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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Thrb

Z-value: 1.24

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Transcription factors associated with Thrb

Gene Symbol Gene ID Gene Info
Thrb
ENSMUSG00000021779.20 Thrb

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Thrbmm39_v1_chr14_-_4506874_45068940.142.5e-01Click!

Activity profile of Thrb motif

Sorted Z-values of Thrb motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Thrb

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_+_105775224 21.08 ENSMUST00000093222.13
ENSMUST00000093223.5
Ces3a
carboxylesterase 3A
chr7_-_105249308 20.62 ENSMUST00000210531.2
ENSMUST00000033185.10
Hpx
hemopexin
chr2_+_58457370 17.51 ENSMUST00000071543.12
Upp2
uridine phosphorylase 2
chr10_+_87357782 17.02 ENSMUST00000219813.2
Pah
phenylalanine hydroxylase
chr10_+_87357657 14.51 ENSMUST00000020241.17
Pah
phenylalanine hydroxylase
chr3_+_14928561 14.19 ENSMUST00000029076.6
Car3
carbonic anhydrase 3
chr2_+_118998235 12.20 ENSMUST00000057454.4
Gchfr
GTP cyclohydrolase I feedback regulator
chr9_-_107546166 11.17 ENSMUST00000177567.8
Slc38a3
solute carrier family 38, member 3
chr2_-_25359752 11.09 ENSMUST00000114259.3
ENSMUST00000015234.13
Ptgds
prostaglandin D2 synthase (brain)
chr9_-_107546195 10.55 ENSMUST00000192990.6
Slc38a3
solute carrier family 38, member 3
chr2_-_25360043 9.33 ENSMUST00000114251.8
Ptgds
prostaglandin D2 synthase (brain)
chr12_+_108300599 7.99 ENSMUST00000021684.6
Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr2_+_92213256 6.94 ENSMUST00000054316.9
ENSMUST00000111280.3
1700029I15Rik
RIKEN cDNA 1700029I15 gene
chr16_-_28571820 6.70 ENSMUST00000232352.2
Fgf12
fibroblast growth factor 12
chr1_-_83385911 6.16 ENSMUST00000160953.8
Sphkap
SPHK1 interactor, AKAP domain containing
chr17_-_28908757 6.12 ENSMUST00000233398.2
Slc26a8
solute carrier family 26, member 8
chr13_-_59892731 6.03 ENSMUST00000180139.3
1700014D04Rik
RIKEN cDNA 1700014D04 gene
chr14_-_61597843 4.19 ENSMUST00000022494.10
Ebpl
emopamil binding protein-like
chr14_+_14475188 4.14 ENSMUST00000026315.8
Dnase1l3
deoxyribonuclease 1-like 3
chr17_-_14223966 4.08 ENSMUST00000189454.3
Gm7356
predicted gene 7356
chr16_+_8498618 3.93 ENSMUST00000201722.2
Gm5767
predicted gene 5767
chr13_+_34923589 3.90 ENSMUST00000221037.2
Fam50b
family with sequence similarity 50, member B
chr11_+_46295547 3.90 ENSMUST00000063166.6
Fam71b
family with sequence similarity 71, member B
chr15_-_76193955 3.89 ENSMUST00000210024.2
Oplah
5-oxoprolinase (ATP-hydrolysing)
chr7_+_27222678 3.52 ENSMUST00000108353.9
Hipk4
homeodomain interacting protein kinase 4
chr7_-_24705320 3.44 ENSMUST00000102858.10
ENSMUST00000196684.2
ENSMUST00000080882.11
Atp1a3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
chr11_-_113600346 3.33 ENSMUST00000173655.8
ENSMUST00000100248.6
Cpsf4l
cleavage and polyadenylation specific factor 4-like
chr2_+_152804405 3.06 ENSMUST00000099197.9
ENSMUST00000103155.10
Ttll9
tubulin tyrosine ligase-like family, member 9
chr11_-_113600838 2.56 ENSMUST00000018871.8
Cpsf4l
cleavage and polyadenylation specific factor 4-like
chr11_+_109376432 2.54 ENSMUST00000106697.8
Arsg
arylsulfatase G
chr7_-_33065747 2.51 ENSMUST00000179248.2
Scgb2b20
secretoglobin, family 2B, member 20
chr10_-_18662526 2.17 ENSMUST00000216654.2
Gm4922
predicted gene 4922
chr5_+_130248547 2.15 ENSMUST00000202305.4
ENSMUST00000065329.13
ENSMUST00000200802.4
Tmem248
transmembrane protein 248
chr19_-_46314945 2.10 ENSMUST00000225781.2
ENSMUST00000223903.2
Psd
pleckstrin and Sec7 domain containing
chr11_-_83412952 2.09 ENSMUST00000019069.4
Heatr9
HEAT repeat containing 9
chr6_+_114435480 2.02 ENSMUST00000160780.2
Hrh1
histamine receptor H1
chr8_+_112262729 1.94 ENSMUST00000172856.8
Znrf1
zinc and ring finger 1
chr4_+_130519788 1.86 ENSMUST00000070478.4
Sdc3
syndecan 3
chr5_+_35971697 1.85 ENSMUST00000130233.8
Ablim2
actin-binding LIM protein 2
chr5_-_30619246 1.84 ENSMUST00000114747.9
ENSMUST00000074171.10
Otof
otoferlin
chr3_-_79749949 1.80 ENSMUST00000029568.7
Tmem144
transmembrane protein 144
chr16_-_16962279 1.58 ENSMUST00000232033.2
ENSMUST00000231597.2
ENSMUST00000232540.2
Ccdc116
coiled-coil domain containing 116
chr6_-_121450547 1.56 ENSMUST00000046373.8
ENSMUST00000151397.3
Iqsec3
IQ motif and Sec7 domain 3
chr9_-_102503180 1.51 ENSMUST00000216281.2
ENSMUST00000093791.10
Cep63
centrosomal protein 63
chr16_-_16962256 1.49 ENSMUST00000115711.10
Ccdc116
coiled-coil domain containing 116
chr11_+_70350436 1.44 ENSMUST00000039093.10
Zmynd15
zinc finger, MYND-type containing 15
chr14_+_54713703 1.28 ENSMUST00000164697.8
Rem2
rad and gem related GTP binding protein 2
chr14_+_53315909 1.11 ENSMUST00000103608.4
Trav14d-3-dv8
T cell receptor alpha variable 14D-3-DV8
chr9_-_117843228 1.11 ENSMUST00000187803.3
Zcwpw2
zinc finger, CW type with PWWP domain 2
chr11_+_70350252 1.07 ENSMUST00000108563.9
Zmynd15
zinc finger, MYND-type containing 15
chr3_+_67281424 1.03 ENSMUST00000077916.12
Mlf1
myeloid leukemia factor 1
chr14_+_54713557 0.99 ENSMUST00000164766.8
Rem2
rad and gem related GTP binding protein 2
chr9_-_102503708 0.88 ENSMUST00000161645.8
ENSMUST00000162297.2
ENSMUST00000213636.2
ENSMUST00000162655.9
Cep63
centrosomal protein 63
chr16_-_58930996 0.85 ENSMUST00000076262.4
Olfr193
olfactory receptor 193
chr3_+_67281449 0.84 ENSMUST00000061322.10
Mlf1
myeloid leukemia factor 1
chr5_+_95021656 0.82 ENSMUST00000180076.2
Gm3183
predicted gene 3183
chr9_+_95739650 0.79 ENSMUST00000034980.9
Atr
ataxia telangiectasia and Rad3 related
chr11_+_24030663 0.76 ENSMUST00000118955.2
Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chr11_+_49094292 0.73 ENSMUST00000150284.8
ENSMUST00000109197.8
ENSMUST00000151228.2
Zfp62
zinc finger protein 62
chr1_-_24626492 0.58 ENSMUST00000051344.6
ENSMUST00000115244.9
Col19a1
collagen, type XIX, alpha 1
chr15_-_103160082 0.56 ENSMUST00000149111.8
ENSMUST00000132836.8
Nfe2
nuclear factor, erythroid derived 2
chr4_+_116078830 0.54 ENSMUST00000030464.14
Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
chr14_+_53607470 0.52 ENSMUST00000103652.5
Trav14n-3
T cell receptor alpha variable 14N-3
chr2_-_58457168 0.49 ENSMUST00000056376.12
Acvr1
activin A receptor, type 1
chr5_+_94365864 0.47 ENSMUST00000179743.3
Pramel38
PRAME like 38
chr17_+_57297280 0.37 ENSMUST00000002735.9
Clpp
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr9_+_102503815 0.35 ENSMUST00000038673.14
ENSMUST00000186693.2
Anapc13
anaphase promoting complex subunit 13
chr9_+_102503476 0.35 ENSMUST00000190279.7
ENSMUST00000188398.7
Anapc13
anaphase promoting complex subunit 13
chr15_-_103159892 0.20 ENSMUST00000133600.8
ENSMUST00000134554.2
ENSMUST00000156927.8
Nfe2
nuclear factor, erythroid derived 2
chr7_+_101546059 0.14 ENSMUST00000143835.8
Anapc15
anaphase promoting complex C subunit 15
chr18_+_77369654 0.13 ENSMUST00000096547.11
ENSMUST00000148341.9
ENSMUST00000123410.9
Loxhd1
lipoxygenase homology domains 1
chr6_-_38814159 0.09 ENSMUST00000160962.8
Hipk2
homeodomain interacting protein kinase 2
chr8_-_120228434 0.08 ENSMUST00000133821.2
ENSMUST00000036748.15
Slc38a8
solute carrier family 38, member 8

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.5 31.5 GO:0006571 tyrosine biosynthetic process(GO:0006571) aromatic amino acid family biosynthetic process(GO:0009073) aromatic amino acid family biosynthetic process, prephenate pathway(GO:0009095)
7.2 21.7 GO:2000487 asparagine transport(GO:0006867) positive regulation of glutamine transport(GO:2000487)
3.4 20.4 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
2.9 20.6 GO:0060332 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) heme transport(GO:0015886) positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
1.3 6.7 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.7 6.1 GO:0019532 oxalate transport(GO:0019532)
0.5 5.9 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.5 8.0 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.4 2.3 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.3 2.0 GO:0071421 manganese ion transmembrane transport(GO:0071421)
0.3 6.2 GO:0035404 histone-serine phosphorylation(GO:0035404)
0.3 2.4 GO:0098535 de novo centriole assembly(GO:0098535)
0.3 14.2 GO:0006730 one-carbon metabolic process(GO:0006730)
0.2 3.4 GO:0036376 sodium ion export from cell(GO:0036376)
0.2 0.8 GO:1904884 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.2 0.8 GO:1904800 regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800)
0.2 4.1 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.1 6.2 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 1.9 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.1 17.5 GO:0009166 nucleotide catabolic process(GO:0009166)
0.1 3.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.5 GO:0003274 endocardial cushion fusion(GO:0003274) positive regulation of determination of dorsal identity(GO:2000017)
0.1 3.5 GO:0016572 histone phosphorylation(GO:0016572)
0.1 1.8 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.1 1.8 GO:0016082 synaptic vesicle priming(GO:0016082)
0.1 12.2 GO:0051291 protein heterooligomerization(GO:0051291)
0.1 0.8 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.0 3.9 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.7 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 4.2 GO:0016125 sterol metabolic process(GO:0016125)
0.0 1.9 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 2.5 GO:0007286 spermatid development(GO:0007286)
0.0 0.4 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 17.5 GO:0045098 type III intermediate filament(GO:0045098)
0.3 3.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.3 12.2 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.3 5.9 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.2 6.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.2 0.5 GO:0048179 activin receptor complex(GO:0048179)
0.2 20.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 1.8 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 17.5 GO:0072562 blood microparticle(GO:0072562)
0.1 3.9 GO:0045171 intercellular bridge(GO:0045171)
0.1 21.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.9 GO:0097546 ciliary base(GO:0097546)
0.0 1.6 GO:0060077 inhibitory synapse(GO:0060077)
0.0 2.1 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 2.4 GO:0005814 centriole(GO:0005814)
0.0 0.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 37.0 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 2.4 GO:0030018 Z disc(GO:0030018)
0.0 1.8 GO:0030016 myofibril(GO:0030016)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 21.7 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
5.3 31.5 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
5.1 20.4 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
3.4 20.6 GO:0015232 heme transporter activity(GO:0015232)
2.9 17.5 GO:0004850 uridine phosphorylase activity(GO:0004850)
1.1 14.2 GO:0016151 nickel cation binding(GO:0016151)
0.5 2.0 GO:0051381 histamine binding(GO:0051381)
0.4 3.9 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.3 6.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.3 12.2 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.3 3.4 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.3 6.2 GO:0035174 histone serine kinase activity(GO:0035174)
0.2 4.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 8.0 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.2 6.7 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 2.5 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 0.8 GO:0032405 MutLalpha complex binding(GO:0032405)
0.1 21.1 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.1 5.9 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 1.8 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 3.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 6.2 GO:0051018 protein kinase A binding(GO:0051018)
0.1 0.5 GO:0016361 activin receptor activity, type I(GO:0016361)
0.1 4.1 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.0 0.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 1.8 GO:1901476 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.0 0.8 GO:0050699 WW domain binding(GO:0050699)
0.0 2.5 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 3.1 GO:0016874 ligase activity(GO:0016874)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 19.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.8 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 6.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 17.5 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.6 12.2 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.5 8.0 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.3 21.7 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.3 2.5 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 31.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 3.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 1.9 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 0.8 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 3.4 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 2.0 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 2.4 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.5 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling