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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Tbp
Z-value: 3.70
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Transcription factors associated with Tbp
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tbp | mm39_v1_chr17_+_15720150_15720222 | -0.44 | 1.2e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tbp
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_94863825 Show fit | 45.00 |
ENSMUST00000034207.8
|
metallothionein 4 |
|
| chr19_+_39049442 Show fit | 40.18 |
ENSMUST00000087236.5
|
cytochrome P450, family 2, subfamily c, polypeptide 65 |
|
| chr3_+_106020545 Show fit | 34.77 |
ENSMUST00000079132.12
ENSMUST00000139086.2 |
chitinase, acidic 1 |
|
| chr11_-_100012384 Show fit | 33.18 |
ENSMUST00000007275.3
|
keratin 13 |
|
| chr3_-_92366022 Show fit | 30.26 |
ENSMUST00000058142.4
|
small proline-rich protein 3 |
|
| chr6_-_113696390 Show fit | 28.03 |
ENSMUST00000203588.2
ENSMUST00000204163.3 ENSMUST00000203363.3 |
ghrelin |
|
| chr2_-_164197987 Show fit | 26.14 |
ENSMUST00000165980.2
|
secretory leukocyte peptidase inhibitor |
|
| chr6_-_113696809 Show fit | 24.25 |
ENSMUST00000203770.3
ENSMUST00000064993.8 |
ghrelin |
|
| chr17_-_31383976 Show fit | 23.78 |
ENSMUST00000235870.2
|
trefoil factor 1 |
|
| chr9_+_98372575 Show fit | 23.65 |
ENSMUST00000035029.3
|
retinol binding protein 2, cellular |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 134.8 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 3.3 | 133.5 | GO:0031424 | keratinization(GO:0031424) |
| 0.5 | 69.4 | GO:0007586 | digestion(GO:0007586) |
| 1.8 | 63.3 | GO:0019731 | antibacterial humoral response(GO:0019731) |
| 13.1 | 52.3 | GO:1904346 | regulation of gastric mucosal blood circulation(GO:1904344) positive regulation of gastric mucosal blood circulation(GO:1904346) gastric mucosal blood circulation(GO:1990768) negative regulation of energy homeostasis(GO:2000506) |
| 1.0 | 48.6 | GO:0046686 | response to cadmium ion(GO:0046686) |
| 1.3 | 41.3 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 4.3 | 38.5 | GO:0006032 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
| 3.7 | 32.9 | GO:0038033 | positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033) |
| 1.1 | 28.7 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 238.4 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 197.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 104.7 | GO:0031012 | extracellular matrix(GO:0031012) |
| 2.3 | 99.0 | GO:0045095 | keratin filament(GO:0045095) |
| 0.2 | 81.0 | GO:0030141 | secretory granule(GO:0030141) |
| 0.0 | 58.4 | GO:0005576 | extracellular region(GO:0005576) |
| 0.7 | 44.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 29.1 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 1.4 | 27.4 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 1.4 | 19.9 | GO:0020005 | symbiont-containing vacuole membrane(GO:0020005) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 196.3 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.3 | 82.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 11.4 | 56.9 | GO:0008390 | testosterone 16-alpha-hydroxylase activity(GO:0008390) |
| 0.5 | 54.6 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 17.4 | 52.3 | GO:0031768 | ghrelin receptor binding(GO:0031768) |
| 0.3 | 49.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.3 | 42.1 | GO:0005179 | hormone activity(GO:0005179) |
| 0.2 | 40.1 | GO:0008083 | growth factor activity(GO:0008083) |
| 4.3 | 38.5 | GO:0004568 | chitinase activity(GO:0004568) |
| 5.7 | 34.0 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 88.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.1 | 72.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.8 | 56.0 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.5 | 33.5 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.5 | 29.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.5 | 28.3 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.3 | 26.2 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.3 | 23.7 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.3 | 19.9 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.3 | 18.8 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 72.4 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.7 | 44.8 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.5 | 32.4 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.8 | 24.4 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 1.2 | 19.9 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.3 | 19.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 1.1 | 17.6 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.5 | 16.4 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 1.4 | 15.6 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.5 | 15.5 | REACTOME KINESINS | Genes involved in Kinesins |