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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Rfx3_Rfx1_Rfx4
Z-value: 7.81
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Transcription factors associated with Rfx3_Rfx1_Rfx4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rfx4 | mm39_v1_chr10_+_84591919_84591948 | 0.93 | 1.2e-31 | Click! |
| Rfx3 | mm39_v1_chr19_-_27988534_27988581 | 0.72 | 1.2e-12 | Click! |
| Rfx1 | mm39_v1_chr8_+_84793453_84793511 | 0.48 | 1.8e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Rfx3_Rfx1_Rfx4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 296.4 | GO:0007283 | spermatogenesis(GO:0007283) |
| 1.2 | 239.1 | GO:0060271 | cilium morphogenesis(GO:0060271) |
| 9.3 | 232.1 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 13.0 | 181.7 | GO:0098953 | receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628) |
| 3.6 | 128.8 | GO:0035082 | axoneme assembly(GO:0035082) |
| 1.4 | 118.2 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 4.2 | 113.9 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 3.0 | 109.4 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 1.0 | 108.3 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 1.7 | 98.8 | GO:0048013 | ephrin receptor signaling pathway(GO:0048013) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 487.1 | GO:0005929 | cilium(GO:0005929) |
| 0.6 | 253.9 | GO:0005874 | microtubule(GO:0005874) |
| 5.6 | 244.7 | GO:0097546 | ciliary base(GO:0097546) |
| 0.5 | 172.0 | GO:0060076 | excitatory synapse(GO:0060076) |
| 1.7 | 164.7 | GO:0005814 | centriole(GO:0005814) |
| 4.9 | 147.9 | GO:0034451 | centriolar satellite(GO:0034451) |
| 1.4 | 143.8 | GO:0097014 | ciliary plasm(GO:0097014) |
| 5.2 | 135.2 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 7.1 | 127.8 | GO:0036038 | MKS complex(GO:0036038) |
| 3.0 | 122.7 | GO:0097228 | sperm principal piece(GO:0097228) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 282.9 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.4 | 195.5 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 1.4 | 117.8 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 9.0 | 117.3 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 3.7 | 115.3 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 9.1 | 109.5 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 0.3 | 109.0 | GO:0005525 | GTP binding(GO:0005525) |
| 1.9 | 108.7 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 1.2 | 105.7 | GO:0030507 | spectrin binding(GO:0030507) |
| 1.3 | 99.4 | GO:0051018 | protein kinase A binding(GO:0051018) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 152.4 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 3.2 | 118.2 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 1.0 | 90.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 1.2 | 60.5 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.8 | 57.2 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 1.0 | 57.0 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.4 | 54.6 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 1.2 | 53.2 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 1.3 | 37.8 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 1.9 | 35.6 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 224.0 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.4 | 81.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.3 | 63.4 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 3.0 | 60.2 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 2.1 | 55.8 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 1.2 | 48.9 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.8 | 46.2 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.7 | 44.6 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 1.3 | 33.3 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.6 | 29.5 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |