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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Smad2

Z-value: 0.66

Motif logo

Transcription factors associated with Smad2

Gene Symbol Gene ID Gene Info
ENSMUSG00000024563.17 Smad2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Smad2mm39_v1_chr18_+_76375206_763752450.056.5e-01Click!

Activity profile of Smad2 motif

Sorted Z-values of Smad2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Smad2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr7_-_126062272 7.57 ENSMUST00000032974.13
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr7_+_19144950 7.28 ENSMUST00000208710.2
ENSMUST00000003643.3
creatine kinase, muscle
chr1_-_172125555 4.50 ENSMUST00000085913.11
ENSMUST00000097464.4
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr1_-_173195236 3.45 ENSMUST00000005470.5
ENSMUST00000111220.8
cell adhesion molecule 3
chr12_-_103304573 2.99 ENSMUST00000149431.2
ankyrin repeat and SOCS box-containing 2
chr4_+_42950367 2.91 ENSMUST00000084662.12
DnaJ heat shock protein family (Hsp40) member B5
chr16_-_34334314 2.62 ENSMUST00000151491.8
ENSMUST00000114960.9
kalirin, RhoGEF kinase
chr3_-_116762617 2.46 ENSMUST00000143611.2
ENSMUST00000040097.14
palmdelphin
chr6_+_30639217 2.44 ENSMUST00000031806.10
carboxypeptidase A1, pancreatic
chr7_+_98916635 2.40 ENSMUST00000122101.8
ENSMUST00000068973.11
ENSMUST00000207883.2
microtubule-associated protein 6
chr15_+_82136598 2.35 ENSMUST00000136948.3
RIKEN cDNA 1500009C09 gene
chr12_+_51640097 2.31 ENSMUST00000164782.10
ENSMUST00000085412.7
cochlin
chr15_-_101833160 2.26 ENSMUST00000023797.8
keratin 4
chr16_-_34334454 2.24 ENSMUST00000089655.12
kalirin, RhoGEF kinase
chr10_-_5019044 2.21 ENSMUST00000095899.5
spectrin repeat containing, nuclear envelope 1
chr11_+_63022328 2.19 ENSMUST00000018361.10
peripheral myelin protein 22
chr17_-_46343291 2.01 ENSMUST00000071648.12
ENSMUST00000142351.9
vascular endothelial growth factor A
chr5_-_113938417 1.84 ENSMUST00000160374.2
ENSMUST00000067853.6
transmembrane protein 119
chr4_+_117706390 1.74 ENSMUST00000132043.9
ENSMUST00000169990.8
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr7_+_98916677 1.63 ENSMUST00000127492.2
microtubule-associated protein 6
chr13_-_78347876 1.57 ENSMUST00000091458.13
nuclear receptor subfamily 2, group F, member 1
chr8_-_69636825 1.55 ENSMUST00000185176.8
leucine zipper, putative tumor suppressor 1
chr3_+_87878378 1.55 ENSMUST00000090973.12
nestin
chr3_+_87878436 1.48 ENSMUST00000160694.2
nestin
chr4_-_155095441 1.42 ENSMUST00000105631.9
ENSMUST00000139976.9
ENSMUST00000145662.9
phospholipase C, eta 2
chr9_+_110074574 1.42 ENSMUST00000197850.5
chondroitin sulfate proteoglycan 5
chr5_-_146521629 1.37 ENSMUST00000200112.2
ENSMUST00000197431.2
ENSMUST00000197825.2
G-protein coupled receptor 12
chr18_+_37847792 1.36 ENSMUST00000192511.2
ENSMUST00000193476.2
protocadherin gamma subfamily A, 7
chr11_-_33097400 1.35 ENSMUST00000020507.8
fibroblast growth factor 18
chr4_+_117706559 1.28 ENSMUST00000163288.2
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr11_-_96720738 1.28 ENSMUST00000107657.8
ENSMUST00000081775.12
nuclear factor, erythroid derived 2,-like 1
chr3_-_116762476 1.25 ENSMUST00000119557.8
palmdelphin
chr7_+_142030744 1.21 ENSMUST00000149521.8
lymphocyte specific 1
chr11_+_69737491 1.17 ENSMUST00000019605.4
phospholipid scramblase 3
chr7_+_28151370 1.15 ENSMUST00000190954.7
leucine rich repeat and fibronectin type III domain containing 1
chr10_-_49664839 1.08 ENSMUST00000220263.2
ENSMUST00000218823.2
glutamate receptor, ionotropic, kainate 2 (beta 2)
chr6_+_117818135 1.04 ENSMUST00000112859.8
ENSMUST00000137224.8
ENSMUST00000164472.8
ENSMUST00000112861.8
ENSMUST00000223041.2
zinc finger protein 637
chr6_-_6882068 1.03 ENSMUST00000142635.2
ENSMUST00000052609.9
distal-less homeobox 5
chrX_+_98864627 1.01 ENSMUST00000096363.3
transmembrane protein 28
chr12_+_55883101 1.00 ENSMUST00000059250.8
breast cancer metastasis-suppressor 1-like
chr6_+_117818216 0.98 ENSMUST00000136889.8
ENSMUST00000134526.8
ENSMUST00000112858.8
ENSMUST00000112860.2
zinc finger protein 637
chr8_+_66838927 0.96 ENSMUST00000039540.12
ENSMUST00000110253.3
membrane associated ring-CH-type finger 1
chr1_+_75456173 0.96 ENSMUST00000113575.9
ENSMUST00000148980.2
ENSMUST00000050899.7
ENSMUST00000187411.2
transmembrane protein 198
chr11_+_69737437 0.95 ENSMUST00000152566.8
ENSMUST00000108633.9
phospholipid scramblase 3
chr13_-_104953631 0.94 ENSMUST00000154165.2
CWC27 spliceosome-associated protein
chrX_-_20797736 0.93 ENSMUST00000001156.8
complement factor properdin
chr2_-_148285450 0.84 ENSMUST00000099269.4
CD93 antigen
chr11_+_101010764 0.81 ENSMUST00000043680.9
tubulin, gamma 1
chr15_-_84007373 0.77 ENSMUST00000230566.2
ENSMUST00000019012.4
patatin-like phospholipase domain containing 5
chr13_-_100240570 0.77 ENSMUST00000038104.12
B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
chr1_-_150868802 0.76 ENSMUST00000074783.12
ENSMUST00000137197.9
hemicentin 1
chr4_+_117692583 0.75 ENSMUST00000169885.8
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr14_+_10123804 0.72 ENSMUST00000022262.6
ENSMUST00000224714.2
Fez family zinc finger 2
chr2_+_173918715 0.71 ENSMUST00000087908.10
ENSMUST00000044638.13
ENSMUST00000156054.2
syntaxin 16
chr9_+_35332837 0.71 ENSMUST00000119129.10
cell adhesion molecule-related/down-regulated by oncogenes
chr13_-_104953370 0.68 ENSMUST00000022228.13
CWC27 spliceosome-associated protein
chr6_-_90758954 0.64 ENSMUST00000238821.2
IQ motif and Sec7 domain 1
chr14_+_4137837 0.50 ENSMUST00000022296.7
ubiquitin-conjugating enzyme E2E 1
chr17_-_24752683 0.50 ENSMUST00000061764.14
RAB26, member RAS oncogene family
chr15_-_101471324 0.49 ENSMUST00000023714.5
keratin 90
chr14_+_4137944 0.48 ENSMUST00000225612.2
ubiquitin-conjugating enzyme E2E 1
chr4_+_83335947 0.48 ENSMUST00000030206.10
ENSMUST00000071544.11
small nuclear RNA activating complex, polypeptide 3
chr6_-_124733441 0.41 ENSMUST00000088357.12
atrophin 1
chr18_+_37440497 0.40 ENSMUST00000056712.4
protocadherin beta 4
chr8_+_19343376 0.39 ENSMUST00000033852.8
defensin beta 3
chr17_+_3447465 0.39 ENSMUST00000072156.7
T cell lymphoma invasion and metastasis 2
chr3_+_58484057 0.38 ENSMUST00000107924.3
selenoprotein T
chr5_+_115769960 0.36 ENSMUST00000031492.15
RAB35, member RAS oncogene family
chr10_-_37014859 0.35 ENSMUST00000092584.6
myristoylated alanine rich protein kinase C substrate
chr11_-_101010715 0.31 ENSMUST00000017946.6
reticulophagy regulator family member 3
chr6_+_83114020 0.30 ENSMUST00000121093.8
rhotekin
chr12_-_115129697 0.30 ENSMUST00000103524.2
ENSMUST00000193145.2
immunoglobulin heavy variable V8-6
chr6_+_83114086 0.29 ENSMUST00000087938.11
rhotekin
chr6_-_142647985 0.27 ENSMUST00000205202.3
ENSMUST00000073173.12
ENSMUST00000111771.8
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr12_-_114370581 0.25 ENSMUST00000191918.2
immunoglobulin heavy variable V6-4
chr7_-_99276310 0.24 ENSMUST00000178124.3
trophoblast glycoprotein-like
chr1_-_160079007 0.24 ENSMUST00000191909.6
RAB GTPase activating protein 1-like
chr12_-_113294138 0.24 ENSMUST00000194304.6
ENSMUST00000103420.3
immunoglobulin heavy constant gamma 1 (G1m marker)
chr7_-_44702269 0.20 ENSMUST00000057293.8
proline rich 12
chr6_-_55152002 0.20 ENSMUST00000003569.6
indolethylamine N-methyltransferase
chr16_-_18165876 0.12 ENSMUST00000125287.9
transport and golgi organization 2
chr16_+_18166045 0.07 ENSMUST00000239533.1
ENSMUST00000239534.1
armadillo repeat deleted in velocardiofacial syndrome
chr6_-_142647944 0.07 ENSMUST00000100827.5
ENSMUST00000087527.11
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr17_-_34834745 0.03 ENSMUST00000168353.4
EGF-like domain 8
chr1_+_153767478 0.03 ENSMUST00000050660.6
transmembrane epididymal protein 1A
chr12_-_113271532 0.02 ENSMUST00000192188.3
ENSMUST00000103418.3
immunoglobulin heavy constant gamma 2B
chr13_+_104953679 0.02 ENSMUST00000022230.15
splicing regulatory glutamine/lysine-rich protein 1interacting protein 1
chr3_+_135144202 0.01 ENSMUST00000166033.6
ubiquitin-conjugating enzyme E2D 3
chr11_-_75081284 0.01 ENSMUST00000044949.11
diphthamide biosynthesis 1
chr11_-_101010640 0.00 ENSMUST00000107295.10
reticulophagy regulator family member 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.6 GO:0051659 maintenance of mitochondrion location(GO:0051659) relaxation of skeletal muscle(GO:0090076)
1.3 3.8 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
1.1 4.5 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.7 2.0 GO:0038190 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190)
0.6 4.9 GO:0061366 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.3 1.0 GO:0060166 olfactory pit development(GO:0060166)
0.3 2.2 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.2 1.3 GO:1904849 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.2 1.8 GO:1903012 positive regulation of bone development(GO:1903012)
0.1 0.8 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 1.0 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 7.3 GO:0042398 cellular modified amino acid biosynthetic process(GO:0042398)
0.1 0.2 GO:0001788 antibody-dependent cellular cytotoxicity(GO:0001788)
0.1 0.7 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 2.2 GO:0032060 bleb assembly(GO:0032060)
0.1 1.0 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 1.1 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 0.9 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 1.6 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.4 GO:0009405 pathogenesis(GO:0009405)
0.0 0.4 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.5 GO:0009301 snRNA transcription(GO:0009301)
0.0 0.7 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.8 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 1.5 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.0 4.0 GO:0032418 lysosome localization(GO:0032418)
0.0 3.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 3.0 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 2.1 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 0.4 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.0 5.4 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.8 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.0 GO:0001796 type IIa hypersensitivity(GO:0001794) regulation of type IIa hypersensitivity(GO:0001796) positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type I hypersensitivity(GO:0001812) type II hypersensitivity(GO:0002445) regulation of type II hypersensitivity(GO:0002892) positive regulation of type II hypersensitivity(GO:0002894)
0.0 0.6 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 2.9 GO:0006457 protein folding(GO:0006457)
0.0 0.4 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.3 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 2.3 GO:0050680 negative regulation of epithelial cell proliferation(GO:0050680)
0.0 1.0 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.0 2.8 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)
0.0 0.5 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 7.6 GO:0031673 H zone(GO:0031673)
0.4 4.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.4 3.0 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 2.2 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 1.1 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 0.8 GO:0005827 polar microtubule(GO:0005827)
0.1 2.2 GO:0043218 compact myelin(GO:0043218)
0.1 0.8 GO:0090576 RNA polymerase III transcription factor complex(GO:0090576)
0.1 0.4 GO:0042585 germinal vesicle(GO:0042585)
0.1 2.3 GO:0045095 keratin filament(GO:0045095)
0.0 1.0 GO:0070822 Sin3-type complex(GO:0070822)
0.0 3.0 GO:0005882 intermediate filament(GO:0005882)
0.0 1.4 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 2.8 GO:0005604 basement membrane(GO:0005604)
0.0 5.3 GO:0043197 dendritic spine(GO:0043197)
0.0 4.9 GO:0014069 postsynaptic density(GO:0014069)
0.0 0.4 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 4.3 GO:0098793 presynapse(GO:0098793)
0.0 0.7 GO:0031201 SNARE complex(GO:0031201)
0.0 1.6 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 3.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 7.3 GO:0004111 creatine kinase activity(GO:0004111)
0.7 2.0 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.6 7.6 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.4 4.5 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391) steroid hormone binding(GO:1990239)
0.3 1.0 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.3 1.3 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.3 3.8 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.3 0.8 GO:0001156 TFIIIC-class transcription factor binding(GO:0001156)
0.3 3.0 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.2 1.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 0.5 GO:0019002 GMP binding(GO:0019002)
0.2 1.0 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 4.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.8 GO:0001849 complement component C1q binding(GO:0001849)
0.1 1.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 0.6 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 2.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 2.2 GO:0005521 lamin binding(GO:0005521)
0.1 2.1 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 1.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 1.4 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 0.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 1.6 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.2 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 2.9 GO:0051087 unfolded protein binding(GO:0051082) chaperone binding(GO:0051087)
0.0 0.4 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 1.0 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 1.6 GO:0005518 collagen binding(GO:0005518)
0.0 5.6 GO:0008017 microtubule binding(GO:0008017)
0.0 0.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.8 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.4 GO:0008432 JUN kinase binding(GO:0008432)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 4.9 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.1 7.0 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 1.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 2.2 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.8 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 1.3 PID FGF PATHWAY FGF signaling pathway
0.0 1.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.6 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.8 PID PLK1 PATHWAY PLK1 signaling events
0.0 2.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.6 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.2 2.0 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 3.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 4.5 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.5 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 1.3 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 0.8 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 5.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 1.1 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.0 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 0.5 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 2.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 7.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 1.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME MYOGENESIS Genes involved in Myogenesis