Project

PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

Navigation
Downloads

Results for Sox8

Z-value: 0.77

Motif logo

logo of

Transcription factors associated with Sox8

Gene Symbol Gene ID Gene Info
Sox8
ENSMUSG00000024176.11 Sox8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sox8mm39_v1_chr17_-_25789652_257896700.588.7e-08Click!

Activity profile of Sox8 motif

Sorted Z-values of Sox8 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox8

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:

Promoter Score Transcript Gene Gene Info
chr13_-_51723473 8.46 ENSMUST00000239056.2
ENSMUST00000223543.3
Shc3
src homology 2 domain-containing transforming protein C3
chr7_-_126399778 5.28 ENSMUST00000141355.4
Aldoa
aldolase A, fructose-bisphosphate
chr7_-_126399208 4.79 ENSMUST00000133514.8
ENSMUST00000151137.8
Aldoa
aldolase A, fructose-bisphosphate
chr4_+_11758147 4.51 ENSMUST00000029871.12
ENSMUST00000108303.2
Cdh17
cadherin 17
chr7_-_126399574 4.20 ENSMUST00000106348.8
Aldoa
aldolase A, fructose-bisphosphate
chr9_+_36744016 3.97 ENSMUST00000214772.2
Fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr13_+_93441307 3.90 ENSMUST00000080127.12
Homer1
homer scaffolding protein 1
chr1_-_79838897 3.86 ENSMUST00000190724.2
Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr3_+_65016750 3.81 ENSMUST00000049230.11
Kcnab1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr9_+_109881083 3.49 ENSMUST00000164930.8
ENSMUST00000199498.5
Map4
microtubule-associated protein 4
chr1_+_109911467 3.28 ENSMUST00000172005.8
Cdh7
cadherin 7, type 2
chr9_-_95697441 3.26 ENSMUST00000119760.2
Pls1
plastin 1 (I-isoform)
chr17_+_44445659 3.13 ENSMUST00000239215.2
Clic5
chloride intracellular channel 5
chr5_-_103174794 2.93 ENSMUST00000128869.8
Mapk10
mitogen-activated protein kinase 10
chr7_-_100306160 2.93 ENSMUST00000107046.8
ENSMUST00000107045.9
ENSMUST00000139708.9
Plekhb1
pleckstrin homology domain containing, family B (evectins) member 1
chr10_-_33972503 2.75 ENSMUST00000069125.8
Calhm5
calcium homeostasis modulator family member 5
chr9_+_65008735 2.72 ENSMUST00000213533.2
ENSMUST00000035499.5
ENSMUST00000077696.13
ENSMUST00000166273.2
Igdcc4
immunoglobulin superfamily, DCC subclass, member 4
chrX_+_133305529 2.72 ENSMUST00000113224.9
ENSMUST00000113226.2
Drp2
dystrophin related protein 2
chr2_-_73605387 2.69 ENSMUST00000166199.9
Chn1
chimerin 1
chr12_-_115722081 2.68 ENSMUST00000103541.3
Ighv1-72
immunoglobulin heavy variable 1-72
chr2_+_109522781 2.66 ENSMUST00000111050.10
Bdnf
brain derived neurotrophic factor
chr18_+_37085673 2.54 ENSMUST00000192512.6
ENSMUST00000192295.2
ENSMUST00000115661.5
Pcdha4
Gm42416
protocadherin alpha 4
predicted gene, 42416
chr16_-_29360301 2.52 ENSMUST00000057018.15
ENSMUST00000182627.8
Atp13a4
ATPase type 13A4
chr4_-_116263183 2.36 ENSMUST00000123072.8
ENSMUST00000144281.2
Mast2
microtubule associated serine/threonine kinase 2
chr8_-_34237752 2.25 ENSMUST00000179364.3
Smim18
small integral membrane protein 18
chr1_+_135710803 2.19 ENSMUST00000132795.8
Tnni1
troponin I, skeletal, slow 1
chr19_+_4771089 2.09 ENSMUST00000238976.3
Sptbn2
spectrin beta, non-erythrocytic 2
chrX_-_161426542 2.02 ENSMUST00000101102.2
Reps2
RALBP1 associated Eps domain containing protein 2
chr18_+_37637317 2.02 ENSMUST00000052179.8
Pcdhb20
protocadherin beta 20
chr4_+_127062924 1.94 ENSMUST00000046659.14
Dlgap3
DLG associated protein 3
chrX_-_161426624 1.90 ENSMUST00000112334.8
Reps2
RALBP1 associated Eps domain containing protein 2
chr4_-_58553553 1.79 ENSMUST00000107575.9
ENSMUST00000107574.8
ENSMUST00000147354.8
Lpar1
lysophosphatidic acid receptor 1
chr12_-_115109539 1.79 ENSMUST00000192554.6
ENSMUST00000103522.3
Ighv1-52
immunoglobulin heavy variable 1-52
chr11_-_46057224 1.70 ENSMUST00000020679.3
Nipal4
NIPA-like domain containing 4
chr5_-_44259293 1.62 ENSMUST00000074113.13
Prom1
prominin 1
chr10_-_128016135 1.62 ENSMUST00000238843.2
ENSMUST00000099139.9
Rbms2
RNA binding motif, single stranded interacting protein 2
chr13_-_19579898 1.62 ENSMUST00000197565.3
ENSMUST00000221380.2
ENSMUST00000200323.3
ENSMUST00000199924.2
ENSMUST00000222869.2
Stard3nl
STARD3 N-terminal like
chr15_-_103123711 1.62 ENSMUST00000122182.2
ENSMUST00000108813.10
ENSMUST00000127191.2
Cbx5
chromobox 5
chr12_-_115083839 1.55 ENSMUST00000103521.3
Ighv1-50
immunoglobulin heavy variable 1-50
chr13_-_19579961 1.53 ENSMUST00000039694.13
Stard3nl
STARD3 N-terminal like
chr12_-_115172211 1.53 ENSMUST00000103526.3
Ighv1-55
immunoglobulin heavy variable 1-55
chrX_+_157993303 1.48 ENSMUST00000112493.8
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr5_-_44259010 1.44 ENSMUST00000087441.11
Prom1
prominin 1
chr13_+_93440572 1.43 ENSMUST00000109493.9
Homer1
homer scaffolding protein 1
chr14_-_52628228 1.29 ENSMUST00000078171.2
Olfr1511
olfactory receptor 1511
chr2_+_116709167 1.22 ENSMUST00000123598.8
ENSMUST00000155470.8
Tmco5
transmembrane and coiled-coil domains 5
chr2_-_180844582 1.08 ENSMUST00000016511.6
Ptk6
PTK6 protein tyrosine kinase 6
chr11_+_113550109 1.07 ENSMUST00000137878.2
Cog1
component of oligomeric golgi complex 1
chr13_-_31134281 1.03 ENSMUST00000102946.8
Exoc2
exocyst complex component 2
chr12_-_115425105 0.99 ENSMUST00000103532.3
Ighv1-62-3
immunoglobulin heavy variable 1-62-3
chr14_+_21881794 0.97 ENSMUST00000152562.8
Vdac2
voltage-dependent anion channel 2
chr1_+_136059101 0.97 ENSMUST00000075164.11
Kif21b
kinesin family member 21B
chr11_-_107685383 0.84 ENSMUST00000021066.4
Cacng4
calcium channel, voltage-dependent, gamma subunit 4
chr5_+_53424471 0.84 ENSMUST00000147148.5
Smim20
small integral membrane protein 20
chr17_-_26052335 0.76 ENSMUST00000044911.10
ENSMUST00000237186.2
Stub1
STIP1 homology and U-Box containing protein 1
chr2_+_116709179 0.73 ENSMUST00000028834.3
Tmco5
transmembrane and coiled-coil domains 5
chr17_+_26934617 0.72 ENSMUST00000062519.14
ENSMUST00000144221.2
ENSMUST00000142539.8
ENSMUST00000151681.2
Crebrf
CREB3 regulatory factor
chr17_-_40553176 0.71 ENSMUST00000026499.6
Crisp3
cysteine-rich secretory protein 3
chr12_-_114843941 0.69 ENSMUST00000191862.6
ENSMUST00000103513.3
Ighv1-36
immunoglobulin heavy variable 1-36
chr12_-_114451189 0.68 ENSMUST00000103493.3
Ighv1-4
immunoglobulin heavy variable 1-4
chrX_-_23151771 0.67 ENSMUST00000115319.9
Klhl13
kelch-like 13
chr19_-_33764859 0.59 ENSMUST00000148137.9
Lipo1
lipase, member O1
chr18_+_65831324 0.51 ENSMUST00000115097.8
ENSMUST00000117694.2
ENSMUST00000235962.2
Oacyl
O-acyltransferase like
chr10_+_58207229 0.45 ENSMUST00000238939.2
Lims1
LIM and senescent cell antigen-like domains 1
chr7_-_104646109 0.39 ENSMUST00000050599.5
Olfr672
olfactory receptor 672
chr1_-_157072060 0.38 ENSMUST00000129880.8
Rasal2
RAS protein activator like 2
chr7_+_106513407 0.38 ENSMUST00000098140.2
Olfr1532-ps1
olfactory receptor 1532, pseudogene 1
chr19_-_40365318 0.28 ENSMUST00000239304.2
Sorbs1
sorbin and SH3 domain containing 1
chr13_+_19526322 0.24 ENSMUST00000184430.2
Trgj4
T cell receptor gamma joining 4
chr9_-_61883845 0.23 ENSMUST00000113990.2
Paqr5
progestin and adipoQ receptor family member V
chr9_+_108566513 0.22 ENSMUST00000192344.2
Prkar2a
protein kinase, cAMP dependent regulatory, type II alpha
chr7_-_86044743 0.21 ENSMUST00000053958.6
Olfr303
olfactory receptor 303
chrX_-_71961890 0.20 ENSMUST00000152200.2
Cetn2
centrin 2
chr11_+_114618209 0.17 ENSMUST00000069325.14
Dnai2
dynein axonemal intermediate chain 2
chr4_+_154226819 0.17 ENSMUST00000030895.12
Wrap73
WD repeat containing, antisense to Trp73
chr11_-_43638790 0.15 ENSMUST00000048578.3
ENSMUST00000109278.8
Ttc1
tetratricopeptide repeat domain 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0002314 germinal center B cell differentiation(GO:0002314)
1.3 3.9 GO:0061107 seminal vesicle development(GO:0061107)
0.9 2.7 GO:0061193 taste bud development(GO:0061193)
0.8 3.3 GO:1902896 terminal web assembly(GO:1902896)
0.8 14.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.6 3.1 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
0.5 3.5 GO:0051012 microtubule sliding(GO:0051012)
0.4 1.8 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.4 2.9 GO:0007258 JUN phosphorylation(GO:0007258)
0.3 5.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.2 4.0 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.2 2.4 GO:0042090 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.2 0.8 GO:0090034 regulation of chaperone-mediated protein complex assembly(GO:0090034) positive regulation of chaperone-mediated protein complex assembly(GO:0090035)
0.1 3.1 GO:0002024 diet induced thermogenesis(GO:0002024)
0.1 1.0 GO:0001927 exocyst assembly(GO:0001927)
0.1 3.8 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.1 0.7 GO:0038161 prolactin signaling pathway(GO:0038161)
0.1 2.2 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.1 1.7 GO:0015693 magnesium ion transport(GO:0015693)
0.1 2.1 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.1 0.8 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 8.5 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 8.5 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.1 2.7 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 1.1 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 0.5 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.0 1.1 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 3.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.5 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 4.1 GO:0050808 synapse organization(GO:0050808)
0.0 0.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 14.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 3.1 GO:0071914 prominosome(GO:0071914)
0.4 3.3 GO:1990357 terminal web(GO:1990357)
0.3 3.9 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.3 2.1 GO:0008091 spectrin(GO:0008091)
0.2 3.8 GO:1990635 proximal dendrite(GO:1990635)
0.2 3.2 GO:0044232 organelle membrane contact site(GO:0044232)
0.1 2.7 GO:0030061 mitochondrial crista(GO:0030061)
0.1 2.2 GO:0005861 troponin complex(GO:0005861)
0.1 5.3 GO:0043034 costamere(GO:0043034)
0.1 1.9 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.1 GO:0017119 Golgi transport complex(GO:0017119)
0.1 8.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 1.6 GO:0010369 chromocenter(GO:0010369)
0.1 0.8 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.1 0.2 GO:0071942 XPC complex(GO:0071942)
0.0 0.3 GO:0005899 insulin receptor complex(GO:0005899)
0.0 1.0 GO:0000145 exocyst(GO:0000145)
0.0 3.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.0 GO:0046930 pore complex(GO:0046930)
0.0 3.5 GO:0072686 mitotic spindle(GO:0072686)
0.0 1.8 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 2.9 GO:0043204 perikaryon(GO:0043204)
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.0 GO:0005871 kinesin complex(GO:0005871)
0.0 1.3 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 4.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.7 GO:0045211 postsynaptic membrane(GO:0045211)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 14.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
1.1 4.5 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.9 2.7 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.6 2.9 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.4 5.3 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.3 1.8 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 3.8 GO:0070402 NADPH binding(GO:0070402)
0.1 1.0 GO:0015288 porin activity(GO:0015288)
0.1 8.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 2.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 1.7 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 0.8 GO:0030911 TPR domain binding(GO:0030911)
0.1 4.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 8.5 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 2.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 3.2 GO:0015485 cholesterol binding(GO:0015485)
0.0 3.1 GO:0042805 actinin binding(GO:0042805)
0.0 1.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 3.1 GO:0005254 chloride channel activity(GO:0005254)
0.0 3.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.2 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 1.6 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 5.2 GO:0008017 microtubule binding(GO:0008017)
0.0 0.2 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.8 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 10.5 GO:0005509 calcium ion binding(GO:0005509)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 14.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 11.1 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 2.9 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 1.5 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 2.3 PID AURORA B PATHWAY Aurora B signaling
0.0 2.7 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.3 PID INSULIN PATHWAY Insulin Pathway
0.0 1.8 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.8 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 3.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.5 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.3 14.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 2.9 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 3.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 3.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.5 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 2.1 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.0 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 2.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.8 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.8 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 2.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.8 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production