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PRJNA375882: Comprehensive Mouse Transcriptomic BodyMap

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Results for Zscan4c

Z-value: 1.26

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Transcription factors associated with Zscan4c

Gene Symbol Gene ID Gene Info
Zscan4c
ENSMUSG00000054272.7 Zscan4c

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zscan4cmm39_v1_chr7_+_10739672_10739672-0.171.6e-01Click!

Activity profile of Zscan4c motif

Sorted Z-values of Zscan4c motif

Network of associatons between targets according to the STRING database.

First level regulatory network of Zscan4c

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr15_-_98705791 24.41 ENSMUST00000075444.8
Ddn
dendrin
chr2_+_102488985 20.37 ENSMUST00000080210.10
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr2_+_102489558 16.17 ENSMUST00000111213.8
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr6_-_55658242 14.11 ENSMUST00000044767.10
Neurod6
neurogenic differentiation 6
chr4_-_46991842 13.27 ENSMUST00000107749.4
Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr15_-_37458768 11.65 ENSMUST00000116445.9
Ncald
neurocalcin delta
chr4_+_123077286 11.35 ENSMUST00000126995.2
Hpcal4
hippocalcin-like 4
chr13_+_58955506 10.97 ENSMUST00000079828.7
Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr9_-_44710480 10.73 ENSMUST00000214833.2
ENSMUST00000213972.2
ENSMUST00000214431.2
ENSMUST00000213363.2
ENSMUST00000114705.9
ENSMUST00000002100.8
Tmem25
transmembrane protein 25
chr9_+_26645024 10.33 ENSMUST00000160899.8
ENSMUST00000161431.3
ENSMUST00000159799.8
B3gat1
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr9_+_89791943 9.89 ENSMUST00000189545.2
ENSMUST00000034909.11
ENSMUST00000034912.6
Rasgrf1
RAS protein-specific guanine nucleotide-releasing factor 1
chr9_+_21848282 9.70 ENSMUST00000046371.13
Plppr2
phospholipid phosphatase related 2
chr3_-_158267771 9.44 ENSMUST00000199890.5
ENSMUST00000238317.3
ENSMUST00000200137.5
ENSMUST00000106044.6
Lrrc7
leucine rich repeat containing 7
chrX_+_47608122 9.01 ENSMUST00000033430.3
Rab33a
RAB33A, member RAS oncogene family
chr1_+_182591425 8.50 ENSMUST00000155229.7
ENSMUST00000153348.8
Susd4
sushi domain containing 4
chr8_+_63404228 8.38 ENSMUST00000118003.8
Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr10_-_114638202 8.26 ENSMUST00000239411.2
Trhde
TRH-degrading enzyme
chr9_-_49710190 7.97 ENSMUST00000114476.8
ENSMUST00000193547.6
Ncam1
neural cell adhesion molecule 1
chr9_-_49710058 7.91 ENSMUST00000192584.2
ENSMUST00000166811.9
Ncam1
neural cell adhesion molecule 1
chr3_+_13538266 7.69 ENSMUST00000211860.2
Ralyl
RALY RNA binding protein-like
chr8_+_63404395 7.68 ENSMUST00000119068.8
Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr13_+_58955675 7.51 ENSMUST00000224402.2
Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr18_-_23174698 7.14 ENSMUST00000097651.10
Nol4
nucleolar protein 4
chr9_+_36744016 7.12 ENSMUST00000214772.2
Fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr16_-_9812410 7.00 ENSMUST00000115835.8
Grin2a
glutamate receptor, ionotropic, NMDA2A (epsilon 1)
chr16_-_9812787 6.95 ENSMUST00000199708.5
Grin2a
glutamate receptor, ionotropic, NMDA2A (epsilon 1)
chr5_-_129030111 6.00 ENSMUST00000196085.5
Rimbp2
RIMS binding protein 2
chr9_+_26645141 5.80 ENSMUST00000115269.9
B3gat1
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr5_-_129030367 5.66 ENSMUST00000111346.6
ENSMUST00000200470.5
Rimbp2
RIMS binding protein 2
chr19_+_8641369 5.65 ENSMUST00000035444.10
ENSMUST00000163785.2
Chrm1
cholinergic receptor, muscarinic 1, CNS
chrX_-_63320543 5.62 ENSMUST00000114679.2
ENSMUST00000069926.14
Slitrk4
SLIT and NTRK-like family, member 4
chr19_-_21449916 5.57 ENSMUST00000087600.10
Gda
guanine deaminase
chr19_-_41732104 5.52 ENSMUST00000025993.10
Slit1
slit guidance ligand 1
chr15_-_85462271 5.49 ENSMUST00000229191.2
Wnt7b
wingless-type MMTV integration site family, member 7B
chr11_-_101676076 5.01 ENSMUST00000164750.8
ENSMUST00000107176.8
ENSMUST00000017868.7
Etv4
ets variant 4
chr11_-_37126709 4.75 ENSMUST00000102801.8
Tenm2
teneurin transmembrane protein 2
chr15_-_77037972 4.69 ENSMUST00000111581.4
ENSMUST00000166610.8
Rbfox2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr15_-_77037756 4.68 ENSMUST00000227314.2
ENSMUST00000227930.2
ENSMUST00000227533.2
Rbfox2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr10_+_74802996 4.63 ENSMUST00000037813.5
Gnaz
guanine nucleotide binding protein, alpha z subunit
chr19_+_16933471 4.46 ENSMUST00000087689.5
Prune2
prune homolog 2
chr1_+_132119169 4.46 ENSMUST00000188169.7
ENSMUST00000112357.9
ENSMUST00000188175.2
Lemd1
Gm29695
LEM domain containing 1
predicted gene, 29695
chr9_-_50650663 4.32 ENSMUST00000117093.2
ENSMUST00000121634.8
Dixdc1
DIX domain containing 1
chr2_+_57128309 4.22 ENSMUST00000112618.9
ENSMUST00000028167.3
Gpd2
glycerol phosphate dehydrogenase 2, mitochondrial
chr2_+_169475436 4.15 ENSMUST00000109157.2
Tshz2
teashirt zinc finger family member 2
chr14_+_57762191 3.97 ENSMUST00000089494.6
Il17d
interleukin 17D
chr16_-_38533597 3.96 ENSMUST00000023487.5
Arhgap31
Rho GTPase activating protein 31
chr3_-_63758672 3.96 ENSMUST00000162269.9
ENSMUST00000159676.9
ENSMUST00000175947.8
Plch1
phospholipase C, eta 1
chr2_+_179684288 3.82 ENSMUST00000041126.9
Ss18l1
SS18, nBAF chromatin remodeling complex subunit like 1
chr2_-_115895528 3.73 ENSMUST00000028639.13
ENSMUST00000102538.11
Meis2
Meis homeobox 2
chr10_+_81128795 3.68 ENSMUST00000163075.8
ENSMUST00000105327.10
ENSMUST00000045469.15
Pip5k1c
phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma
chr5_+_19431976 3.56 ENSMUST00000197354.5
ENSMUST00000088516.10
ENSMUST00000197443.5
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr15_-_77037926 3.36 ENSMUST00000228087.2
Rbfox2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr4_+_17853452 3.28 ENSMUST00000029881.10
Mmp16
matrix metallopeptidase 16
chr14_+_122712809 3.24 ENSMUST00000075888.6
Zic2
zinc finger protein of the cerebellum 2
chr2_-_35995283 3.01 ENSMUST00000112960.8
ENSMUST00000112967.12
ENSMUST00000112963.8
Lhx6
LIM homeobox protein 6
chr5_-_44956932 2.96 ENSMUST00000199261.2
ENSMUST00000199534.5
Ldb2
LIM domain binding 2
chr3_+_133942244 2.94 ENSMUST00000181904.3
Cxxc4
CXXC finger 4
chr6_+_128376729 2.84 ENSMUST00000001561.12
Nrip2
nuclear receptor interacting protein 2
chr2_-_91013193 2.72 ENSMUST00000111370.9
ENSMUST00000111376.8
ENSMUST00000099723.9
Madd
MAP-kinase activating death domain
chr3_-_107667499 2.70 ENSMUST00000153114.2
ENSMUST00000118593.8
ENSMUST00000120243.8
Csf1
colony stimulating factor 1 (macrophage)
chr2_-_115894993 2.59 ENSMUST00000074285.8
Meis2
Meis homeobox 2
chr7_-_45519853 2.58 ENSMUST00000211713.2
Grin2d
glutamate receptor, ionotropic, NMDA2D (epsilon 4)
chr19_-_6117815 2.52 ENSMUST00000162575.8
ENSMUST00000159084.8
ENSMUST00000161718.8
ENSMUST00000162810.8
ENSMUST00000025713.12
ENSMUST00000113543.9
ENSMUST00000160417.8
ENSMUST00000161528.2
Tm7sf2
transmembrane 7 superfamily member 2
chr11_+_61967821 2.50 ENSMUST00000092415.9
ENSMUST00000201015.4
ENSMUST00000202744.4
ENSMUST00000201723.4
ENSMUST00000202179.2
Specc1
sperm antigen with calponin homology and coiled-coil domains 1
chr2_-_115895202 2.49 ENSMUST00000110906.9
Meis2
Meis homeobox 2
chr5_-_44957016 2.46 ENSMUST00000199256.5
Ldb2
LIM domain binding 2
chr9_-_50639367 2.34 ENSMUST00000117646.8
Dixdc1
DIX domain containing 1
chr6_+_128376844 2.16 ENSMUST00000120405.4
Nrip2
nuclear receptor interacting protein 2
chr19_+_28941292 2.11 ENSMUST00000045674.4
Plpp6
phospholipid phosphatase 6
chr5_-_44956981 2.08 ENSMUST00000070748.10
Ldb2
LIM domain binding 2
chr2_+_30254239 2.08 ENSMUST00000077977.14
ENSMUST00000140075.9
ENSMUST00000142801.8
ENSMUST00000100214.10
Miga2
mitoguardin 2
chr1_+_182591771 1.99 ENSMUST00000193660.6
Susd4
sushi domain containing 4
chr10_+_18345706 1.87 ENSMUST00000162891.8
ENSMUST00000100054.4
Nhsl1
NHS-like 1
chr2_+_19914573 1.87 ENSMUST00000114610.8
Etl4
enhancer trap locus 4
chr13_-_76205115 1.80 ENSMUST00000056130.8
Gpr150
G protein-coupled receptor 150
chr9_-_31824758 1.66 ENSMUST00000116615.5
Barx2
BarH-like homeobox 2
chr2_-_165997551 1.62 ENSMUST00000109249.9
ENSMUST00000146497.9
Sulf2
sulfatase 2
chr6_-_122317484 1.58 ENSMUST00000112600.9
Phc1
polyhomeotic 1
chr19_-_38807600 1.54 ENSMUST00000025963.8
Noc3l
NOC3 like DNA replication regulator
chr3_+_125197722 1.17 ENSMUST00000173932.8
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr5_+_99002293 1.16 ENSMUST00000031278.6
ENSMUST00000200388.2
Bmp3
bone morphogenetic protein 3
chr13_+_55517545 1.12 ENSMUST00000063771.14
Rgs14
regulator of G-protein signaling 14
chr17_-_63188139 1.12 ENSMUST00000078839.5
ENSMUST00000076840.12
Efna5
ephrin A5
chr13_-_9815276 1.08 ENSMUST00000130151.8
Zmynd11
zinc finger, MYND domain containing 11
chr8_-_49008881 0.91 ENSMUST00000110345.8
Tenm3
teneurin transmembrane protein 3
chr13_-_9815350 0.87 ENSMUST00000110636.9
ENSMUST00000152725.8
Zmynd11
zinc finger, MYND domain containing 11
chr7_+_46490899 0.83 ENSMUST00000147535.8
Ldha
lactate dehydrogenase A
chr12_-_69939931 0.80 ENSMUST00000049239.8
ENSMUST00000110570.8
Map4k5
mitogen-activated protein kinase kinase kinase kinase 5
chr9_+_21279299 0.79 ENSMUST00000214852.2
ENSMUST00000115414.3
Ilf3
interleukin enhancer binding factor 3
chr17_-_28779678 0.77 ENSMUST00000114785.3
ENSMUST00000025062.5
Clps
colipase, pancreatic
chr6_-_122317156 0.75 ENSMUST00000159384.8
Phc1
polyhomeotic 1
chr19_-_28941264 0.74 ENSMUST00000161813.2
Spata6l
spermatogenesis associated 6 like
chr4_-_136620376 0.61 ENSMUST00000046332.6
C1qc
complement component 1, q subcomponent, C chain
chr9_+_37466989 0.60 ENSMUST00000213126.2
Siae
sialic acid acetylesterase
chr18_+_37108994 0.49 ENSMUST00000193984.2
Gm37388
predicted gene, 37388
chr2_-_165997179 0.42 ENSMUST00000088086.4
Sulf2
sulfatase 2
chr9_+_43978369 0.41 ENSMUST00000177054.8
Usp2
ubiquitin specific peptidase 2
chr2_-_35994819 0.37 ENSMUST00000148852.4
Lhx6
LIM homeobox protein 6
chr18_-_79152504 0.33 ENSMUST00000025430.11
Setbp1
SET binding protein 1
chr5_-_68004743 0.25 ENSMUST00000072971.13
ENSMUST00000113652.8
ENSMUST00000113651.8
ENSMUST00000037380.15
Atp8a1
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
chr15_+_44482545 0.18 ENSMUST00000227691.2
Ebag9
estrogen receptor-binding fragment-associated gene 9
chr13_-_9815173 0.16 ENSMUST00000062658.15
ENSMUST00000222358.2
Zmynd11
zinc finger, MYND domain containing 11
chr12_-_69939762 0.12 ENSMUST00000110567.8
ENSMUST00000171211.8
Map4k5
mitogen-activated protein kinase kinase kinase kinase 5
chr12_+_52550775 0.11 ENSMUST00000219443.2
Arhgap5
Rho GTPase activating protein 5
chr2_+_85804239 0.11 ENSMUST00000217244.2
Olfr1029
olfactory receptor 1029
chr2_+_169474916 0.08 ENSMUST00000109159.3
Tshz2
teashirt zinc finger family member 2
chr17_+_78815493 0.06 ENSMUST00000024880.11
ENSMUST00000232859.2
Vit
vitrin
chr13_-_9814901 0.02 ENSMUST00000223421.2
ENSMUST00000128658.8
Zmynd11
zinc finger, MYND domain containing 11
chr9_-_57168777 0.02 ENSMUST00000217657.2
1700017B05Rik
RIKEN cDNA 1700017B05 gene
chr1_+_87983189 0.01 ENSMUST00000173325.2
Ugt1a10
UDP glycosyltransferase 1 family, polypeptide A10

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 36.5 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
4.0 15.9 GO:0001928 regulation of exocyst assembly(GO:0001928)
3.1 18.5 GO:0099551 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
2.6 10.5 GO:0030450 regulation of complement activation, classical pathway(GO:0030450)
1.7 13.9 GO:0033058 directional locomotion(GO:0033058)
1.4 5.6 GO:0046098 guanine metabolic process(GO:0046098)
1.4 5.5 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
1.2 14.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
1.1 5.6 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
1.0 12.7 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.9 5.5 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.9 2.7 GO:1902277 negative regulation of pancreatic amylase secretion(GO:1902277)
0.9 2.7 GO:1902226 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
0.9 16.1 GO:0030204 chondroitin sulfate metabolic process(GO:0030204)
0.8 3.2 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.6 3.4 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.5 14.1 GO:0021542 dentate gyrus development(GO:0021542)
0.5 5.0 GO:0060762 negative regulation of mammary gland epithelial cell proliferation(GO:0033600) regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.5 6.7 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.4 7.1 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.4 4.2 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.3 2.0 GO:0014846 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.3 9.0 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.3 3.6 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.3 5.7 GO:0097264 self proteolysis(GO:0097264)
0.3 13.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.3 3.7 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.2 9.9 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.2 1.9 GO:0097475 motor neuron migration(GO:0097475)
0.2 9.7 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.2 3.3 GO:0035988 chondrocyte proliferation(GO:0035988)
0.2 6.8 GO:0043171 peptide catabolic process(GO:0043171)
0.1 1.7 GO:0042637 catagen(GO:0042637)
0.1 11.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 9.9 GO:0008542 visual learning(GO:0008542)
0.1 1.1 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 0.8 GO:0019660 lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.1 11.7 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.1 4.6 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.1 2.6 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.1 0.6 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.1 3.8 GO:0050775 positive regulation of dendrite morphogenesis(GO:0050775)
0.1 2.1 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 5.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.0 GO:0010669 epithelial structure maintenance(GO:0010669)
0.0 2.5 GO:0006695 cholesterol biosynthetic process(GO:0006695)
0.0 1.3 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0 2.2 GO:0016574 histone ubiquitination(GO:0016574)
0.0 0.2 GO:0061091 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.0 9.4 GO:0010976 positive regulation of neuron projection development(GO:0010976)
0.0 5.0 GO:0007219 Notch signaling pathway(GO:0007219)
0.0 0.4 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.0 0.8 GO:0032094 response to food(GO:0032094)
0.0 2.7 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 1.9 GO:0048706 embryonic skeletal system development(GO:0048706)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 13.3 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.8 4.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.7 2.7 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.7 16.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.7 36.5 GO:0030673 axolemma(GO:0030673)
0.4 5.6 GO:0032279 asymmetric synapse(GO:0032279)
0.3 18.5 GO:0048786 presynaptic active zone(GO:0048786)
0.3 9.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 9.4 GO:0043194 axon initial segment(GO:0043194)
0.2 3.6 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 2.2 GO:0001739 sex chromatin(GO:0001739)
0.1 3.8 GO:0071565 nBAF complex(GO:0071565)
0.1 16.4 GO:0031225 anchored component of membrane(GO:0031225)
0.1 4.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 6.7 GO:0043679 axon terminus(GO:0043679)
0.0 37.4 GO:0030425 dendrite(GO:0030425)
0.0 12.9 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 2.7 GO:0008021 synaptic vesicle(GO:0008021)
0.0 2.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 19.5 GO:0005730 nucleolus(GO:0005730)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 36.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
3.1 18.5 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
2.7 16.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
2.2 13.3 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
1.4 4.2 GO:0004368 glycerol-3-phosphate dehydrogenase activity(GO:0004368) oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
1.4 5.5 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
1.2 16.5 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
1.1 5.6 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.9 5.5 GO:0048495 Roundabout binding(GO:0048495)
0.9 2.7 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.7 16.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.6 9.7 GO:0042577 lipid phosphatase activity(GO:0042577)
0.6 15.9 GO:0030275 LRR domain binding(GO:0030275)
0.6 4.6 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.4 3.6 GO:0070699 type II activin receptor binding(GO:0070699)
0.4 11.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.4 3.7 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.4 1.1 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.3 2.0 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 11.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 3.7 GO:0030274 LIM domain binding(GO:0030274)
0.2 13.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 11.3 GO:0005246 calcium channel regulator activity(GO:0005246)
0.2 4.0 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 5.0 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 1.2 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 5.6 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1 9.9 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 0.8 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 2.5 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 4.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.9 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 37.0 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 2.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 1.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 11.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 9.4 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 8.1 GO:0003924 GTPase activity(GO:0003924)
0.0 4.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 2.9 GO:0030165 PDZ domain binding(GO:0030165)
0.0 3.8 GO:0003713 transcription coactivator activity(GO:0003713)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 16.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.3 24.0 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.3 4.6 PID S1P S1P4 PATHWAY S1P4 pathway
0.2 13.9 PID REELIN PATHWAY Reelin signaling pathway
0.2 15.9 PID FGF PATHWAY FGF signaling pathway
0.2 2.7 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 3.7 PID NECTIN PATHWAY Nectin adhesion pathway
0.2 5.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 9.9 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 5.0 PID LKB1 PATHWAY LKB1 signaling events
0.1 2.9 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 4.3 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.1 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 2.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.9 PID TNF PATHWAY TNF receptor signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 26.4 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.7 11.7 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.6 13.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.5 15.6 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.3 27.0 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.3 5.6 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.3 15.9 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.2 3.7 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 5.6 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 3.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 4.6 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 3.6 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 2.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 18.5 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.1 0.6 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 5.5 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 3.1 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.2 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.8 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 0.8 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D