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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Wrnip1_Mta3_Rcor1
Z-value: 5.38
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Transcription factors associated with Wrnip1_Mta3_Rcor1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Wrnip1 | mm39_v1_chr13_+_32985990_32986135 | 0.43 | 1.5e-04 | Click! |
| Mta3 | mm39_v1_chr17_+_84013575_84013634 | 0.35 | 3.0e-03 | Click! |
| Rcor1 | mm39_v1_chr12_+_111005768_111005834 | 0.03 | 8.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Wrnip1_Mta3_Rcor1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_45349267 Show fit | 54.55 |
ENSMUST00000003360.10
|
carbonic anhydrase 11 |
|
| chr2_+_83642910 Show fit | 52.77 |
ENSMUST00000051454.4
|
family with sequence similarity 171, member B |
|
| chr2_-_180798785 Show fit | 42.85 |
ENSMUST00000055990.8
|
eukaryotic translation elongation factor 1 alpha 2 |
|
| chr2_-_180956293 Show fit | 41.53 |
ENSMUST00000103045.4
|
stathmin-like 3 |
|
| chr13_+_19132375 Show fit | 40.46 |
ENSMUST00000239207.2
ENSMUST00000003345.10 ENSMUST00000200466.5 |
amphiphysin |
|
| chr14_-_9184969 Show fit | 40.43 |
ENSMUST00000070323.12
|
synaptoporin |
|
| chr9_-_53882530 Show fit | 38.78 |
ENSMUST00000048409.14
|
ELMO/CED-12 domain containing 1 |
|
| chr1_-_75240551 Show fit | 38.29 |
ENSMUST00000186178.7
ENSMUST00000189769.7 ENSMUST00000027404.12 |
protein tyrosine phosphatase, receptor type, N |
|
| chr4_-_129015027 Show fit | 38.02 |
ENSMUST00000030572.10
|
hippocalcin |
|
| chr5_-_108697857 Show fit | 37.36 |
ENSMUST00000129040.2
ENSMUST00000046892.10 |
complexin 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 541.9 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 8.9 | 222.3 | GO:0035641 | locomotory exploration behavior(GO:0035641) |
| 3.2 | 188.4 | GO:1901379 | regulation of potassium ion transmembrane transport(GO:1901379) |
| 4.7 | 187.0 | GO:0016079 | synaptic vesicle exocytosis(GO:0016079) |
| 4.8 | 183.3 | GO:0090662 | ATP hydrolysis coupled transmembrane transport(GO:0090662) |
| 4.5 | 178.8 | GO:1900449 | regulation of glutamate receptor signaling pathway(GO:1900449) |
| 6.9 | 165.5 | GO:0035640 | exploration behavior(GO:0035640) |
| 4.9 | 161.6 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 2.1 | 152.0 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 6.5 | 149.3 | GO:0071420 | cellular response to histamine(GO:0071420) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2328.7 | GO:0016021 | integral component of membrane(GO:0016021) |
| 3.7 | 1199.8 | GO:0014069 | postsynaptic density(GO:0014069) |
| 1.5 | 902.3 | GO:0043005 | neuron projection(GO:0043005) |
| 3.2 | 708.4 | GO:0043209 | myelin sheath(GO:0043209) |
| 5.1 | 517.1 | GO:0034705 | potassium channel complex(GO:0034705) |
| 3.5 | 517.0 | GO:0098793 | presynapse(GO:0098793) |
| 5.2 | 446.4 | GO:0043198 | dendritic shaft(GO:0043198) |
| 1.1 | 418.6 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 1.6 | 399.0 | GO:0045202 | synapse(GO:0045202) |
| 4.5 | 379.4 | GO:0043195 | terminal bouton(GO:0043195) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 591.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 4.1 | 481.1 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 1.3 | 415.4 | GO:0015631 | tubulin binding(GO:0015631) |
| 4.3 | 369.2 | GO:0035254 | glutamate receptor binding(GO:0035254) |
| 2.3 | 287.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 3.5 | 284.7 | GO:0030276 | clathrin binding(GO:0030276) |
| 1.1 | 267.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 3.4 | 243.2 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 3.4 | 242.3 | GO:0019894 | kinesin binding(GO:0019894) |
| 4.1 | 231.0 | GO:0001540 | beta-amyloid binding(GO:0001540) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 278.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.3 | 270.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 2.9 | 198.4 | PID REELIN PATHWAY | Reelin signaling pathway |
| 4.1 | 193.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 2.7 | 175.6 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 3.1 | 166.4 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 4.1 | 136.2 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 2.1 | 131.8 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 1.8 | 130.5 | PID LKB1 PATHWAY | LKB1 signaling events |
| 2.6 | 109.5 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.1 | 387.4 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 11.3 | 270.8 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 4.9 | 237.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 2.7 | 230.4 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 9.6 | 229.7 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 4.8 | 226.3 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 4.6 | 223.0 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 6.5 | 215.0 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 1.5 | 203.3 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 11.6 | 197.8 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |