ISMARA results: Runx2

Project

PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

Navigation

Downloads

Results for Runx2_Bcl11a

Z-value: 2.88

Motif logo

Transcription factors associated with Runx2_Bcl11a

Gene Symbol	Gene ID	Gene Info
Runx2 Ensembl NCBI MGI UniProt	ENSMUSG00000039153.18	Runx2
Bcl11a Ensembl NCBI MGI UniProt	ENSMUSG00000000861.16	Bcl11a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Runx2	mm39_v1_chr17_-_45125537_45125684	0.41	3.5e-04	Click!
Bcl11a	mm39_v1_chr11_+_24028173_24028220	0.18	1.2e-01	Click!

Activity profile of Runx2_Bcl11a motif

Sorted Z-values of Runx2_Bcl11a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx2_Bcl11a

View svg image
View png image

Top targets:

Search:

Show entries

Promoter	Score	Transcript	Gene	Gene Info
chr18_-_35782412 Show fit	33.11	ENSMUST00000025211.6	Mzb1 Ensembl NCBI MGI UniProt Show fit	marginal zone B and B1 cell-specific protein 1
chr11_-_106205320 Show fit	30.15	ENSMUST00000167143.2	Cd79b Ensembl NCBI MGI UniProt Show fit	CD79B antigen
chr7_-_103477126 Show fit	28.41	ENSMUST00000023934.8	Hbb-bs Ensembl NCBI MGI UniProt Show fit	hemoglobin, beta adult s chain
chr3_+_103767581 Show fit	28.30	ENSMUST00000029433.9	Ptpn22 Ensembl NCBI MGI UniProt Show fit	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr7_+_142559414 Show fit	26.28	ENSMUST00000082008.12 ENSMUST00000105925.8 ENSMUST00000105924.8	Tspan32 Ensembl NCBI MGI UniProt Show fit	tetraspanin 32
chrX_-_100311824 Show fit	26.16	ENSMUST00000033664.14	Il2rg Ensembl NCBI MGI UniProt Show fit	interleukin 2 receptor, gamma chain
chr3_-_59009231 Show fit	25.71	ENSMUST00000085040.5	Gpr171 Ensembl NCBI MGI UniProt Show fit	G protein-coupled receptor 171
chr6_-_87510200 Show fit	25.61	ENSMUST00000113637.9 ENSMUST00000071024.7	Arhgap25 Ensembl NCBI MGI UniProt Show fit	Rho GTPase activating protein 25
chr7_+_142559375 Show fit	24.59	ENSMUST00000075172.12 ENSMUST00000105923.8	Tspan32 Ensembl NCBI MGI UniProt Show fit	tetraspanin 32
chr7_+_142558783 Show fit	23.82	ENSMUST00000009396.13	Tspan32 Ensembl NCBI MGI UniProt Show fit	tetraspanin 32

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
11.9	130.7	GO:0030886	negative regulation of myeloid dendritic cell activation(GO:0030886)
0.5	85.8	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.3	66.0	GO:0002377	immunoglobulin production(GO:0002377)
10.0	50.0	GO:0050902	leukocyte adhesive activation(GO:0050902)
2.3	46.6	GO:0001865	NK T cell differentiation(GO:0001865)
12.3	36.8	GO:2000566	positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
5.9	35.7	GO:0032831	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831)
6.9	34.4	GO:2001274	negative regulation of glucose import in response to insulin stimulus(GO:2001274)
0.5	32.1	GO:0035456	response to interferon-beta(GO:0035456)
1.8	27.6	GO:0001771	immunological synapse formation(GO:0001771)

Showing 1 to 10 of 411 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	223.9	GO:0009897	external side of plasma membrane(GO:0009897)
0.4	135.3	GO:0009898	cytoplasmic side of plasma membrane(GO:0009898)
22.3	111.5	GO:0070442	integrin alphaIIb-beta3 complex(GO:0070442)
3.8	64.5	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
9.0	45.1	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
3.9	39.4	GO:0019815	B cell receptor complex(GO:0019815)
2.2	33.3	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.5	27.2	GO:0001772	immunological synapse(GO:0001772)
0.1	25.2	GO:0005884	actin filament(GO:0005884)
2.5	24.6	GO:0044214	spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)

Showing 1 to 10 of 151 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	76.1	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.3	59.1	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
10.9	54.6	GO:0019976	interleukin-2 binding(GO:0019976)
0.4	53.2	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.2	36.7	GO:0001047	core promoter binding(GO:0001047)
0.1	29.9	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.3	29.2	GO:0070491	repressing transcription factor binding(GO:0070491)
7.1	28.4	GO:0031720	haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
1.0	28.1	GO:0008009	chemokine activity(GO:0008009)
1.3	26.8	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)

Showing 1 to 10 of 259 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.4	113.4	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
1.0	108.2	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
1.0	57.8	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.4	45.7	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.7	33.5	PID BCR 5PATHWAY	BCR signaling pathway
1.4	32.7	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.4	31.1	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.5	24.3	PID IL12 2PATHWAY	IL12-mediated signaling events
0.5	23.4	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.5	22.9	PID CXCR3 PATHWAY	CXCR3-mediated signaling events

Showing 1 to 10 of 64 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
2.5	98.2	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
1.4	76.1	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
1.0	51.8	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
1.0	46.1	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
1.7	41.5	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	28.4	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.8	26.5	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.1	24.5	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
0.4	22.4	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.4	21.2	REACTOME G1 PHASE	Genes involved in G1 Phase

Showing 1 to 10 of 103 entries

Results for Runx2_Bcl11a

Z-value: 2.88

Motif logo

Transcription factors associated with Runx2_Bcl11a

Activity-expression correlation:

Activity profile of Runx2_Bcl11a motif

Sorted Z-values of Runx2_Bcl11a motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx2_Bcl11a

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: