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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Phox2a

Z-value: 0.59

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Transcription factors associated with Phox2a

Gene Symbol Gene ID Gene Info
Phox2a
ENSMUSG00000007946.12 Phox2a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Phox2amm39_v1_chr7_+_101467512_101467529-0.019.1e-01Click!

Activity profile of Phox2a motif

Sorted Z-values of Phox2a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Phox2a

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_+_93301003 4.60 ENSMUST00000045912.3
Rptn
repetin
chr16_-_56688024 4.13 ENSMUST00000232373.2
Tmem45a
transmembrane protein 45a
chr19_-_47680528 2.95 ENSMUST00000026045.14
ENSMUST00000086923.6
Col17a1
collagen, type XVII, alpha 1
chr19_-_45224251 2.42 ENSMUST00000099401.6
Lbx1
ladybird homeobox 1
chr4_-_14621805 2.38 ENSMUST00000042221.14
Slc26a7
solute carrier family 26, member 7
chr6_+_145879839 2.26 ENSMUST00000032383.14
Sspn
sarcospan
chr5_+_13448833 2.19 ENSMUST00000137798.10
Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr1_+_172383499 2.17 ENSMUST00000061835.10
Vsig8
V-set and immunoglobulin domain containing 8
chr4_-_14621669 2.00 ENSMUST00000143105.2
Slc26a7
solute carrier family 26, member 7
chr1_-_171854818 1.89 ENSMUST00000138714.2
ENSMUST00000027837.13
ENSMUST00000111264.8
Vangl2
VANGL planar cell polarity 2
chr19_-_24178000 1.82 ENSMUST00000233658.3
Tjp2
tight junction protein 2
chr4_-_14621497 1.58 ENSMUST00000149633.2
Slc26a7
solute carrier family 26, member 7
chr6_-_147165623 1.56 ENSMUST00000052296.9
ENSMUST00000204197.2
Pthlh
parathyroid hormone-like peptide
chr2_+_36120438 1.55 ENSMUST00000062069.6
Ptgs1
prostaglandin-endoperoxide synthase 1
chr8_-_85389470 1.52 ENSMUST00000060427.6
Ier2
immediate early response 2
chr5_+_13448647 1.50 ENSMUST00000125629.8
Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr3_+_66127330 1.41 ENSMUST00000029421.6
Ptx3
pentraxin related gene
chr2_-_164080172 1.32 ENSMUST00000109374.2
Svs2
seminal vesicle secretory protein 2
chr9_+_118892497 1.30 ENSMUST00000141185.8
ENSMUST00000126251.8
ENSMUST00000136561.2
Vill
villin-like
chr13_-_103042554 1.24 ENSMUST00000171791.8
Mast4
microtubule associated serine/threonine kinase family member 4
chr1_-_144427302 1.18 ENSMUST00000184189.3
Rgs21
regulator of G-protein signalling 21
chr9_-_85631361 1.07 ENSMUST00000039213.15
Ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr2_-_168608949 1.07 ENSMUST00000075044.10
Sall4
spalt like transcription factor 4
chrX_+_159551171 0.98 ENSMUST00000112368.3
Rs1
retinoschisis (X-linked, juvenile) 1 (human)
chr2_-_168609110 0.95 ENSMUST00000029061.12
ENSMUST00000103074.2
Sall4
spalt like transcription factor 4
chr4_+_134658209 0.92 ENSMUST00000030622.3
Syf2
SYF2 homolog, RNA splicing factor (S. cerevisiae)
chr4_+_138606671 0.91 ENSMUST00000105804.2
Pla2g2e
phospholipase A2, group IIE
chrX_+_159551009 0.89 ENSMUST00000033650.14
Rs1
retinoschisis (X-linked, juvenile) 1 (human)
chr2_-_89855921 0.82 ENSMUST00000216616.3
Olfr1264
olfactory receptor 1264
chr13_-_103042294 0.81 ENSMUST00000167462.8
Mast4
microtubule associated serine/threonine kinase family member 4
chr7_-_101486983 0.78 ENSMUST00000185929.2
ENSMUST00000165052.8
Inppl1
inositol polyphosphate phosphatase-like 1
chr2_-_111843053 0.68 ENSMUST00000213559.3
Olfr1310
olfactory receptor 1310
chrX_+_9751861 0.67 ENSMUST00000067529.9
ENSMUST00000086165.4
Sytl5
synaptotagmin-like 5
chr2_-_111820618 0.66 ENSMUST00000216948.2
ENSMUST00000214935.2
ENSMUST00000217452.2
ENSMUST00000215045.2
Olfr1309
olfactory receptor 1309
chr7_-_44752508 0.40 ENSMUST00000209830.2
Fcgrt
Fc fragment of IgG receptor and transporter
chr10_-_129000620 0.39 ENSMUST00000214271.2
Olfr771
olfactory receptor 771
chr3_-_72875187 0.38 ENSMUST00000167334.8
Sis
sucrase isomaltase (alpha-glucosidase)
chr4_-_43710231 0.37 ENSMUST00000217544.2
ENSMUST00000107862.3
Olfr71
olfactory receptor 71
chr2_-_168607166 0.36 ENSMUST00000137536.2
Sall4
spalt like transcription factor 4
chr13_-_22289994 0.35 ENSMUST00000227357.2
ENSMUST00000228428.2
Vmn1r189
vomeronasal 1 receptor 189
chr2_+_89642395 0.34 ENSMUST00000214508.2
Olfr1255
olfactory receptor 1255
chr11_+_116734104 0.33 ENSMUST00000106370.10
Mettl23
methyltransferase like 23
chr14_+_65612788 0.29 ENSMUST00000224687.2
Zfp395
zinc finger protein 395
chr2_-_164427367 0.28 ENSMUST00000109342.2
Wfdc6a
WAP four-disulfide core domain 6A
chr17_-_37430949 0.27 ENSMUST00000214994.2
ENSMUST00000216341.2
Olfr92
olfactory receptor 92
chr2_-_27365633 0.23 ENSMUST00000138693.8
ENSMUST00000113941.9
ENSMUST00000077737.13
Brd3
bromodomain containing 3
chr1_+_173924457 0.21 ENSMUST00000213832.2
Olfr427
olfactory receptor 427
chr14_+_26722319 0.19 ENSMUST00000035433.10
Hesx1
homeobox gene expressed in ES cells
chr8_-_3675024 0.18 ENSMUST00000133459.8
Pcp2
Purkinje cell protein 2 (L7)
chr5_-_34817412 0.14 ENSMUST00000041364.13
Nop14
NOP14 nucleolar protein
chr7_-_44753168 0.14 ENSMUST00000211085.2
ENSMUST00000210642.2
ENSMUST00000003512.9
Fcgrt
Fc fragment of IgG receptor and transporter
chr10_-_129965752 0.12 ENSMUST00000215217.2
ENSMUST00000214192.2
Olfr824
olfactory receptor 824
chr6_+_37847721 0.11 ENSMUST00000031859.14
ENSMUST00000120428.8
Trim24
tripartite motif-containing 24
chr19_-_41921676 0.08 ENSMUST00000075280.12
ENSMUST00000112123.4
Exosc1
exosome component 1
chr17_-_37511885 0.08 ENSMUST00000222190.2
Olfr94
olfactory receptor 94
chr15_+_98350469 0.07 ENSMUST00000217517.2
Olfr281
olfactory receptor 281
chr10_-_53252210 0.05 ENSMUST00000095691.7
Cep85l
centrosomal protein 85-like
chr19_+_12364643 0.05 ENSMUST00000217062.3
ENSMUST00000216145.2
ENSMUST00000213657.2
Olfr1440
olfactory receptor 1440
chr12_+_30934320 0.01 ENSMUST00000067087.7
Alkal2
ALK and LTK ligand 2
chr6_-_30936013 0.00 ENSMUST00000101589.5
Klf14
Kruppel-like factor 14

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.7 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.7 6.0 GO:0019532 oxalate transport(GO:0019532)
0.6 1.9 GO:0060448 dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.5 1.6 GO:0060618 nipple development(GO:0060618)
0.5 1.4 GO:0052422 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.5 1.9 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.3 1.8 GO:2001205 negative regulation of osteoclast development(GO:2001205)
0.2 1.6 GO:0035633 cyclooxygenase pathway(GO:0019371) maintenance of blood-brain barrier(GO:0035633)
0.2 2.4 GO:0048664 neuron fate determination(GO:0048664)
0.1 2.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.8 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 0.3 GO:1901317 regulation of sperm motility(GO:1901317)
0.0 0.9 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
0.0 1.3 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.9 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.2 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
0.0 0.2 GO:0030916 otic vesicle formation(GO:0030916)
0.0 1.3 GO:0051693 actin filament capping(GO:0051693)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 1.5 GO:0071774 response to fibroblast growth factor(GO:0071774)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0060187 cell pole(GO:0060187)
0.1 2.9 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.9 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 2.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 3.6 GO:0001533 cornified envelope(GO:0001533)
0.0 1.8 GO:0005921 gap junction(GO:0005921)
0.0 0.1 GO:0030689 Noc complex(GO:0030689)
0.0 6.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 2.4 GO:0000792 heterochromatin(GO:0000792)
0.0 1.6 GO:0001750 photoreceptor outer segment(GO:0001750)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.0 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.2 3.7 GO:0038191 neuropilin binding(GO:0038191)
0.2 1.4 GO:0001849 complement component C1q binding(GO:0001849)
0.2 1.9 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 1.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.4 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.1 0.5 GO:0019770 IgG receptor activity(GO:0019770)
0.0 1.6 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.8 GO:0046030 inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030)
0.0 0.9 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 1.6 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.9 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.6 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.4 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.8 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 3.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.4 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.1 PID BCR 5PATHWAY BCR signaling pathway
0.0 4.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.8 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 0.9 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 2.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 6.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.2 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.8 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 1.6 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)