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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Stat5a
Z-value: 2.28
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Transcription factors associated with Stat5a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Stat5a | mm39_v1_chr11_+_100750177_100750312 | 0.07 | 5.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Stat5a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 47.1 | GO:0052697 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.3 | 36.1 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.2 | 34.0 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.4 | 30.4 | GO:0050829 | defense response to Gram-negative bacterium(GO:0050829) |
| 9.9 | 29.6 | GO:1904446 | positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161) positive regulation of establishment of Sertoli cell barrier(GO:1904446) negative regulation of type B pancreatic cell development(GO:2000077) |
| 2.1 | 27.3 | GO:1903207 | neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208) |
| 1.0 | 20.3 | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886) |
| 6.4 | 19.3 | GO:0051977 | lysophospholipid transport(GO:0051977) |
| 1.6 | 19.0 | GO:0010838 | positive regulation of keratinocyte proliferation(GO:0010838) |
| 0.9 | 18.2 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 182.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 45.1 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.4 | 44.5 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.3 | 39.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.8 | 31.8 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.9 | 29.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 4.2 | 29.6 | GO:0031205 | endoplasmic reticulum Sec complex(GO:0031205) |
| 0.6 | 21.0 | GO:0030057 | desmosome(GO:0030057) |
| 0.3 | 19.4 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.4 | 19.2 | GO:0001533 | cornified envelope(GO:0001533) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 80.0 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.3 | 77.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 51.2 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 9.9 | 29.6 | GO:0005260 | channel-conductance-controlling ATPase activity(GO:0005260) |
| 0.1 | 27.8 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.2 | 26.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 25.4 | GO:0019838 | growth factor binding(GO:0019838) |
| 0.1 | 23.6 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.6 | 22.5 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
| 0.6 | 21.4 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 54.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 35.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.5 | 32.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.4 | 22.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.4 | 20.3 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.3 | 18.6 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.2 | 17.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.3 | 15.6 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.3 | 15.5 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.2 | 11.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 35.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.7 | 30.1 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.5 | 28.5 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.5 | 26.6 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 1.3 | 22.9 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 1.0 | 22.6 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 2.0 | 21.5 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.4 | 20.3 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.9 | 20.1 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.4 | 18.7 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |