ISMARA results: Tal1

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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Tal1

Z-value: 1.96

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Transcription factors associated with Tal1

Gene Symbol	Gene ID	Gene Info
Tal1 Ensembl NCBI MGI UniProt	ENSMUSG00000028717.13	Tal1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tal1	mm39_v1_chr4_+_114916703_114916759	0.81	4.0e-18	Click!

Activity profile of Tal1 motif

Sorted Z-values of Tal1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Tal1

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Promoter	Score	Transcript	Gene	Gene Info
chr15_-_103159892 Show fit	29.64	ENSMUST00000133600.8 ENSMUST00000134554.2 ENSMUST00000156927.8	Nfe2 Ensembl NCBI MGI UniProt Show fit	nuclear factor, erythroid derived 2
chr15_-_103160082 Show fit	24.72	ENSMUST00000149111.8 ENSMUST00000132836.8	Nfe2 Ensembl NCBI MGI UniProt Show fit	nuclear factor, erythroid derived 2
chr4_+_132701413 Show fit	21.84	ENSMUST00000030693.13	Fgr Ensembl NCBI MGI UniProt Show fit	FGR proto-oncogene, Src family tyrosine kinase
chr17_+_41121979 Show fit	21.08	ENSMUST00000024721.8 ENSMUST00000233740.2	Rhag Ensembl NCBI MGI UniProt Show fit	Rhesus blood group-associated A glycoprotein
chr17_+_37180437 Show fit	18.84	ENSMUST00000060524.11	Trim10 Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 10
chr1_+_131566044 Show fit	16.79	ENSMUST00000073350.13	Ctse Ensembl NCBI MGI UniProt Show fit	cathepsin E
chr8_+_81220410 Show fit	16.42	ENSMUST00000063359.8	Gypa Ensembl NCBI MGI UniProt Show fit	glycophorin A
chr1_+_131566223 Show fit	16.27	ENSMUST00000112411.2	Ctse Ensembl NCBI MGI UniProt Show fit	cathepsin E
chr1_+_174000304 Show fit	15.73	ENSMUST00000027817.8	Spta1 Ensembl NCBI MGI UniProt Show fit	spectrin alpha, erythrocytic 1
chr5_+_90920294 Show fit	15.55	ENSMUST00000031320.8	Pf4 Ensembl NCBI MGI UniProt Show fit	platelet factor 4

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.6	54.4	GO:0034242	negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
8.5	34.0	GO:0072488	ammonium transmembrane transport(GO:0072488)
1.7	33.1	GO:0016540	protein autoprocessing(GO:0016540)
6.1	30.4	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
1.2	21.8	GO:0061365	positive regulation of triglyceride lipase activity(GO:0061365)
0.8	21.8	GO:0033008	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.9	20.4	GO:0038065	collagen-activated signaling pathway(GO:0038065)
0.8	19.3	GO:0046597	negative regulation of viral entry into host cell(GO:0046597)
0.5	19.1	GO:0006779	porphyrin-containing compound biosynthetic process(GO:0006779)
1.5	17.5	GO:0001955	blood vessel maturation(GO:0001955)

Showing 1 to 10 of 111 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	104.6	GO:0005615	extracellular space(GO:0005615)
0.3	57.7	GO:0032993	protein-DNA complex(GO:0032993)
0.0	57.1	GO:0005887	integral component of plasma membrane(GO:0005887)
0.1	53.2	GO:0009897	external side of plasma membrane(GO:0009897)
2.6	36.8	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
0.0	28.8	GO:0005768	endosome(GO:0005768)
0.4	21.8	GO:0016235	aggresome(GO:0016235)
0.1	18.1	GO:0031225	anchored component of membrane(GO:0031225)
0.1	17.2	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
2.2	15.7	GO:0032437	cuticular plate(GO:0032437)

Showing 1 to 10 of 53 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	62.2	GO:0004540	ribonuclease activity(GO:0004540)
0.9	54.4	GO:0050699	WW domain binding(GO:0050699)
1.0	35.0	GO:0004190	aspartic-type endopeptidase activity(GO:0004190)
1.0	32.4	GO:0008519	ammonium transmembrane transporter activity(GO:0008519)
5.1	30.4	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
1.3	26.4	GO:0004806	triglyceride lipase activity(GO:0004806)
3.6	21.8	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.0	19.9	GO:0000976	transcription regulatory region sequence-specific DNA binding(GO:0000976)
0.1	17.2	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.1	15.4	GO:0004252	serine-type endopeptidase activity(GO:0004252)

Showing 1 to 10 of 89 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	32.8	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.5	25.3	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.1	24.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.6	11.0	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.3	10.6	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.1	9.7	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.2	9.1	PID EPO PATHWAY	EPO signaling pathway
0.2	7.7	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.5	7.3	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2	6.0	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions

Showing 1 to 10 of 25 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	49.1	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.5	37.0	REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT	Genes involved in Lipid digestion, mobilization, and transport
1.8	30.4	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.6	21.8	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.4	21.8	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.5	20.7	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.3	18.5	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.2	12.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.6	9.6	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.1	9.6	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors

Showing 1 to 10 of 38 entries

Results for Tal1

Z-value: 1.96

Motif logo

Transcription factors associated with Tal1

Activity-expression correlation:

Activity profile of Tal1 motif

Sorted Z-values of Tal1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Tal1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: