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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Tbx20

Z-value: 0.49

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Transcription factors associated with Tbx20

Gene Symbol Gene ID Gene Info
Tbx20
ENSMUSG00000031965.16 Tbx20

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tbx20mm39_v1_chr9_-_24685572_24685599-0.371.2e-03Click!

Activity profile of Tbx20 motif

Sorted Z-values of Tbx20 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx20

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_+_122129379 4.56 ENSMUST00000028656.2
Duoxa2
dual oxidase maturation factor 2
chr2_-_122128930 3.65 ENSMUST00000237546.2
Duox2
dual oxidase 2
chr8_-_106660470 3.64 ENSMUST00000034368.8
Ctrl
chymotrypsin-like
chr8_-_3744167 3.07 ENSMUST00000005678.6
Fcer2a
Fc receptor, IgE, low affinity II, alpha polypeptide
chr4_-_118294521 2.88 ENSMUST00000006565.13
Cdc20
cell division cycle 20
chr19_+_38043446 2.41 ENSMUST00000236044.2
ENSMUST00000116506.8
ENSMUST00000096096.12
ENSMUST00000169673.3
Cep55
centrosomal protein 55
chr9_-_99592116 2.12 ENSMUST00000035048.12
Cldn18
claudin 18
chr7_+_79309938 2.10 ENSMUST00000035977.9
Ticrr
TOPBP1-interacting checkpoint and replication regulator
chr5_-_53864874 2.04 ENSMUST00000031093.5
Cckar
cholecystokinin A receptor
chr9_-_99592058 1.90 ENSMUST00000136429.8
Cldn18
claudin 18
chr12_-_114487525 1.83 ENSMUST00000103495.3
Ighv10-3
immunoglobulin heavy variable V10-3
chr11_+_98239230 1.37 ENSMUST00000078694.13
Ppp1r1b
protein phosphatase 1, regulatory inhibitor subunit 1B
chr5_-_120915693 1.18 ENSMUST00000044833.9
Oas3
2'-5' oligoadenylate synthetase 3
chr6_+_15196950 1.10 ENSMUST00000140557.8
ENSMUST00000131414.8
ENSMUST00000115469.8
Foxp2
forkhead box P2
chr12_+_51395047 0.99 ENSMUST00000119211.8
G2e3
G2/M-phase specific E3 ubiquitin ligase
chr12_+_51395154 0.98 ENSMUST00000121521.2
G2e3
G2/M-phase specific E3 ubiquitin ligase
chr17_-_23964807 0.79 ENSMUST00000046525.10
Kremen2
kringle containing transmembrane protein 2
chr15_+_75140241 0.62 ENSMUST00000023247.13
Ly6f
lymphocyte antigen 6 complex, locus F
chr3_-_143908111 0.57 ENSMUST00000121796.8
Lmo4
LIM domain only 4
chr1_-_136876902 0.55 ENSMUST00000195428.2
Nr5a2
nuclear receptor subfamily 5, group A, member 2
chr3_-_143908060 0.53 ENSMUST00000121112.6
Lmo4
LIM domain only 4
chr2_+_74512638 0.51 ENSMUST00000142312.3
Hoxd11
homeobox D11
chr15_-_76702170 0.48 ENSMUST00000175843.3
ENSMUST00000177026.3
ENSMUST00000176736.3
ENSMUST00000036176.16
ENSMUST00000176219.9
ENSMUST00000239134.2
ENSMUST00000239003.2
ENSMUST00000077821.10
Arhgap39
Rho GTPase activating protein 39
chr8_+_129793635 0.44 ENSMUST00000026912.8
Ccdc7b
coiled-coil domain containing 7B
chr8_-_86281946 0.37 ENSMUST00000034138.7
Dnaja2
DnaJ heat shock protein family (Hsp40) member A2
chr10_+_75160692 0.32 ENSMUST00000217703.2
Adora2a
adenosine A2a receptor
chr8_+_129793610 0.27 ENSMUST00000108745.8
Ccdc7b
coiled-coil domain containing 7B
chr11_-_23720953 0.24 ENSMUST00000102864.5
Rel
reticuloendotheliosis oncogene
chr16_-_19241884 0.23 ENSMUST00000206110.4
Olfr165
olfactory receptor 165
chr1_-_136877277 0.21 ENSMUST00000168126.7
Nr5a2
nuclear receptor subfamily 5, group A, member 2
chr8_-_129791969 0.20 ENSMUST00000125112.8
ENSMUST00000108747.3
ENSMUST00000214889.2
ENSMUST00000095158.11
Ccdc7a
coiled-coil domain containing 7A
chr6_-_122317457 0.17 ENSMUST00000160843.8
Phc1
polyhomeotic 1
chrY_+_7722941 0.12 ENSMUST00000189007.2
Gm28576
predicted gene 28576
chr7_-_105436775 0.12 ENSMUST00000078482.13
Dchs1
dachsous cadherin related 1
chr15_-_102425241 0.10 ENSMUST00000169162.8
ENSMUST00000023812.10
ENSMUST00000165174.8
ENSMUST00000169367.8
ENSMUST00000169377.8
Map3k12
mitogen-activated protein kinase kinase kinase 12
chrY_+_7253787 0.10 ENSMUST00000186194.2
Gm28998
predicted gene 28998
chrX_-_133652080 0.08 ENSMUST00000113194.8
Armcx6
armadillo repeat containing, X-linked 6
chr5_+_57879201 0.05 ENSMUST00000199310.2
Pcdh7
protocadherin 7
chrX_-_133652140 0.03 ENSMUST00000052431.12
Armcx6
armadillo repeat containing, X-linked 6
chr2_-_88157559 0.02 ENSMUST00000214207.2
Olfr1175
olfactory receptor 1175
chr9_+_72946994 0.01 ENSMUST00000184126.3
Pigbos1
Pigb opposite strand 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.6 GO:0048850 hypophysis morphogenesis(GO:0048850)
0.6 2.9 GO:0098763 mitotic cell cycle phase(GO:0098763)
0.6 4.0 GO:2001205 negative regulation of osteoclast development(GO:2001205)
0.6 4.6 GO:2000609 regulation of thyroid hormone generation(GO:2000609)
0.4 3.1 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.3 2.0 GO:0090274 reduction of food intake in response to dietary excess(GO:0002023) positive regulation of somatostatin secretion(GO:0090274)
0.3 2.1 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.2 1.4 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.1 1.2 GO:0060700 regulation of ribonuclease activity(GO:0060700)
0.1 2.4 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 1.1 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 0.3 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.1 0.8 GO:0061113 pancreas morphogenesis(GO:0061113)
0.1 1.1 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.0 0.5 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.0 0.1 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.2 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 2.0 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway(GO:2001243)
0.0 1.8 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.4 GO:0042026 protein refolding(GO:0042026)
0.0 0.1 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 GO:0090543 Flemming body(GO:0090543)
0.1 2.9 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 4.0 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.8 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.3 GO:0032279 asymmetric synapse(GO:0032279)
0.0 2.0 GO:0043195 terminal bouton(GO:0043195)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.9 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.5 1.4 GO:0031751 D4 dopamine receptor binding(GO:0031751)
0.4 3.1 GO:0019863 IgE binding(GO:0019863)
0.3 3.6 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 1.2 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.3 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 1.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 3.6 GO:0008236 serine-type peptidase activity(GO:0008236)
0.0 2.1 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.9 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.8 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.1 PID IL6 7 PATHWAY IL6-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 4.0 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 1.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.2 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.8 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.3 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 2.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors