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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Pou5f1
Z-value: 2.94
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Transcription factors associated with Pou5f1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pou5f1 | mm39_v1_chr17_+_35816915_35816968 | -0.28 | 1.6e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Pou5f1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_121888520 Show fit | 27.00 |
ENSMUST00000064989.12
ENSMUST00000064921.5 |
protein kinase C, beta |
|
| chr6_+_68247469 Show fit | 23.72 |
ENSMUST00000103321.3
|
immunoglobulin kappa variable 1-110 |
|
| chr6_-_70237939 Show fit | 22.69 |
ENSMUST00000103386.3
|
immunoglobulin kappa variable 6-23 |
|
| chr12_-_114252202 Show fit | 22.20 |
ENSMUST00000195124.6
ENSMUST00000103481.3 |
immunoglobulin heavy variable 3-6 |
|
| chr6_-_68713748 Show fit | 21.73 |
ENSMUST00000183936.2
ENSMUST00000196863.2 |
immunoglobulin kappa chain variable 19-93 |
|
| chr6_-_70292451 Show fit | 21.32 |
ENSMUST00000103387.3
|
immunoglobulin kappa variable 8-21 |
|
| chr6_+_70348416 Show fit | 21.15 |
ENSMUST00000103391.4
|
immunoglobulin kappa variable 6-17 |
|
| chr6_-_70383976 Show fit | 20.98 |
ENSMUST00000103393.2
|
immunoglobulin kappa variable 6-15 |
|
| chr6_+_67586695 Show fit | 20.87 |
ENSMUST00000103303.3
|
immunoglobulin kappa variable 1-135 |
|
| chr6_-_70194405 Show fit | 20.78 |
ENSMUST00000103384.2
|
immunoglobulin kappa chain variable 8-24 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 512.4 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 3.4 | 509.6 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 3.0 | 33.1 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 0.4 | 25.2 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 7.6 | 22.9 | GO:1903045 | neural crest cell migration involved in sympathetic nervous system development(GO:1903045) |
| 2.6 | 21.1 | GO:0002432 | granuloma formation(GO:0002432) |
| 0.4 | 21.0 | GO:0001919 | regulation of receptor recycling(GO:0001919) |
| 0.7 | 18.5 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 3.4 | 17.2 | GO:0043309 | regulation of eosinophil degranulation(GO:0043309) |
| 2.3 | 16.1 | GO:0010519 | negative regulation of phospholipase activity(GO:0010519) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 509.6 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.2 | 391.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 27.0 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 25.6 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.1 | 24.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.5 | 24.0 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 2.1 | 21.1 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.2 | 18.8 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.2 | 17.6 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.1 | 16.8 | GO:0032993 | protein-DNA complex(GO:0032993) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 509.6 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.3 | 34.8 | GO:0003823 | antigen binding(GO:0003823) |
| 0.6 | 33.0 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.9 | 28.3 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 2.5 | 27.0 | GO:0035184 | histone threonine kinase activity(GO:0035184) |
| 1.2 | 26.2 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 24.8 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 22.1 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 21.1 | GO:0003779 | actin binding(GO:0003779) |
| 2.6 | 21.0 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 36.1 | PID BCR 5PATHWAY | BCR signaling pathway |
| 2.1 | 35.4 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 22.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.8 | 22.1 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.6 | 21.5 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.2 | 17.4 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.2 | 14.9 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.2 | 12.0 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.1 | 11.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 11.4 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 48.5 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 2.0 | 48.0 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.5 | 37.0 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 1.0 | 24.3 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.4 | 16.9 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.6 | 14.9 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 13.7 | REACTOME SIGNALING BY ILS | Genes involved in Signaling by Interleukins |
| 0.2 | 13.0 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.4 | 12.8 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.2 | 12.6 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |