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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Pbx1_Pbx3
Z-value: 1.55
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Transcription factors associated with Pbx1_Pbx3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pbx1 | mm39_v1_chr1_-_168259839_168259916 | 0.50 | 7.1e-06 | Click! |
| Pbx3 | mm39_v1_chr2_-_34261121_34261265 | 0.28 | 1.5e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Pbx1_Pbx3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_19024994 Show fit | 16.70 |
ENSMUST00000108468.5
|
reticulon 2 (Z-band associated protein) |
|
| chr2_-_76812799 Show fit | 15.11 |
ENSMUST00000011934.13
ENSMUST00000099981.10 ENSMUST00000099980.10 ENSMUST00000111882.9 ENSMUST00000140091.8 |
titin |
|
| chr13_-_93281065 Show fit | 11.30 |
ENSMUST00000062122.4
|
cardiomyopathy associated 5 |
|
| chr9_-_63619251 Show fit | 10.19 |
ENSMUST00000154323.8
|
SMAD family member 3 |
|
| chrX_+_135723531 Show fit | 9.68 |
ENSMUST00000113085.2
|
proteolipid protein (myelin) 1 |
|
| chr13_-_25454058 Show fit | 8.47 |
ENSMUST00000057866.13
|
neurensin 1 |
|
| chrX_+_135723420 Show fit | 8.28 |
ENSMUST00000033800.13
|
proteolipid protein (myelin) 1 |
|
| chr8_+_120840883 Show fit | 8.06 |
ENSMUST00000108948.8
ENSMUST00000034281.13 ENSMUST00000108951.8 |
RIKEN cDNA 6430548M08 gene |
|
| chr4_+_42949814 Show fit | 7.85 |
ENSMUST00000037872.10
ENSMUST00000098112.9 |
DnaJ heat shock protein family (Hsp40) member B5 |
|
| chr8_-_91860655 Show fit | 7.61 |
ENSMUST00000125257.3
|
AKT interacting protein |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 18.0 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 0.2 | 17.7 | GO:0065002 | intracellular protein transmembrane transport(GO:0065002) protein transmembrane transport(GO:0071806) |
| 0.3 | 16.7 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.3 | 15.7 | GO:0045022 | early endosome to late endosome transport(GO:0045022) |
| 3.0 | 15.1 | GO:0043056 | forward locomotion(GO:0043056) |
| 0.0 | 11.9 | GO:0003012 | muscle system process(GO:0003012) |
| 1.9 | 11.3 | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade(GO:0070885) |
| 0.6 | 11.3 | GO:0071374 | cellular response to parathyroid hormone stimulus(GO:0071374) |
| 3.4 | 10.2 | GO:0044413 | evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834) |
| 0.1 | 9.2 | GO:0050885 | neuromuscular process controlling balance(GO:0050885) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 19.5 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.1 | 19.5 | GO:0043209 | myelin sheath(GO:0043209) |
| 4.2 | 16.7 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.1 | 15.5 | GO:0005901 | caveola(GO:0005901) |
| 2.1 | 15.0 | GO:0070695 | FHF complex(GO:0070695) |
| 0.1 | 13.7 | GO:0016234 | inclusion body(GO:0016234) |
| 0.2 | 11.3 | GO:0043034 | costamere(GO:0043034) |
| 2.0 | 10.2 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.0 | 9.3 | GO:0030141 | secretory granule(GO:0030141) |
| 2.2 | 8.7 | GO:0099573 | glutamatergic postsynaptic density(GO:0099573) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 25.1 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 1.1 | 19.5 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 18.0 | GO:0061659 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 1.3 | 15.1 | GO:0031433 | telethonin binding(GO:0031433) |
| 0.1 | 11.5 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.2 | 10.9 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 2.0 | 10.2 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.0 | 9.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.5 | 8.7 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.3 | 8.4 | GO:0030275 | LRR domain binding(GO:0030275) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.5 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.4 | 9.3 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.2 | 8.7 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.2 | 7.4 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 7.0 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.2 | 6.8 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 6.5 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 6.4 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 5.5 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 5.3 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.1 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 11.1 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.4 | 10.2 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.2 | 8.9 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.3 | 8.7 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.1 | 8.6 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 8.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 8.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 6.2 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 5.6 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |