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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Thra
Z-value: 1.14
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Transcription factors associated with Thra
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Thra | mm39_v1_chr11_+_98632631_98632642 | -0.47 | 3.0e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Thra
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_84817547 Show fit | 9.61 |
ENSMUST00000097672.4
|
F-box protein 36 |
|
| chr11_+_69856222 Show fit | 9.03 |
ENSMUST00000018713.13
|
claudin 7 |
|
| chr7_+_141995545 Show fit | 7.31 |
ENSMUST00000105971.8
ENSMUST00000145287.8 |
troponin I, skeletal, fast 2 |
|
| chr7_+_19144950 Show fit | 6.83 |
ENSMUST00000208710.2
ENSMUST00000003643.3 |
creatine kinase, muscle |
|
| chr9_+_122980006 Show fit | 6.75 |
ENSMUST00000026890.6
|
C-type lectin domain family 3, member b |
|
| chr7_-_142050663 Show fit | 6.71 |
ENSMUST00000238347.2
|
proline rich 33 |
|
| chr16_-_10608766 Show fit | 5.57 |
ENSMUST00000050864.7
|
protamine 3 |
|
| chr7_-_140793990 Show fit | 5.17 |
ENSMUST00000026573.7
ENSMUST00000170841.9 |
lamin tail domain containing 2 |
|
| chr15_+_102353802 Show fit | 4.79 |
ENSMUST00000023809.11
ENSMUST00000229278.2 ENSMUST00000229566.2 |
anti-Mullerian hormone type 2 receptor |
|
| chr7_+_75879603 Show fit | 4.78 |
ENSMUST00000156166.8
|
ATP/GTP binding protein-like 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.0 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 1.2 | 7.5 | GO:1901314 | negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) |
| 0.2 | 7.1 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 1.1 | 6.8 | GO:0032911 | negative regulation of transforming growth factor beta1 production(GO:0032911) |
| 0.8 | 6.8 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 0.1 | 6.8 | GO:0042398 | cellular modified amino acid biosynthetic process(GO:0042398) |
| 0.0 | 6.8 | GO:0007346 | regulation of mitotic cell cycle(GO:0007346) |
| 0.2 | 6.6 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 1.9 | 5.6 | GO:0018931 | naphthalene metabolic process(GO:0018931) naphthalene-containing compound metabolic process(GO:0090420) |
| 0.1 | 5.6 | GO:0030261 | chromosome condensation(GO:0030261) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.8 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.3 | 11.5 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 11.4 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 10.0 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.4 | 7.3 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 7.0 | GO:0005925 | cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) |
| 0.8 | 6.8 | GO:0001652 | granular component(GO:0001652) |
| 0.2 | 5.6 | GO:0000786 | nucleosome(GO:0000786) |
| 0.1 | 5.2 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 4.8 | GO:0031965 | nuclear membrane(GO:0031965) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.0 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.0 | 8.7 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.7 | 7.3 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.2 | 7.3 | GO:0017166 | vinculin binding(GO:0017166) |
| 1.0 | 6.8 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.0 | 5.7 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.3 | 5.6 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.2 | 5.6 | GO:0019825 | oxygen binding(GO:0019825) |
| 0.1 | 5.6 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.0 | 5.4 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 10.6 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 9.2 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 7.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 6.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.4 | 4.8 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.1 | 4.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 3.8 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 3.3 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 2.9 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 11.7 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 10.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 9.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.3 | 8.7 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 7.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 6.5 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.1 | 4.9 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 3.8 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 3.7 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.2 | 3.6 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |