ISMARA results: Tfeb_Usf1_Srebf1_Usf2_Bhlhe41

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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Z-value: 2.32

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Transcription factors associated with Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Gene Symbol	Gene ID	Gene Info
Tfeb Ensembl NCBI MGI UniProt	ENSMUSG00000023990.19	Tfeb
Usf1 Ensembl NCBI MGI UniProt	ENSMUSG00000026641.14	Usf1
Srebf1 Ensembl NCBI MGI UniProt	ENSMUSG00000020538.16	Srebf1
Usf2 Ensembl NCBI MGI UniProt	ENSMUSG00000058239.14	Usf2
Bhlhe41 Ensembl NCBI MGI UniProt	ENSMUSG00000030256.12	Bhlhe41
Srebf2 Ensembl NCBI MGI UniProt	ENSMUSG00000022463.9	Srebf2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Srebf2	mm39_v1_chr15_+_82031382_82031476	0.71	2.9e-12	Click!
Usf1	mm39_v1_chr1_+_171238873_171238906	0.63	2.1e-09	Click!
Bhlhe41	mm39_v1_chr6_-_145811274_145811284	0.60	2.4e-08	Click!
Usf2	mm39_v1_chr7_-_30656167_30656228	0.50	9.2e-06	Click!
Srebf1	mm39_v1_chr11_-_60111391_60111458	-0.22	5.8e-02	Click!
Tfeb	mm39_v1_chr17_+_48047955_48048033	0.19	1.0e-01	Click!

Activity profile of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

Sorted Z-values of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr9_+_21279161 Show fit	62.22	ENSMUST00000067646.12	Ilf3 Ensembl NCBI MGI UniProt Show fit	interleukin enhancer binding factor 3
chr9_+_21279179 Show fit	58.99	ENSMUST00000213518.2 ENSMUST00000216892.2	Ilf3 Ensembl NCBI MGI UniProt Show fit	interleukin enhancer binding factor 3
chr9_+_21279299 Show fit	53.08	ENSMUST00000214852.2 ENSMUST00000115414.3	Ilf3 Ensembl NCBI MGI UniProt Show fit	interleukin enhancer binding factor 3
chr4_-_148123223 Show fit	45.46	ENSMUST00000030879.12 ENSMUST00000137724.8	Clcn6 Ensembl NCBI MGI UniProt Show fit	chloride channel, voltage-sensitive 6
chrX_+_151922936 Show fit	44.57	ENSMUST00000039720.11 ENSMUST00000144175.3	Rragb Ensembl NCBI MGI UniProt Show fit	Ras-related GTP binding B
chr19_-_4251589 Show fit	31.35	ENSMUST00000237923.2 ENSMUST00000025740.8 ENSMUST00000237723.2	Rad9a Ensembl NCBI MGI UniProt Show fit	RAD9 checkpoint clamp component A
chr5_-_136199525 Show fit	26.75	ENSMUST00000041048.6	Orai2 Ensembl NCBI MGI UniProt Show fit	ORAI calcium release-activated calcium modulator 2
chrX_+_135171002 Show fit	26.15	ENSMUST00000178632.8 ENSMUST00000053540.11	Bex3 Ensembl NCBI MGI UniProt Show fit	brain expressed X-linked 3
chr4_+_148123490 Show fit	25.30	ENSMUST00000097788.11	Mthfr Ensembl NCBI MGI UniProt Show fit	methylenetetrahydrofolate reductase
chrX_-_134968985 Show fit	25.24	ENSMUST00000049130.8	Bex2 Ensembl NCBI MGI UniProt Show fit	brain expressed X-linked 2

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	170.5	GO:0045071	negative regulation of viral genome replication(GO:0045071)
2.6	64.2	GO:0036295	cellular response to increased oxygen levels(GO:0036295)
0.7	55.3	GO:1902476	chloride transmembrane transport(GO:1902476)
17.7	53.0	GO:1990117	release of matrix enzymes from mitochondria(GO:0032976) B cell receptor apoptotic signaling pathway(GO:1990117)
4.7	51.9	GO:1990253	cellular response to leucine starvation(GO:1990253)
10.1	50.4	GO:0070829	heterochromatin maintenance(GO:0070829)
1.6	46.2	GO:0002115	store-operated calcium entry(GO:0002115)
5.3	42.0	GO:1903564	regulation of protein localization to cilium(GO:1903564)
2.5	39.2	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)
2.8	33.9	GO:0035751	regulation of lysosomal lumen pH(GO:0035751)

Showing 1 to 10 of 513 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	159.6	GO:0030529	intracellular ribonucleoprotein complex(GO:0030529)
0.5	120.5	GO:0005765	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.3	88.4	GO:0030426	growth cone(GO:0030426)
1.1	84.4	GO:0031519	PcG protein complex(GO:0031519)
6.6	79.3	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
11.2	56.1	GO:1990131	Gtr1-Gtr2 GTPase complex(GO:1990131)
17.7	53.0	GO:0097144	BAX complex(GO:0097144)
0.0	41.8	GO:0005794	Golgi apparatus(GO:0005794)
5.1	41.1	GO:0033263	CORVET complex(GO:0033263)
0.1	40.9	GO:0030424	axon(GO:0030424)

Showing 1 to 10 of 228 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	161.6	GO:0003725	double-stranded RNA binding(GO:0003725)
0.3	102.7	GO:0005096	GTPase activator activity(GO:0005096)
3.0	98.9	GO:0046961	proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.3	86.6	GO:0003924	GTPase activity(GO:0003924)
5.3	53.0	GO:0051434	BH3 domain binding(GO:0051434)
0.9	52.6	GO:0050699	WW domain binding(GO:0050699)
1.6	50.6	GO:0005123	death receptor binding(GO:0005123)
16.8	50.4	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
3.3	49.9	GO:0015279	store-operated calcium channel activity(GO:0015279)
2.2	49.3	GO:0005247	voltage-gated chloride channel activity(GO:0005247)

Showing 1 to 10 of 349 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	57.5	PID MTOR 4PATHWAY	mTOR signaling pathway
2.3	53.1	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
1.2	45.1	PID ATM PATHWAY	ATM pathway
1.5	26.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.4	19.5	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.2	18.4	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.4	18.2	PID RAS PATHWAY	Regulation of Ras family activation
0.5	15.4	ST GA12 PATHWAY	G alpha 12 Pathway
0.5	15.2	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	15.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors

Showing 1 to 10 of 82 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	93.4	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
1.0	55.8	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.9	43.4	REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	Genes involved in Activation of ATR in response to replication stress
0.9	39.8	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.7	26.6	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.2	25.2	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.1	25.1	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.3	24.9	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3	24.3	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.3	22.9	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane

Showing 1 to 10 of 117 entries

Results for Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Z-value: 2.32

Motif logo

Transcription factors associated with Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Activity-expression correlation:

Activity profile of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

Sorted Z-values of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: