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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Spic
Z-value: 3.42
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Transcription factors associated with Spic
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Spic | mm39_v1_chr10_-_88518878_88518892 | 0.83 | 2.9e-19 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Spic
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_136918671 Show fit | 28.13 |
ENSMUST00000032344.12
|
Rho, GDP dissociation inhibitor (GDI) beta |
|
| chr6_-_136918844 Show fit | 27.99 |
ENSMUST00000204934.2
|
Rho, GDP dissociation inhibitor (GDI) beta |
|
| chr7_+_43057611 Show fit | 25.61 |
ENSMUST00000005592.7
|
sialic acid binding Ig-like lectin G |
|
| chr7_-_126303351 Show fit | 25.35 |
ENSMUST00000106364.8
|
coronin, actin binding protein 1A |
|
| chrX_+_106132840 Show fit | 23.66 |
ENSMUST00000118666.8
ENSMUST00000053375.4 |
purinergic receptor P2Y, G-protein coupled 10 |
|
| chr11_-_79414542 Show fit | 23.63 |
ENSMUST00000179322.2
|
ecotropic viral integration site 2b |
|
| chr7_-_126303887 Show fit | 23.53 |
ENSMUST00000131415.8
|
coronin, actin binding protein 1A |
|
| chr7_+_28682253 Show fit | 22.20 |
ENSMUST00000085835.8
|
mitogen-activated protein kinase kinase kinase kinase 1 |
|
| chr4_+_130640436 Show fit | 22.13 |
ENSMUST00000151698.8
|
lysosomal-associated protein transmembrane 5 |
|
| chr11_-_115024807 Show fit | 21.89 |
ENSMUST00000106561.8
ENSMUST00000051264.14 ENSMUST00000106562.3 |
CD300 molecule like family member F |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.3 | 92.4 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 8.5 | 67.7 | GO:0061502 | uropod organization(GO:0032796) early endosome to recycling endosome transport(GO:0061502) |
| 8.0 | 63.9 | GO:0033277 | abortive mitotic cell cycle(GO:0033277) |
| 4.4 | 48.8 | GO:0030886 | negative regulation of myeloid dendritic cell activation(GO:0030886) |
| 1.2 | 45.1 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
| 12.4 | 37.2 | GO:0071846 | actin filament debranching(GO:0071846) |
| 0.2 | 36.1 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 11.4 | 34.1 | GO:0014805 | smooth muscle adaptation(GO:0014805) |
| 0.9 | 33.2 | GO:0045730 | respiratory burst(GO:0045730) |
| 5.5 | 33.1 | GO:0006742 | NADP catabolic process(GO:0006742) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.3 | 100.4 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 1.6 | 93.3 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 92.7 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.1 | 87.0 | GO:0005615 | extracellular space(GO:0005615) |
| 2.6 | 67.7 | GO:0032426 | stereocilium tip(GO:0032426) |
| 5.3 | 63.9 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.0 | 61.5 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.1 | 59.7 | GO:0000323 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 53.0 | GO:0005829 | cytosol(GO:0005829) |
| 0.1 | 49.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.3 | 92.4 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.2 | 79.8 | GO:0005525 | GTP binding(GO:0005525) |
| 3.2 | 67.7 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 5.1 | 66.3 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 4.9 | 63.9 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.2 | 61.2 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.7 | 48.6 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 1.5 | 37.9 | GO:0051400 | BH domain binding(GO:0051400) |
| 2.7 | 37.2 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 3.1 | 34.1 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 94.5 | PID EPO PATHWAY | EPO signaling pathway |
| 0.9 | 89.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 1.0 | 80.5 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.9 | 47.4 | PID ATR PATHWAY | ATR signaling pathway |
| 1.2 | 36.9 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.2 | 34.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.8 | 28.2 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.6 | 27.7 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.6 | 27.0 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 1.5 | 26.2 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 143.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 3.1 | 74.5 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 1.5 | 74.0 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.9 | 55.6 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.2 | 38.5 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.7 | 36.3 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.5 | 31.6 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 1.7 | 30.7 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.3 | 30.6 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.9 | 28.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |