Project
PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
Navigation
Downloads
Results for Spib
Z-value: 4.05
Motif logo
Transcription factors associated with Spib
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Spib | mm39_v1_chr7_-_44181477_44181502 | 0.94 | 2.9e-33 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Spib
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.5 | 93.6 | GO:0030886 | negative regulation of myeloid dendritic cell activation(GO:0030886) |
| 0.3 | 89.5 | GO:0019221 | cytokine-mediated signaling pathway(GO:0019221) |
| 8.5 | 76.5 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 0.8 | 74.2 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 8.8 | 70.7 | GO:0032796 | uropod organization(GO:0032796) |
| 1.8 | 57.3 | GO:0032060 | bleb assembly(GO:0032060) |
| 18.5 | 55.6 | GO:0002277 | myeloid dendritic cell activation involved in immune response(GO:0002277) |
| 1.5 | 47.0 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
| 3.0 | 45.2 | GO:0002551 | mast cell chemotaxis(GO:0002551) |
| 0.4 | 38.5 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 230.9 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.1 | 141.6 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 139.7 | GO:0005829 | cytosol(GO:0005829) |
| 2.0 | 107.9 | GO:0001772 | immunological synapse(GO:0001772) |
| 3.2 | 104.6 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.2 | 94.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.4 | 82.9 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.5 | 68.7 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
| 0.4 | 55.9 | GO:0032587 | ruffle membrane(GO:0032587) |
| 11.0 | 55.0 | GO:0005944 | phosphatidylinositol 3-kinase complex, class IB(GO:0005944) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 151.2 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 1.6 | 103.3 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.3 | 94.0 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 8.5 | 76.5 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 3.4 | 70.7 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 1.0 | 66.5 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 2.4 | 47.7 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 1.4 | 46.5 | GO:0008187 | poly-pyrimidine tract binding(GO:0008187) |
| 0.2 | 45.0 | GO:0019903 | protein phosphatase binding(GO:0019903) |
| 1.7 | 43.3 | GO:0042608 | T cell receptor binding(GO:0042608) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 120.1 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 3.3 | 112.2 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.9 | 89.0 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 1.5 | 88.1 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 1.3 | 87.8 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.8 | 71.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.5 | 43.7 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.7 | 38.7 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.6 | 37.7 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.6 | 37.5 | PID IL4 2PATHWAY | IL4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 129.9 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 2.4 | 97.4 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.4 | 91.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.8 | 66.5 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 3.4 | 64.7 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 1.5 | 57.0 | REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING | Genes involved in Integrin alphaIIb beta3 signaling |
| 0.8 | 50.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 2.7 | 47.7 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 1.0 | 40.1 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.4 | 35.5 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |