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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Runx3

Z-value: 0.86

Motif logo

Transcription factors associated with Runx3

Gene Symbol Gene ID Gene Info
ENSMUSG00000070691.11 Runx3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Runx3mm39_v1_chr4_+_134847949_134847973-0.235.2e-02Click!

Activity profile of Runx3 motif

Sorted Z-values of Runx3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx3

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr15_-_78739717 16.40 ENSMUST00000044584.6
lectin, galactose-binding, soluble 2
chr16_+_4825216 9.97 ENSMUST00000185147.8
small integral membrane protein 22
chr7_-_25516041 9.07 ENSMUST00000043314.10
cytochrome P450, family 2, subfamily s, polypeptide 1
chr11_-_100098333 7.03 ENSMUST00000007272.8
keratin 14
chr16_-_20972750 5.66 ENSMUST00000170665.3
transmembrane epididymal family member 3
chr7_+_140796537 5.38 ENSMUST00000141804.2
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr14_-_20231871 4.92 ENSMUST00000024011.10
potassium channel, subfamily K, member 5
chr5_+_135382149 4.92 ENSMUST00000111180.9
ENSMUST00000065785.4
tripartite motif-containing 50
chr6_-_69626340 4.19 ENSMUST00000198328.2
immunoglobulin kappa variable 4-53
chrX_+_98179725 4.08 ENSMUST00000052839.7
ephrin B1
chr1_-_24139263 3.72 ENSMUST00000187369.7
ENSMUST00000187752.7
ENSMUST00000186999.7
family with sequence similarity 135, member A
chr1_-_24139387 3.26 ENSMUST00000027337.15
family with sequence similarity 135, member A
chr8_+_27513819 2.62 ENSMUST00000033873.9
ENSMUST00000211043.2
ER lipid raft associated 2
chrX_-_146337046 2.51 ENSMUST00000112819.9
ENSMUST00000136789.8
leucine-rich repeats and calponin homology (CH) domain containing 2
chr19_-_20368029 2.39 ENSMUST00000235280.2
annexin A1
chr8_+_27513839 2.30 ENSMUST00000209563.2
ENSMUST00000209520.2
ER lipid raft associated 2
chr5_+_45650821 2.28 ENSMUST00000198534.2
leucine aminopeptidase 3
chr4_-_133225849 2.26 ENSMUST00000125541.2
TMF1-regulated nuclear protein 1
chr8_+_27513289 2.12 ENSMUST00000209795.2
ENSMUST00000209976.2
ER lipid raft associated 2
chr10_+_76367427 1.95 ENSMUST00000048678.7
lanosterol synthase
chr5_+_45650716 1.93 ENSMUST00000046122.11
leucine aminopeptidase 3
chr10_-_24588030 1.88 ENSMUST00000105520.8
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr16_-_10131804 1.74 ENSMUST00000078357.5
epithelial membrane protein 2
chr17_+_28547548 1.67 ENSMUST00000233895.2
ENSMUST00000232867.2
ribosomal protein L10A
chr17_+_28547533 1.60 ENSMUST00000233427.2
ENSMUST00000233937.2
ribosomal protein L10A
chr18_-_47501513 1.59 ENSMUST00000076043.13
ENSMUST00000135790.8
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr17_+_28547445 1.44 ENSMUST00000042334.16
ribosomal protein L10A
chr15_+_98953776 1.36 ENSMUST00000229268.2
peripherin
chr14_-_72946972 1.26 ENSMUST00000162478.8
fibronectin type III domain containing 3A
chr9_-_58065800 1.24 ENSMUST00000168864.4
immunoglobulin superfamily containing leucine-rich repeat
chr10_+_79590910 1.23 ENSMUST00000219981.2
ENSMUST00000219228.2
ENSMUST00000020577.4
fibroblast growth factor 22
chr13_+_46822992 1.18 ENSMUST00000099547.4
family with sequence similarity 8, member A1
chr5_+_33176160 1.16 ENSMUST00000019109.8
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr2_+_145627900 1.08 ENSMUST00000110005.8
ENSMUST00000094480.11
Ras and Rab interactor 2
chr10_+_127919142 1.03 ENSMUST00000026459.6
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr7_+_140796559 0.99 ENSMUST00000148975.3
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr9_-_78389006 0.97 ENSMUST00000042235.15
eukaryotic translation elongation factor 1 alpha 1
chr11_+_75570085 0.93 ENSMUST00000017920.14
ENSMUST00000108426.8
ENSMUST00000108425.8
ENSMUST00000093115.4
v-crk avian sarcoma virus CT10 oncogene homolog
chr13_+_51799268 0.89 ENSMUST00000075853.6
CDC28 protein kinase regulatory subunit 2
chr13_+_21919225 0.79 ENSMUST00000087714.6
H4 clustered histone 11
chr6_-_100648086 0.78 ENSMUST00000089245.7
ENSMUST00000113312.9
ENSMUST00000170667.8
SHQ1 homolog (S. cerevisiae)
chr14_-_72947422 0.78 ENSMUST00000089017.12
fibronectin type III domain containing 3A
chr11_-_5712357 0.69 ENSMUST00000120306.8
ENSMUST00000170116.8
ENSMUST00000053427.11
ENSMUST00000118076.8
upregulator of cell proliferation
chr13_-_115238427 0.68 ENSMUST00000224997.2
ENSMUST00000061673.9
predicted gene, 49395
integrin alpha 1
chr5_+_115149170 0.67 ENSMUST00000031530.9
signal peptide peptidase 3
chr13_-_22016364 0.65 ENSMUST00000102979.2
H4 clustered histone 18
chr11_-_70111796 0.62 ENSMUST00000060010.3
ENSMUST00000190533.2
solute carrier family 16 (monocarboxylic acid transporters), member 13
chr11_+_86375441 0.60 ENSMUST00000020827.7
ring finger protein, transmembrane 1
chr7_-_141794815 0.55 ENSMUST00000211591.2
predicted gene, 40460
chr9_+_106306736 0.55 ENSMUST00000098994.7
ENSMUST00000059802.7
ENSMUST00000213448.2
ENSMUST00000217081.2
ribosomal protein L29
chr11_-_70111602 0.52 ENSMUST00000141290.2
ENSMUST00000159867.2
solute carrier family 16 (monocarboxylic acid transporters), member 13
chr12_-_98225676 0.51 ENSMUST00000021390.9
galactosylceramidase
chr9_+_106306598 0.51 ENSMUST00000150576.8
ribosomal protein L29
chr2_-_53081199 0.51 ENSMUST00000239398.2
ENSMUST00000076313.14
ENSMUST00000210789.3
pre-mRNA processing factor 40A
chr1_+_58752415 0.47 ENSMUST00000114309.8
ENSMUST00000069333.8
CASP8 and FADD-like apoptosis regulator
chr10_-_62438040 0.47 ENSMUST00000045866.9
DExD box helicase 21
chr13_-_14237980 0.47 ENSMUST00000222687.2
ENSMUST00000221338.2
ENSMUST00000221713.2
ENSMUST00000170957.3
geranylgeranyl diphosphate synthase 1
chr1_+_74317709 0.46 ENSMUST00000077985.4
G protein-coupled bile acid receptor 1
chr8_+_72662437 0.44 ENSMUST00000110002.8
ENSMUST00000125802.8
ENSMUST00000131544.8
zinc finger protein 882
zinc finger protein 617
chr13_-_25204272 0.41 ENSMUST00000021772.4
MRS2 magnesium transporter
chr6_+_124690060 0.39 ENSMUST00000130279.2
prohibitin 2
chr11_-_57722830 0.37 ENSMUST00000036917.3
heart and neural crest derivatives expressed 1
chr16_-_94327689 0.37 ENSMUST00000023615.7
VPS26 endosomal protein sorting factor C
chr13_-_14237958 0.37 ENSMUST00000223174.2
geranylgeranyl diphosphate synthase 1
chr7_-_78432774 0.34 ENSMUST00000032841.7
mitochondrial ribosomal protein L46
chr10_+_42378193 0.33 ENSMUST00000105499.2
sorting nexin 3
chr13_+_38009951 0.27 ENSMUST00000138043.8
ras responsive element binding protein 1
chr11_-_5828251 0.26 ENSMUST00000102922.10
polymerase (DNA directed), delta 2, regulatory subunit
chr7_-_141017500 0.25 ENSMUST00000172654.8
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr9_-_107971640 0.24 ENSMUST00000081309.13
ENSMUST00000191985.2
acylpeptide hydrolase
chr13_-_21934675 0.23 ENSMUST00000102983.2
H4 clustered histone 12
chr2_-_50186690 0.22 ENSMUST00000144143.8
ENSMUST00000102769.11
ENSMUST00000133768.2
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr10_-_116417333 0.22 ENSMUST00000218744.2
ENSMUST00000105267.8
ENSMUST00000105265.8
ENSMUST00000167706.8
ENSMUST00000168036.8
ENSMUST00000169921.8
ENSMUST00000020374.6
CCR4-NOT transcription complex, subunit 2
chr16_-_58647137 0.22 ENSMUST00000215069.2
ENSMUST00000079955.6
olfactory receptor 175
chr13_+_14238361 0.21 ENSMUST00000129488.8
ENSMUST00000110536.8
ENSMUST00000110534.8
ENSMUST00000039538.15
ENSMUST00000110533.2
AT rich interactive domain 4B (RBP1-like)
chr5_+_21629932 0.21 ENSMUST00000056045.5
family with sequence similarity 185, member A
chr13_+_38010203 0.20 ENSMUST00000128570.9
ras responsive element binding protein 1
chr1_-_83037090 0.19 ENSMUST00000193762.2
RIKEN cDNA A030005K14 gene
chr7_-_141017742 0.18 ENSMUST00000019226.14
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chrX_-_95400846 0.18 ENSMUST00000179832.8
heat shock transcription factor 3
chr16_+_92098166 0.18 ENSMUST00000063641.11
ENSMUST00000118064.2
small integral membrane protein 11
chr17_-_45744637 0.17 ENSMUST00000024727.10
cell division cycle 5-like (S. pombe)
chr1_+_82891043 0.15 ENSMUST00000220768.2
RIKEN cDNA A030005L19 gene
chrX_-_72502595 0.15 ENSMUST00000033737.15
ENSMUST00000077243.5
HAUS augmin-like complex, subunit 7
chr6_+_115908709 0.15 ENSMUST00000032471.9
rhodopsin
chr2_+_157756535 0.14 ENSMUST00000109523.2
V-set and transmembrane domain containing 2-like
chrX_-_97934387 0.12 ENSMUST00000113826.8
ENSMUST00000033560.9
ENSMUST00000142267.2
oligophrenin 1
chr7_-_141017525 0.10 ENSMUST00000106006.8
ENSMUST00000201710.4
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr14_-_98406977 0.08 ENSMUST00000071533.13
ENSMUST00000069334.8
dachshund family transcription factor 1
chr13_+_38009981 0.07 ENSMUST00000110238.10
ras responsive element binding protein 1
chr3_-_7678785 0.03 ENSMUST00000194279.6
interleukin 7
chr3_+_95566082 0.03 ENSMUST00000037947.15
ENSMUST00000178686.2
myeloid cell leukemia sequence 1
chr3_-_7678796 0.02 ENSMUST00000192202.6
interleukin 7
chr4_+_19575128 0.01 ENSMUST00000108253.8
ENSMUST00000029888.4
regulator of microtubule dynamics 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 7.0 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.6 7.0 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.5 2.4 GO:0097350 neutrophil clearance(GO:0097350)
0.4 1.2 GO:0006713 glucocorticoid catabolic process(GO:0006713)
0.3 0.9 GO:1990859 cellular response to endothelin(GO:1990859)
0.3 9.1 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.3 0.8 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.2 4.9 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 1.9 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
0.2 1.7 GO:0070836 caveola assembly(GO:0070836)
0.1 1.0 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.1 4.7 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.1 0.4 GO:0003218 cardiac left ventricle formation(GO:0003218)
0.1 0.5 GO:1903943 skeletal muscle atrophy(GO:0014732) negative regulation of myoblast fusion(GO:1901740) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1 4.1 GO:0031295 T cell costimulation(GO:0031295)
0.1 0.3 GO:0070676 intralumenal vesicle formation(GO:0070676) negative regulation of early endosome to late endosome transport(GO:2000642)
0.1 0.5 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1 0.7 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.1 2.2 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.4 GO:0031536 positive regulation of exit from mitosis(GO:0031536) thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 1.6 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.5 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 0.2 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 2.3 GO:0021696 cerebellar cortex morphogenesis(GO:0021696)
0.0 0.8 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
0.0 0.1 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.0 1.9 GO:0006695 cholesterol biosynthetic process(GO:0006695)
0.0 1.4 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 1.0 GO:1903427 negative regulation of reactive oxygen species biosynthetic process(GO:1903427)
0.0 0.7 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.4 GO:0015693 magnesium ion transport(GO:0015693)
0.0 5.7 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 0.2 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.5 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.3 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.0 4.2 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.9 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0 0.5 GO:2000810 regulation of bicellular tight junction assembly(GO:2000810)
0.0 1.1 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.1 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
0.0 1.2 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 GO:0097441 basilar dendrite(GO:0097441)
0.2 0.7 GO:0034665 integrin alpha1-beta1 complex(GO:0034665)
0.2 2.4 GO:0042629 mast cell granule(GO:0042629)
0.2 1.4 GO:0044299 C-fiber(GO:0044299)
0.1 6.0 GO:0045095 keratin filament(GO:0045095)
0.1 1.0 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 0.7 GO:0098553 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 4.9 GO:0016235 aggresome(GO:0016235)
0.1 1.1 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 4.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.5 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 2.3 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 13.8 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.5 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 4.2 GO:0030496 midbody(GO:0030496)
0.0 0.3 GO:0032009 early phagosome(GO:0032009)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 1.9 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.2 GO:0000974 Prp19 complex(GO:0000974)
0.0 1.2 GO:0014704 intercalated disc(GO:0014704)
0.0 0.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 2.0 GO:0001669 acrosomal vesicle(GO:0001669)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 16.4 GO:0016936 galactoside binding(GO:0016936)
1.0 7.0 GO:1990254 keratin filament binding(GO:1990254)
0.4 1.9 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.3 2.4 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.3 9.1 GO:0070330 aromatase activity(GO:0070330)
0.3 1.0 GO:0043532 angiostatin binding(GO:0043532)
0.2 4.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 0.8 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.1 0.9 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 0.7 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.5 GO:0038181 bile acid receptor activity(GO:0038181)
0.1 7.0 GO:0015485 cholesterol binding(GO:0015485)
0.1 5.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 0.7 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 4.2 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 1.9 GO:0016866 intramolecular transferase activity(GO:0016866)
0.0 0.5 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 1.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.2 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.5 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.5 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.2 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 1.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 5.9 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 1.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 4.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 1.1 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.3 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.5 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.7 GO:0005178 integrin binding(GO:0005178)
0.0 0.2 GO:0031996 thioesterase binding(GO:0031996)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 19.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.1 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 0.9 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.2 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.5 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.7 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 1.1 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.1 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 2.8 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 2.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 6.7 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 1.0 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.2 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.9 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.5 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 1.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.1 REACTOME OPSINS Genes involved in Opsins
0.0 2.4 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.5 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism