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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Tfap4
Z-value: 1.65
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Transcription factors associated with Tfap4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tfap4 | mm39_v1_chr16_-_4377640_4377718 | -0.22 | 6.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tfap4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.1 | GO:0030239 | myofibril assembly(GO:0030239) |
| 0.3 | 16.4 | GO:0060765 | regulation of androgen receptor signaling pathway(GO:0060765) |
| 1.8 | 14.1 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.1 | 12.0 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.6 | 11.9 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 0.3 | 11.6 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 1.6 | 11.3 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.3 | 11.1 | GO:0071625 | vocalization behavior(GO:0071625) |
| 0.2 | 11.1 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 2.7 | 10.9 | GO:1904209 | regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.8 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.0 | 16.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 15.8 | GO:0030017 | sarcomere(GO:0030017) |
| 0.2 | 15.6 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.3 | 15.0 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 13.1 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.2 | 12.9 | GO:0031672 | A band(GO:0031672) |
| 0.1 | 11.0 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 1.4 | 10.9 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 10.9 | GO:0070382 | exocytic vesicle(GO:0070382) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.7 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 1.1 | 14.7 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
| 1.0 | 14.1 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.2 | 13.0 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.7 | 10.9 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.1 | 10.1 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 10.0 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.1 | 9.8 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.1 | 9.7 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 2.4 | 9.6 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 15.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 13.7 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.2 | 13.7 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.5 | 12.5 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.2 | 11.2 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.2 | 9.5 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.2 | 9.5 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.2 | 8.8 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.2 | 7.8 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.3 | 16.6 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 13.2 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.5 | 8.1 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.3 | 8.0 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.4 | 7.4 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 7.2 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.3 | 7.1 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.2 | 6.7 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.2 | 6.7 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |