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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Smad4

Z-value: 1.09

Motif logo

Transcription factors associated with Smad4

Gene Symbol Gene ID Gene Info
ENSMUSG00000024515.14 Smad4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Smad4mm39_v1_chr18_-_73836810_738368770.094.3e-01Click!

Activity profile of Smad4 motif

Sorted Z-values of Smad4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Smad4

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr9_-_45847344 21.36 ENSMUST00000034590.4
transgelin
chr6_+_146934082 6.54 ENSMUST00000036194.6
RAB15 effector protein
chr16_+_34605282 6.36 ENSMUST00000023538.9
myosin, light polypeptide kinase
chr17_+_34482183 6.09 ENSMUST00000040828.7
ENSMUST00000237342.2
ENSMUST00000237866.2
histocompatibility 2, class II antigen A, beta 1
chrX_+_55824797 5.81 ENSMUST00000114773.10
four and a half LIM domains 1
chr11_+_105866030 5.52 ENSMUST00000001964.8
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chrX_-_7537580 5.51 ENSMUST00000033486.6
proteolipid protein 2
chr1_-_74130488 5.39 ENSMUST00000187584.7
tensin 1
chr7_-_70010341 5.37 ENSMUST00000032768.15
nuclear receptor subfamily 2, group F, member 2
chr6_-_52217821 5.37 ENSMUST00000121043.2
homeobox A10
chr10_+_18720760 5.35 ENSMUST00000019998.9
PERP, TP53 apoptosis effector
chr12_-_103304573 4.87 ENSMUST00000149431.2
ankyrin repeat and SOCS box-containing 2
chr17_+_75485791 4.79 ENSMUST00000135447.8
ENSMUST00000112516.8
latent transforming growth factor beta binding protein 1
chr6_-_68681962 4.64 ENSMUST00000103330.2
immunoglobulin kappa variable 10-94
chr19_-_40260060 4.56 ENSMUST00000068439.13
PDZ and LIM domain 1 (elfin)
chr18_-_52662917 4.38 ENSMUST00000171470.8
lysyl oxidase
chr18_-_52662728 4.37 ENSMUST00000025409.9
lysyl oxidase
chr7_+_130633776 4.21 ENSMUST00000084509.7
ENSMUST00000213064.3
ENSMUST00000208311.4
deleted in malignant brain tumors 1
chr10_+_79986280 4.21 ENSMUST00000153477.8
midnolin
chr4_+_138694422 4.16 ENSMUST00000116094.5
ENSMUST00000239443.2
ring finger protein 186
chr2_+_125876566 4.15 ENSMUST00000064794.14
fibroblast growth factor 7
chr17_+_75485906 4.15 ENSMUST00000112514.2
latent transforming growth factor beta binding protein 1
chr2_+_69500444 4.09 ENSMUST00000100050.4
kelch-like 41
chr19_-_40260286 4.09 ENSMUST00000182432.2
PDZ and LIM domain 1 (elfin)
chr19_+_5790918 4.03 ENSMUST00000081496.6
latent transforming growth factor beta binding protein 3
chr11_+_67131403 3.90 ENSMUST00000170942.2
myosin, heavy polypeptide 4, skeletal muscle
chr12_-_112766266 3.83 ENSMUST00000239525.1
AHNAK nucleoprotein 2
chr5_+_92831468 3.83 ENSMUST00000168878.8
shroom family member 3
chr14_-_25903524 3.81 ENSMUST00000052286.16
placenta specific 9a
chr2_+_152578164 3.73 ENSMUST00000038368.9
ENSMUST00000109824.2
inhibitor of DNA binding 1, HLH protein
chr5_+_64960705 3.70 ENSMUST00000165536.8
Kruppel-like factor 3 (basic)
chr5_+_31070739 3.69 ENSMUST00000031055.8
elastin microfibril interfacer 1
chr6_+_113448388 3.45 ENSMUST00000058300.14
interleukin 17 receptor C
chr2_+_125876883 3.38 ENSMUST00000110442.2
fibroblast growth factor 7
chr19_-_23425757 3.37 ENSMUST00000036069.8
MAM domain containing 2
chr15_+_58381886 3.35 ENSMUST00000161028.2
fer-1-like 6 (C. elegans)
chr7_+_18817767 3.34 ENSMUST00000032568.14
ENSMUST00000122999.8
ENSMUST00000108473.10
ENSMUST00000108474.2
ENSMUST00000238982.2
dystrophia myotonica-protein kinase
chr2_-_163592127 3.26 ENSMUST00000017841.4
adenosine deaminase
chr6_+_113449237 3.23 ENSMUST00000204447.3
interleukin 17 receptor C
chr7_+_45063079 3.19 ENSMUST00000058879.8
neurotrophin 5
chr17_+_34372046 3.18 ENSMUST00000114232.4
histocompatibility 2, class II, locus Mb1
chr4_-_148584906 3.15 ENSMUST00000030840.4
angiopoietin-like 7
chr19_-_6947112 3.13 ENSMUST00000025912.10
phospholipase C, beta 3
chr19_-_6947076 3.07 ENSMUST00000237074.2
phospholipase C, beta 3
chr11_-_101062111 2.95 ENSMUST00000164474.8
ENSMUST00000043397.14
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr4_+_150171822 2.94 ENSMUST00000094451.4
G protein-coupled receptor 157
chr2_+_27567246 2.93 ENSMUST00000166775.8
retinoid X receptor alpha
chr1_+_171509565 2.85 ENSMUST00000015499.14
ENSMUST00000068584.7
CD48 antigen
chr4_-_94940425 2.77 ENSMUST00000107094.2
jun proto-oncogene
chr11_-_33097400 2.73 ENSMUST00000020507.8
fibroblast growth factor 18
chr2_-_164231015 2.73 ENSMUST00000167427.2
secretory leukocyte peptidase inhibitor
chr7_+_44865177 2.69 ENSMUST00000033060.14
ENSMUST00000210447.2
ENSMUST00000211744.2
ENSMUST00000107801.10
TEA domain family member 2
chr12_-_114286421 2.68 ENSMUST00000103483.3
immunoglobulin heavy variable V3-8
chr3_+_89344006 2.67 ENSMUST00000038942.10
ENSMUST00000130858.8
ENSMUST00000146630.8
ENSMUST00000145753.2
pre B cell leukemia transcription factor interacting protein 1
chr6_-_69800923 2.66 ENSMUST00000103368.3
immunoglobulin kappa chain variable 5-43
chr2_-_155676765 2.57 ENSMUST00000029143.7
ENSMUST00000239423.2
family with sequence similarity 83, member C
chr10_+_39488930 2.48 ENSMUST00000019987.7
TRAF3 interacting protein 2
chrX_+_21581135 2.47 ENSMUST00000033414.8
solute carrier family 6 (neurotransmitter transporter), member 14
chr4_-_133981387 2.44 ENSMUST00000060050.6
glycine/arginine rich protein 1
chr15_-_103275190 2.44 ENSMUST00000023128.8
integrin alpha 5 (fibronectin receptor alpha)
chr13_-_22016364 2.38 ENSMUST00000102979.2
H4 clustered histone 18
chr12_-_36206780 2.33 ENSMUST00000223382.2
ENSMUST00000020856.6
basic leucine zipper and W2 domains 2
chr12_-_36206750 2.30 ENSMUST00000221388.2
basic leucine zipper and W2 domains 2
chr15_+_102885467 2.30 ENSMUST00000001706.7
homeobox C9
chr14_-_54651442 2.24 ENSMUST00000227334.2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr17_-_46342739 2.24 ENSMUST00000024747.14
vascular endothelial growth factor A
chr2_+_27567213 2.20 ENSMUST00000077257.12
retinoid X receptor alpha
chr7_+_25386418 2.19 ENSMUST00000002678.10
transforming growth factor, beta 1
chr7_+_140796537 2.15 ENSMUST00000141804.2
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr6_-_112364974 2.14 ENSMUST00000238755.2
ENSMUST00000060847.6
ssu-2 homolog (C. elegans)
chr10_-_37014859 2.11 ENSMUST00000092584.6
myristoylated alanine rich protein kinase C substrate
chrX_-_71318353 2.11 ENSMUST00000064780.4
gamma-aminobutyric acid (GABA) A receptor, subunit epsilon
chr6_+_68414401 2.08 ENSMUST00000103324.3
immunoglobulin kappa chain variable 15-103
chr4_+_8691303 2.07 ENSMUST00000051558.10
chromodomain helicase DNA binding protein 7
chr5_-_138980690 2.04 ENSMUST00000046901.14
ENSMUST00000076095.14
platelet derived growth factor, alpha
chr9_-_58065800 2.01 ENSMUST00000168864.4
immunoglobulin superfamily containing leucine-rich repeat
chr17_+_34816826 2.01 ENSMUST00000015596.10
ENSMUST00000174496.9
ENSMUST00000173992.8
advanced glycosylation end product-specific receptor
chr19_+_4282487 2.00 ENSMUST00000235306.2
polymerase (DNA-directed), delta 4
chr17_-_71158703 1.98 ENSMUST00000166395.9
TGFB-induced factor homeobox 1
chr5_-_41921834 1.95 ENSMUST00000060820.8
NK3 homeobox 2
chr8_+_96078886 1.95 ENSMUST00000034243.7
matrix metallopeptidase 15
chr1_-_153061758 1.93 ENSMUST00000185356.7
laminin, gamma 2
chr7_-_81642034 1.92 ENSMUST00000026096.10
basonuclin 1
chr15_+_102884874 1.88 ENSMUST00000173306.2
homeobox C9
chr9_+_108782664 1.84 ENSMUST00000026740.6
collagen, type VII, alpha 1
chr12_-_36206626 1.84 ENSMUST00000220828.2
basic leucine zipper and W2 domains 2
chr15_-_96358612 1.84 ENSMUST00000047835.8
SR-related CTD-associated factor 11
chr1_+_171197660 1.81 ENSMUST00000111286.9
nectin cell adhesion molecule 4
chr9_+_7344357 1.81 ENSMUST00000150167.2
ENSMUST00000120655.8
matrix metallopeptidase 12
chr7_+_101043568 1.81 ENSMUST00000098243.4
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr6_+_38410848 1.80 ENSMUST00000160583.8
ubinuclein 2
chr10_-_118705029 1.78 ENSMUST00000004281.10
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr3_-_135397298 1.77 ENSMUST00000029812.14
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
chr10_+_90918802 1.75 ENSMUST00000020150.10
ENSMUST00000020149.6
IKBKB interacting protein
chr7_+_45055077 1.75 ENSMUST00000107774.3
potassium voltage-gated channel, shaker-related subfamily, member 7
chr19_+_4282040 1.74 ENSMUST00000237518.2
polymerase (DNA-directed), delta 4
chr9_+_108782646 1.74 ENSMUST00000112070.8
collagen, type VII, alpha 1
chr11_-_3881995 1.72 ENSMUST00000020710.11
ENSMUST00000109989.10
ENSMUST00000109991.8
ENSMUST00000109993.9
transcobalamin 2
chr17_-_25300112 1.72 ENSMUST00000024984.7
transmembrane protein 204
chr3_+_60436570 1.71 ENSMUST00000192607.6
muscleblind like splicing factor 1
chrX_+_98179725 1.71 ENSMUST00000052839.7
ephrin B1
chr2_-_173117936 1.70 ENSMUST00000139306.2
prostate transmembrane protein, androgen induced 1
chr6_-_129428746 1.69 ENSMUST00000204012.2
ENSMUST00000037481.10
C-type lectin domain family 1, member a
chr19_-_31641770 1.68 ENSMUST00000073581.6
protein kinase, cGMP-dependent, type I
chr13_+_21995906 1.68 ENSMUST00000104941.4
H4 clustered histone 17
chr12_-_113928438 1.66 ENSMUST00000103478.4
immunoglobulin heavy variable 3-1
chr9_+_61280501 1.66 ENSMUST00000162583.8
ENSMUST00000161993.8
ENSMUST00000160882.8
ENSMUST00000160724.8
ENSMUST00000162973.8
ENSMUST00000159050.8
transducin-like enhancer of split 3
chr14_-_55950545 1.65 ENSMUST00000002389.9
ENSMUST00000226907.2
transglutaminase 1, K polypeptide
chr5_+_88523967 1.65 ENSMUST00000073363.2
amelotin
chr1_+_187730018 1.64 ENSMUST00000027906.13
estrogen-related receptor gamma
chr9_+_53678801 1.63 ENSMUST00000048670.10
solute carrier family 35, member F2
chr11_-_3881789 1.62 ENSMUST00000109992.8
ENSMUST00000109988.2
transcobalamin 2
chr11_-_69304501 1.54 ENSMUST00000094077.5
KDM1 lysine (K)-specific demethylase 6B
chr13_+_23715220 1.52 ENSMUST00000102972.6
H4 clustered histone 8
chr6_+_15720653 1.51 ENSMUST00000101663.10
ENSMUST00000190255.7
ENSMUST00000189359.7
ENSMUST00000125326.8
MyoD family inhibitor domain containing
chr15_+_102012782 1.50 ENSMUST00000230474.2
tensin 2
chr12_-_11200306 1.46 ENSMUST00000055673.2
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr11_-_3881960 1.46 ENSMUST00000109990.8
transcobalamin 2
chr17_-_46343291 1.42 ENSMUST00000071648.12
ENSMUST00000142351.9
vascular endothelial growth factor A
chr15_-_98505508 1.42 ENSMUST00000096224.6
adenylate cyclase 6
chr19_+_4281953 1.39 ENSMUST00000025773.5
polymerase (DNA-directed), delta 4
chr19_+_4147391 1.39 ENSMUST00000174514.2
ENSMUST00000174149.8
CDK2-associated protein 2
chr1_+_53100796 1.38 ENSMUST00000027269.7
ENSMUST00000191197.2
myostatin
chr9_+_61280764 1.35 ENSMUST00000160541.8
ENSMUST00000161207.8
ENSMUST00000159630.8
transducin-like enhancer of split 3
chr3_+_63203516 1.35 ENSMUST00000029400.7
membrane metallo endopeptidase
chr14_-_30890544 1.32 ENSMUST00000036618.14
stabilin 1
chrX_-_94070277 1.30 ENSMUST00000096367.5
spindlin family, member 4
chr8_-_41469786 1.26 ENSMUST00000117735.8
mitochondrial tumor suppressor 1
chr4_-_133972890 1.22 ENSMUST00000030644.8
zinc finger protein 593
chr4_-_148215135 1.21 ENSMUST00000030862.5
dorsal inhibitory axon guidance protein
chr19_+_4015900 1.20 ENSMUST00000025794.7
aldehyde dehydrogenase 3 family, member B3
chr6_-_129428869 1.20 ENSMUST00000203162.3
C-type lectin domain family 1, member a
chr15_-_98676007 1.18 ENSMUST00000226655.2
ENSMUST00000228546.2
ENSMUST00000023732.12
ENSMUST00000226610.2
wingless-type MMTV integration site family, member 10B
chr14_+_76652369 1.16 ENSMUST00000110888.8
TSC22 domain family, member 1
chr7_+_19197192 1.12 ENSMUST00000137613.9
exocyst complex component 3-like 2
chr15_+_102011415 1.12 ENSMUST00000046144.10
tensin 2
chr7_-_119494918 1.09 ENSMUST00000059851.14
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr4_-_117035922 1.09 ENSMUST00000153953.2
ENSMUST00000106436.8
kinesin family member 2C
chr15_+_102011352 1.08 ENSMUST00000169627.9
tensin 2
chr18_-_33597060 1.08 ENSMUST00000168890.2
neuronal regeneration related protein
chr11_+_69737437 1.07 ENSMUST00000152566.8
ENSMUST00000108633.9
phospholipid scramblase 3
chr1_-_180524587 1.07 ENSMUST00000027778.8
Mix1 homeobox-like 1 (Xenopus laevis)
chr15_-_103161237 1.04 ENSMUST00000154510.8
nuclear factor, erythroid derived 2
chr14_+_65187485 1.03 ENSMUST00000043914.8
ENSMUST00000239450.2
integrator complex subunit 9
chr2_+_29759495 1.03 ENSMUST00000047521.7
ENSMUST00000134152.2
cerebral endothelial cell adhesion molecule
chr10_+_79986988 1.03 ENSMUST00000146516.8
ENSMUST00000144526.2
midnolin
chr7_+_44866095 1.02 ENSMUST00000209437.2
TEA domain family member 2
chr1_+_59802543 1.00 ENSMUST00000087435.7
bone morphogenetic protein receptor, type II (serine/threonine kinase)
chr5_+_76632178 1.00 ENSMUST00000172369.2
predicted gene 7271
chr10_-_107321938 0.99 ENSMUST00000000445.2
myogenic factor 5
chr5_-_123822338 0.99 ENSMUST00000111561.8
CAP-GLY domain containing linker protein 1
chr8_+_79754980 0.98 ENSMUST00000087927.11
ENSMUST00000098614.9
zinc finger protein 827
chr1_+_187730032 0.98 ENSMUST00000110938.2
estrogen-related receptor gamma
chr9_-_14292453 0.95 ENSMUST00000167549.2
endonuclease domain containing 1
chr18_+_69478790 0.93 ENSMUST00000202116.4
ENSMUST00000114982.8
ENSMUST00000078486.13
ENSMUST00000202772.4
ENSMUST00000201288.4
transcription factor 4
chr11_+_97554192 0.92 ENSMUST00000044730.12
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
chr3_+_102641822 0.90 ENSMUST00000029451.12
tetraspanin 2
chr3_+_116761916 0.86 ENSMUST00000117592.2
RIKEN cDNA 4930455H04 gene
chr1_-_87029312 0.82 ENSMUST00000113270.3
alkaline phosphatase, intestinal
chr3_+_63203235 0.80 ENSMUST00000194134.6
membrane metallo endopeptidase
chr11_-_118233326 0.80 ENSMUST00000103024.4
CEP295 N-terminal like
chr5_+_76631887 0.79 ENSMUST00000191515.8
predicted gene 7271
chr9_+_21336300 0.79 ENSMUST00000172482.8
ENSMUST00000174050.8
dynamin 2
chr4_-_137309415 0.78 ENSMUST00000238941.2
low density lipoprotein receptor class A domain containing 2
chr14_+_54409257 0.77 ENSMUST00000197949.2
T cell receptor alpha joining 47
chr14_+_32321824 0.77 ENSMUST00000068938.7
ENSMUST00000228878.2
paired related homeobox protein-like 1
chr18_+_67338437 0.75 ENSMUST00000210564.3
charged multivesicular body protein 1B
chr10_-_90918515 0.74 ENSMUST00000159110.8
apoptotic peptidase activating factor 1
chrX_+_158491589 0.73 ENSMUST00000080394.13
SH3-domain kinase binding protein 1
chr7_+_140796559 0.72 ENSMUST00000148975.3
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr11_-_55498559 0.70 ENSMUST00000108853.8
ENSMUST00000075603.5
glycine receptor, alpha 1 subunit
chr13_-_98773862 0.69 ENSMUST00000050389.5
transmembrane protein 174
chr9_+_61280890 0.68 ENSMUST00000161689.8
transducin-like enhancer of split 3
chr11_-_115310743 0.68 ENSMUST00000106537.8
ENSMUST00000043931.9
ENSMUST00000073791.10
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit D
chr14_-_54791816 0.67 ENSMUST00000022784.9
HAUS augmin-like complex, subunit 4
chr14_-_58063585 0.62 ENSMUST00000022536.3
spindle and kinetochore associated complex subunit 3
chr7_+_99412714 0.61 ENSMUST00000220001.2
ENSMUST00000219663.2
olfactory receptor 521
chr13_+_111391544 0.60 ENSMUST00000054716.4
actin, beta-like 2
chr11_-_52104814 0.59 ENSMUST00000075844.4
olfactory receptor 1371
chr4_-_119047146 0.59 ENSMUST00000124626.9
erythroblast membrane-associated protein
chr5_-_124490296 0.59 ENSMUST00000111472.6
CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr1_+_152275575 0.59 ENSMUST00000044311.9
collagen beta(1-O)galactosyltransferase 2
chr11_+_69737491 0.58 ENSMUST00000019605.4
phospholipid scramblase 3
chr7_+_100970435 0.57 ENSMUST00000210192.2
ENSMUST00000172630.8
START domain containing 10
chr5_-_123822351 0.57 ENSMUST00000111564.8
ENSMUST00000063905.12
CAP-GLY domain containing linker protein 1
chr19_-_10716335 0.56 ENSMUST00000025571.9
ENSMUST00000238167.2
CD5 antigen
chr4_-_119047180 0.55 ENSMUST00000150864.3
ENSMUST00000141227.9
erythroblast membrane-associated protein
chr9_+_40098375 0.54 ENSMUST00000062229.6
olfactory receptor 986
chr13_-_23735822 0.52 ENSMUST00000102971.2
H4 clustered histone 6
chr1_-_133728779 0.51 ENSMUST00000143567.8
ATPase, Ca++ transporting, plasma membrane 4
chr18_-_84104507 0.51 ENSMUST00000060303.10
teashirt zinc finger family member 1
chr3_+_127426783 0.50 ENSMUST00000029587.9
neurogenin 2
chr12_+_36207113 0.49 ENSMUST00000041640.5
ankyrin repeat and MYND domain containing 2
chr17_+_28259749 0.49 ENSMUST00000233869.2
ankyrin repeat and SAM domain containing 1
chr3_-_96833336 0.49 ENSMUST00000062944.7
gap junction protein, alpha 8
chr9_-_110576192 0.47 ENSMUST00000199791.2
parathyroid hormone 1 receptor
chr15_+_82230155 0.47 ENSMUST00000023086.15
single-pass membrane protein with aspartate rich tail 1
chr18_+_69479211 0.46 ENSMUST00000201235.4
transcription factor 4
chr18_-_84104574 0.46 ENSMUST00000175783.3
teashirt zinc finger family member 1
chr9_-_110576124 0.46 ENSMUST00000199862.5
ENSMUST00000198865.5
parathyroid hormone 1 receptor

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.5 GO:0061033 secretion by lung epithelial cell involved in lung growth(GO:0061033)
2.1 6.4 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
2.0 6.1 GO:0002344 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
1.8 5.5 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
1.3 5.4 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
1.3 4.0 GO:0036363 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
1.2 3.7 GO:0038190 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190)
1.1 3.3 GO:0046101 germinal center B cell differentiation(GO:0002314) adenosine catabolic process(GO:0006154) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101) purine deoxyribonucleoside metabolic process(GO:0046122) negative regulation of mucus secretion(GO:0070256)
1.1 3.2 GO:0061193 taste bud development(GO:0061193)
1.0 5.1 GO:0006447 regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
1.0 1.0 GO:2000137 negative regulation of cell proliferation involved in heart morphogenesis(GO:2000137)
0.9 6.2 GO:0031161 phosphatidylinositol catabolic process(GO:0031161)
0.8 4.8 GO:0015889 cobalamin transport(GO:0015889)
0.7 8.8 GO:0048251 elastic fiber assembly(GO:0048251)
0.7 2.2 GO:0019049 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834) negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.7 1.4 GO:1904117 response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.7 2.1 GO:0021553 olfactory nerve development(GO:0021553)
0.7 2.0 GO:0010512 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512)
0.7 2.0 GO:2001200 positive regulation of dendritic cell differentiation(GO:2001200)
0.7 3.3 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.6 1.8 GO:1904631 negative regulation of interleukin-12 biosynthetic process(GO:0045083) response to diterpene(GO:1904629) cellular response to diterpene(GO:1904630) response to glucoside(GO:1904631) cellular response to glucoside(GO:1904632)
0.6 1.7 GO:0070175 positive regulation of enamel mineralization(GO:0070175)
0.5 4.9 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.5 7.3 GO:0033572 transferrin transport(GO:0033572)
0.5 2.8 GO:0051365 leading edge cell differentiation(GO:0035026) cellular response to potassium ion starvation(GO:0051365)
0.4 2.7 GO:1904849 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.4 5.3 GO:0002934 desmosome organization(GO:0002934)
0.4 1.1 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.3 1.4 GO:0014732 skeletal muscle atrophy(GO:0014732)
0.3 2.7 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.3 1.7 GO:1902608 regulation of large conductance calcium-activated potassium channel activity(GO:1902606) positive regulation of large conductance calcium-activated potassium channel activity(GO:1902608)
0.3 1.6 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.3 2.2 GO:0071492 cellular response to UV-A(GO:0071492)
0.3 0.9 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160)
0.3 6.7 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.3 3.4 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.3 8.9 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.3 4.3 GO:0031272 regulation of pseudopodium assembly(GO:0031272)
0.2 1.9 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.2 1.2 GO:0051885 positive regulation of anagen(GO:0051885)
0.2 1.4 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.2 3.8 GO:0001778 plasma membrane repair(GO:0001778)
0.2 7.8 GO:0014823 response to activity(GO:0014823)
0.2 1.8 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.2 1.5 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.2 1.7 GO:0010838 positive regulation of keratinocyte proliferation(GO:0010838)
0.2 2.9 GO:0060019 radial glial cell differentiation(GO:0060019)
0.2 1.8 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054) negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.2 1.1 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.2 2.4 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.2 1.0 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.2 4.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 3.7 GO:0048368 lateral mesoderm development(GO:0048368)
0.2 3.2 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.1 5.1 GO:0000731 DNA synthesis involved in DNA repair(GO:0000731)
0.1 1.9 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.1 1.0 GO:0060023 soft palate development(GO:0060023)
0.1 5.4 GO:0060065 uterus development(GO:0060065)
0.1 0.4 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 0.4 GO:2000321 positive regulation of T-helper 17 cell differentiation(GO:2000321)
0.1 5.8 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.1 0.9 GO:0014004 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.1 2.0 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 2.5 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 1.9 GO:0070831 basement membrane assembly(GO:0070831)
0.1 1.0 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.1 2.2 GO:0021516 dorsal spinal cord development(GO:0021516)
0.1 2.7 GO:0019731 antibacterial humoral response(GO:0019731)
0.1 1.2 GO:0010225 response to UV-C(GO:0010225)
0.1 0.4 GO:1900109 regulation of histone H3-K9 dimethylation(GO:1900109)
0.1 0.4 GO:2000870 regulation of progesterone secretion(GO:2000870)
0.1 0.7 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.1 1.4 GO:2000035 regulation of stem cell division(GO:2000035)
0.1 2.3 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.1 2.1 GO:0051764 actin crosslink formation(GO:0051764)
0.1 2.4 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.1 2.3 GO:0006356 regulation of transcription from RNA polymerase I promoter(GO:0006356)
0.1 1.1 GO:0051601 exocyst localization(GO:0051601)
0.1 0.6 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.1 5.5 GO:0010761 fibroblast migration(GO:0010761)
0.1 0.7 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.1 1.5 GO:0050434 positive regulation of viral transcription(GO:0050434)
0.1 3.7 GO:0070207 protein homotrimerization(GO:0070207)
0.1 1.7 GO:0001945 lymph vessel development(GO:0001945)
0.1 0.9 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.1 0.3 GO:0061198 maintenance of chromatin silencing(GO:0006344) fungiform papilla formation(GO:0061198)
0.0 0.4 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 2.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 2.6 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.9 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.5 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.0 1.0 GO:0016180 snRNA processing(GO:0016180)
0.0 0.5 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 2.7 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.0 0.1 GO:0043686 co-translational protein modification(GO:0043686)
0.0 0.7 GO:0039702 viral budding via host ESCRT complex(GO:0039702)
0.0 3.1 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 1.3 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.3 GO:0035630 bone mineralization involved in bone maturation(GO:0035630)
0.0 1.8 GO:0046718 viral entry into host cell(GO:0046718)
0.0 0.4 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.0 7.3 GO:0002377 immunoglobulin production(GO:0002377)
0.0 3.4 GO:0048704 embryonic skeletal system morphogenesis(GO:0048704)
0.0 2.5 GO:0045576 mast cell activation(GO:0045576)
0.0 3.1 GO:0045445 myoblast differentiation(GO:0045445)
0.0 2.1 GO:0042476 odontogenesis(GO:0042476)
0.0 0.6 GO:0060325 face morphogenesis(GO:0060325)
0.0 3.7 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 13.8 GO:0030855 epithelial cell differentiation(GO:0030855)
0.0 0.7 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 1.7 GO:0055092 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 3.8 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 1.3 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 0.5 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 2.5 GO:0009636 response to toxic substance(GO:0009636)
0.0 1.2 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 0.2 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 3.7 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 8.9 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
1.0 5.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.9 3.7 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.8 9.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.7 4.9 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.6 1.9 GO:0005607 laminin-2 complex(GO:0005607)
0.6 2.8 GO:0035976 AP1 complex(GO:0035976)
0.4 2.1 GO:0042585 germinal vesicle(GO:0042585)
0.3 4.2 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.2 6.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 5.5 GO:0097225 sperm midpiece(GO:0097225)
0.2 1.6 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 0.7 GO:0043293 apoptosome(GO:0043293)
0.1 3.9 GO:0032982 myosin filament(GO:0032982)
0.1 1.8 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 15.1 GO:0005581 collagen trimer(GO:0005581)
0.1 3.4 GO:0005614 interstitial matrix(GO:0005614)
0.1 5.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.7 GO:0070652 HAUS complex(GO:0070652)
0.1 4.2 GO:0016235 aggresome(GO:0016235)
0.1 3.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 3.8 GO:0043034 costamere(GO:0043034)
0.1 12.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 1.7 GO:0005605 basal lamina(GO:0005605)
0.1 0.5 GO:1990246 uniplex complex(GO:1990246)
0.1 0.7 GO:0000815 ESCRT III complex(GO:0000815)
0.1 0.6 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 1.4 GO:0031528 microvillus membrane(GO:0031528)
0.1 1.0 GO:0032039 integrator complex(GO:0032039)
0.1 2.1 GO:0008305 integrin complex(GO:0008305)
0.1 0.4 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.0 1.1 GO:0000145 exocyst(GO:0000145)
0.0 0.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 3.5 GO:0005604 basement membrane(GO:0005604)
0.0 4.8 GO:0005902 microvillus(GO:0005902)
0.0 0.6 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 2.0 GO:0009925 basal plasma membrane(GO:0009925)
0.0 6.5 GO:0055037 recycling endosome(GO:0055037)
0.0 1.2 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 2.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 6.9 GO:0042383 sarcolemma(GO:0042383)
0.0 1.1 GO:0035371 microtubule plus-end(GO:0035371)
0.0 18.6 GO:0005912 adherens junction(GO:0005912)
0.0 3.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 5.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.3 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 8.9 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.0 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.9 GO:0032993 protein-DNA complex(GO:0032993)
0.0 21.7 GO:0005615 extracellular space(GO:0005615)
0.0 0.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 5.9 GO:0005789 endoplasmic reticulum membrane(GO:0005789)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 9.4 GO:0050436 microfibril binding(GO:0050436)
1.5 10.3 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
1.5 8.8 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
1.4 4.2 GO:0035375 zymogen binding(GO:0035375)
1.2 3.7 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
1.2 3.7 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
1.1 5.5 GO:0008240 tripeptidyl-peptidase activity(GO:0008240) bradykinin receptor binding(GO:0031711)
0.7 6.7 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.7 6.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.7 2.0 GO:0050785 advanced glycation end-product receptor activity(GO:0050785)
0.6 5.1 GO:0070644 vitamin D response element binding(GO:0070644)
0.5 2.5 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.4 4.8 GO:0031419 cobalamin binding(GO:0031419)
0.4 3.2 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.4 6.1 GO:1990405 protein antigen binding(GO:1990405)
0.4 2.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.3 8.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.3 1.7 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.3 5.4 GO:0001972 retinoic acid binding(GO:0001972)
0.2 6.2 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.2 3.3 GO:0004000 adenosine deaminase activity(GO:0004000)
0.2 1.5 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.2 1.4 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.2 2.6 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.2 5.5 GO:0019956 chemokine binding(GO:0019956)
0.2 1.0 GO:0098821 BMP receptor activity(GO:0098821)
0.2 3.7 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.2 5.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 1.7 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 4.0 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 3.7 GO:0070628 proteasome binding(GO:0070628)
0.1 0.7 GO:0030977 taurine binding(GO:0030977)
0.1 2.8 GO:0035497 cAMP response element binding(GO:0035497)
0.1 1.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 1.2 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 0.9 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.1 1.7 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 3.2 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.1 2.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.8 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 2.4 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.1 0.4 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 2.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 2.2 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.1 0.3 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.1 1.3 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 26.8 GO:0051015 actin filament binding(GO:0051015)
0.1 0.3 GO:0035851 Krueppel-associated box domain binding(GO:0035851)
0.1 1.4 GO:0070412 R-SMAD binding(GO:0070412)
0.1 1.5 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.8 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 2.0 GO:0070410 co-SMAD binding(GO:0070410)
0.1 2.1 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 0.9 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 1.7 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 0.3 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 0.7 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 5.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.5 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235) protein phosphatase 2B binding(GO:0030346)
0.0 6.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 3.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.7 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 6.6 GO:0003823 antigen binding(GO:0003823)
0.0 1.7 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 1.7 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.2 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 1.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.4 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 3.3 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.2 GO:0034061 DNA polymerase activity(GO:0034061)
0.0 0.6 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 5.4 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.2 GO:0031432 titin binding(GO:0031432)
0.0 3.2 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 1.1 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.6 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.0 3.6 GO:0044325 ion channel binding(GO:0044325)
0.0 1.8 GO:0051082 unfolded protein binding(GO:0051082)
0.0 6.5 GO:0045296 cadherin binding(GO:0045296)
0.0 3.7 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 0.1 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.7 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.4 3.7 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.2 2.8 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 5.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 6.2 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.1 7.4 PID AURORA B PATHWAY Aurora B signaling
0.1 1.8 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 4.7 PID ALK1 PATHWAY ALK1 signaling events
0.1 8.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 1.9 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 6.0 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.1 5.1 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 5.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 1.7 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 20.8 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.1 19.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.0 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 17.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 1.7 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.1 2.1 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 16.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.6 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 3.3 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.7 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 2.9 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.7 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.8 PID P53 REGULATION PATHWAY p53 pathway
0.0 2.4 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 8.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.4 5.1 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.4 3.7 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.3 10.3 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.2 8.8 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 2.8 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 3.3 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 6.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.0 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 3.9 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 1.4 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 2.0 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 4.0 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 6.5 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.9 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 3.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 7.5 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.1 3.2 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.8 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 1.4 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 1.1 REACTOME KINESINS Genes involved in Kinesins
0.0 0.7 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.7 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 1.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 2.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.4 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 2.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.2 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.7 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 1.9 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 1.6 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.7 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis