chr8_+_61108574 1.83 ENSMUST00000034066.4
Mfap3l
microfibrillar-associated protein 3-like
chr9_-_103107460 1.75 ENSMUST00000165296.8
ENSMUST00000112645.8
Trf
transferrin
chr11_+_100900278 1.73 ENSMUST00000103110.10
ENSMUST00000044721.13
ENSMUST00000168757.9
Atp6v0a1
ATPase, H+ transporting, lysosomal V0 subunit A1
chr18_+_69654900 1.64 ENSMUST00000202057.4
Tcf4
transcription factor 4
chr9_-_103107495 1.61 ENSMUST00000035158.16
Trf
transferrin
chr15_+_99600475 1.60 ENSMUST00000228984.2
ENSMUST00000229845.2
Smarcd1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr17_+_21910767 1.58 ENSMUST00000072133.5
Gm10226
predicted gene 10226
chr1_+_6557455 1.50 ENSMUST00000140079.8
ENSMUST00000131494.8
St18
suppression of tumorigenicity 18
chr7_+_114367971 1.49 ENSMUST00000117543.3
ENSMUST00000151464.2
Insc
INSC spindle orientation adaptor protein
chr4_+_6191084 1.45 ENSMUST00000029907.6
Ubxn2b
UBX domain protein 2B
chr18_+_69654992 1.42 ENSMUST00000201627.4
Tcf4
transcription factor 4
chr19_+_46064409 1.34 ENSMUST00000223728.2
ENSMUST00000235620.2
Nolc1
nucleolar and coiled-body phosphoprotein 1
chr1_+_74582044 1.21 ENSMUST00000113749.8
ENSMUST00000067916.13
ENSMUST00000113747.8
ENSMUST00000113750.8
Plcd4
phospholipase C, delta 4
chr5_+_107655487 1.19 ENSMUST00000143074.2
Gm42669
predicted gene 42669
chr19_+_46064437 1.13 ENSMUST00000223683.2
Nolc1
nucleolar and coiled-body phosphoprotein 1
chr13_-_63712140 1.08 ENSMUST00000195756.6
Ptch1
patched 1
chr7_-_29605504 1.02 ENSMUST00000053521.15
Zfp27
zinc finger protein 27
chrX_+_81992467 0.80 ENSMUST00000114000.8
Dmd
dystrophin, muscular dystrophy
chr7_+_12631727 0.72 ENSMUST00000055528.11
ENSMUST00000117189.2
ENSMUST00000120809.2
ENSMUST00000119989.3
Zscan22
zinc finger and SCAN domain containing 22
chr15_+_54274151 0.65 ENSMUST00000036737.4
Colec10
collectin sub-family member 10
chr8_-_46577183 0.64 ENSMUST00000170416.8
Snx25
sorting nexin 25
chr6_-_68784692 0.48 ENSMUST00000103334.4
Igkv4-90
immunoglobulin kappa chain variable 4-90
chr13_-_62924903 0.48 ENSMUST00000167516.3
Gm5141
predicted gene 5141
chr1_+_65225886 0.46 ENSMUST00000097707.5
Pikfyve
phosphoinositide kinase, FYVE type zinc finger containing
chr12_+_71095112 0.44 ENSMUST00000135709.2
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr18_-_12254562 0.43 ENSMUST00000055447.14
ENSMUST00000209859.2
Tmem241
transmembrane protein 241
chr14_+_53220658 0.36 ENSMUST00000200548.2
Trav9d-4
T cell receptor alpha variable 9D-4
chr4_+_119397710 0.36 ENSMUST00000160219.2
Foxj3
forkhead box J3
chr2_+_128809268 0.35 ENSMUST00000110320.9
ENSMUST00000110319.3
Zc3h6
zinc finger CCCH type containing 6
chr4_-_57301475 0.35 ENSMUST00000130900.2
Ptpn3
protein tyrosine phosphatase, non-receptor type 3
chr5_-_137305895 0.33 ENSMUST00000199243.5
ENSMUST00000197466.5
ENSMUST00000040873.12
Srrt
serrate RNA effector molecule homolog (Arabidopsis)
chr4_+_156300325 0.27 ENSMUST00000105572.3
Perm1
PPARGC1 and ESRR induced regulator, muscle 1
chr6_+_127049865 0.16 ENSMUST00000000186.9
Fgf23
fibroblast growth factor 23
chr14_+_53100756 0.15 ENSMUST00000103616.5
ENSMUST00000186370.2
Trav15d-1-dv6d-1
T cell receptor alpha variable 15D-1-DV6D-1
chr14_+_50683002 0.15 ENSMUST00000214792.2
Olfr740
olfactory receptor 740
chr17_+_38106337 0.12 ENSMUST00000054748.6
Olfr123
olfactory receptor 123
chr14_+_50741057 0.11 ENSMUST00000217437.2
ENSMUST00000213935.2
Olfr742
olfactory receptor 742
chr5_-_151051000 0.08 ENSMUST00000202111.4
Stard13
StAR-related lipid transfer (START) domain containing 13
chr11_-_87788066 0.06 ENSMUST00000217095.2
ENSMUST00000215150.2
Olfr463
olfactory receptor 463
chr12_-_28632514 0.05 ENSMUST00000110917.2
ENSMUST00000020965.14
Allc
allantoicase
chr5_+_117495337 0.03 ENSMUST00000031309.16
Wsb2
WD repeat and SOCS box-containing 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
1.1 3.2 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.6 2.5 GO:1904800 regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800)
0.4 3.4 GO:0070447 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
0.4 2.1 GO:0098886 modification of dendritic spine(GO:0098886)
0.3 4.4 GO:0007000 nucleolus organization(GO:0007000)
0.3 0.8 GO:0021629 olfactory nerve morphogenesis(GO:0021627) olfactory nerve structural organization(GO:0021629)
0.2 3.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302) liver regeneration(GO:0097421)
0.2 1.1 GO:0010157 response to chlorate(GO:0010157)
0.2 2.5 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.1 2.6 GO:2000252 negative regulation of feeding behavior(GO:2000252)
0.1 1.7 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 3.1 GO:0042118 endothelial cell activation(GO:0042118)
0.1 1.4 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.1 1.6 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 1.5 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 4.8 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 2.5 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.4 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.2 GO:0010980 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0 0.6 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.3 GO:0031053 primary miRNA processing(GO:0031053)
0.0 1.5 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)
0.0 0.3 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 1.2 GO:0007340 acrosome reaction(GO:0007340)
0.0 3.1 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 0.1 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.0 0.3 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.5 GO:0032288 myelin assembly(GO:0032288)
0.0 0.1 GO:0000255 allantoin metabolic process(GO:0000255)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.0 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.3 3.4 GO:0097433 dense body(GO:0097433)
0.3 2.1 GO:0097444 spine apparatus(GO:0097444)
0.2 1.7 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 4.4 GO:0015030 Cajal body(GO:0015030)
0.1 4.2 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 1.1 GO:0044294 dendritic growth cone(GO:0044294)
0.1 1.6 GO:0071564 npBAF complex(GO:0071564)
0.0 0.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) filopodium membrane(GO:0031527) glycoprotein complex(GO:0090665)
0.0 9.5 GO:0030426 growth cone(GO:0030426)
0.0 0.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 4.6 GO:0032993 protein-DNA complex(GO:0032993)
0.0 3.2 GO:0005901 caveola(GO:0005901)
0.0 4.1 GO:0005938 cell cortex(GO:0005938)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.5 2.5 GO:2001069 glycogen binding(GO:2001069)
0.5 3.4 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.2 4.8 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.2 3.1 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 1.1 GO:0005119 smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158)
0.1 4.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 3.0 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 3.2 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 1.7 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 0.5 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 1.2 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 2.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.6 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.8 GO:0002162 dystroglycan binding(GO:0002162)
0.0 3.1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.7 GO:0005537 mannose binding(GO:0005537)
0.0 1.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 1.6 GO:0032947 protein complex scaffold(GO:0032947)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.6 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 3.2 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 1.1 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 4.4 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 2.6 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 2.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 3.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 4.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.6 PID REG GR PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.2 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 3.2 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 3.1 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 3.0 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.1 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.6 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 0.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 2.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases