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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Six4

Z-value: 0.76

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Transcription factors associated with Six4

Gene Symbol Gene ID Gene Info
Six4
ENSMUSG00000034460.10 Six4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Six4mm39_v1_chr12_-_73160181_73160230-0.404.2e-04Click!

Activity profile of Six4 motif

Sorted Z-values of Six4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Six4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr9_+_78137927 6.87 ENSMUST00000098537.4
Gsta1
glutathione S-transferase, alpha 1 (Ya)
chr9_+_78197205 6.17 ENSMUST00000119823.8
ENSMUST00000121273.2
Gsta5
glutathione S-transferase alpha 5
chr12_-_57592907 5.29 ENSMUST00000044380.8
Foxa1
forkhead box A1
chr13_+_93810911 5.24 ENSMUST00000048001.8
Dmgdh
dimethylglycine dehydrogenase precursor
chr3_+_40905066 4.60 ENSMUST00000191805.7
Larp1b
La ribonucleoprotein domain family, member 1B
chr2_+_24970327 4.58 ENSMUST00000044078.10
ENSMUST00000114380.9
Entpd8
ectonucleoside triphosphate diphosphohydrolase 8
chr13_-_93810808 4.42 ENSMUST00000015941.8
Bhmt2
betaine-homocysteine methyltransferase 2
chr7_+_26819334 4.36 ENSMUST00000003100.10
Cyp2f2
cytochrome P450, family 2, subfamily f, polypeptide 2
chr3_+_40905216 4.14 ENSMUST00000191872.6
ENSMUST00000200432.2
Larp1b
La ribonucleoprotein domain family, member 1B
chr3_+_92864693 3.85 ENSMUST00000059053.11
Lce3d
late cornified envelope 3D
chr17_+_48717007 2.44 ENSMUST00000167180.8
ENSMUST00000046651.7
ENSMUST00000233426.2
Oard1
O-acyl-ADP-ribose deacylase 1
chr13_-_72111832 2.17 ENSMUST00000077337.9
Irx1
Iroquois homeobox 1
chr17_-_25564501 2.15 ENSMUST00000153118.2
ENSMUST00000146856.3
Tpsab1
tryptase alpha/beta 1
chr10_+_75399920 2.15 ENSMUST00000141062.8
ENSMUST00000152657.8
Ggt1
gamma-glutamyltransferase 1
chr18_+_60515755 2.06 ENSMUST00000237185.2
Iigp1
interferon inducible GTPase 1
chr18_+_60345152 2.05 ENSMUST00000031549.6
Gm4951
predicted gene 4951
chr3_-_75864195 2.00 ENSMUST00000038563.14
ENSMUST00000167078.8
ENSMUST00000117242.8
Golim4
golgi integral membrane protein 4
chr15_-_103163860 1.97 ENSMUST00000075192.13
Nfe2
nuclear factor, erythroid derived 2
chr2_+_31204314 1.94 ENSMUST00000113532.9
Hmcn2
hemicentin 2
chr9_+_30941924 1.84 ENSMUST00000216649.2
ENSMUST00000115222.10
Zbtb44
zinc finger and BTB domain containing 44
chr6_+_35229628 1.77 ENSMUST00000130875.8
1810058I24Rik
RIKEN cDNA 1810058I24 gene
chr13_+_51799268 1.65 ENSMUST00000075853.6
Cks2
CDC28 protein kinase regulatory subunit 2
chr10_-_3217767 1.62 ENSMUST00000170893.3
H60c
histocompatibility 60c
chr4_-_133746138 1.60 ENSMUST00000051674.3
Lin28a
lin-28 homolog A (C. elegans)
chr14_-_56322654 1.57 ENSMUST00000015594.9
Mcpt8
mast cell protease 8
chr11_+_3939924 1.52 ENSMUST00000109981.2
Gal3st1
galactose-3-O-sulfotransferase 1
chr10_-_3217718 1.47 ENSMUST00000216211.2
H60c
histocompatibility 60c
chr13_+_54225828 1.40 ENSMUST00000021930.10
Sfxn1
sideroflexin 1
chr7_+_37883300 1.38 ENSMUST00000179992.10
1600014C10Rik
RIKEN cDNA 1600014C10 gene
chr5_-_41921834 1.32 ENSMUST00000060820.8
Nkx3-2
NK3 homeobox 2
chr19_-_6957789 1.32 ENSMUST00000070878.9
ENSMUST00000177752.9
Fkbp2
FK506 binding protein 2
chr11_+_49135018 1.29 ENSMUST00000167400.8
ENSMUST00000081794.7
Mgat1
mannoside acetylglucosaminyltransferase 1
chr10_+_127478844 1.28 ENSMUST00000092074.12
ENSMUST00000120279.2
Stat6
signal transducer and activator of transcription 6
chr5_-_132570710 1.21 ENSMUST00000182974.9
Auts2
autism susceptibility candidate 2
chr5_-_145128321 1.21 ENSMUST00000161845.2
Atp5j2
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2
chr3_+_138058139 1.13 ENSMUST00000090166.5
Adh6b
alcohol dehydrogenase 6B (class V)
chr18_-_70186503 1.12 ENSMUST00000117692.8
ENSMUST00000069749.9
Rab27b
RAB27B, member RAS oncogene family
chr2_-_89774457 1.12 ENSMUST00000090695.3
Olfr1259
olfactory receptor 1259
chr10_-_79481565 1.07 ENSMUST00000095464.3
Odf3l2
outer dense fiber of sperm tails 3-like 2
chr4_-_144513121 1.02 ENSMUST00000105746.3
Aadacl4fm5
AADACL4 family member 5
chr2_+_119181703 1.01 ENSMUST00000028780.4
Chac1
ChaC, cation transport regulator 1
chr19_+_6450641 0.99 ENSMUST00000113467.2
Rasgrp2
RAS, guanyl releasing protein 2
chr6_+_149031668 0.95 ENSMUST00000087348.4
Gm10203
predicted gene 10203
chr3_-_129616183 0.95 ENSMUST00000196902.5
Rrh
retinal pigment epithelium derived rhodopsin homolog
chr8_-_21392510 0.94 ENSMUST00000122025.9
Gm15056
predicted gene 15056
chr7_+_43474819 0.93 ENSMUST00000107967.3
Klk6
kallikrein related-peptidase 6
chr14_+_54422156 0.92 ENSMUST00000103707.2
Traj34
T cell receptor alpha joining 34
chr7_+_37883216 0.82 ENSMUST00000177983.2
1600014C10Rik
RIKEN cDNA 1600014C10 gene
chr9_+_19047613 0.82 ENSMUST00000215699.2
Olfr837
olfactory receptor 837
chr1_-_13197387 0.81 ENSMUST00000047577.7
Prdm14
PR domain containing 14
chr6_+_124908439 0.79 ENSMUST00000032214.14
Mlf2
myeloid leukemia factor 2
chr9_-_76120939 0.78 ENSMUST00000074880.6
Gfral
GDNF family receptor alpha like
chr6_+_3993774 0.77 ENSMUST00000031673.7
Gngt1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr2_-_76671491 0.77 ENSMUST00000137854.8
Ttn
titin
chr6_+_124908341 0.76 ENSMUST00000203021.3
Mlf2
myeloid leukemia factor 2
chr7_+_17799863 0.73 ENSMUST00000108487.9
Ceacam12
carcinoembryonic antigen-related cell adhesion molecule 12
chr2_-_34951443 0.73 ENSMUST00000028233.7
Hc
hemolytic complement
chr10_+_79590910 0.69 ENSMUST00000219981.2
ENSMUST00000219228.2
ENSMUST00000020577.4
Fgf22
fibroblast growth factor 22
chr2_-_90123185 0.66 ENSMUST00000117141.4
Olfr1272
olfactory receptor 1272
chr12_+_119356318 0.66 ENSMUST00000221866.2
Macc1
metastasis associated in colon cancer 1
chr6_+_124908389 0.62 ENSMUST00000180095.4
Mlf2
myeloid leukemia factor 2
chr7_-_127534601 0.60 ENSMUST00000141385.7
ENSMUST00000156152.3
Prss36
protease, serine 36
chr7_-_103142086 0.54 ENSMUST00000055787.8
Olfr609
olfactory receptor 609
chr16_-_20141815 0.53 ENSMUST00000023513.12
Cyp2ab1
cytochrome P450, family 2, subfamily ab, polypeptide 1
chr17_+_25588241 0.52 ENSMUST00000160377.8
ENSMUST00000160485.8
Tpsg1
tryptase gamma 1
chr12_-_114160354 0.51 ENSMUST00000103476.2
ENSMUST00000191693.2
Ighv3-3
immunoglobulin heavy variable V3-3
chr11_-_87805829 0.50 ENSMUST00000074874.5
Olfr464
olfactory receptor 464
chr4_-_101750986 0.50 ENSMUST00000051043.4
C130073F10Rik
RIKEN cDNA C130073F10 gene
chr3_+_138911648 0.43 ENSMUST00000062306.7
Stpg2
sperm tail PG rich repeat containing 2
chr6_-_72357398 0.40 ENSMUST00000101285.10
ENSMUST00000074231.6
Vamp5
vesicle-associated membrane protein 5
chr11_-_34048538 0.39 ENSMUST00000223852.2
4930469K13Rik
RIKEN cDNA 4930469K13 gene
chr2_-_88587017 0.38 ENSMUST00000099813.2
Olfr1199
olfactory receptor 1199
chr6_+_132572871 0.37 ENSMUST00000076061.4
ENSMUST00000178961.2
Prp2
proline rich protein 2
chr1_+_20801127 0.36 ENSMUST00000027061.5
Il17a
interleukin 17A
chr17_+_25115461 0.34 ENSMUST00000024978.7
Nme3
NME/NM23 nucleoside diphosphate kinase 3
chr17_+_35268942 0.31 ENSMUST00000007257.10
Clic1
chloride intracellular channel 1
chr1_-_153726930 0.31 ENSMUST00000059607.8
Teddm2
transmembrane epididymal family member 2
chr3_-_92493507 0.28 ENSMUST00000194965.6
Smcp
sperm mitochondria-associated cysteine-rich protein
chr12_-_114117264 0.24 ENSMUST00000103461.5
Ighv7-3
immunoglobulin heavy variable 7-3
chr7_-_107357104 0.24 ENSMUST00000208217.2
ENSMUST00000052438.8
Cyb5r2
cytochrome b5 reductase 2
chr7_+_17799849 0.23 ENSMUST00000032520.9
Ceacam12
carcinoembryonic antigen-related cell adhesion molecule 12
chr19_+_29388312 0.23 ENSMUST00000112576.4
Pdcd1lg2
programmed cell death 1 ligand 2
chr12_-_54703281 0.22 ENSMUST00000056228.8
Sptssa
serine palmitoyltransferase, small subunit A
chr2_+_87686206 0.21 ENSMUST00000217376.2
Olfr1151
olfactory receptor 1151
chr9_-_106421834 0.19 ENSMUST00010181660.1
ENSMUST00000215525.2
ENSMUSG00001074846.1
ENSMUSG00000118396.3
IQ motif containing F3
IQ motif containing F3
chr7_+_17799889 0.18 ENSMUST00000108483.2
Ceacam12
carcinoembryonic antigen-related cell adhesion molecule 12
chr19_-_38212544 0.17 ENSMUST00000067167.6
Fra10ac1
FRA10AC1 homolog (human)
chr1_+_54289833 0.17 ENSMUST00000027128.11
Ccdc150
coiled-coil domain containing 150
chr7_-_102591782 0.12 ENSMUST00000210571.2
ENSMUST00000064830.6
Olfr573-ps1
olfactory receptor 573, pseudogene 1
chr2_-_104324035 0.12 ENSMUST00000111124.8
Hipk3
homeodomain interacting protein kinase 3
chr3_+_138911419 0.11 ENSMUST00000106239.8
Stpg2
sperm tail PG rich repeat containing 2
chr9_+_108782646 0.11 ENSMUST00000112070.8
Col7a1
collagen, type VII, alpha 1
chr7_+_27879650 0.06 ENSMUST00000172467.8
Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr19_-_10952009 0.02 ENSMUST00000191343.7
Ms4a10
membrane-spanning 4-domains, subfamily A, member 10
chr19_+_27194757 0.01 ENSMUST00000047645.13
ENSMUST00000167487.8
Vldlr
very low density lipoprotein receptor
chr3_+_145643760 0.01 ENSMUST00000039571.14
2410004B18Rik
RIKEN cDNA 2410004B18 gene
chr9_+_108782664 0.00 ENSMUST00000026740.6
Col7a1
collagen, type VII, alpha 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0061144 alveolar secondary septum development(GO:0061144)
1.5 4.4 GO:0018931 naphthalene metabolic process(GO:0018931) naphthalene-containing compound metabolic process(GO:0090420)
0.7 4.4 GO:0071267 amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.6 5.2 GO:0019695 choline metabolic process(GO:0019695)
0.5 2.2 GO:0072268 pattern specification involved in metanephros development(GO:0072268)
0.4 4.6 GO:0009133 nucleoside diphosphate biosynthetic process(GO:0009133)
0.3 1.3 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.3 1.3 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296) interleukin-4-mediated signaling pathway(GO:0035771)
0.3 1.2 GO:0098582 innate vocalization behavior(GO:0098582)
0.3 2.1 GO:1901748 peptide modification(GO:0031179) leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.3 1.6 GO:0010587 miRNA catabolic process(GO:0010587)
0.2 6.9 GO:0035634 response to stilbenoid(GO:0035634)
0.2 0.8 GO:0001827 inner cell mass cell fate commitment(GO:0001827)
0.2 1.5 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.2 1.0 GO:0006751 glutathione catabolic process(GO:0006751)
0.2 1.1 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.2 0.8 GO:0043056 forward locomotion(GO:0043056)
0.1 0.7 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.1 2.0 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.1 1.3 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.1 4.1 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.1 3.1 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.1 0.9 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 2.2 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.1 0.4 GO:0032747 positive regulation of necrotic cell death(GO:0010940) positive regulation of interleukin-23 production(GO:0032747)
0.0 2.9 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.3 GO:0007341 penetration of zona pellucida(GO:0007341)
0.0 2.2 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 0.3 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 0.8 GO:0007602 phototransduction(GO:0007602)
0.0 1.4 GO:0006826 iron ion transport(GO:0006826)
0.0 0.9 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0 1.2 GO:0006754 ATP biosynthetic process(GO:0006754)
0.0 0.2 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 1.3 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 1.6 GO:0007127 meiosis I(GO:0007127)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 GO:0042629 mast cell granule(GO:0042629)
0.1 2.1 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.1 1.1 GO:0032585 multivesicular body membrane(GO:0032585)
0.1 0.7 GO:0005579 membrane attack complex(GO:0005579)
0.1 1.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 3.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 2.3 GO:0001533 cornified envelope(GO:0001533)
0.0 5.3 GO:0005902 microvillus(GO:0005902)
0.0 0.8 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.2 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 1.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 2.0 GO:0005604 basement membrane(GO:0005604)
0.0 1.1 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.2 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.6 4.4 GO:0008172 S-methyltransferase activity(GO:0008172)
0.4 1.5 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.3 1.3 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.3 1.6 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2 6.9 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.2 4.6 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.2 2.1 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.2 4.4 GO:0019825 oxygen binding(GO:0019825)
0.2 1.0 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.2 3.1 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 1.6 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 0.9 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.1 0.8 GO:0031433 telethonin binding(GO:0031433)
0.1 1.3 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.2 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 3.2 GO:0019003 GDP binding(GO:0019003)
0.0 2.4 GO:0019213 deacetylase activity(GO:0019213)
0.0 2.0 GO:0050699 WW domain binding(GO:0050699)
0.0 5.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.7 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.3 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.3 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.8 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 0.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.8 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.4 PID IL27 PATHWAY IL27-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 15.2 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 0.8 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 0.9 REACTOME OPSINS Genes involved in Opsins
0.1 2.2 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.2 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.5 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.7 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 1.3 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.8 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 2.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.2 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling