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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Tead3_Tead4
Z-value: 3.77
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Transcription factors associated with Tead3_Tead4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tead4 | mm39_v1_chr6_-_128277701_128277786 | 0.77 | 2.0e-15 | Click! |
| Tead3 | mm39_v1_chr17_-_28569574_28569685 | 0.70 | 9.7e-12 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tead3_Tead4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 63.7 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 10.3 | 61.7 | GO:1900085 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 14.2 | 56.8 | GO:0007522 | visceral muscle development(GO:0007522) |
| 10.9 | 54.5 | GO:0060931 | sinoatrial node cell development(GO:0060931) |
| 4.5 | 44.6 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 6.7 | 40.1 | GO:0035026 | leading edge cell differentiation(GO:0035026) |
| 1.3 | 35.8 | GO:0097435 | fibril organization(GO:0097435) |
| 5.8 | 34.9 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 3.0 | 29.9 | GO:0086023 | adrenergic receptor signaling pathway involved in heart process(GO:0086023) |
| 0.3 | 29.9 | GO:0030032 | lamellipodium assembly(GO:0030032) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 141.7 | GO:0005859 | muscle myosin complex(GO:0005859) myosin filament(GO:0032982) |
| 0.6 | 96.1 | GO:0005901 | caveola(GO:0005901) |
| 0.7 | 91.3 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.4 | 78.5 | GO:0042383 | sarcolemma(GO:0042383) |
| 3.6 | 60.5 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.4 | 52.3 | GO:0031674 | I band(GO:0031674) |
| 17.2 | 51.6 | GO:0016014 | dystrobrevin complex(GO:0016014) |
| 0.1 | 46.5 | GO:0045177 | apical part of cell(GO:0045177) |
| 0.3 | 42.7 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 8.0 | 40.1 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 72.5 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.1 | 62.7 | GO:0003779 | actin binding(GO:0003779) |
| 10.3 | 61.7 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 0.3 | 60.3 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 8.1 | 56.8 | GO:0030899 | calcium-dependent ATPase activity(GO:0030899) |
| 1.2 | 55.5 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 1.1 | 52.6 | GO:0030552 | cAMP binding(GO:0030552) |
| 2.4 | 45.0 | GO:0038191 | neuropilin binding(GO:0038191) |
| 2.1 | 40.1 | GO:0098748 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.4 | 36.1 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 76.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 67.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.8 | 61.6 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.5 | 45.7 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.5 | 38.6 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 35.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 32.8 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.6 | 29.9 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.3 | 21.1 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.3 | 19.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 143.2 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 2.1 | 60.4 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 1.6 | 55.6 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 1.2 | 45.3 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 2.2 | 43.7 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.9 | 26.4 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.8 | 25.7 | REACTOME GRB2 EVENTS IN ERBB2 SIGNALING | Genes involved in GRB2 events in ERBB2 signaling |
| 0.8 | 25.3 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.8 | 22.9 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 19.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |