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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Pparg_Rxrg
Z-value: 3.50
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Transcription factors associated with Pparg_Rxrg
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rxrg | mm39_v1_chr1_+_167425953_167425978 | -0.11 | 3.5e-01 | Click! |
| Pparg | mm39_v1_chr6_+_115339303_115339321 | -0.09 | 4.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Pparg_Rxrg
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 155.4 | GO:0019369 | arachidonic acid metabolic process(GO:0019369) |
| 4.8 | 150.0 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 6.2 | 142.5 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 25.9 | 103.7 | GO:0010982 | regulation of high-density lipoprotein particle clearance(GO:0010982) |
| 2.8 | 70.7 | GO:0080184 | response to phenylpropanoid(GO:0080184) |
| 17.5 | 52.5 | GO:0042450 | arginine biosynthetic process via ornithine(GO:0042450) |
| 17.4 | 52.3 | GO:0006553 | lysine metabolic process(GO:0006553) |
| 12.3 | 49.2 | GO:0061402 | positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402) |
| 12.2 | 49.0 | GO:0090341 | negative regulation of secretion of lysosomal enzymes(GO:0090341) |
| 5.3 | 48.0 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 263.7 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 172.3 | GO:0005615 | extracellular space(GO:0005615) |
| 11.7 | 128.7 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.1 | 124.1 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.8 | 116.8 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.4 | 73.5 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.4 | 70.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 7.5 | 67.6 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 1.0 | 66.9 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 16.2 | 64.7 | GO:0017133 | mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.4 | 242.3 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 30.3 | 121.2 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.4 | 84.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 2.1 | 61.6 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 3.1 | 58.5 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 3.0 | 53.7 | GO:0008430 | selenium binding(GO:0008430) |
| 8.7 | 52.3 | GO:0016647 | oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647) |
| 8.2 | 49.0 | GO:0032810 | sterol response element binding(GO:0032810) |
| 2.3 | 48.2 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 2.8 | 48.0 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 183.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.4 | 104.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.2 | 67.5 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.6 | 29.8 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.2 | 25.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.5 | 19.8 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 17.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.4 | 17.0 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.5 | 15.5 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.2 | 14.3 | PID LKB1 PATHWAY | LKB1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 188.7 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.8 | 164.4 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 6.1 | 103.8 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 5.2 | 89.2 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.8 | 84.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 3.4 | 79.2 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 4.6 | 74.3 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 1.0 | 73.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.9 | 72.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 1.3 | 64.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |