ISMARA results: Xbp1

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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Xbp1_Creb3l1

Z-value: 2.11

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Transcription factors associated with Xbp1_Creb3l1

Gene Symbol	Gene ID	Gene Info
Xbp1 Ensembl NCBI MGI UniProt	ENSMUSG00000020484.20	Xbp1
Creb3l1 Ensembl NCBI MGI UniProt	ENSMUSG00000027230.10	Creb3l1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Creb3l1	mm39_v1_chr2_-_91854844_91854847	0.48	2.1e-05	Click!
Xbp1	mm39_v1_chr11_+_5470968_5470996	0.43	1.7e-04	Click!

Activity profile of Xbp1_Creb3l1 motif

Sorted Z-values of Xbp1_Creb3l1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Xbp1_Creb3l1

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Promoter	Score	Transcript	Gene	Gene Info
chr7_-_44741622 Show fit	22.32	ENSMUST00000210469.2 ENSMUST00000211352.2 ENSMUST00000019683.11	Rcn3 Ensembl NCBI MGI UniProt Show fit	reticulocalbin 3, EF-hand calcium binding domain
chr7_-_44741609 Show fit	21.88	ENSMUST00000210734.2	Rcn3 Ensembl NCBI MGI UniProt Show fit	reticulocalbin 3, EF-hand calcium binding domain
chr15_+_79400597 Show fit	20.41	ENSMUST00000010974.9	Kdelr3 Ensembl NCBI MGI UniProt Show fit	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr3_+_123061094 Show fit	15.27	ENSMUST00000047923.12 ENSMUST00000200333.2	Sec24d Ensembl NCBI MGI UniProt Show fit	Sec24 related gene family, member D (S. cerevisiae)
chr7_-_44741138 Show fit	14.59	ENSMUST00000210527.2	Rcn3 Ensembl NCBI MGI UniProt Show fit	reticulocalbin 3, EF-hand calcium binding domain
chr2_-_143853122 Show fit	12.97	ENSMUST00000016072.12 ENSMUST00000037875.6	Rrbp1 Ensembl NCBI MGI UniProt Show fit	ribosome binding protein 1
chr13_-_38712387 Show fit	12.05	ENSMUST00000035988.16	Txndc5 Ensembl NCBI MGI UniProt Show fit	thioredoxin domain containing 5
chr18_+_57487908 Show fit	11.62	ENSMUST00000238069.2	Prrc1 Ensembl NCBI MGI UniProt Show fit	proline-rich coiled-coil 1
chr15_+_31224460 Show fit	11.59	ENSMUST00000044524.16	Dap Ensembl NCBI MGI UniProt Show fit	death-associated protein
chr15_+_31224616 Show fit	10.61	ENSMUST00000186547.7	Dap Ensembl NCBI MGI UniProt Show fit	death-associated protein

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	30.0	GO:0034198	cellular response to amino acid starvation(GO:0034198)
3.5	24.2	GO:0006621	protein retention in ER lumen(GO:0006621)
1.2	21.0	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.4	20.9	GO:0060445	branching involved in salivary gland morphogenesis(GO:0060445)
1.9	19.3	GO:0048207	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
6.0	17.9	GO:2000845	positive regulation of testosterone secretion(GO:2000845)
1.4	17.3	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
4.3	17.2	GO:0031204	posttranslational protein targeting to membrane, translocation(GO:0031204)
2.1	16.6	GO:0071569	protein ufmylation(GO:0071569)
1.3	14.2	GO:0031584	activation of phospholipase D activity(GO:0031584)

Showing 1 to 10 of 92 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	140.2	GO:0005783	endoplasmic reticulum(GO:0005783)
4.0	28.0	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
1.1	20.4	GO:0030127	COPII vesicle coat(GO:0030127)
0.8	17.9	GO:0005640	nuclear outer membrane(GO:0005640)
0.1	17.4	GO:0016323	basolateral plasma membrane(GO:0016323)
0.0	16.8	GO:0005794	Golgi apparatus(GO:0005794)
0.1	15.7	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.3	14.8	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.1	14.2	GO:0032587	ruffle membrane(GO:0032587)
0.3	14.1	GO:0034364	high-density lipoprotein particle(GO:0034364)

Showing 1 to 10 of 57 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	69.7	GO:0005509	calcium ion binding(GO:0005509)
1.4	30.0	GO:0070513	death domain binding(GO:0070513)
0.1	26.3	GO:0000149	SNARE binding(GO:0000149)
4.8	24.2	GO:0046923	ER retention sequence binding(GO:0046923)
0.5	21.9	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.1	20.6	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.4	17.9	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.8	17.4	GO:0016864	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0	16.3	GO:0045296	cadherin binding(GO:0045296)
2.5	15.1	GO:0048408	epidermal growth factor binding(GO:0048408)

Showing 1 to 10 of 76 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	20.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	14.0	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.2	6.1	PID ARF 3PATHWAY	Arf1 pathway
0.1	6.0	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.1	5.3	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	3.0	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	2.2	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.0	2.1	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	1.4	PID MTOR 4PATHWAY	mTOR signaling pathway
0.1	0.7	ST STAT3 PATHWAY	STAT3 Pathway

Showing 1 to 10 of 14 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	56.7	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.7	38.5	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.8	21.9	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
1.0	20.0	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3	12.0	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.3	11.7	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.9	10.4	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.6	9.9	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.1	8.8	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.1	6.5	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors

Showing 1 to 10 of 28 entries

Results for Xbp1_Creb3l1

Z-value: 2.11

Motif logo

Transcription factors associated with Xbp1_Creb3l1

Activity-expression correlation:

Activity profile of Xbp1_Creb3l1 motif

Sorted Z-values of Xbp1_Creb3l1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Xbp1_Creb3l1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: