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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Snai1_Zeb1_Snai2
Z-value: 6.75
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Transcription factors associated with Snai1_Zeb1_Snai2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zeb1 | mm39_v1_chr18_+_5591864_5591902 | -0.39 | 6.1e-04 | Click! |
| Snai2 | mm39_v1_chr16_+_14523696_14523722 | -0.16 | 1.7e-01 | Click! |
| Snai1 | mm39_v1_chr2_+_167380112_167380130 | -0.06 | 6.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Snai1_Zeb1_Snai2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.5 | 225.0 | GO:0060445 | branching involved in salivary gland morphogenesis(GO:0060445) |
| 8.1 | 145.9 | GO:0070673 | response to interleukin-18(GO:0070673) |
| 6.4 | 141.5 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 2.8 | 122.5 | GO:0050891 | multicellular organismal water homeostasis(GO:0050891) |
| 11.0 | 121.0 | GO:0045198 | establishment of epithelial cell apical/basal polarity(GO:0045198) |
| 2.4 | 120.2 | GO:0045104 | intermediate filament cytoskeleton organization(GO:0045104) |
| 38.9 | 116.6 | GO:0060672 | epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672) |
| 0.7 | 109.1 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 7.1 | 106.0 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 25.7 | 102.7 | GO:1902896 | terminal web assembly(GO:1902896) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1196.1 | GO:0070062 | extracellular exosome(GO:0070062) |
| 2.7 | 511.2 | GO:0070160 | occluding junction(GO:0070160) |
| 0.3 | 409.2 | GO:0005615 | extracellular space(GO:0005615) |
| 10.8 | 357.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 297.5 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.5 | 194.7 | GO:0005925 | focal adhesion(GO:0005925) |
| 21.5 | 193.2 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 3.4 | 143.3 | GO:0045095 | keratin filament(GO:0045095) |
| 1.2 | 140.6 | GO:0032587 | ruffle membrane(GO:0032587) |
| 1.1 | 140.4 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 385.6 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 1.5 | 243.3 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.9 | 179.6 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.2 | 153.2 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 8.7 | 138.4 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 1.1 | 136.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 2.2 | 125.8 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 5.1 | 117.5 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 3.2 | 103.4 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 4.5 | 98.3 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 163.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 1.5 | 146.2 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.6 | 119.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 2.5 | 117.9 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 5.5 | 93.6 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 1.2 | 90.0 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 1.5 | 89.4 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 5.1 | 86.9 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 2.8 | 83.1 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 2.5 | 79.2 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.3 | 340.6 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 13.7 | 301.5 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 9.4 | 140.6 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 5.0 | 120.8 | REACTOME P38MAPK EVENTS | Genes involved in p38MAPK events |
| 1.4 | 114.4 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 1.6 | 108.5 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 1.5 | 101.5 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 2.0 | 98.4 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 1.1 | 95.0 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 1.5 | 89.4 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |