ISMARA results: Rest

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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Rest

Z-value: 5.52

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Transcription factors associated with Rest

Gene Symbol	Gene ID	Gene Info
Rest Ensembl NCBI MGI UniProt	ENSMUSG00000029249.16	Rest

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Rest	mm39_v1_chr5_+_77413282_77413396	-0.56	2.6e-07	Click!

Activity profile of Rest motif

Sorted Z-values of Rest motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Rest

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Promoter	Score	Transcript	Gene	Gene Info
chr16_-_23709564 Show fit	153.24	ENSMUST00000004480.5	Sst Ensembl NCBI MGI UniProt Show fit	somatostatin
chr6_-_121450547 Show fit	107.44	ENSMUST00000046373.8 ENSMUST00000151397.3	Iqsec3 Ensembl NCBI MGI UniProt Show fit	IQ motif and Sec7 domain 3
chr19_+_42244143 Show fit	106.95	ENSMUST00000087123.6	Golga7b Ensembl NCBI MGI UniProt Show fit	golgi autoantigen, golgin subfamily a, 7B
chr2_-_180956293 Show fit	106.13	ENSMUST00000103045.4	Stmn3 Ensembl NCBI MGI UniProt Show fit	stathmin-like 3
chrX_+_7504913 Show fit	96.44	ENSMUST00000128890.2	Syp Ensembl NCBI MGI UniProt Show fit	synaptophysin
chr5_-_121148143 Show fit	84.94	ENSMUST00000202406.4 ENSMUST00000200792.2	Rph3a Ensembl NCBI MGI UniProt Show fit	rabphilin 3A
chr3_-_80710097 Show fit	79.73	ENSMUST00000075316.10 ENSMUST00000107745.8	Gria2 Ensembl NCBI MGI UniProt Show fit	glutamate receptor, ionotropic, AMPA2 (alpha 2)
chr18_-_31580436 Show fit	79.02	ENSMUST00000025110.5	Syt4 Ensembl NCBI MGI UniProt Show fit	synaptotagmin IV
chr12_-_70394074 Show fit	77.61	ENSMUST00000223160.2 ENSMUST00000222316.2 ENSMUST00000167755.3 ENSMUST00000110520.10 ENSMUST00000110522.10 ENSMUST00000221041.2 ENSMUST00000222603.3	Trim9 Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 9
chr5_-_121147593 Show fit	76.06	ENSMUST00000079204.9	Rph3a Ensembl NCBI MGI UniProt Show fit	rabphilin 3A

Showing 1 to 10 of 114 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
9.3	176.6	GO:0043084	penile erection(GO:0043084)
43.8	175.4	GO:0021586	pons maturation(GO:0021586)
3.2	161.0	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1	128.9	GO:0030334	regulation of cell migration(GO:0030334)
14.0	125.8	GO:0051971	positive regulation of transmission of nerve impulse(GO:0051971)
4.9	123.7	GO:0099517	anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
38.2	114.6	GO:0035544	negative regulation of SNARE complex assembly(GO:0035544)
2.9	107.4	GO:0032012	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
8.9	106.9	GO:0018230	peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
10.6	106.1	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)

Showing 1 to 10 of 78 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.0	525.7	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.4	300.3	GO:0043025	neuronal cell body(GO:0043025)
0.0	251.0	GO:0005886	plasma membrane(GO:0005886)
0.1	232.5	GO:0016021	integral component of membrane(GO:0016021)
0.2	200.0	GO:0016604	nuclear body(GO:0016604)
3.3	162.0	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.4	135.9	GO:0030141	secretory granule(GO:0030141)
7.7	123.7	GO:0030123	AP-3 adaptor complex(GO:0030123)
24.1	120.6	GO:0044307	dendritic branch(GO:0044307)
1.3	117.9	GO:0030667	secretory granule membrane(GO:0030667)

Showing 1 to 10 of 43 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	225.7	GO:0000149	SNARE binding(GO:0000149)
1.8	197.9	GO:0005179	hormone activity(GO:0005179)
0.0	182.6	GO:0005515	protein binding(GO:0005515)
5.1	177.7	GO:0005184	neuropeptide hormone activity(GO:0005184)
10.1	161.0	GO:0070679	inositol 1,4,5 trisphosphate binding(GO:0070679)
4.5	134.1	GO:0017075	syntaxin-1 binding(GO:0017075)
15.1	120.6	GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
2.6	107.4	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
3.2	106.9	GO:0019706	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.3	103.3	GO:0008022	protein C-terminus binding(GO:0008022)

Showing 1 to 10 of 59 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	92.9	PID REELIN PATHWAY	Reelin signaling pathway
0.4	89.5	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
1.4	79.7	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.3	65.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.5	62.7	PID NOTCH PATHWAY	Notch signaling pathway
0.5	34.3	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.4	24.8	PID EPHB FWD PATHWAY	EPHB forward signaling
0.3	20.9	PID IL4 2PATHWAY	IL4-mediated signaling events
0.1	19.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.7	12.5	ST STAT3 PATHWAY	STAT3 Pathway

Showing 1 to 10 of 11 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	201.6	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
5.9	200.3	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
3.1	163.7	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.4	114.6	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
2.8	91.1	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
3.9	66.4	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
4.0	63.2	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
1.4	62.7	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.9	58.7	REACTOME GLUCAGON TYPE LIGAND RECEPTORS	Genes involved in Glucagon-type ligand receptors
2.2	54.8	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling

Showing 1 to 10 of 23 entries

Results for Rest

Z-value: 5.52

Motif logo

Transcription factors associated with Rest

Activity-expression correlation:

Activity profile of Rest motif

Sorted Z-values of Rest motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Rest

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: