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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap
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Results for Zbtb33_Chd2
Z-value: 1.98
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Transcription factors associated with Zbtb33_Chd2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Chd2 | mm39_v1_chr7_-_73187369_73187513 | 0.59 | 4.5e-08 | Click! |
| Zbtb33 | mm39_v1_chrX_+_37278636_37278722 | 0.47 | 3.5e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Zbtb33_Chd2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 17.8 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.5 | 17.5 | GO:0071425 | hematopoietic stem cell proliferation(GO:0071425) |
| 1.4 | 15.9 | GO:2000051 | negative regulation of non-canonical Wnt signaling pathway(GO:2000051) |
| 1.1 | 15.8 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
| 0.5 | 15.2 | GO:0033962 | cytoplasmic mRNA processing body assembly(GO:0033962) |
| 1.9 | 14.9 | GO:0031508 | pericentric heterochromatin assembly(GO:0031508) |
| 0.1 | 14.7 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.4 | 12.7 | GO:0000470 | maturation of LSU-rRNA(GO:0000470) |
| 1.0 | 12.2 | GO:0051415 | interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418) |
| 0.3 | 10.1 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 34.5 | GO:0000796 | condensin complex(GO:0000796) |
| 0.0 | 24.9 | GO:0005815 | microtubule organizing center(GO:0005815) |
| 0.3 | 19.7 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 1.3 | 19.5 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 19.1 | GO:0000922 | spindle pole(GO:0000922) |
| 0.2 | 17.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.4 | 15.9 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 1.8 | 12.3 | GO:0000931 | gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274) |
| 2.4 | 9.5 | GO:0035101 | FACT complex(GO:0035101) |
| 0.3 | 9.1 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 31.7 | GO:0003677 | DNA binding(GO:0003677) |
| 0.2 | 26.8 | GO:0004386 | helicase activity(GO:0004386) |
| 0.2 | 22.2 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.2 | 17.8 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.1 | 17.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.9 | 13.1 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.6 | 12.2 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.0 | 10.5 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.2 | 10.1 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.8 | 8.1 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 38.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.3 | 21.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 9.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 9.0 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 7.3 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 6.5 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.2 | 6.0 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.2 | 5.4 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 5.0 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 4.7 | ST GA12 PATHWAY | G alpha 12 Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 47.1 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.3 | 34.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.7 | 12.2 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.6 | 10.2 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.5 | 9.1 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.2 | 7.5 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.2 | 7.4 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.2 | 7.0 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| 0.3 | 6.9 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.1 | 6.7 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |