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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for UGUGCUU
Z-value: 3.19
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miRNA associated with seed UGUGCUU
Network of associatons between targets according to the STRING database.
First level regulatory network of UGUGCUU
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_114259596 Show fit | 38.55 |
ENSMUST00000032454.8
|
solute carrier family 6 (neurotransmitter transporter, GABA), member 1 |
|
| chr5_+_37025810 Show fit | 38.21 |
ENSMUST00000031003.11
|
protein phosphatase 2, regulatory subunit B, gamma |
|
| chr13_-_54914366 Show fit | 37.83 |
ENSMUST00000036825.14
|
synuclein, beta |
|
| chr7_+_108610032 Show fit | 36.27 |
ENSMUST00000033341.12
|
tubby bipartite transcription factor |
|
| chr19_-_8816530 Show fit | 35.76 |
ENSMUST00000096259.6
|
guanine nucleotide binding protein (G protein), gamma 3 |
|
| chr2_+_102488985 Show fit | 33.55 |
ENSMUST00000080210.10
|
solute carrier family 1 (glial high affinity glutamate transporter), member 2 |
|
| chr8_-_70573465 Show fit | 31.88 |
ENSMUST00000002412.9
|
neurocan |
|
| chr2_-_127363251 Show fit | 30.72 |
ENSMUST00000028850.15
ENSMUST00000103215.11 |
Kv channel interacting protein 3, calsenilin |
|
| chr3_+_96088467 Show fit | 29.91 |
ENSMUST00000035371.9
|
synaptic vesicle glycoprotein 2 a |
|
| chr1_-_83385911 Show fit | 29.29 |
ENSMUST00000160953.8
|
SPHK1 interactor, AKAP domain containing |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 80.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 1.5 | 65.5 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.9 | 56.0 | GO:0019228 | neuronal action potential(GO:0019228) |
| 2.4 | 54.8 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.4 | 53.3 | GO:0007416 | synapse assembly(GO:0007416) |
| 8.2 | 49.1 | GO:0099525 | presynaptic dense core granule exocytosis(GO:0099525) |
| 0.4 | 44.6 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 2.9 | 40.3 | GO:0051823 | regulation of synapse structural plasticity(GO:0051823) |
| 1.7 | 38.7 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 4.8 | 38.5 | GO:0014054 | positive regulation of gamma-aminobutyric acid secretion(GO:0014054) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 166.9 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.2 | 89.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 1.6 | 81.7 | GO:0030673 | axolemma(GO:0030673) |
| 2.9 | 79.0 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.3 | 72.1 | GO:0098793 | presynapse(GO:0098793) |
| 1.6 | 66.7 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.3 | 60.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 2.1 | 57.2 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 3.3 | 56.5 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.6 | 56.1 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 61.1 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 59.5 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.6 | 52.3 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 1.9 | 50.5 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 44.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 1.3 | 42.0 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 6.6 | 39.5 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 1.9 | 38.8 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 5.5 | 38.5 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
| 1.4 | 38.0 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 37.7 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 1.6 | 36.1 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.6 | 34.0 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.2 | 32.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 27.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.6 | 27.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.4 | 23.7 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.9 | 22.5 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.7 | 14.6 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.2 | 14.4 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 93.2 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 5.0 | 69.9 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 2.3 | 54.8 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 1.1 | 51.1 | REACTOME G PROTEIN ACTIVATION | Genes involved in G-protein activation |
| 1.4 | 50.9 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 1.8 | 43.4 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.6 | 39.9 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 2.4 | 38.5 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.8 | 36.6 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 2.3 | 31.9 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |