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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Tbx3

Z-value: 0.66

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Transcription factors associated with Tbx3

Gene Symbol Gene ID Gene Info
Tbx3
ENSMUSG00000018604.19 Tbx3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tbx3mm39_v1_chr5_+_119808722_119808741-0.161.9e-01Click!

Activity profile of Tbx3 motif

Sorted Z-values of Tbx3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr7_-_4525426 10.43 ENSMUST00000209148.2
ENSMUST00000098859.10
Tnni3
troponin I, cardiac 3
chr7_-_4525793 9.45 ENSMUST00000140424.8
Tnni3
troponin I, cardiac 3
chr3_-_122828592 6.76 ENSMUST00000029761.14
Myoz2
myozenin 2
chr2_+_173561208 4.75 ENSMUST00000073081.6
1700010B08Rik
RIKEN cDNA 1700010B08 gene
chr16_-_13548307 4.19 ENSMUST00000115807.9
Pla2g10
phospholipase A2, group X
chr16_-_13548833 4.16 ENSMUST00000023364.7
Pla2g10
phospholipase A2, group X
chr10_+_56253418 3.83 ENSMUST00000068581.9
ENSMUST00000217789.2
Gja1
gap junction protein, alpha 1
chr10_+_127350820 3.53 ENSMUST00000035735.11
Ndufa4l2
Ndufa4, mitochondrial complex associated like 2
chr18_-_43526411 3.39 ENSMUST00000025379.14
Dpysl3
dihydropyrimidinase-like 3
chr7_-_43885522 2.70 ENSMUST00000206686.2
ENSMUST00000037220.5
1700028J19Rik
RIKEN cDNA 1700028J19 gene
chr12_-_84408576 2.42 ENSMUST00000021659.2
ENSMUST00000065536.9
Fam161b
family with sequence similarity 161, member B
chr7_+_43885573 2.38 ENSMUST00000223070.2
ENSMUST00000205530.2
Gm36864
predicted gene, 36864
chr11_-_100861713 2.36 ENSMUST00000060792.6
Cavin1
caveolae associated 1
chr3_-_51184895 2.33 ENSMUST00000108051.8
ENSMUST00000108053.9
Elf2
E74-like factor 2
chr3_-_87985602 2.28 ENSMUST00000050258.9
Ttc24
tetratricopeptide repeat domain 24
chr7_-_43885552 2.22 ENSMUST00000236952.2
1700028J19Rik
RIKEN cDNA 1700028J19 gene
chrX_-_133377225 2.01 ENSMUST00000009740.9
Taf7l
TATA-box binding protein associated factor 7 like
chr5_-_107074110 1.93 ENSMUST00000117588.8
Hfm1
HFM1, ATP-dependent DNA helicase homolog
chrX_+_126301916 1.86 ENSMUST00000051530.4
4921511C20Rik
RIKEN cDNA 4921511C20 gene
chr13_-_59853995 1.75 ENSMUST00000066510.8
ENSMUST00000224469.2
Spata31d1a
spermatogenesis associated 31 subfamily D, member 1A
chr16_+_17437367 1.57 ENSMUST00000231887.2
Smpd4
sphingomyelin phosphodiesterase 4
chr7_+_28222261 1.40 ENSMUST00000078364.4
Ifnl3
interferon lambda 3
chr10_+_80062468 1.36 ENSMUST00000130260.2
Pwwp3a
PWWP domain containing 3A, DNA repair factor
chr19_+_5754395 1.16 ENSMUST00000052448.4
Kcnk7
potassium channel, subfamily K, member 7
chr6_-_97037366 1.05 ENSMUST00000089295.6
Tafa4
TAFA chemokine like family member 4
chr2_+_154393691 0.97 ENSMUST00000104928.2
Actl10
actin-like 10
chr1_-_31261678 0.95 ENSMUST00000187892.8
ENSMUST00000233331.2
4931428L18Rik
RIKEN cDNA 4931428L18 gene
chr12_+_84408803 0.88 ENSMUST00000110278.8
ENSMUST00000145522.2
Coq6
coenzyme Q6 monooxygenase
chr15_-_97806142 0.87 ENSMUST00000023119.15
Vdr
vitamin D (1,25-dihydroxyvitamin D3) receptor
chr12_+_84408742 0.84 ENSMUST00000021661.13
Coq6
coenzyme Q6 monooxygenase
chr8_+_22313550 0.37 ENSMUST00000078879.7
Defb50
defensin beta 50
chr2_-_90101376 0.27 ENSMUST00000216383.2
Olfr1271
olfactory receptor 1271
chr11_+_73241609 0.23 ENSMUST00000120137.3
Olfr20
olfactory receptor 20
chr10_-_18619439 0.23 ENSMUST00000019999.7
Arfgef3
ARFGEF family member 3
chr19_+_7471398 0.18 ENSMUST00000170373.9
ENSMUST00000236308.2
ENSMUST00000235557.2
Atl3
atlastin GTPase 3
chr14_+_67982630 0.18 ENSMUST00000223929.2
ENSMUST00000111095.4
Gnrh1
gonadotropin releasing hormone 1
chr19_-_10434837 0.13 ENSMUST00000171400.4
Lrrc10b
leucine rich repeat containing 10B
chr3_+_60380243 0.11 ENSMUST00000195724.6
Mbnl1
muscleblind like splicing factor 1
chr16_+_17437205 0.06 ENSMUST00000006053.13
ENSMUST00000231311.2
ENSMUST00000163476.10
ENSMUST00000231257.2
ENSMUST00000165363.10
ENSMUST00000232043.2
ENSMUST00000090159.13
ENSMUST00000232442.2
Smpd4
sphingomyelin phosphodiesterase 4
chr16_-_19241884 0.04 ENSMUST00000206110.4
Olfr165
olfactory receptor 165
chr10_-_18619658 0.02 ENSMUST00000215836.2
Arfgef3
ARFGEF family member 3
chr1_+_39574829 0.02 ENSMUST00000003219.14
Cnot11
CCR4-NOT transcription complex, subunit 11
chr7_-_119744509 0.02 ENSMUST00000208874.2
ENSMUST00000033207.6
Zp2
zona pellucida glycoprotein 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 19.9 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
2.8 8.3 GO:0051977 lysophospholipid transport(GO:0051977)
1.3 3.8 GO:0010232 vascular transport(GO:0010232) milk ejection(GO:0060156)
0.6 2.4 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.2 0.9 GO:0010979 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980) bile acid signaling pathway(GO:0038183)
0.2 1.6 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 3.4 GO:0051764 actin crosslink formation(GO:0051764)
0.1 1.9 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 1.7 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.1 1.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 6.8 GO:0030239 myofibril assembly(GO:0030239)
0.1 2.0 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.2 GO:2000354 regulation of ovarian follicle development(GO:2000354)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 19.9 GO:1990584 cardiac Troponin complex(GO:1990584)
0.2 3.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 3.8 GO:0005916 fascia adherens(GO:0005916)
0.1 0.9 GO:0001651 dense fibrillar component(GO:0001651)
0.1 2.0 GO:0010369 chromocenter(GO:0010369)
0.0 3.4 GO:0031941 filamentous actin(GO:0031941)
0.0 5.5 GO:0030018 Z disc(GO:0030018)
0.0 0.2 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 2.4 GO:0005901 caveola(GO:0005901)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 19.9 GO:0030172 troponin C binding(GO:0030172)
1.4 6.8 GO:0051373 FATZ binding(GO:0051373)
0.5 3.8 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.3 3.4 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.3 2.4 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.3 0.9 GO:1902121 lithocholic acid binding(GO:1902121)
0.2 8.3 GO:0004623 phospholipase A2 activity(GO:0004623)
0.2 1.6 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 3.5 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 1.7 GO:0071949 FAD binding(GO:0071949)
0.0 2.0 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.9 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.8 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.3 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.9 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 8.3 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.3 19.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.2 3.8 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.1 3.4 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 1.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.6 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors