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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Taf1
Z-value: 3.85
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Transcription factors associated with Taf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Taf1 | mm39_v1_chrX_+_100576340_100576383 | 0.51 | 5.8e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Taf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 94.5 | GO:0006397 | mRNA processing(GO:0006397) |
| 1.9 | 76.6 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 2.6 | 44.3 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
| 1.7 | 32.7 | GO:0080182 | histone H3-K4 trimethylation(GO:0080182) |
| 3.0 | 30.1 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.4 | 29.9 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 1.4 | 28.0 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 2.7 | 26.7 | GO:0031086 | nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) |
| 0.4 | 25.8 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
| 2.2 | 24.4 | GO:2000051 | negative regulation of non-canonical Wnt signaling pathway(GO:2000051) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 182.6 | GO:0005634 | nucleus(GO:0005634) |
| 0.2 | 144.9 | GO:0016604 | nuclear body(GO:0016604) |
| 0.1 | 132.9 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.3 | 62.4 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.6 | 62.1 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 1.7 | 55.8 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.6 | 49.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.5 | 46.2 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 1.4 | 43.3 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.4 | 39.5 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 292.1 | GO:0003723 | RNA binding(GO:0003723) |
| 0.2 | 72.4 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 67.7 | GO:0003676 | nucleic acid binding(GO:0003676) |
| 0.3 | 58.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 54.2 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.4 | 33.3 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.2 | 33.1 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 33.1 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.8 | 30.7 | GO:0043175 | RNA polymerase core enzyme binding(GO:0043175) |
| 0.4 | 30.7 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 79.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.6 | 47.3 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.4 | 46.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.4 | 40.9 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.9 | 39.7 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.3 | 24.8 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.4 | 22.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.5 | 22.2 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 1.2 | 19.9 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.2 | 17.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 111.9 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.7 | 90.4 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.1 | 56.9 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 1.4 | 46.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 39.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.5 | 38.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 3.2 | 34.7 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.5 | 29.2 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS | Genes involved in CREB phosphorylation through the activation of Ras |
| 0.6 | 28.1 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.2 | 27.6 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |