ISMARA results: Rfx2

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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Rfx2_Rfx7

Z-value: 4.84

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Transcription factors associated with Rfx2_Rfx7

Gene Symbol	Gene ID	Gene Info
Rfx2 Ensembl NCBI MGI UniProt	ENSMUSG00000024206.16	Rfx2
Rfx7 Ensembl NCBI MGI UniProt	ENSMUSG00000037674.16	Rfx7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Rfx2	mm39_v1_chr17_-_57137898_57138013	0.54	8.2e-07	Click!
Rfx7	mm39_v1_chr9_+_72439891_72440113	0.17	1.5e-01	Click!

Activity profile of Rfx2_Rfx7 motif

Sorted Z-values of Rfx2_Rfx7 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Rfx2_Rfx7

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Promoter	Score	Transcript	Gene	Gene Info
chr8_+_117231712 Show fit	52.96	ENSMUST00000213007.2 ENSMUST00000078170.7	Dynlrb2 Ensembl NCBI MGI UniProt Show fit	dynein light chain roadblock-type 2
chr2_-_3420056 Show fit	50.55	ENSMUST00000115084.8 ENSMUST00000115083.8	Meig1 Ensembl NCBI MGI UniProt Show fit	meiosis expressed gene 1
chr2_-_3420102 Show fit	50.12	ENSMUST00000115082.10	Meig1 Ensembl NCBI MGI UniProt Show fit	meiosis expressed gene 1
chr12_+_33444853 Show fit	48.57	ENSMUST00000020878.8	Efcab10 Ensembl NCBI MGI UniProt Show fit	EF-hand calcium binding domain 10
chr2_-_21210151 Show fit	46.54	ENSMUST00000027992.3	Enkur Ensembl NCBI MGI UniProt Show fit	enkurin, TRPC channel interacting protein
chr17_+_25690538 Show fit	45.64	ENSMUST00000234449.2 ENSMUST00000025002.3 ENSMUST00000235033.2	Tekt4 Ensembl NCBI MGI UniProt Show fit	tektin 4
chr3_+_108444837 Show fit	45.53	ENSMUST00000029485.6	1700013F07Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 1700013F07 gene
chr17_-_11059172 Show fit	44.90	ENSMUST00000041463.7	Pacrg Ensembl NCBI MGI UniProt Show fit	PARK2 co-regulated
chr11_-_96932220 Show fit	42.54	ENSMUST00000021251.7	Lrrc46 Ensembl NCBI MGI UniProt Show fit	leucine rich repeat containing 46
chr12_-_110807330 Show fit	42.21	ENSMUST00000177224.2 ENSMUST00000084974.11 ENSMUST00000070565.15	Mok Ensembl NCBI MGI UniProt Show fit	MOK protein kinase

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	293.0	GO:0007283	spermatogenesis(GO:0007283)
12.4	210.2	GO:0036159	inner dynein arm assembly(GO:0036159)
2.6	76.0	GO:0003341	cilium movement(GO:0003341)
5.1	71.1	GO:0003351	epithelial cilium movement(GO:0003351)
0.6	70.2	GO:1903955	positive regulation of protein targeting to mitochondrion(GO:1903955)
11.8	59.0	GO:0080154	regulation of fertilization(GO:0080154)
0.3	49.6	GO:0060271	cilium morphogenesis(GO:0060271)
0.2	43.4	GO:0007018	microtubule-based movement(GO:0007018)
0.2	43.3	GO:0002244	hematopoietic progenitor cell differentiation(GO:0002244)
3.0	42.4	GO:0035721	intraciliary retrograde transport(GO:0035721)

Showing 1 to 10 of 167 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	201.8	GO:0005929	cilium(GO:0005929)
1.8	157.1	GO:0005930	axoneme(GO:0005930)
10.9	141.4	GO:0036156	inner dynein arm(GO:0036156)
1.6	106.7	GO:0036126	sperm flagellum(GO:0036126)
3.1	99.8	GO:0097225	sperm midpiece(GO:0097225)
1.3	85.4	GO:0031514	motile cilium(GO:0031514)
6.6	66.2	GO:0005858	axonemal dynein complex(GO:0005858)
2.0	65.0	GO:0097228	sperm principal piece(GO:0097228)
4.2	42.4	GO:0030991	intraciliary transport particle A(GO:0030991)
4.3	38.6	GO:1990075	periciliary membrane compartment(GO:1990075)

Showing 1 to 10 of 89 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.5	185.8	GO:0045505	dynein intermediate chain binding(GO:0045505)
1.1	68.4	GO:0048487	beta-tubulin binding(GO:0048487)
0.1	62.3	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.5	59.4	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.7	52.1	GO:0004712	protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.9	47.7	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
2.5	47.6	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2	46.3	GO:0017124	SH3 domain binding(GO:0017124)
8.6	34.3	GO:0004127	cytidylate kinase activity(GO:0004127)
0.1	30.0	GO:0005525	GTP binding(GO:0005525)

Showing 1 to 10 of 117 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	31.3	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.3	28.4	PID RAC1 PATHWAY	RAC1 signaling pathway
0.1	22.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	17.1	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.3	14.4	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.2	12.0	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.3	8.4	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.2	7.7	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.1	7.5	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.1	7.5	PID PLK1 PATHWAY	PLK1 signaling events

Showing 1 to 10 of 26 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	46.9	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.7	21.6	REACTOME KINESINS	Genes involved in Kinesins
0.3	18.9	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.4	14.4	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
1.8	10.8	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2	10.2	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.3	9.8	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.2	9.8	REACTOME G1 PHASE	Genes involved in G1 Phase
0.3	8.6	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.1	8.4	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)

Showing 1 to 10 of 33 entries

Results for Rfx2_Rfx7

Z-value: 4.84

Motif logo

Transcription factors associated with Rfx2_Rfx7

Activity-expression correlation:

Activity profile of Rfx2_Rfx7 motif

Sorted Z-values of Rfx2_Rfx7 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Rfx2_Rfx7

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: