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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Rora
Z-value: 1.00
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Transcription factors associated with Rora
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rora | mm39_v1_chr9_+_68561042_68561068 | -0.14 | 2.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Rora
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_52165682 Show fit | 7.83 |
ENSMUST00000238914.2
|
transcription factor 7, T cell specific |
|
| chr15_-_42540363 Show fit | 7.81 |
ENSMUST00000022921.7
|
angiopoietin 1 |
|
| chr7_+_28140352 Show fit | 6.45 |
ENSMUST00000078845.13
|
glia maturation factor, gamma |
|
| chr15_-_66673425 Show fit | 6.24 |
ENSMUST00000168589.8
|
src-like adaptor |
|
| chr7_-_126014027 Show fit | 6.09 |
ENSMUST00000032968.7
ENSMUST00000206325.2 |
CD19 antigen |
|
| chr2_+_131028861 Show fit | 5.82 |
ENSMUST00000028804.15
ENSMUST00000079857.9 |
cell division cycle 25B |
|
| chr7_+_127728712 Show fit | 5.26 |
ENSMUST00000033053.8
ENSMUST00000205460.2 |
integrin alpha X |
|
| chr3_-_83947416 Show fit | 5.03 |
ENSMUST00000192095.6
ENSMUST00000191758.6 ENSMUST00000052342.9 |
transmembrane 131 like |
|
| chr10_+_84412490 Show fit | 4.60 |
ENSMUST00000020223.8
|
t-complex 11 (mouse) like 2 |
|
| chr7_+_28140450 Show fit | 4.41 |
ENSMUST00000135686.2
|
glia maturation factor, gamma |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 10.9 | GO:0071846 | actin filament debranching(GO:0071846) |
| 2.3 | 9.1 | GO:0030210 | heparin biosynthetic process(GO:0030210) |
| 0.8 | 7.8 | GO:0002681 | somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153) |
| 0.1 | 7.2 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.1 | 7.2 | GO:0006096 | glycolytic process(GO:0006096) |
| 0.6 | 6.8 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 2.2 | 6.7 | GO:1904156 | DN2 thymocyte differentiation(GO:1904155) DN3 thymocyte differentiation(GO:1904156) |
| 0.0 | 6.6 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.1 | 6.2 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 0.4 | 6.1 | GO:0006968 | cellular defense response(GO:0006968) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.9 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
| 0.1 | 7.8 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.6 | 7.5 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 1.1 | 7.4 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.5 | 6.8 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.2 | 6.8 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 6.7 | GO:0000922 | spindle pole(GO:0000922) |
| 0.9 | 5.6 | GO:1990707 | subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707) |
| 0.0 | 5.5 | GO:0005930 | axoneme(GO:0005930) |
| 0.0 | 5.4 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 10.9 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.0 | 8.4 | GO:0005539 | glycosaminoglycan binding(GO:0005539) |
| 0.5 | 7.8 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.1 | 7.6 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 1.1 | 7.4 | GO:0030172 | troponin C binding(GO:0030172) |
| 0.5 | 6.8 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.5 | 6.7 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.0 | 6.6 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 6.0 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 5.9 | GO:0051219 | phosphoprotein binding(GO:0051219) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.9 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 11.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 10.4 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 9.5 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 9.5 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 6.4 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.6 | 5.8 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.2 | 5.3 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 5.0 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 4.3 | PID E2F PATHWAY | E2F transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 11.9 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 9.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.3 | 7.8 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.2 | 7.8 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.1 | 6.9 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.7 | 6.7 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.0 | 6.3 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.2 | 6.1 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 6.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.3 | 5.8 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |