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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Rest

Z-value: 5.52

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Transcription factors associated with Rest

Gene Symbol Gene ID Gene Info
Rest
ENSMUSG00000029249.16 Rest

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Restmm39_v1_chr5_+_77413282_77413396-0.562.6e-07Click!

Activity profile of Rest motif

Sorted Z-values of Rest motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Rest

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr16_-_23709564 153.24 ENSMUST00000004480.5
Sst
somatostatin
chr6_-_121450547 107.44 ENSMUST00000046373.8
ENSMUST00000151397.3
Iqsec3
IQ motif and Sec7 domain 3
chr19_+_42244143 106.95 ENSMUST00000087123.6
Golga7b
golgi autoantigen, golgin subfamily a, 7B
chr2_-_180956293 106.13 ENSMUST00000103045.4
Stmn3
stathmin-like 3
chrX_+_7504913 96.44 ENSMUST00000128890.2
Syp
synaptophysin
chr5_-_121148143 84.94 ENSMUST00000202406.4
ENSMUST00000200792.2
Rph3a
rabphilin 3A
chr3_-_80710097 79.73 ENSMUST00000075316.10
ENSMUST00000107745.8
Gria2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
chr18_-_31580436 79.02 ENSMUST00000025110.5
Syt4
synaptotagmin IV
chr12_-_70394074 77.61 ENSMUST00000223160.2
ENSMUST00000222316.2
ENSMUST00000167755.3
ENSMUST00000110520.10
ENSMUST00000110522.10
ENSMUST00000221041.2
ENSMUST00000222603.3
Trim9
tripartite motif-containing 9
chr5_-_121147593 76.06 ENSMUST00000079204.9
Rph3a
rabphilin 3A
chr2_+_132623198 76.05 ENSMUST00000028826.4
Chgb
chromogranin B
chr2_-_25209107 74.45 ENSMUST00000114318.10
ENSMUST00000114310.10
ENSMUST00000114308.10
ENSMUST00000114317.10
ENSMUST00000028335.13
ENSMUST00000114314.10
ENSMUST00000114307.8
Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
chr4_-_129015027 72.53 ENSMUST00000030572.10
Hpca
hippocalcin
chr5_+_137059127 71.11 ENSMUST00000041543.9
ENSMUST00000186451.2
Vgf
VGF nerve growth factor inducible
chr2_+_22512195 69.79 ENSMUST00000028123.4
Gad2
glutamic acid decarboxylase 2
chr12_-_112477536 68.63 ENSMUST00000066791.7
Tmem179
transmembrane protein 179
chrX_-_20787150 66.41 ENSMUST00000081893.7
ENSMUST00000115345.8
Syn1
synapsin I
chr1_+_159351337 65.93 ENSMUST00000192069.6
Tnr
tenascin R
chr7_-_81143412 65.82 ENSMUST00000238438.2
ENSMUST00000238711.2
Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr1_-_84673903 62.69 ENSMUST00000049126.13
Dner
delta/notch-like EGF repeat containing
chr2_-_27032441 62.27 ENSMUST00000151224.3
Fam163b
family with sequence similarity 163, member B
chr11_-_35689711 62.26 ENSMUST00000160726.4
Fbll1
fibrillarin-like 1
chr11_+_102284229 61.29 ENSMUST00000107105.9
ENSMUST00000107102.8
ENSMUST00000107103.8
ENSMUST00000006750.8
Rundc3a
RUN domain containing 3A
chr13_-_100037149 59.84 ENSMUST00000022150.8
Cartpt
CART prepropeptide
chr2_+_164810139 59.08 ENSMUST00000202479.4
Slc12a5
solute carrier family 12, member 5
chr7_+_27353331 59.04 ENSMUST00000008088.9
Ttc9b
tetratricopeptide repeat domain 9B
chr10_+_5589210 58.70 ENSMUST00000019906.6
Vip
vasoactive intestinal polypeptide
chr1_-_124773767 58.40 ENSMUST00000239072.2
Dpp10
dipeptidylpeptidase 10
chr7_-_81143631 57.86 ENSMUST00000082090.15
Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr12_+_102521225 57.73 ENSMUST00000021610.7
Chga
chromogranin A
chr1_-_175319842 57.19 ENSMUST00000195324.6
ENSMUST00000192227.6
ENSMUST00000194555.6
Rgs7
regulator of G protein signaling 7
chr11_+_80367839 54.77 ENSMUST00000053413.12
ENSMUST00000147694.2
Cdk5r1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr2_-_179746227 54.74 ENSMUST00000056480.10
Hrh3
histamine receptor H3
chr15_-_76406102 54.57 ENSMUST00000164703.2
Scrt1
scratch family zinc finger 1
chr7_+_51271742 52.31 ENSMUST00000032710.7
Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr13_-_54897425 52.00 ENSMUST00000099506.2
Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr3_+_94385602 50.55 ENSMUST00000199884.5
ENSMUST00000198316.5
ENSMUST00000197558.5
Celf3
CUGBP, Elav-like family member 3
chr13_-_54897660 49.97 ENSMUST00000135343.2
Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr17_-_91400499 49.04 ENSMUST00000160844.10
Nrxn1
neurexin I
chr11_+_77821626 48.94 ENSMUST00000093995.10
ENSMUST00000000646.14
Sez6
seizure related gene 6
chr4_+_15881256 48.60 ENSMUST00000029876.2
Calb1
calbindin 1
chr6_+_113259262 47.47 ENSMUST00000041203.6
Cpne9
copine family member IX
chr5_+_137059522 46.78 ENSMUST00000187382.2
Vgf
VGF nerve growth factor inducible
chr7_+_122270599 46.77 ENSMUST00000182563.2
Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr2_-_25209199 46.14 ENSMUST00000114312.2
Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
chr7_+_122270623 44.30 ENSMUST00000182095.2
Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr19_+_22116392 44.06 ENSMUST00000237357.2
ENSMUST00000237820.2
ENSMUST00000236312.2
ENSMUST00000074770.13
ENSMUST00000087576.12
Trpm3
transient receptor potential cation channel, subfamily M, member 3
chr13_-_105191403 43.55 ENSMUST00000063551.7
Rgs7bp
regulator of G-protein signalling 7 binding protein
chr9_-_57375269 41.92 ENSMUST00000215059.2
ENSMUST00000046587.8
ENSMUST00000214256.2
Scamp5
secretory carrier membrane protein 5
chr15_-_76406602 41.82 ENSMUST00000096365.5
Scrt1
scratch family zinc finger 1
chr3_+_94385661 41.80 ENSMUST00000200342.5
Celf3
CUGBP, Elav-like family member 3
chr1_+_34618738 41.40 ENSMUST00000052670.11
Amer3
APC membrane recruitment 3
chr6_+_8948608 41.01 ENSMUST00000160300.2
Nxph1
neurexophilin 1
chr4_+_101407608 40.90 ENSMUST00000094953.11
ENSMUST00000106933.2
Dnajc6
DnaJ heat shock protein family (Hsp40) member C6
chr16_-_37205277 40.04 ENSMUST00000114787.8
ENSMUST00000114782.8
ENSMUST00000114775.8
Stxbp5l
syntaxin binding protein 5-like
chr12_-_84745388 39.99 ENSMUST00000221905.2
ENSMUST00000222422.2
ENSMUST00000095550.4
Syndig1l
synapse differentiation inducing 1 like
chr7_-_27095964 39.84 ENSMUST00000108363.8
Sptbn4
spectrin beta, non-erythrocytic 4
chr12_+_102915709 39.78 ENSMUST00000179002.8
Unc79
unc-79 homolog
chr3_+_114697710 39.65 ENSMUST00000081752.13
Olfm3
olfactomedin 3
chr9_+_104446682 38.93 ENSMUST00000057742.15
Cpne4
copine IV
chr7_+_63094489 38.60 ENSMUST00000058476.14
Otud7a
OTU domain containing 7A
chr2_-_92231598 38.16 ENSMUST00000050312.3
Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr13_+_54519161 37.68 ENSMUST00000026985.9
Cplx2
complexin 2
chr9_+_104446957 37.32 ENSMUST00000077190.7
Cpne4
copine IV
chr12_-_70394272 37.02 ENSMUST00000221370.2
Trim9
tripartite motif-containing 9
chr12_+_119909692 36.34 ENSMUST00000058644.15
Tmem196
transmembrane protein 196
chr15_-_76606361 36.29 ENSMUST00000049956.5
Lrrc24
leucine rich repeat containing 24
chr16_-_37205302 36.04 ENSMUST00000114781.8
ENSMUST00000114780.8
Stxbp5l
syntaxin binding protein 5-like
chr14_+_32043944 35.82 ENSMUST00000022480.8
ENSMUST00000228529.2
Ogdhl
oxoglutarate dehydrogenase-like
chr17_-_91400142 35.55 ENSMUST00000160800.9
Nrxn1
neurexin I
chr17_+_69746321 35.25 ENSMUST00000169935.2
Akain1
A kinase (PRKA) anchor inhibitor 1
chr11_-_3724706 34.42 ENSMUST00000155197.2
Osbp2
oxysterol binding protein 2
chr8_+_56393488 34.35 ENSMUST00000000275.10
Glra3
glycine receptor, alpha 3 subunit
chrX_-_72913410 34.29 ENSMUST00000066576.12
ENSMUST00000114430.8
L1cam
L1 cell adhesion molecule
chr5_-_116729870 32.57 ENSMUST00000076124.7
Srrm4
serine/arginine repetitive matrix 4
chr11_+_74510413 31.71 ENSMUST00000100866.3
Ccdc92b
coiled-coil domain containing 92B
chr1_+_70764874 31.27 ENSMUST00000053922.12
ENSMUST00000161937.2
ENSMUST00000162182.2
Vwc2l
von Willebrand factor C domain-containing protein 2-like
chr3_-_89671888 30.55 ENSMUST00000200558.5
ENSMUST00000029562.5
Chrnb2
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
chr9_+_40180497 30.50 ENSMUST00000049941.12
Scn3b
sodium channel, voltage-gated, type III, beta
chr5_+_28047147 30.42 ENSMUST00000036227.7
Htr5a
5-hydroxytryptamine (serotonin) receptor 5A
chr9_+_40180726 29.55 ENSMUST00000171835.9
Scn3b
sodium channel, voltage-gated, type III, beta
chr9_+_40180569 29.48 ENSMUST00000176185.8
Scn3b
sodium channel, voltage-gated, type III, beta
chr16_-_90808196 24.79 ENSMUST00000121759.8
Synj1
synaptojanin 1
chr16_-_17394495 23.67 ENSMUST00000231645.2
ENSMUST00000232226.2
ENSMUST00000232336.2
ENSMUST00000232385.2
ENSMUST00000231615.2
ENSMUST00000231283.2
ENSMUST00000172164.10
Slc7a4
solute carrier family 7 (cationic amino acid transporter, y+ system), member 4
chr1_-_192718064 23.15 ENSMUST00000215093.2
ENSMUST00000195354.6
Syt14
synaptotagmin XIV
chr4_-_153567221 22.27 ENSMUST00000105646.3
Ajap1
adherens junction associated protein 1
chr2_+_155617251 19.75 ENSMUST00000029141.6
Mmp24
matrix metallopeptidase 24
chr10_-_40948275 19.71 ENSMUST00000061796.8
Gpr6
G protein-coupled receptor 6
chr9_+_59485475 19.41 ENSMUST00000118549.8
ENSMUST00000034840.10
Celf6
CUGBP, Elav-like family member 6
chr17_+_6307123 18.60 ENSMUST00000232383.2
Tmem181a
transmembrane protein 181A
chr17_+_28794615 17.98 ENSMUST00000232862.2
ENSMUST00000080780.8
Lhfpl5
lipoma HMGIC fusion partner-like 5
chr15_-_11038077 15.52 ENSMUST00000058007.7
Rxfp3
relaxin family peptide receptor 3
chr17_-_23959334 15.15 ENSMUST00000024702.5
Paqr4
progestin and adipoQ receptor family member IV
chr4_+_12906838 13.87 ENSMUST00000143186.8
ENSMUST00000183345.2
Triqk
triple QxxK/R motif containing
chr2_+_157298836 12.48 ENSMUST00000109529.2
Src
Rous sarcoma oncogene
chr1_-_192717958 11.87 ENSMUST00000016344.9
Syt14
synaptotagmin XIV
chr6_-_134864731 11.38 ENSMUST00000203762.4
ENSMUST00000215088.2
ENSMUST00000066107.10
Gpr19
G protein-coupled receptor 19
chr10_-_128505096 11.29 ENSMUST00000238610.2
ENSMUST00000238712.2
Ikzf4
IKAROS family zinc finger 4
chr10_+_6738809 10.83 ENSMUST00000105602.8
ENSMUST00000078634.12
ENSMUST00000000783.13
ENSMUST00000092731.11
ENSMUST00000154906.8
ENSMUST00000105605.8
ENSMUST00000135502.8
ENSMUST00000052751.14
ENSMUST00000105611.8
ENSMUST00000105603.2
ENSMUST00000105604.8
Oprm1
opioid receptor, mu 1
chr7_-_3619132 10.34 ENSMUST00000039507.15
ENSMUST00000108645.8
ENSMUST00000148012.2
Oscar
osteoclast associated receptor
chr10_+_6738575 10.06 ENSMUST00000152674.2
Oprm1
opioid receptor, mu 1
chr1_+_81054992 7.98 ENSMUST00000068275.12
ENSMUST00000113494.9
Nyap2
neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
chr16_-_17394080 7.85 ENSMUST00000231552.2
Slc7a4
solute carrier family 7 (cationic amino acid transporter, y+ system), member 4
chr13_-_24175141 6.33 ENSMUST00000021770.8
Scgn
secretagogin, EF-hand calcium binding protein
chr7_-_28209880 5.59 ENSMUST00000081684.3
Ifnl2
interferon lambda 2
chr8_+_18896267 5.57 ENSMUST00000149565.8
ENSMUST00000033847.5
Agpat5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr7_+_28222261 5.30 ENSMUST00000078364.4
Ifnl3
interferon lambda 3
chr11_-_87811788 4.55 ENSMUST00000216461.2
ENSMUST00000217112.2
Olfr464
olfactory receptor 464
chr9_-_121620150 4.06 ENSMUST00000215910.2
ENSMUST00000215477.2
ENSMUST00000163981.3
Hhatl
hedgehog acyltransferase-like
chr13_-_57043550 3.94 ENSMUST00000022023.13
ENSMUST00000174457.9
ENSMUST00000109871.8
Trpc7
transient receptor potential cation channel, subfamily C, member 7
chr19_+_5088854 3.49 ENSMUST00000053705.8
ENSMUST00000235776.2
B4gat1
beta-1,4-glucuronyltransferase 1
chr7_+_28455563 3.22 ENSMUST00000178767.3
Ccer2
coiled-coil glutamate-rich protein 2
chr1_+_81054921 2.73 ENSMUST00000123720.8
Nyap2
neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
chr17_+_28794727 2.65 ENSMUST00000232974.2
Lhfpl5
lipoma HMGIC fusion partner-like 5

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
43.8 175.4 GO:0021586 pons maturation(GO:0021586)
38.2 114.6 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
32.1 96.4 GO:2000474 regulation of opioid receptor signaling pathway(GO:2000474)
24.2 72.5 GO:0031283 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
20.8 62.3 GO:0033967 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
19.7 59.1 GO:0040040 thermosensory behavior(GO:0040040)
14.4 57.7 GO:2000705 positive regulation of relaxation of muscle(GO:1901079) regulation of dense core granule biogenesis(GO:2000705)
14.1 84.6 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
14.0 125.8 GO:0051971 positive regulation of transmission of nerve impulse(GO:0051971)
14.0 69.8 GO:0006538 glutamate catabolic process(GO:0006538)
12.1 48.6 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
10.9 54.7 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
10.6 106.1 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
10.4 20.9 GO:0071315 cellular response to morphine(GO:0071315)
10.2 30.5 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
10.1 30.4 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
9.3 176.6 GO:0043084 penile erection(GO:0043084)
8.9 106.9 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
8.8 79.0 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
8.3 24.8 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
7.5 89.5 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
7.4 22.3 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
6.4 38.6 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
5.7 34.4 GO:0072318 clathrin coat disassembly(GO:0072318)
5.5 38.2 GO:0007258 JUN phosphorylation(GO:0007258)
5.2 52.3 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
4.9 123.7 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
4.2 12.5 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
4.0 39.8 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
3.4 34.4 GO:0097688 glutamate receptor clustering(GO:0097688)
3.2 61.3 GO:0030828 positive regulation of cGMP biosynthetic process(GO:0030828)
3.2 161.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
3.0 66.4 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
3.0 62.7 GO:0007220 Notch receptor processing(GO:0007220)
3.0 92.4 GO:0030575 nuclear body organization(GO:0030575)
2.9 107.4 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
2.7 37.7 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
2.7 18.6 GO:0009405 pathogenesis(GO:0009405)
2.5 39.8 GO:0048149 behavioral response to ethanol(GO:0048149)
2.5 19.7 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
2.4 34.3 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
2.3 91.1 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
2.3 79.7 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
1.7 47.5 GO:1903861 positive regulation of dendrite extension(GO:1903861)
1.4 48.9 GO:0060074 synapse maturation(GO:0060074)
1.4 4.1 GO:0006500 N-terminal protein palmitoylation(GO:0006500)
1.3 96.4 GO:2001222 regulation of neuron migration(GO:2001222)
1.1 33.9 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
1.1 76.1 GO:0046676 negative regulation of insulin secretion(GO:0046676)
1.0 19.7 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.9 35.8 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.8 35.3 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.8 19.4 GO:0071625 vocalization behavior(GO:0071625)
0.8 58.4 GO:1903078 positive regulation of protein localization to plasma membrane(GO:1903078)
0.7 20.6 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910) auditory receptor cell stereocilium organization(GO:0060088)
0.7 39.7 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.6 31.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.4 15.5 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.4 32.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.4 31.3 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.4 36.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.4 53.2 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.3 3.5 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.2 35.0 GO:0006906 vesicle fusion(GO:0006906)
0.2 5.6 GO:0002385 organ or tissue specific immune response(GO:0002251) mucosal immune response(GO:0002385)
0.1 3.9 GO:0006828 manganese ion transport(GO:0006828)
0.1 128.9 GO:0030334 regulation of cell migration(GO:0030334)
0.1 28.6 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
0.1 10.7 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.1 6.7 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 34.4 GO:0006869 lipid transport(GO:0006869)
0.1 73.1 GO:0031175 neuron projection development(GO:0031175)
0.1 11.3 GO:0051291 protein heterooligomerization(GO:0051291)
0.1 5.6 GO:0006639 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639)
0.0 32.5 GO:0009968 negative regulation of signal transduction(GO:0009968)
0.0 6.3 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.0 5.3 GO:0097696 JAK-STAT cascade(GO:0007259) STAT cascade(GO:0097696)
0.0 15.6 GO:0006812 cation transport(GO:0006812)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
24.1 120.6 GO:0044307 dendritic branch(GO:0044307)
16.5 65.9 GO:0072534 perineuronal net(GO:0072534)
13.7 54.8 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
12.7 38.2 GO:0044302 dentate gyrus mossy fiber(GO:0044302)
9.6 57.7 GO:0042583 chromaffin granule(GO:0042583)
7.7 123.7 GO:0030123 AP-3 adaptor complex(GO:0030123)
7.5 37.7 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
7.1 106.9 GO:0002178 palmitoyltransferase complex(GO:0002178)
6.9 62.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
6.0 525.7 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
5.0 39.8 GO:0008091 spectrin(GO:0008091)
4.8 72.5 GO:0044327 dendritic spine head(GO:0044327)
4.6 79.0 GO:0031045 dense core granule(GO:0031045)
4.5 84.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
4.2 91.5 GO:0044292 dendrite terminus(GO:0044292)
3.6 35.8 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
3.4 89.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
3.3 162.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
2.6 99.4 GO:0060077 inhibitory synapse(GO:0060077)
2.2 22.3 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
2.0 80.0 GO:0032590 dendrite membrane(GO:0032590)
1.7 83.4 GO:0097440 apical dendrite(GO:0097440)
1.4 30.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
1.3 117.9 GO:0030667 secretory granule membrane(GO:0030667)
1.3 48.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.8 20.6 GO:0032426 stereocilium tip(GO:0032426)
0.8 24.8 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.7 108.1 GO:0008021 synaptic vesicle(GO:0008021)
0.5 48.6 GO:0043195 terminal bouton(GO:0043195)
0.5 34.4 GO:0034707 chloride channel complex(GO:0034707)
0.5 58.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.4 135.9 GO:0030141 secretory granule(GO:0030141)
0.4 300.3 GO:0043025 neuronal cell body(GO:0043025)
0.3 12.5 GO:0002102 podosome(GO:0002102)
0.2 54.7 GO:0043209 myelin sheath(GO:0043209)
0.2 200.0 GO:0016604 nuclear body(GO:0016604)
0.2 40.9 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.2 104.8 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 232.5 GO:0016021 integral component of membrane(GO:0016021)
0.1 6.3 GO:0045202 synapse(GO:0045202)
0.0 86.4 GO:0070062 extracellular exosome(GO:0070062)
0.0 251.0 GO:0005886 plasma membrane(GO:0005886)
0.0 42.9 GO:0005576 extracellular region(GO:0005576)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
26.3 79.0 GO:0030348 syntaxin-3 binding(GO:0030348)
20.8 62.3 GO:1990259 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
15.1 120.6 GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
13.3 79.7 GO:0015277 AMPA glutamate receptor activity(GO:0004971) kainate selective glutamate receptor activity(GO:0015277)
11.2 89.5 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
10.2 61.3 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
10.1 161.0 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
10.0 69.8 GO:0004351 glutamate decarboxylase activity(GO:0004351)
7.8 54.7 GO:0004969 histamine receptor activity(GO:0004969)
7.7 92.4 GO:0097322 7SK snRNA binding(GO:0097322)
6.1 48.6 GO:0005499 vitamin D binding(GO:0005499)
6.0 84.6 GO:0097109 neuroligin family protein binding(GO:0097109)
5.4 59.1 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
5.1 35.8 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
5.1 177.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
5.0 24.8 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
4.5 134.1 GO:0017075 syntaxin-1 binding(GO:0017075)
3.8 26.3 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
3.7 65.9 GO:0046625 sphingolipid binding(GO:0046625)
3.2 106.9 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
3.1 34.3 GO:0033691 sialic acid binding(GO:0033691)
3.1 58.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
3.0 78.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)
2.6 15.5 GO:0004966 galanin receptor activity(GO:0004966)
2.6 107.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
2.2 52.3 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
2.2 30.4 GO:0051378 serotonin binding(GO:0051378)
2.1 38.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
1.8 197.9 GO:0005179 hormone activity(GO:0005179)
1.7 62.7 GO:0005112 Notch binding(GO:0005112)
1.7 54.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
1.5 30.5 GO:0042166 acetylcholine binding(GO:0042166)
1.5 225.7 GO:0000149 SNARE binding(GO:0000149)
1.4 91.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
1.4 38.6 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
1.3 19.7 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
1.1 35.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
1.0 18.6 GO:0015643 toxic substance binding(GO:0015643)
1.0 12.5 GO:0071253 connexin binding(GO:0071253)
0.8 31.8 GO:0030506 ankyrin binding(GO:0030506)
0.7 66.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.5 102.0 GO:0051219 phosphoprotein binding(GO:0051219)
0.5 41.4 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.5 3.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.4 34.4 GO:0015485 cholesterol binding(GO:0015485)
0.3 103.3 GO:0008022 protein C-terminus binding(GO:0008022)
0.3 40.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 11.3 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.2 5.6 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2 22.3 GO:0008013 beta-catenin binding(GO:0008013)
0.2 19.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 54.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 44.1 GO:0005261 cation channel activity(GO:0005261)
0.1 72.5 GO:0003779 actin binding(GO:0003779)
0.1 11.2 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.1 32.6 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 3.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 17.1 GO:0003723 RNA binding(GO:0003723)
0.0 182.6 GO:0005515 protein binding(GO:0005515)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 92.9 PID REELIN PATHWAY Reelin signaling pathway
1.4 79.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.7 12.5 ST STAT3 PATHWAY STAT3 Pathway
0.5 62.7 PID NOTCH PATHWAY Notch signaling pathway
0.5 34.3 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.4 89.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.4 24.8 PID EPHB FWD PATHWAY EPHB forward signaling
0.3 65.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 20.9 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 19.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 6.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 200.3 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
4.0 63.2 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
3.9 66.4 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
3.1 163.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
2.8 91.1 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
2.5 30.4 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
2.2 54.8 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
2.0 30.5 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
1.7 50.8 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
1.6 20.9 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
1.4 62.7 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
1.3 40.9 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
1.0 201.6 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.9 58.7 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.9 12.5 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.7 26.3 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.6 19.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.6 52.3 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.6 39.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.5 24.8 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.4 3.9 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.4 114.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 5.6 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA