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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Tead1

Z-value: 1.32

Motif logo

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Transcription factors associated with Tead1

Gene Symbol Gene ID Gene Info
Tead1
ENSMUSG00000055320.19 Tead1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tead1mm39_v1_chr7_+_112341233_1123412680.701.2e-11Click!

Activity profile of Tead1 motif

Sorted Z-values of Tead1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Tead1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_+_17306334 11.04 ENSMUST00000007799.13
ENSMUST00000115456.6
Cav1
caveolin 1, caveolae protein
chr6_+_17307038 9.59 ENSMUST00000123439.8
Cav1
caveolin 1, caveolae protein
chr1_+_135764092 9.48 ENSMUST00000188028.7
ENSMUST00000178204.8
ENSMUST00000190451.7
ENSMUST00000189732.7
ENSMUST00000189355.7
Tnnt2
troponin T2, cardiac
chr6_+_17306379 9.38 ENSMUST00000115455.3
Cav1
caveolin 1, caveolae protein
chr17_+_35960600 9.36 ENSMUST00000171166.3
Sfta2
surfactant associated 2
chr9_-_107486381 8.41 ENSMUST00000102531.7
ENSMUST00000102530.8
ENSMUST00000195057.2
ENSMUST00000102532.10
Sema3b
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr6_+_17306414 8.32 ENSMUST00000150901.2
Cav1
caveolin 1, caveolae protein
chr11_-_100861713 8.23 ENSMUST00000060792.6
Cavin1
caveolae associated 1
chr14_-_55204054 7.82 ENSMUST00000226297.2
Myh6
myosin, heavy polypeptide 6, cardiac muscle, alpha
chr14_-_55204092 7.78 ENSMUST00000081857.14
Myh6
myosin, heavy polypeptide 6, cardiac muscle, alpha
chr15_+_78726824 7.09 ENSMUST00000059619.3
Cdc42ep1
CDC42 effector protein (Rho GTPase binding) 1
chr19_-_23425757 6.56 ENSMUST00000036069.8
Mamdc2
MAM domain containing 2
chr2_+_156617329 6.41 ENSMUST00000088552.7
Myl9
myosin, light polypeptide 9, regulatory
chr14_-_55204383 6.35 ENSMUST00000111456.2
Myh6
myosin, heavy polypeptide 6, cardiac muscle, alpha
chr11_+_62711057 6.27 ENSMUST00000055006.12
ENSMUST00000072639.10
Trim16
tripartite motif-containing 16
chr1_+_192984278 6.23 ENSMUST00000016315.16
Lamb3
laminin, beta 3
chr1_+_189460461 5.81 ENSMUST00000097442.9
Ptpn14
protein tyrosine phosphatase, non-receptor type 14
chr6_+_113435716 5.41 ENSMUST00000203661.3
ENSMUST00000204774.3
ENSMUST00000053569.7
ENSMUST00000101065.8
Il17re
interleukin 17 receptor E
chr11_+_62711295 5.30 ENSMUST00000108703.2
Trim16
tripartite motif-containing 16
chr7_-_33832640 5.23 ENSMUST00000038537.9
Wtip
WT1-interacting protein
chr7_+_140796537 5.16 ENSMUST00000141804.2
Rassf7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr14_-_55204023 5.12 ENSMUST00000124930.8
Myh6
myosin, heavy polypeptide 6, cardiac muscle, alpha
chr17_-_71309815 4.98 ENSMUST00000123686.8
Myl12a
myosin, light chain 12A, regulatory, non-sarcomeric
chr8_+_129450766 4.98 ENSMUST00000149116.2
Itgb1
integrin beta 1 (fibronectin receptor beta)
chr19_-_57185928 4.95 ENSMUST00000111544.8
Ablim1
actin-binding LIM protein 1
chr14_-_55231998 4.83 ENSMUST00000227518.2
ENSMUST00000226424.2
ENSMUST00000153783.2
ENSMUST00000102803.11
ENSMUST00000168485.8
Myh7
myosin, heavy polypeptide 7, cardiac muscle, beta
chr5_+_136996713 4.74 ENSMUST00000001790.6
Cldn15
claudin 15
chr3_-_69767208 4.71 ENSMUST00000171529.4
ENSMUST00000051239.13
Sptssb
serine palmitoyltransferase, small subunit B
chr9_-_8004586 4.46 ENSMUST00000086580.12
ENSMUST00000065353.13
Yap1
yes-associated protein 1
chr16_-_38620688 4.31 ENSMUST00000057767.6
Upk1b
uroplakin 1B
chr15_+_6416229 4.31 ENSMUST00000110664.9
ENSMUST00000110663.9
ENSMUST00000161812.8
ENSMUST00000160134.8
Dab2
disabled 2, mitogen-responsive phosphoprotein
chr19_-_57185861 4.18 ENSMUST00000111550.8
Ablim1
actin-binding LIM protein 1
chr6_-_128277701 4.18 ENSMUST00000143004.2
ENSMUST00000006311.13
ENSMUST00000112157.4
ENSMUST00000133118.2
Tead4
TEA domain family member 4
chr19_-_57185988 4.13 ENSMUST00000099294.9
Ablim1
actin-binding LIM protein 1
chr12_+_85793313 4.01 ENSMUST00000040461.4
Flvcr2
feline leukemia virus subgroup C cellular receptor 2
chr6_+_146789978 3.96 ENSMUST00000016631.14
ENSMUST00000203730.3
ENSMUST00000111623.9
Ppfibp1
PTPRF interacting protein, binding protein 1 (liprin beta 1)
chr19_-_57185808 3.94 ENSMUST00000111546.8
Ablim1
actin-binding LIM protein 1
chr5_+_103573367 3.84 ENSMUST00000048957.11
Ptpn13
protein tyrosine phosphatase, non-receptor type 13
chr14_-_54815000 3.76 ENSMUST00000054487.10
Ajuba
ajuba LIM protein
chr15_+_6416079 3.62 ENSMUST00000080880.12
Dab2
disabled 2, mitogen-responsive phosphoprotein
chr10_+_93476903 3.60 ENSMUST00000020204.5
Ntn4
netrin 4
chr9_-_44624496 3.54 ENSMUST00000144251.8
ENSMUST00000156918.8
Phldb1
pleckstrin homology like domain, family B, member 1
chr1_+_51328265 3.52 ENSMUST00000051572.8
Cavin2
caveolae associated 2
chr11_-_101061153 3.50 ENSMUST00000123864.2
Plekhh3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr10_+_24471340 3.46 ENSMUST00000020171.12
Ccn2
cellular communication network factor 2
chr10_+_32959472 3.43 ENSMUST00000095762.5
ENSMUST00000218281.2
ENSMUST00000217779.2
ENSMUST00000219665.2
ENSMUST00000219931.2
Trdn
triadin
chr7_+_3340013 3.37 ENSMUST00000204541.2
Myadm
myeloid-associated differentiation marker
chr11_-_55310724 3.24 ENSMUST00000108858.8
ENSMUST00000141530.2
Sparc
secreted acidic cysteine rich glycoprotein
chr2_+_90948481 3.17 ENSMUST00000137942.8
ENSMUST00000111430.10
ENSMUST00000169776.2
Mybpc3
myosin binding protein C, cardiac
chr6_-_119173348 3.12 ENSMUST00000187474.7
ENSMUST00000187940.7
Cacna1c
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr18_+_50186349 3.09 ENSMUST00000148159.3
Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr1_+_135693818 3.04 ENSMUST00000038945.6
Phlda3
pleckstrin homology like domain, family A, member 3
chr6_+_125297596 3.04 ENSMUST00000176655.8
ENSMUST00000176110.8
Scnn1a
sodium channel, nonvoltage-gated 1 alpha
chr7_+_130247912 2.87 ENSMUST00000207549.2
ENSMUST00000209108.2
Tacc2
transforming, acidic coiled-coil containing protein 2
chr1_-_87322443 2.85 ENSMUST00000113212.4
Kcnj13
potassium inwardly-rectifying channel, subfamily J, member 13
chr6_+_34575435 2.83 ENSMUST00000079391.10
ENSMUST00000142512.8
ENSMUST00000115027.8
ENSMUST00000115026.8
Cald1
caldesmon 1
chr6_-_37419030 2.81 ENSMUST00000041093.6
Creb3l2
cAMP responsive element binding protein 3-like 2
chr17_-_71309012 2.74 ENSMUST00000128179.2
ENSMUST00000150456.2
ENSMUST00000233357.2
ENSMUST00000233417.2
Myl12a
Gm49909
myosin, light chain 12A, regulatory, non-sarcomeric
predicted gene, 49909
chr6_-_42350188 2.69 ENSMUST00000073387.5
ENSMUST00000204357.2
Epha1
Eph receptor A1
chr7_+_43441315 2.69 ENSMUST00000005891.7
Klk9
kallikrein related-peptidase 9
chr18_+_50164043 2.65 ENSMUST00000145726.2
ENSMUST00000128377.2
Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr2_-_104324035 2.58 ENSMUST00000111124.8
Hipk3
homeodomain interacting protein kinase 3
chr7_+_140796096 2.53 ENSMUST00000153081.2
Rassf7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr10_-_12702674 2.48 ENSMUST00000219130.2
Utrn
utrophin
chr7_+_27196760 2.41 ENSMUST00000238964.2
Prx
periaxin
chr8_-_123278054 2.39 ENSMUST00000156333.9
ENSMUST00000067252.14
Piezo1
piezo-type mechanosensitive ion channel component 1
chr1_-_168259710 2.31 ENSMUST00000072863.6
Pbx1
pre B cell leukemia homeobox 1
chr5_+_24631829 2.19 ENSMUST00000155598.8
Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr2_-_60711706 2.17 ENSMUST00000164147.8
ENSMUST00000112509.2
Rbms1
RNA binding motif, single stranded interacting protein 1
chr2_+_90865958 2.14 ENSMUST00000111445.10
ENSMUST00000111446.10
ENSMUST00000050323.6
Rapsn
receptor-associated protein of the synapse
chr6_-_128101275 2.13 ENSMUST00000127105.8
Tspan9
tetraspanin 9
chr12_-_98703664 2.12 ENSMUST00000170188.8
Ptpn21
protein tyrosine phosphatase, non-receptor type 21
chr5_-_86616849 2.09 ENSMUST00000101073.3
Tmprss11a
transmembrane protease, serine 11a
chr7_-_65020655 1.98 ENSMUST00000032729.8
Tjp1
tight junction protein 1
chr17_+_35878332 1.97 ENSMUST00000044326.5
2300002M23Rik
RIKEN cDNA 2300002M23 gene
chr4_+_154321982 1.96 ENSMUST00000152159.8
Megf6
multiple EGF-like-domains 6
chr11_+_70591299 1.90 ENSMUST00000152618.9
ENSMUST00000102554.8
ENSMUST00000094499.11
ENSMUST00000072187.12
ENSMUST00000137119.3
Kif1c
kinesin family member 1C
chr10_+_27950809 1.71 ENSMUST00000166468.2
ENSMUST00000218359.2
ENSMUST00000218276.2
Ptprk
protein tyrosine phosphatase, receptor type, K
chr6_-_115569504 1.70 ENSMUST00000112957.2
Mkrn2os
makorin, ring finger protein 2, opposite strand
chr11_+_115865535 1.69 ENSMUST00000021107.14
ENSMUST00000169928.8
ENSMUST00000106461.8
Itgb4
integrin beta 4
chr7_-_109215754 1.57 ENSMUST00000084738.5
Denn2b
DENN domain containing 2B
chr8_+_86567600 1.56 ENSMUST00000053771.14
ENSMUST00000161850.8
Phkb
phosphorylase kinase beta
chr3_+_96011810 1.54 ENSMUST00000132980.8
ENSMUST00000138206.8
ENSMUST00000090785.9
ENSMUST00000035519.12
Otud7b
OTU domain containing 7B
chr5_+_31274046 1.51 ENSMUST00000013771.15
Trim54
tripartite motif-containing 54
chr4_+_62278932 1.49 ENSMUST00000084526.12
Slc31a1
solute carrier family 31, member 1
chr7_-_143056252 1.46 ENSMUST00000010904.5
Phlda2
pleckstrin homology like domain, family A, member 2
chr11_+_77353218 1.43 ENSMUST00000102493.8
Coro6
coronin 6
chr7_-_28071919 1.39 ENSMUST00000119990.8
Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr5_+_31274064 1.36 ENSMUST00000202769.2
Trim54
tripartite motif-containing 54
chr11_+_68961599 1.32 ENSMUST00000075980.12
ENSMUST00000094081.5
Tmem107
transmembrane protein 107
chr12_+_55349422 1.28 ENSMUST00000021411.15
Prorp
protein only RNase P catalytic subunit
chr3_+_31049896 1.27 ENSMUST00000108249.9
Prkci
protein kinase C, iota
chr17_-_48145466 1.19 ENSMUST00000066368.13
Mdfi
MyoD family inhibitor
chr12_+_9023892 1.12 ENSMUST00000085745.13
ENSMUST00000111113.3
Wdr35
WD repeat domain 35
chr8_+_122985359 1.03 ENSMUST00000187142.3
Zfp469
zinc finger protein 469
chr7_-_28071658 1.01 ENSMUST00000094644.11
Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr8_+_46081213 0.87 ENSMUST00000130850.8
Sorbs2
sorbin and SH3 domain containing 2
chr15_+_102875229 0.84 ENSMUST00000001699.8
Hoxc10
homeobox C10
chr9_-_65298934 0.83 ENSMUST00000068307.4
Kbtbd13
kelch repeat and BTB (POZ) domain containing 13
chr8_-_96033213 0.81 ENSMUST00000119870.9
ENSMUST00000093268.5
Cngb1
cyclic nucleotide gated channel beta 1
chr4_+_149629559 0.79 ENSMUST00000105692.2
Ctnnbip1
catenin beta interacting protein 1
chr11_-_83320281 0.76 ENSMUST00000052521.9
Gas2l2
growth arrest-specific 2 like 2
chr5_+_77099229 0.71 ENSMUST00000141687.2
Paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
chr5_-_21850579 0.71 ENSMUST00000051358.11
Fbxl13
F-box and leucine-rich repeat protein 13
chr1_+_156138286 0.69 ENSMUST00000027896.10
Nphs2
nephrosis 2, podocin
chr2_+_20524587 0.68 ENSMUST00000114604.9
ENSMUST00000066509.10
Etl4
enhancer trap locus 4
chrX_-_6232775 0.64 ENSMUST00000024049.8
Bmp15
bone morphogenetic protein 15
chr1_+_4878460 0.64 ENSMUST00000131119.2
Lypla1
lysophospholipase 1
chr5_-_115438971 0.64 ENSMUST00000112090.2
Dynll1
dynein light chain LC8-type 1
chr10_-_42152684 0.63 ENSMUST00000175881.8
ENSMUST00000056974.4
ENSMUST00000105502.8
ENSMUST00000105501.2
Foxo3
forkhead box O3
chr8_+_70755402 0.61 ENSMUST00000150968.8
Cope
coatomer protein complex, subunit epsilon
chr17_-_71575584 0.57 ENSMUST00000233148.2
Emilin2
elastin microfibril interfacer 2
chr8_-_105036664 0.52 ENSMUST00000160596.8
ENSMUST00000164175.2
Cmtm1
CKLF-like MARVEL transmembrane domain containing 1
chr4_-_62278761 0.47 ENSMUST00000107461.2
ENSMUST00000084528.10
Fkbp15
FK506 binding protein 15
chr19_-_42117420 0.46 ENSMUST00000161873.2
ENSMUST00000018965.4
Avpi1
arginine vasopressin-induced 1
chr7_+_140796559 0.41 ENSMUST00000148975.3
Rassf7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr4_+_43267165 0.40 ENSMUST00000107942.9
ENSMUST00000102953.4
Atp8b5
ATPase, class I, type 8B, member 5
chr18_+_62086122 0.39 ENSMUST00000051720.6
ENSMUST00000235860.2
Sh3tc2
SH3 domain and tetratricopeptide repeats 2
chr11_+_115865756 0.36 ENSMUST00000106460.9
Itgb4
integrin beta 4
chr8_-_106692668 0.34 ENSMUST00000116429.9
ENSMUST00000034370.17
Slc12a4
solute carrier family 12, member 4
chr5_-_30401416 0.32 ENSMUST00000125367.4
Adgrf3
adhesion G protein-coupled receptor F3
chr8_+_70755168 0.31 ENSMUST00000066469.14
Cope
coatomer protein complex, subunit epsilon
chr8_-_48443525 0.31 ENSMUST00000057561.9
Wwc2
WW, C2 and coiled-coil domain containing 2
chr18_-_9449947 0.31 ENSMUST00000234102.2
Ccny
cyclin Y
chr8_-_105036739 0.30 ENSMUST00000159039.2
Cmtm1
CKLF-like MARVEL transmembrane domain containing 1
chr6_-_120341304 0.28 ENSMUST00000146667.2
Ccdc77
coiled-coil domain containing 77
chr17_-_13271183 0.28 ENSMUST00000091648.4
Gpr31b
G protein-coupled receptor 31, D17Leh66b region
chr6_-_134543876 0.28 ENSMUST00000032322.15
ENSMUST00000126836.4
Lrp6
low density lipoprotein receptor-related protein 6
chr8_-_70755132 0.19 ENSMUST00000008004.10
Ddx49
DEAD box helicase 49
chr14_-_123151162 0.17 ENSMUST00000160401.8
Ggact
gamma-glutamylamine cyclotransferase
chr18_-_35795175 0.17 ENSMUST00000236574.2
ENSMUST00000236971.2
Spata24
spermatogenesis associated 24
chr2_-_32665596 0.15 ENSMUST00000161430.8
Ttc16
tetratricopeptide repeat domain 16
chr18_-_9450097 0.14 ENSMUST00000053917.6
Ccny
cyclin Y
chr4_+_58285957 0.12 ENSMUST00000081919.12
ENSMUST00000177951.8
ENSMUST00000098059.10
ENSMUST00000179951.2
ENSMUST00000102893.10
ENSMUST00000084578.12
ENSMUST00000098057.10
Musk
muscle, skeletal, receptor tyrosine kinase
chr4_-_139695337 0.11 ENSMUST00000105031.4
Klhdc7a
kelch domain containing 7A
chr5_-_135518098 0.10 ENSMUST00000201998.2
Hip1
huntingtin interacting protein 1
chr4_-_62278673 0.09 ENSMUST00000084527.10
ENSMUST00000098033.10
Fkbp15
FK506 binding protein 15
chr2_-_120234539 0.09 ENSMUST00000090042.12
ENSMUST00000110729.2
ENSMUST00000090046.12
Tmem87a
transmembrane protein 87A
chr8_+_84267722 0.09 ENSMUST00000058609.5
Olfr370
olfactory receptor 370
chr7_+_43645253 0.03 ENSMUST00000007156.5
Klk1b11
kallikrein 1-related peptidase b11
chr7_-_44174065 0.03 ENSMUST00000165208.4
Mybpc2
myosin binding protein C, fast-type
chr7_+_98092628 0.01 ENSMUST00000098274.5
Gucy2d
guanylate cyclase 2d

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.8 27.1 GO:0007522 visceral muscle development(GO:0007522)
6.4 38.3 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
2.4 9.5 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
2.1 8.2 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
1.7 5.0 GO:0010710 regulation of collagen catabolic process(GO:0010710)
1.6 4.8 GO:0014862 regulation of the force of skeletal muscle contraction(GO:0014728) regulation of skeletal muscle contraction by chemo-mechanical energy conversion(GO:0014862)
1.3 7.9 GO:0035026 leading edge cell differentiation(GO:0035026)
0.9 9.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.9 11.6 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.8 4.2 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
0.6 4.7 GO:1904220 regulation of serine C-palmitoyltransferase activity(GO:1904220)
0.6 3.4 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.5 6.6 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.5 4.5 GO:0060449 contact inhibition(GO:0060242) bud elongation involved in lung branching(GO:0060449)
0.5 1.5 GO:0060720 spongiotrophoblast cell proliferation(GO:0060720) cell proliferation involved in embryonic placenta development(GO:0060722)
0.5 2.4 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.4 3.6 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.4 7.1 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.4 2.4 GO:0032290 peripheral nervous system myelin formation(GO:0032290)
0.4 2.5 GO:0007527 adult somatic muscle development(GO:0007527)
0.3 2.8 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.3 2.2 GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
0.3 1.3 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.3 1.5 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.2 3.5 GO:1904261 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.2 1.5 GO:0072719 cellular response to cisplatin(GO:0072719) copper ion import across plasma membrane(GO:0098705) copper ion import into cell(GO:1902861)
0.2 5.8 GO:0001946 lymphangiogenesis(GO:0001946)
0.2 3.2 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.2 2.1 GO:0035878 nail development(GO:0035878)
0.1 1.8 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.1 17.2 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 0.3 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.1 2.6 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.1 0.8 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.1 8.4 GO:0050919 negative chemotaxis(GO:0050919)
0.1 2.9 GO:0030953 astral microtubule organization(GO:0030953)
0.1 1.8 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.1 3.5 GO:0097320 membrane tubulation(GO:0097320)
0.1 2.0 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 1.7 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.1 0.6 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 1.3 GO:0035089 establishment of apical/basal cell polarity(GO:0035089) Golgi vesicle budding(GO:0048194)
0.1 0.8 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 0.6 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
0.1 3.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 0.4 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 6.2 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 2.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 5.7 GO:0032611 interleukin-1 beta production(GO:0032611)
0.1 3.2 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.1 2.3 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.1 2.8 GO:0010107 potassium ion import(GO:0010107)
0.1 3.0 GO:0050891 multicellular organismal water homeostasis(GO:0050891)
0.0 1.2 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 0.8 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 3.0 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 2.7 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 8.1 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 2.8 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.0 3.2 GO:0070527 platelet aggregation(GO:0070527)
0.0 2.8 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 3.8 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling(GO:0014066)
0.0 0.1 GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000588)
0.0 0.4 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.0 3.8 GO:0008360 regulation of cell shape(GO:0008360)
0.0 2.0 GO:0051453 regulation of intracellular pH(GO:0051453)
0.0 1.6 GO:0005977 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042)
0.0 5.0 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 0.7 GO:0007588 excretion(GO:0007588)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 38.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
1.7 5.0 GO:0034681 integrin alpha1-beta1 complex(GO:0034665) integrin alpha7-beta1 complex(GO:0034677) integrin alpha10-beta1 complex(GO:0034680) integrin alpha11-beta1 complex(GO:0034681)
1.6 7.9 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
1.6 14.1 GO:0016460 myosin II complex(GO:0016460)
1.4 9.5 GO:1990584 cardiac Troponin complex(GO:1990584)
1.3 35.1 GO:0005859 muscle myosin complex(GO:0005859) myosin filament(GO:0032982)
1.1 4.5 GO:0071149 TEAD-1-YAP complex(GO:0071148) TEAD-2-YAP complex(GO:0071149)
1.0 6.2 GO:0005610 laminin-5 complex(GO:0005610)
0.9 3.4 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.8 3.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.7 2.2 GO:0002095 caveolar macromolecular signaling complex(GO:0002095)
0.5 4.7 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.3 2.8 GO:0030478 actin cap(GO:0030478)
0.3 8.5 GO:0005614 interstitial matrix(GO:0005614)
0.2 1.6 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.2 3.5 GO:0045180 basal cortex(GO:0045180)
0.2 2.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 16.2 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 1.1 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 2.0 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 2.5 GO:0070938 contractile ring(GO:0070938)
0.1 0.8 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.1 14.2 GO:0016605 PML body(GO:0016605)
0.1 2.1 GO:0030056 hemidesmosome(GO:0030056)
0.1 3.0 GO:0034706 sodium channel complex(GO:0034706)
0.1 0.4 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 2.1 GO:0099634 postsynaptic specialization membrane(GO:0099634)
0.1 11.6 GO:0005901 caveola(GO:0005901)
0.1 0.9 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 0.8 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 1.3 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.1 8.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 7.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 4.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 3.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.7 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 1.3 GO:0035869 ciliary transition zone(GO:0035869)
0.0 0.6 GO:1904115 axon cytoplasm(GO:1904115)
0.0 3.6 GO:0005604 basement membrane(GO:0005604)
0.0 2.9 GO:0005875 microtubule associated complex(GO:0005875)
0.0 2.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.9 GO:0005871 kinesin complex(GO:0005871)
0.0 3.8 GO:0030496 midbody(GO:0030496)
0.0 0.1 GO:0098890 extrinsic component of postsynaptic membrane(GO:0098890)
0.0 6.5 GO:0016324 apical plasma membrane(GO:0016324)
0.0 3.2 GO:0032993 protein-DNA complex(GO:0032993)
0.0 1.9 GO:0055037 recycling endosome(GO:0055037)
0.0 0.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.4 38.3 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
3.9 27.1 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
1.6 9.5 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
1.2 8.2 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.9 4.7 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.9 11.6 GO:0019966 interleukin-1 binding(GO:0019966)
0.8 5.0 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.7 4.0 GO:0015232 heme transporter activity(GO:0015232)
0.6 5.4 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.5 2.0 GO:0070052 collagen V binding(GO:0070052)
0.5 9.6 GO:0032036 myosin heavy chain binding(GO:0032036)
0.4 3.6 GO:0043237 laminin-1 binding(GO:0043237)
0.4 8.4 GO:0038191 neuropilin binding(GO:0038191)
0.4 7.9 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.4 2.7 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.3 2.2 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.3 7.1 GO:0017049 GTP-Rho binding(GO:0017049)
0.3 3.0 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.2 3.8 GO:0045294 alpha-catenin binding(GO:0045294)
0.2 1.6 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.2 4.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.2 2.1 GO:0038132 neuregulin binding(GO:0038132)
0.2 2.4 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.2 3.8 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.2 3.0 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.2 2.0 GO:0071253 connexin binding(GO:0071253)
0.1 2.8 GO:0035497 cAMP response element binding(GO:0035497)
0.1 2.1 GO:0043495 protein anchor(GO:0043495)
0.1 1.5 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 4.5 GO:0070064 proline-rich region binding(GO:0070064)
0.1 2.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 1.5 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 5.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 0.3 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.1 0.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 7.7 GO:0035254 glutamate receptor binding(GO:0035254)
0.1 1.3 GO:0004697 protein kinase C activity(GO:0004697)
0.1 0.6 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 3.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 5.4 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.8 GO:0043855 cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.6 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.0 3.5 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.3 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 1.0 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 15.7 GO:0003779 actin binding(GO:0003779)
0.0 4.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 4.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.6 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 3.4 GO:0044325 ion channel binding(GO:0044325)
0.0 1.9 GO:0003777 microtubule motor activity(GO:0003777)
0.0 2.7 GO:0035257 nuclear hormone receptor binding(GO:0035257)
0.0 4.4 GO:0045296 cadherin binding(GO:0045296)
0.0 0.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 38.6 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.5 8.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 5.0 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.1 12.4 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 3.9 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 6.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 2.7 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 3.8 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.8 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 0.6 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 4.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.3 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 1.7 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 4.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 35.8 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.6 36.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.6 17.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.4 5.0 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 4.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.2 8.6 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 6.4 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 5.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 2.8 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.1 2.0 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 8.3 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.1 3.6 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 0.9 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 1.6 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.6 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.6 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.4 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.6 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 2.5 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides