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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Stat2
Z-value: 2.80
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Transcription factors associated with Stat2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Stat2 | mm39_v1_chr10_+_128106414_128106446 | 0.74 | 7.1e-14 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Stat2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 91.7 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
| 2.7 | 77.7 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 7.8 | 47.0 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 2.8 | 39.8 | GO:0046642 | negative regulation of alpha-beta T cell proliferation(GO:0046642) |
| 2.5 | 37.5 | GO:0060330 | regulation of response to interferon-gamma(GO:0060330) |
| 4.2 | 33.7 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 10.6 | 31.7 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 10.2 | 30.5 | GO:2000547 | regulation of dendritic cell dendrite assembly(GO:2000547) |
| 2.5 | 30.2 | GO:0045345 | MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345) |
| 1.0 | 25.7 | GO:0019884 | antigen processing and presentation of exogenous antigen(GO:0019884) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 140.9 | GO:0005829 | cytosol(GO:0005829) |
| 0.1 | 135.5 | GO:0005730 | nucleolus(GO:0005730) |
| 0.2 | 87.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.8 | 47.0 | GO:0015030 | Cajal body(GO:0015030) |
| 0.3 | 46.0 | GO:0016605 | PML body(GO:0016605) |
| 5.2 | 41.7 | GO:0042825 | TAP complex(GO:0042825) |
| 0.0 | 40.4 | GO:0005615 | extracellular space(GO:0005615) |
| 2.3 | 37.0 | GO:0020003 | symbiont-containing vacuole(GO:0020003) |
| 0.2 | 32.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 30.6 | GO:0009986 | cell surface(GO:0009986) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 144.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 2.3 | 70.0 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.2 | 67.3 | GO:0003924 | GTPase activity(GO:0003924) |
| 4.8 | 57.5 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 51.2 | GO:0008270 | zinc ion binding(GO:0008270) |
| 9.4 | 47.0 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.2 | 45.8 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 44.7 | GO:0003677 | DNA binding(GO:0003677) |
| 1.2 | 39.8 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 10.6 | 31.7 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 47.9 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 41.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.4 | 34.9 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 2.8 | 30.3 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.6 | 29.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.4 | 28.4 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.3 | 26.2 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.2 | 24.0 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.6 | 17.5 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.5 | 16.9 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 235.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 1.5 | 63.5 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.7 | 56.0 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 1.0 | 53.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 2.1 | 40.3 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.6 | 39.8 | REACTOME COSTIMULATION BY THE CD28 FAMILY | Genes involved in Costimulation by the CD28 family |
| 1.3 | 27.9 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.5 | 25.5 | REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
| 1.4 | 22.1 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.7 | 17.3 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |