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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Spi1
Z-value: 3.31
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Transcription factors associated with Spi1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Spi1 | mm39_v1_chr2_+_90912710_90912735 | 0.75 | 3.7e-14 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Spi1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 78.1 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
| 1.8 | 67.0 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.4 | 65.5 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 15.4 | 61.7 | GO:2000471 | regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473) |
| 0.4 | 61.3 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.9 | 58.7 | GO:0045576 | mast cell activation(GO:0045576) |
| 1.6 | 50.9 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 1.1 | 50.6 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 2.3 | 48.4 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 5.4 | 48.3 | GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 369.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 2.5 | 133.5 | GO:0001772 | immunological synapse(GO:0001772) |
| 6.8 | 82.0 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 4.9 | 79.1 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 1.4 | 57.5 | GO:0098636 | protein complex involved in cell adhesion(GO:0098636) |
| 0.2 | 57.5 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.8 | 56.1 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.4 | 52.8 | GO:0016605 | PML body(GO:0016605) |
| 0.6 | 52.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 3.0 | 51.0 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 125.8 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) |
| 0.3 | 120.8 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.5 | 69.0 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 4.9 | 63.3 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 1.1 | 62.1 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 2.2 | 55.6 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.1 | 54.7 | GO:0044212 | transcription regulatory region DNA binding(GO:0044212) |
| 1.6 | 54.4 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 1.3 | 54.0 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.7 | 52.0 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 255.8 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 1.8 | 112.4 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 1.0 | 111.6 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 2.1 | 80.6 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 1.6 | 73.5 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.9 | 72.5 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 1.9 | 60.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 1.2 | 55.0 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.7 | 51.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 1.2 | 51.2 | PID BCR 5PATHWAY | BCR signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.3 | 124.4 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 1.9 | 108.7 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 1.9 | 107.9 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.7 | 84.4 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.1 | 64.7 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 1.3 | 64.1 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 1.3 | 63.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 54.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.3 | 52.0 | REACTOME ADP SIGNALLING THROUGH P2RY1 | Genes involved in ADP signalling through P2Y purinoceptor 1 |
| 1.3 | 51.3 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |