Project
PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
Navigation
Downloads
Results for Srf
Z-value: 2.68
Motif logo
Transcription factors associated with Srf
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Srf | mm39_v1_chr17_-_46867083_46867114 | 0.44 | 1.1e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Srf
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_113883285 Show fit | 33.09 |
ENSMUST00000090269.7
|
actin, alpha, cardiac muscle 1 |
|
| chr6_-_83513222 Show fit | 32.19 |
ENSMUST00000075161.12
|
actin, gamma 2, smooth muscle, enteric |
|
| chr6_-_83513184 Show fit | 27.92 |
ENSMUST00000205926.2
|
actin, gamma 2, smooth muscle, enteric |
|
| chr9_+_110592709 Show fit | 26.85 |
ENSMUST00000079784.12
|
myosin, light polypeptide 3 |
|
| chr12_-_103322226 Show fit | 25.74 |
ENSMUST00000021617.14
|
ankyrin repeat and SOCS box-containing 2 |
|
| chrX_+_100492684 Show fit | 25.23 |
ENSMUST00000033674.6
|
integrin beta 1 binding protein 2 |
|
| chr10_+_45211847 Show fit | 20.71 |
ENSMUST00000095715.5
|
blood vessel epicardial substance |
|
| chr8_-_124621483 Show fit | 20.69 |
ENSMUST00000034453.6
ENSMUST00000212584.2 |
actin, alpha 1, skeletal muscle |
|
| chr1_-_43203051 Show fit | 19.56 |
ENSMUST00000008280.14
|
four and a half LIM domains 2 |
|
| chr7_+_19144950 Show fit | 19.34 |
ENSMUST00000208710.2
ENSMUST00000003643.3 |
creatine kinase, muscle |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 55.3 | GO:0045214 | sarcomere organization(GO:0045214) |
| 4.9 | 53.8 | GO:0030240 | skeletal muscle thin filament assembly(GO:0030240) |
| 13.3 | 53.1 | GO:0007522 | visceral muscle development(GO:0007522) |
| 7.5 | 30.2 | GO:0055014 | atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014) |
| 0.6 | 26.9 | GO:0002026 | regulation of the force of heart contraction(GO:0002026) |
| 0.3 | 25.7 | GO:0045445 | myoblast differentiation(GO:0045445) |
| 4.1 | 20.7 | GO:0060931 | sinoatrial node cell development(GO:0060931) |
| 0.2 | 19.3 | GO:0042398 | cellular modified amino acid biosynthetic process(GO:0042398) |
| 3.2 | 19.0 | GO:0090158 | endoplasmic reticulum membrane organization(GO:0090158) |
| 4.6 | 18.4 | GO:1902304 | positive regulation of potassium ion export(GO:1902304) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 74.5 | GO:0031672 | A band(GO:0031672) |
| 2.6 | 70.8 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.4 | 63.2 | GO:0030018 | Z disc(GO:0030018) |
| 0.5 | 57.4 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 11.0 | 33.1 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 0.1 | 28.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 3.7 | 25.7 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.1 | 24.1 | GO:0005925 | cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) |
| 0.3 | 20.7 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 4.7 | 19.0 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 68.0 | GO:0005524 | ATP binding(GO:0005524) |
| 2.1 | 63.3 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 7.6 | 53.1 | GO:0030899 | calcium-dependent ATPase activity(GO:0030899) |
| 0.0 | 38.2 | GO:0042802 | identical protein binding(GO:0042802) |
| 0.2 | 35.2 | GO:0005178 | integrin binding(GO:0005178) |
| 0.4 | 33.6 | GO:0017022 | myosin binding(GO:0017022) |
| 0.7 | 29.2 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 25.7 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.4 | 20.7 | GO:0030552 | cAMP binding(GO:0030552) |
| 2.8 | 19.3 | GO:0004111 | creatine kinase activity(GO:0004111) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 67.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.6 | 33.3 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.8 | 30.2 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.2 | 19.3 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.5 | 15.7 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.2 | 10.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 10.3 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.4 | 9.9 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 8.7 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 8.4 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 158.4 | REACTOME MUSCLE CONTRACTION | Genes involved in Muscle contraction |
| 0.1 | 39.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 32.6 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 1.0 | 29.0 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 19.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.6 | 18.4 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.5 | 15.7 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.5 | 10.7 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 9.9 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.3 | 8.7 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |