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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Ybx1_Nfya_Nfyb_Nfyc_Cebpz
Z-value: 4.73
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Transcription factors associated with Ybx1_Nfya_Nfyb_Nfyc_Cebpz
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSMUSG00000028639.15 | Ybx1 | |
| ENSMUSG00000023994.14 | Nfya | |
| ENSMUSG00000020248.19 | Nfyb | |
| ENSMUSG00000032897.18 | Nfyc | |
| ENSMUSG00000024081.10 | Cebpz |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfya | mm39_v1_chr17_-_48716756_48716934 | 0.62 | 4.5e-09 | Click! |
| Cebpz | mm39_v1_chr17_-_79244460_79244504 | 0.48 | 2.2e-05 | Click! |
| Nfyb | mm39_v1_chr10_-_82599967_82599991 | 0.47 | 2.6e-05 | Click! |
| Ybx1 | mm39_v1_chr4_-_119151717_119151801 | 0.43 | 1.6e-04 | Click! |
| Nfyc | mm39_v1_chr4_-_120672900_120672959 | 0.36 | 1.7e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ybx1_Nfya_Nfyb_Nfyc_Cebpz
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_98915005 Show fit | 52.54 |
ENSMUST00000068031.8
|
topoisomerase (DNA) II alpha |
|
| chr8_+_84682136 Show fit | 48.63 |
ENSMUST00000005607.9
|
anti-silencing function 1B histone chaperone |
|
| chr11_-_86999481 Show fit | 46.16 |
ENSMUST00000051395.9
|
proline rich 11 |
|
| chr6_+_124806541 Show fit | 44.66 |
ENSMUST00000024270.14
|
cell division cycle associated 3 |
|
| chr8_+_57964921 Show fit | 40.21 |
ENSMUST00000067925.8
|
high mobility group box 2 |
|
| chr8_+_57964956 Show fit | 36.38 |
ENSMUST00000210871.2
|
high mobility group box 2 |
|
| chr3_-_27208010 Show fit | 32.70 |
ENSMUST00000108300.8
ENSMUST00000108298.9 |
ect2 oncogene |
|
| chr3_-_27207993 Show fit | 31.93 |
ENSMUST00000176242.9
ENSMUST00000176780.8 |
ect2 oncogene |
|
| chr14_-_67953035 Show fit | 31.75 |
ENSMUST00000163100.8
ENSMUST00000132705.8 ENSMUST00000124045.3 |
cell division cycle associated 2 |
|
| chr6_+_124807176 Show fit | 30.47 |
ENSMUST00000131847.8
ENSMUST00000151674.3 |
cell division cycle associated 3 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.9 | 123.4 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.7 | 112.2 | GO:0007059 | chromosome segregation(GO:0007059) |
| 2.5 | 82.3 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 1.7 | 80.1 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 0.4 | 78.0 | GO:0044843 | cell cycle G1/S phase transition(GO:0044843) |
| 7.7 | 77.2 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 5.9 | 64.7 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.1 | 54.9 | GO:0051301 | cell division(GO:0051301) |
| 10.5 | 52.5 | GO:0045091 | regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091) |
| 6.5 | 52.3 | GO:0090306 | spindle assembly involved in meiosis(GO:0090306) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 305.0 | GO:0005694 | chromosome(GO:0005694) |
| 1.3 | 170.7 | GO:0005814 | centriole(GO:0005814) |
| 1.2 | 149.5 | GO:0000776 | kinetochore(GO:0000776) |
| 0.6 | 147.7 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.3 | 119.3 | GO:0005813 | centrosome(GO:0005813) |
| 16.7 | 100.4 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 1.2 | 86.8 | GO:0005657 | replication fork(GO:0005657) |
| 1.6 | 80.9 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 2.1 | 61.9 | GO:0010369 | chromocenter(GO:0010369) |
| 0.9 | 55.9 | GO:0005871 | kinesin complex(GO:0005871) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 176.7 | GO:0042393 | histone binding(GO:0042393) |
| 1.1 | 123.2 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 107.3 | GO:0003677 | DNA binding(GO:0003677) |
| 0.6 | 91.7 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.2 | 86.0 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.3 | 83.6 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 7.2 | 72.3 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.1 | 70.6 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 1.8 | 58.4 | GO:0035173 | histone kinase activity(GO:0035173) |
| 9.3 | 55.8 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 285.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 3.0 | 139.2 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 1.0 | 84.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 1.8 | 82.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 3.7 | 69.6 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 1.3 | 66.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 1.0 | 56.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 1.6 | 40.3 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 1.8 | 38.3 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 1.5 | 36.5 | PID ATR PATHWAY | ATR signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 165.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 5.5 | 110.8 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 7.9 | 102.9 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.7 | 102.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 2.4 | 80.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.8 | 78.5 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 2.7 | 77.5 | REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | Genes involved in APC-Cdc20 mediated degradation of Nek2A |
| 4.3 | 68.9 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 3.0 | 66.5 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 1.3 | 59.7 | REACTOME G1 PHASE | Genes involved in G1 Phase |