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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Trp63

Z-value: 0.81

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Transcription factors associated with Trp63

Gene Symbol Gene ID Gene Info
Trp63
ENSMUSG00000022510.15 Trp63

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Trp63mm39_v1_chr16_+_25620652_256206780.318.0e-03Click!

Activity profile of Trp63 motif

Sorted Z-values of Trp63 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Trp63

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr17_+_29309942 6.47 ENSMUST00000119901.9
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr2_+_119068012 6.34 ENSMUST00000110817.3
Spint1
serine protease inhibitor, Kunitz type 1
chr2_+_119067832 6.32 ENSMUST00000028783.14
Spint1
serine protease inhibitor, Kunitz type 1
chr2_+_119067929 6.09 ENSMUST00000110816.8
Spint1
serine protease inhibitor, Kunitz type 1
chr12_-_114646685 5.74 ENSMUST00000194350.6
ENSMUST00000103504.3
Ighv1-18
immunoglobulin heavy variable V1-18
chr2_-_13496624 4.96 ENSMUST00000091436.7
Cubn
cubilin (intrinsic factor-cobalamin receptor)
chr2_-_170269748 4.69 ENSMUST00000013667.3
ENSMUST00000109152.9
ENSMUST00000068137.11
Bcas1
breast carcinoma amplified sequence 1
chr3_-_92777521 4.02 ENSMUST00000163439.3
2310050C09Rik
RIKEN cDNA 2310050C09 gene
chr12_-_107969853 3.31 ENSMUST00000066060.11
Bcl11b
B cell leukemia/lymphoma 11B
chr11_-_69838971 3.20 ENSMUST00000179298.3
ENSMUST00000018710.13
ENSMUST00000135437.3
ENSMUST00000141837.9
ENSMUST00000142500.8
Slc2a4
solute carrier family 2 (facilitated glucose transporter), member 4
chr6_+_4505493 2.89 ENSMUST00000031668.10
Col1a2
collagen, type I, alpha 2
chr4_-_127247864 2.76 ENSMUST00000106090.8
ENSMUST00000060419.2
Gjb4
gap junction protein, beta 4
chr8_+_45388466 2.74 ENSMUST00000191428.7
Fat1
FAT atypical cadherin 1
chr12_-_107969673 2.69 ENSMUST00000109887.8
ENSMUST00000109891.3
Bcl11b
B cell leukemia/lymphoma 11B
chr6_+_34686543 2.65 ENSMUST00000031775.13
Cald1
caldesmon 1
chr19_+_53128901 2.65 ENSMUST00000235754.2
ENSMUST00000237301.2
ENSMUST00000238130.2
Add3
adducin 3 (gamma)
chr19_+_53128861 2.26 ENSMUST00000111741.10
Add3
adducin 3 (gamma)
chr10_-_90918566 2.24 ENSMUST00000162618.8
ENSMUST00000020157.13
ENSMUST00000160788.2
Apaf1
apoptotic peptidase activating factor 1
chr19_-_5925239 2.20 ENSMUST00000155227.2
Frmd8
FERM domain containing 8
chrX_+_158038778 1.90 ENSMUST00000126686.8
ENSMUST00000033671.13
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr6_+_34686373 1.89 ENSMUST00000115021.8
Cald1
caldesmon 1
chrX_+_158039107 1.83 ENSMUST00000148570.8
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chrX_+_158038915 1.63 ENSMUST00000112492.8
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr19_-_5925296 1.55 ENSMUST00000025728.13
Frmd8
FERM domain containing 8
chr8_+_27575611 1.53 ENSMUST00000178514.8
ENSMUST00000033876.14
Adgra2
adhesion G protein-coupled receptor A2
chr11_-_101357046 1.50 ENSMUST00000040430.8
Vat1
vesicle amine transport 1
chr11_+_98754434 1.47 ENSMUST00000142414.8
ENSMUST00000037480.9
Wipf2
WAS/WASL interacting protein family, member 2
chr19_-_40365318 1.28 ENSMUST00000239304.2
Sorbs1
sorbin and SH3 domain containing 1
chr4_-_63414188 1.09 ENSMUST00000063650.10
ENSMUST00000102867.8
ENSMUST00000107393.8
ENSMUST00000084510.8
ENSMUST00000095038.8
ENSMUST00000119294.8
ENSMUST00000095037.2
ENSMUST00000063672.10
Whrn
whirlin
chr6_+_11907808 1.09 ENSMUST00000155037.4
Phf14
PHD finger protein 14
chr1_-_160134873 1.05 ENSMUST00000193185.6
Rabgap1l
RAB GTPase activating protein 1-like
chr7_+_24584197 0.93 ENSMUST00000156372.8
ENSMUST00000124035.2
Rps19
ribosomal protein S19
chr6_-_94260806 0.91 ENSMUST00000203519.3
ENSMUST00000204347.3
Magi1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr17_+_47983587 0.87 ENSMUST00000152724.2
Usp49
ubiquitin specific peptidase 49
chr17_-_84495364 0.85 ENSMUST00000060366.7
Zfp36l2
zinc finger protein 36, C3H type-like 2
chr7_-_65020955 0.83 ENSMUST00000102592.10
Tjp1
tight junction protein 1
chr9_+_121245036 0.82 ENSMUST00000211187.2
Trak1
trafficking protein, kinesin binding 1
chr2_+_119803230 0.78 ENSMUST00000229024.2
Mapkbp1
mitogen-activated protein kinase binding protein 1
chr7_+_24584076 0.70 ENSMUST00000153451.9
ENSMUST00000108429.8
Rps19
ribosomal protein S19
chr10_+_3784877 0.64 ENSMUST00000239159.2
Plekhg1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr1_+_180762587 0.63 ENSMUST00000037361.9
Lefty1
left right determination factor 1
chr2_+_59442378 0.62 ENSMUST00000112568.8
ENSMUST00000037526.11
Tanc1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
chr2_+_119803180 0.61 ENSMUST00000066058.8
Mapkbp1
mitogen-activated protein kinase binding protein 1
chr13_-_103470937 0.55 ENSMUST00000167058.8
ENSMUST00000164111.2
Mast4
microtubule associated serine/threonine kinase family member 4
chr7_-_113853894 0.51 ENSMUST00000033012.9
Copb1
coatomer protein complex, subunit beta 1
chr7_+_24583994 0.49 ENSMUST00000108428.8
Rps19
ribosomal protein S19
chr7_-_102264194 0.43 ENSMUST00000098222.2
Olfr553
olfactory receptor 553
chr14_+_64331130 0.38 ENSMUST00000224112.2
ENSMUST00000165710.2
ENSMUST00000170709.2
Prss51
protease, serine 51
chr9_+_108437485 0.37 ENSMUST00000081111.14
ENSMUST00000193421.2
Impdh2
inosine monophosphate dehydrogenase 2
chr2_-_91795910 0.30 ENSMUST00000239257.2
Dgkz
diacylglycerol kinase zeta
chr2_-_87524291 0.30 ENSMUST00000077471.5
Olfr1136
olfactory receptor 1136
chr17_-_68311073 0.29 ENSMUST00000024840.12
Arhgap28
Rho GTPase activating protein 28
chr7_-_65020655 0.19 ENSMUST00000032729.8
Tjp1
tight junction protein 1
chr18_-_15851103 0.12 ENSMUST00000053017.13
Chst9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr8_-_32408380 0.07 ENSMUST00000208497.3
ENSMUST00000207584.3
Nrg1
neuregulin 1
chr3_+_75655504 0.06 ENSMUST00000189155.4
Gm29133
predicted gene 29133
chr14_-_31299275 0.03 ENSMUST00000112027.9
Colq
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr5_-_5315968 0.03 ENSMUST00000115451.8
ENSMUST00000115452.8
ENSMUST00000131392.8
Cdk14
cyclin-dependent kinase 14
chr14_-_55114989 0.02 ENSMUST00000168622.2
ENSMUST00000177403.2
Ppp1r3e
protein phosphatase 1, regulatory subunit 3E

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.0 GO:0097535 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.9 18.7 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.8 5.0 GO:0015889 cobalamin transport(GO:0015889)
0.5 2.1 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
0.4 6.5 GO:0071493 cellular response to UV-B(GO:0071493)
0.3 1.5 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.2 1.5 GO:0090210 regulation of establishment of blood-brain barrier(GO:0090210)
0.2 1.1 GO:2000583 regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.2 1.4 GO:0007256 activation of JNKK activity(GO:0007256) negative regulation of defense response to bacterium(GO:1900425)
0.2 2.2 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.2 2.9 GO:0043589 skin morphogenesis(GO:0043589)
0.2 0.9 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.2 2.8 GO:0042048 olfactory behavior(GO:0042048)
0.2 0.8 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
0.1 0.6 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.1 3.2 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.1 0.9 GO:1904628 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.1 0.3 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 1.1 GO:0045217 cell-cell junction maintenance(GO:0045217)
0.1 4.0 GO:0018149 peptide cross-linking(GO:0018149)
0.1 1.0 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.4 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 2.7 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0 4.4 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.0 5.7 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 5.4 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 1.3 GO:0070875 positive regulation of glycogen biosynthetic process(GO:0045725) positive regulation of glycogen metabolic process(GO:0070875)
0.0 1.0 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.6 GO:0097062 dendritic spine maintenance(GO:0097062)
0.0 4.5 GO:0042493 response to drug(GO:0042493)
0.0 0.3 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 0.5 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.5 GO:0070557 PCNA-p21 complex(GO:0070557)
1.0 5.0 GO:0043202 lysosomal lumen(GO:0043202)
1.0 2.9 GO:0005584 collagen type I trimer(GO:0005584)
0.5 4.5 GO:0030478 actin cap(GO:0030478)
0.4 2.2 GO:0043293 apoptosome(GO:0043293)
0.2 1.1 GO:1990696 stereocilia ankle link complex(GO:0002142) USH2 complex(GO:1990696)
0.2 1.3 GO:0005899 insulin receptor complex(GO:0005899)
0.2 3.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 2.8 GO:0005922 connexon complex(GO:0005922)
0.1 4.0 GO:0001533 cornified envelope(GO:0001533)
0.1 1.0 GO:0005921 gap junction(GO:0005921)
0.0 1.4 GO:0005682 U5 snRNP(GO:0005682)
0.0 5.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.8 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 2.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 4.9 GO:0005903 brush border(GO:0005903)
0.0 2.7 GO:0030175 filopodium(GO:0030175)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.5 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.7 5.0 GO:0030492 hemoglobin binding(GO:0030492)
0.6 3.2 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.2 2.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 0.6 GO:0038100 nodal binding(GO:0038100)
0.1 2.2 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.1 18.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 5.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 1.0 GO:0071253 connexin binding(GO:0071253)
0.1 0.4 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 0.9 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 2.1 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 4.9 GO:0005080 protein kinase C binding(GO:0005080)
0.0 5.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.8 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 1.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.3 GO:0004143 lipid kinase activity(GO:0001727) diacylglycerol kinase activity(GO:0004143)
0.0 0.9 GO:0051393 alpha-actinin binding(GO:0051393)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 6.5 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 5.4 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 2.2 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 3.2 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 2.9 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 1.3 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 1.0 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.0 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 6.5 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 3.2 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.2 2.9 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 2.8 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 5.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 5.4 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 1.0 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.5 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 2.1 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.4 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.6 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.4 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis