ISMARA results: Stat4_Stat3

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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Stat4_Stat3_Stat5b

Z-value: 1.50

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Transcription factors associated with Stat4_Stat3_Stat5b

Gene Symbol	Gene ID	Gene Info
Stat4 Ensembl NCBI MGI UniProt	ENSMUSG00000062939.12	Stat4
Stat3 Ensembl NCBI MGI UniProt	ENSMUSG00000004040.17	Stat3
Stat5b Ensembl NCBI MGI UniProt	ENSMUSG00000020919.12	Stat5b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Stat5b	mm39_v1_chr11_-_100741550_100741588	0.38	8.6e-04	Click!
Stat3	mm39_v1_chr11_-_100830288_100830311	0.34	3.1e-03	Click!
Stat4	mm39_v1_chr1_+_52026296_52026310	-0.17	1.5e-01	Click!

Activity profile of Stat4_Stat3_Stat5b motif

Sorted Z-values of Stat4_Stat3_Stat5b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Stat4_Stat3_Stat5b

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Promoter	Score	Transcript	Gene	Gene Info
chr14_+_30608433 Show fit	29.94	ENSMUST00000120269.11 ENSMUST00000078490.14 ENSMUST00000006703.15	Itih4 Ensembl NCBI MGI UniProt Show fit	inter alpha-trypsin inhibitor, heavy chain 4
chr14_+_30608478 Show fit	25.21	ENSMUST00000168782.4	Itih4 Ensembl NCBI MGI UniProt Show fit	inter alpha-trypsin inhibitor, heavy chain 4
chr4_+_148686985 Show fit	14.35	ENSMUST00000105701.9 ENSMUST00000052060.7	Masp2 Ensembl NCBI MGI UniProt Show fit	mannan-binding lectin serine peptidase 2
chr7_-_30643444 Show fit	13.39	ENSMUST00000062620.9	Hamp Ensembl NCBI MGI UniProt Show fit	hepcidin antimicrobial peptide
chr9_+_20927271 Show fit	12.46	ENSMUST00000086399.6	Icam1 Ensembl NCBI MGI UniProt Show fit	intercellular adhesion molecule 1
chr11_+_78389913 Show fit	11.74	ENSMUST00000017488.5	Vtn Ensembl NCBI MGI UniProt Show fit	vitronectin
chr3_+_82915031 Show fit	10.79	ENSMUST00000048486.13 ENSMUST00000194175.2	Fgg Ensembl NCBI MGI UniProt Show fit	fibrinogen gamma chain
chr10_-_95252712 Show fit	9.01	ENSMUST00000020215.16	Socs2 Ensembl NCBI MGI UniProt Show fit	suppressor of cytokine signaling 2
chr9_+_107174081 Show fit	8.89	ENSMUST00000167072.2	Cish Ensembl NCBI MGI UniProt Show fit	cytokine inducible SH2-containing protein
chr6_+_129374260 Show fit	8.27	ENSMUST00000032262.14	Clec1b Ensembl NCBI MGI UniProt Show fit	C-type lectin domain family 1, member b

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	56.2	GO:0030212	hyaluronan metabolic process(GO:0030212)
0.8	28.0	GO:0006825	copper ion transport(GO:0006825)
0.6	20.0	GO:0060749	mammary gland alveolus development(GO:0060749) mammary gland lobule development(GO:0061377)
4.3	17.1	GO:0034760	negative regulation of iron ion transport(GO:0034757) negative regulation of iron ion transmembrane transport(GO:0034760)
0.5	15.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.4	15.0	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
1.4	14.4	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.3	13.9	GO:0036344	platelet morphogenesis(GO:0036344)
1.3	13.4	GO:0035754	B cell chemotaxis(GO:0035754)
2.1	12.5	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)

Showing 1 to 10 of 307 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	113.2	GO:0072562	blood microparticle(GO:0072562)
0.0	69.5	GO:0005615	extracellular space(GO:0005615)
1.8	16.4	GO:0005577	fibrinogen complex(GO:0005577)
0.0	14.7	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.2	13.3	GO:0001772	immunological synapse(GO:0001772)
1.7	11.7	GO:0048237	rough endoplasmic reticulum lumen(GO:0048237)
0.0	11.3	GO:0005667	transcription factor complex(GO:0005667)
0.3	11.0	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.1	10.5	GO:0005811	lipid particle(GO:0005811)
0.0	9.6	GO:0001650	fibrillar center(GO:0001650)

Showing 1 to 10 of 105 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	55.2	GO:0005540	hyaluronic acid binding(GO:0005540)
1.3	22.8	GO:0001846	opsonin binding(GO:0001846)
1.8	21.3	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1	19.3	GO:0004860	protein kinase inhibitor activity(GO:0004860)
0.1	18.8	GO:0005178	integrin binding(GO:0005178)
0.1	18.8	GO:0003924	GTPase activity(GO:0003924)
2.8	16.7	GO:0008269	JAK pathway signal transduction adaptor activity(GO:0008269)
0.2	15.1	GO:0005507	copper ion binding(GO:0005507)
3.4	13.4	GO:0047016	cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity(GO:0047016)
0.1	12.9	GO:0001046	core promoter sequence-specific DNA binding(GO:0001046)

Showing 1 to 10 of 195 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	110.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.9	30.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.1	27.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	27.2	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.4	21.1	PID IL23 PATHWAY	IL23-mediated signaling events
0.3	19.6	PID IL2 1PATHWAY	IL2-mediated signaling events
1.1	16.1	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.1	15.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.3	14.3	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.5	11.3	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Showing 1 to 10 of 51 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	44.5	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.5	20.8	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.3	20.5	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
1.2	20.2	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
1.2	18.6	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.9	18.6	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
1.9	15.3	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
1.0	12.0	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.2	10.2	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	8.7	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions

Showing 1 to 10 of 86 entries

Results for Stat4_Stat3_Stat5b

Z-value: 1.50

Motif logo

Transcription factors associated with Stat4_Stat3_Stat5b

Activity-expression correlation:

Activity profile of Stat4_Stat3_Stat5b motif

Sorted Z-values of Stat4_Stat3_Stat5b motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Stat4_Stat3_Stat5b

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: