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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for alx1

Z-value: 0.37

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Transcription factors associated with alx1

Gene Symbol Gene ID Gene Info
alx1
ENSDARG00000062824 ALX homeobox 1
alx1
ENSDARG00000110530 ALX homeobox 1
alx1
ENSDARG00000115230 ALX homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
alx1dr11_v1_chr18_+_16246806_16246806-0.428.0e-02Click!

Activity profile of alx1 motif

Sorted Z-values of alx1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_29509133 0.85 ENSDART00000112116
ctss2.1
cathepsin S, ortholog2, tandem duplicate 1
chr21_+_25777425 0.74 ENSDART00000021620
cldnd
claudin d
chr8_+_45334255 0.72 ENSDART00000126848
ENSDART00000134161
ENSDART00000142322
ENSDART00000145011
ENSDART00000183560
pabpc1l
poly(A) binding protein, cytoplasmic 1-like
chr1_-_43905252 0.71 ENSDART00000135477
ENSDART00000132089
si:dkey-22i16.3
si:dkey-22i16.3
chr10_-_21362071 0.68 ENSDART00000125167
avd
avidin
chr15_-_2519640 0.65 ENSDART00000047013
srprb
signal recognition particle receptor, B subunit
chr5_+_37903790 0.64 ENSDART00000162470
tmprss4b
transmembrane protease, serine 4b
chr10_-_21362320 0.64 ENSDART00000189789
avd
avidin
chr10_-_25217347 0.63 ENSDART00000036906
kpna7
karyopherin alpha 7 (importin alpha 8)
chr22_-_17653143 0.62 ENSDART00000089171
hmha1b
histocompatibility (minor) HA-1 b
chr12_-_14143344 0.62 ENSDART00000152742
buc2l
bucky ball 2-like
chr19_+_15440841 0.59 ENSDART00000182329
lin28a
lin-28 homolog A (C. elegans)
chr16_+_39159752 0.58 ENSDART00000122081
sybu
syntabulin (syntaxin-interacting)
chr7_-_51773166 0.58 ENSDART00000054591
bmp15
bone morphogenetic protein 15
chr2_+_41526904 0.57 ENSDART00000127520
acvr1l
activin A receptor, type 1 like
chr14_+_8940326 0.56 ENSDART00000159920
rps6kal
ribosomal protein S6 kinase a, like
chr21_-_36453594 0.55 ENSDART00000193176
cnot8
CCR4-NOT transcription complex, subunit 8
chr11_-_1550709 0.55 ENSDART00000110097
si:ch73-303b9.1
si:ch73-303b9.1
chr5_+_57924611 0.53 ENSDART00000050949
btg4
B-cell translocation gene 4
chr22_-_17652914 0.51 ENSDART00000138483
si:ch73-243b8.4
si:ch73-243b8.4
chr11_-_35171162 0.50 ENSDART00000017393
traip
TRAF-interacting protein
chr5_+_29794058 0.49 ENSDART00000045410
thy1
Thy-1 cell surface antigen
chr8_+_23355484 0.49 ENSDART00000085361
ENSDART00000125729
dnmt3ba
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a
chr8_+_11425048 0.48 ENSDART00000018739
tjp2b
tight junction protein 2b (zona occludens 2)
chr19_+_15441022 0.46 ENSDART00000098970
ENSDART00000140276
lin28a
lin-28 homolog A (C. elegans)
chr3_+_32416948 0.45 ENSDART00000157324
ENSDART00000154267
ENSDART00000186094
ENSDART00000155860
ENSDART00000156986
prrg2
proline rich Gla (G-carboxyglutamic acid) 2
chr24_-_2450597 0.44 ENSDART00000188080
ENSDART00000093331
rreb1a
ras responsive element binding protein 1a
chr5_-_13206878 0.43 ENSDART00000051666
ppm1f
protein phosphatase, Mg2+/Mn2+ dependent, 1F
chr16_-_17347727 0.43 ENSDART00000144392
zyx
zyxin
chr10_+_16911951 0.41 ENSDART00000164933
UNC13B (1 of many)
unc-13 homolog B
chr16_-_29387215 0.40 ENSDART00000148787
s100a1
S100 calcium binding protein A1
chr3_-_30488063 0.40 ENSDART00000055393
ENSDART00000151367
med25
mediator complex subunit 25
chr8_-_25034411 0.39 ENSDART00000135973
nfyal
nuclear transcription factor Y, alpha, like
chr10_-_42147318 0.39 ENSDART00000134890
dusp11
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
chr16_+_13883872 0.39 ENSDART00000101304
ENSDART00000136005
atg12
ATG12 autophagy related 12 homolog (S. cerevisiae)
chr17_+_25856671 0.39 ENSDART00000064817
wapla
WAPL cohesin release factor a
chr5_-_12587053 0.38 ENSDART00000162780
vsig10
V-set and immunoglobulin domain containing 10
chr14_-_6286966 0.38 ENSDART00000168174
elp1
elongator complex protein 1
chr3_-_23575007 0.38 ENSDART00000155282
ENSDART00000087726
igf2bp1
insulin-like growth factor 2 mRNA binding protein 1
chr19_-_82504 0.37 ENSDART00000027864
ENSDART00000160560
hnrnpr
heterogeneous nuclear ribonucleoprotein R
chr2_-_49031303 0.37 ENSDART00000143471
cdc34b
cell division cycle 34 homolog (S. cerevisiae) b
chr25_-_2723682 0.37 ENSDART00000113382
adpgk
ADP-dependent glucokinase
chr5_+_25733774 0.37 ENSDART00000137088
ENSDART00000098467
abhd17b
abhydrolase domain containing 17B
chr14_-_33859149 0.36 ENSDART00000163877
ocrl
oculocerebrorenal syndrome of Lowe
chr7_+_22313533 0.36 ENSDART00000123457
TMEM102
si:dkey-11f12.2
chr17_-_41798856 0.35 ENSDART00000156031
ENSDART00000192801
ENSDART00000180172
ENSDART00000084745
ENSDART00000175577
ralgapa2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr11_+_12811906 0.35 ENSDART00000123445
rtel1
regulator of telomere elongation helicase 1
chr14_-_33945692 0.34 ENSDART00000168546
ENSDART00000189778
zdhhc24
zinc finger, DHHC-type containing 24
chr5_+_44805269 0.34 ENSDART00000136965
ctsla
cathepsin La
chr9_-_12401871 0.34 ENSDART00000191901
nup35
nucleoporin 35
chr8_-_20230802 0.34 ENSDART00000063400
mllt1a
MLLT1, super elongation complex subunit a
chr14_-_33481428 0.34 ENSDART00000147059
ENSDART00000140001
ENSDART00000124242
ENSDART00000164836
ENSDART00000190104
ENSDART00000186833
ENSDART00000180873
lamp2
lysosomal-associated membrane protein 2
chr12_+_22407852 0.34 ENSDART00000178840
hdlbpb
high density lipoprotein binding protein b
chr2_-_23390779 0.33 ENSDART00000020136
ivns1abpb
influenza virus NS1A binding protein b
chr21_-_36453417 0.33 ENSDART00000018350
cnot8
CCR4-NOT transcription complex, subunit 8
chr6_-_41028698 0.33 ENSDART00000134293
trub2
TruB pseudouridine (psi) synthase family member 2
chr8_-_20230559 0.33 ENSDART00000193677
mllt1a
MLLT1, super elongation complex subunit a
chr17_-_24575893 0.32 ENSDART00000141914
aftphb
aftiphilin b
chr15_-_43284021 0.32 ENSDART00000041677
serpine2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr16_+_23431189 0.32 ENSDART00000004679
icn
ictacalcin
chr7_+_26649319 0.32 ENSDART00000173823
ENSDART00000101053
tp53i11a
tumor protein p53 inducible protein 11a
chr20_+_29209926 0.31 ENSDART00000152949
ENSDART00000153016
katnbl1
katanin p80 subunit B-like 1
chr8_+_23356264 0.31 ENSDART00000145062
dnmt3ba
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a
chr17_-_40956035 0.31 ENSDART00000124715
si:dkey-16j16.4
si:dkey-16j16.4
chr3_+_41558682 0.31 ENSDART00000157023
card11
caspase recruitment domain family, member 11
chr15_-_44052927 0.31 ENSDART00000166209
wu:fb44b02
wu:fb44b02
chr14_-_26392146 0.31 ENSDART00000037999
b4galt7
xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)
chr14_-_26392475 0.30 ENSDART00000170614
b4galt7
xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)
chr17_+_26722904 0.30 ENSDART00000114927
nrde2
NRDE-2, necessary for RNA interference, domain containing
chr8_+_3431671 0.30 ENSDART00000017850
ctu1
cytosolic thiouridylase subunit 1 homolog (S. pombe)
chr1_+_513986 0.29 ENSDART00000109083
ENSDART00000081945
txnl4b
thioredoxin-like 4B
chr4_-_70883663 0.29 ENSDART00000170959
si:ch211-108c17.2
si:ch211-108c17.2
chr17_+_16046314 0.29 ENSDART00000154554
ENSDART00000154338
ENSDART00000155336
si:ch73-204p21.2
si:ch73-204p21.2
chr24_+_12835935 0.29 ENSDART00000114762
nanog
nanog homeobox
chr8_-_22538588 0.29 ENSDART00000144041
csde1
cold shock domain containing E1, RNA-binding
chr14_-_25935167 0.29 ENSDART00000139855
g3bp1
GTPase activating protein (SH3 domain) binding protein 1
chr2_-_23391266 0.29 ENSDART00000159048
ivns1abpb
influenza virus NS1A binding protein b
chr6_-_50203682 0.28 ENSDART00000083999
ENSDART00000143050
raly
RALY heterogeneous nuclear ribonucleoprotein
chr2_-_38206034 0.28 ENSDART00000144518
ENSDART00000137395
acin1a
apoptotic chromatin condensation inducer 1a
chr2_-_37312927 0.28 ENSDART00000141214
skila
SKI-like proto-oncogene a
chr14_+_34492288 0.28 ENSDART00000144301
wnt8a
wingless-type MMTV integration site family, member 8a
chr23_+_32028574 0.28 ENSDART00000145501
ENSDART00000143121
ENSDART00000111877
tpx2
TPX2, microtubule-associated, homolog (Xenopus laevis)
chr15_-_34408777 0.28 ENSDART00000139934
agmo
alkylglycerol monooxygenase
chr17_+_16090436 0.28 ENSDART00000136059
ENSDART00000138734
znf395a
zinc finger protein 395a
chr14_+_44860335 0.27 ENSDART00000091620
ENSDART00000173043
ENSDART00000091625
atp8a1
ATPase phospholipid transporting 8A1
chr17_+_16046132 0.27 ENSDART00000155005
si:ch73-204p21.2
si:ch73-204p21.2
chr15_-_33172246 0.27 ENSDART00000158666
nbeab
neurobeachin b
chr16_+_40340523 0.27 ENSDART00000102571
mettl6
methyltransferase like 6
chr20_-_3319642 0.27 ENSDART00000186743
ENSDART00000123096
marcksa
myristoylated alanine-rich protein kinase C substrate a
chr16_+_40340222 0.27 ENSDART00000190631
mettl6
methyltransferase like 6
chr11_+_18873619 0.27 ENSDART00000176141
magi1b
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr5_+_35786141 0.27 ENSDART00000022043
ENSDART00000127383
stard8
StAR-related lipid transfer (START) domain containing 8
chr1_-_55248496 0.27 ENSDART00000098615
nanos3
nanos homolog 3
chr20_+_29209767 0.26 ENSDART00000141252
katnbl1
katanin p80 subunit B-like 1
chr16_+_54209504 0.26 ENSDART00000020033
xrcc1
X-ray repair complementing defective repair in Chinese hamster cells 1
chr14_-_8940499 0.26 ENSDART00000129030
zgc:153681
zgc:153681
chr21_+_38638979 0.26 ENSDART00000143373
rbmx2
RNA binding motif protein, X-linked 2
chr8_-_22542467 0.26 ENSDART00000182588
ENSDART00000134542
csde1
cold shock domain containing E1, RNA-binding
chr10_+_17235370 0.26 ENSDART00000038780
sppl3
signal peptide peptidase 3
chr6_-_40778294 0.25 ENSDART00000019845
arpc4
actin related protein 2/3 complex, subunit 4
chr17_-_11495466 0.25 ENSDART00000020598
hnrnpua
heterogeneous nuclear ribonucleoprotein Ua
chr20_+_29209615 0.25 ENSDART00000062350
katnbl1
katanin p80 subunit B-like 1
chr2_+_42871831 0.25 ENSDART00000171393
efr3a
EFR3 homolog A (S. cerevisiae)
chr6_-_40922971 0.25 ENSDART00000155363
sfi1
SFI1 centrin binding protein
chr24_+_19415124 0.25 ENSDART00000186931
sulf1
sulfatase 1
chr14_-_26498196 0.25 ENSDART00000054175
ENSDART00000145625
ENSDART00000183347
ENSDART00000191084
ENSDART00000191143
smad5
SMAD family member 5
chr14_+_34490445 0.25 ENSDART00000132193
ENSDART00000148044
wnt8a
wingless-type MMTV integration site family, member 8a
chr15_+_1534644 0.25 ENSDART00000130413
smc4
structural maintenance of chromosomes 4
chr13_-_32726178 0.25 ENSDART00000012232
pdss2
prenyl (decaprenyl) diphosphate synthase, subunit 2
chr11_+_44804685 0.24 ENSDART00000163660
strn
striatin, calmodulin binding protein
chr18_+_38807239 0.24 ENSDART00000184332
fam214a
family with sequence similarity 214, member A
chr21_-_32060993 0.24 ENSDART00000131651
si:ch211-160j14.2
si:ch211-160j14.2
chr25_+_3759553 0.24 ENSDART00000180601
ENSDART00000055845
ENSDART00000157050
ENSDART00000153905
thoc5
THO complex 5
chr18_-_15551360 0.24 ENSDART00000159915
ENSDART00000172690
ppfibp1b
PTPRF interacting protein, binding protein 1b (liprin beta 1)
chr5_-_61797220 0.24 ENSDART00000079855
im:7138535
im:7138535
chr21_+_42717424 0.24 ENSDART00000166936
ENSDART00000172135
sh3pxd2b
SH3 and PX domains 2B
chr7_+_24023653 0.24 ENSDART00000141165
tinf2
TERF1 (TRF1)-interacting nuclear factor 2
chr9_+_45428041 0.24 ENSDART00000193087
adarb1b
adenosine deaminase, RNA-specific, B1b
chr24_-_5713799 0.24 ENSDART00000137293
dia1b
deleted in autism 1b
chr17_+_23462972 0.24 ENSDART00000112959
ENSDART00000192168
ankrd1a
ankyrin repeat domain 1a (cardiac muscle)
chr15_+_21262917 0.24 ENSDART00000101000
gkup
glucuronokinase with putative uridyl pyrophosphorylase
chr7_+_59677273 0.23 ENSDART00000039535
ENSDART00000132044
trmt44
tRNA methyltransferase 44 homolog
chr3_+_26244353 0.23 ENSDART00000103733
atad5a
ATPase family, AAA domain containing 5a
chr14_+_35428152 0.23 ENSDART00000172597
sytl4
synaptotagmin-like 4
chr22_+_34784075 0.23 ENSDART00000167538
lcor
ligand dependent nuclear receptor corepressor
chr10_-_33297864 0.23 ENSDART00000163360
PRDM15
PR/SET domain 15
chr11_+_31864921 0.23 ENSDART00000180252
diaph3
diaphanous-related formin 3
chrM_+_3803 0.22 ENSDART00000093596
mt-nd1
NADH dehydrogenase 1, mitochondrial
chr7_-_25133783 0.22 ENSDART00000173781
ENSDART00000121943
ENSDART00000077219
badb
BCL2 associated agonist of cell death b
chr21_+_31253048 0.22 ENSDART00000178521
ENSDART00000132317
ENSDART00000040190
asl
argininosuccinate lyase
chr21_+_34088377 0.22 ENSDART00000170070
mtmr1b
myotubularin related protein 1b
chr4_-_4261673 0.22 ENSDART00000150694
cd9b
CD9 molecule b
chr23_+_31942040 0.22 ENSDART00000088607
nemp1
nuclear envelope integral membrane protein 1
chr23_+_9230431 0.22 ENSDART00000187676
ENSDART00000125122
ENSDART00000190980
ENSDART00000141235
acss2
acyl-CoA synthetase short chain family member 2
chr7_+_1467863 0.22 ENSDART00000173433
emc4
ER membrane protein complex subunit 4
chr11_+_2649891 0.22 ENSDART00000093052
si:ch211-160o17.4
si:ch211-160o17.4
chr3_+_19248973 0.22 ENSDART00000174668
smarca4a
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4a
chr24_-_25166720 0.22 ENSDART00000141601
phldb2b
pleckstrin homology-like domain, family B, member 2b
chr19_+_20793237 0.22 ENSDART00000014774
txnl4a
thioredoxin-like 4A
chr22_-_14161309 0.21 ENSDART00000133365
si:ch211-246m6.5
si:ch211-246m6.5
chr12_+_33361948 0.21 ENSDART00000124982
fasn
fatty acid synthase
chr6_+_29693492 0.21 ENSDART00000114172
pde6d
phosphodiesterase 6D, cGMP-specific, rod, delta
chr20_+_32523576 0.21 ENSDART00000147319
scml4
Scm polycomb group protein like 4
chr23_+_20563779 0.21 ENSDART00000146008
camkvl
CaM kinase-like vesicle-associated, like
chr10_-_35103208 0.21 ENSDART00000192734
zgc:110006
zgc:110006
chr2_-_26596794 0.21 ENSDART00000134685
ENSDART00000056787
zgc:113691
zgc:113691
chr19_+_6990970 0.21 ENSDART00000158758
ENSDART00000160482
ENSDART00000193566
kifc1
kinesin family member C1
chr10_+_11261576 0.21 ENSDART00000155333
hsdl2
hydroxysteroid dehydrogenase like 2
chr10_+_7718156 0.21 ENSDART00000189101
ggcx
gamma-glutamyl carboxylase
chr23_+_33963619 0.21 ENSDART00000140666
ENSDART00000084792
plpbp
pyridoxal phosphate binding protein
chr3_+_18579806 0.20 ENSDART00000180967
ENSDART00000089765
arhgap17b
Rho GTPase activating protein 17b
chr8_+_3820134 0.20 ENSDART00000122454
citb
citron rho-interacting serine/threonine kinase b
chr12_-_4408828 0.20 ENSDART00000152447
si:ch211-173d10.1
si:ch211-173d10.1
chr19_+_9032073 0.20 ENSDART00000127755
ash1l
ash1 (absent, small, or homeotic)-like (Drosophila)
chr20_+_16639848 0.20 ENSDART00000063944
ENSDART00000152359
tmem30ab
transmembrane protein 30Ab
chr5_-_68093169 0.20 ENSDART00000051849
slc25a11
solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
chr19_+_7549854 0.20 ENSDART00000138866
ENSDART00000151758
pbxip1a
pre-B-cell leukemia homeobox interacting protein 1a
chr16_-_28658341 0.20 ENSDART00000148456
abcb4
ATP-binding cassette, sub-family B (MDR/TAP), member 4
chr8_+_28452738 0.20 ENSDART00000062706
tmem189
transmembrane protein 189
chr13_-_35808904 0.20 ENSDART00000171667
map3k4
mitogen-activated protein kinase kinase kinase 4
chr9_-_27398369 0.20 ENSDART00000186499
tex30
testis expressed 30
chr7_-_59165640 0.20 ENSDART00000170853
haus6
HAUS augmin-like complex, subunit 6
chr24_+_1023839 0.20 ENSDART00000082526
zgc:111976
zgc:111976
chr24_+_36204028 0.20 ENSDART00000063832
ENSDART00000155260
rbbp8
retinoblastoma binding protein 8
chr9_+_34397516 0.20 ENSDART00000011304
ENSDART00000192973
med14
mediator complex subunit 14
chr24_-_24724233 0.20 ENSDART00000127044
ENSDART00000012399
armc1
armadillo repeat containing 1
chr22_-_20924564 0.19 ENSDART00000100642
ENSDART00000032770
ell
elongation factor RNA polymerase II
chr2_+_1714640 0.19 ENSDART00000086761
ENSDART00000111613
adgrl2b.1
adgrl2b.1
adhesion G protein-coupled receptor L2b, tandem duplicate 1
adhesion G protein-coupled receptor L2b, tandem duplicate 1
chr17_-_25303486 0.19 ENSDART00000162235
ppie
peptidylprolyl isomerase E (cyclophilin E)
chr3_+_18807006 0.19 ENSDART00000180091
tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chr21_+_34088110 0.19 ENSDART00000145123
ENSDART00000029599
ENSDART00000147519
mtmr1b
myotubularin related protein 1b
chr8_+_50953776 0.19 ENSDART00000013870
zgc:56596
zgc:56596
chr19_+_26922780 0.19 ENSDART00000187396
ENSDART00000188978
nelfe
negative elongation factor complex member E
chr6_-_12172424 0.19 ENSDART00000109344
tanc1a
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1a
chr21_-_13662237 0.19 ENSDART00000091647
ENSDART00000151547
pnpla7a
patatin-like phospholipase domain containing 7a
chr2_-_37098785 0.19 ENSDART00000003670
zgc:101744
zgc:101744
chr6_+_36839509 0.19 ENSDART00000190605
ENSDART00000104160
zgc:110788
zgc:110788
chr15_-_37543591 0.18 ENSDART00000180400
kmt2bb
lysine (K)-specific methyltransferase 2Bb
chr9_+_35014728 0.18 ENSDART00000100700
gabpa
GA binding protein transcription factor, alpha subunit
chr7_-_54217547 0.18 ENSDART00000162777
ENSDART00000188268
ENSDART00000165875
csnk1g1
casein kinase 1, gamma 1
chr3_+_45364849 0.18 ENSDART00000153974
ube2ia
ubiquitin-conjugating enzyme E2Ia
chr3_+_27786601 0.18 ENSDART00000086994
nat15
N-acetyltransferase 15 (GCN5-related, putative)
chr13_-_28308138 0.18 ENSDART00000045351
lbx1a
ladybird homeobox 1a
chr16_+_33163858 0.18 ENSDART00000101943
rragca
Ras-related GTP binding Ca
chr7_+_19483277 0.18 ENSDART00000173750
si:ch211-212k18.7
si:ch211-212k18.7
chr9_-_14683574 0.18 ENSDART00000144022
pard3bb
par-3 family cell polarity regulator beta b
chr11_-_16115804 0.17 ENSDART00000143436
ENSDART00000157928
rpf1
ribosome production factor 1 homolog
chr16_-_25368048 0.17 ENSDART00000132445
rbfa
ribosome binding factor A
chr19_+_46158078 0.17 ENSDART00000183933
ENSDART00000164055
cap2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr4_+_13931578 0.17 ENSDART00000142466
pphln1
periphilin 1
chr10_+_42521943 0.17 ENSDART00000010420
ENSDART00000075303
actr1
ARP1 actin related protein 1, centractin
chr4_-_16124417 0.17 ENSDART00000128079
ENSDART00000077664
atp2b1a
ATPase plasma membrane Ca2+ transporting 1a
chr8_-_23776399 0.17 ENSDART00000114800
INAVA
si:ch211-163l21.4
chr9_+_8396755 0.17 ENSDART00000043067
zgc:171776
zgc:171776
chr10_-_11323134 0.17 ENSDART00000039145
inip
ints3 and nabp interacting protein
chr12_+_8822717 0.17 ENSDART00000021628
reep3b
receptor accessory protein 3b
chr10_+_7593185 0.17 ENSDART00000162617
ENSDART00000162590
ENSDART00000171744
ppp2cb
protein phosphatase 2, catalytic subunit, beta isozyme
chr17_+_22587356 0.16 ENSDART00000157328
birc6
baculoviral IAP repeat containing 6
chr13_-_23095006 0.16 ENSDART00000089242
kif1bp
kif1 binding protein
chr16_+_19637384 0.16 ENSDART00000184773
ENSDART00000191895
ENSDART00000182020
ENSDART00000135359
macc1
metastasis associated in colon cancer 1

Network of associatons between targets according to the STRING database.

First level regulatory network of alx1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0072111 spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111)
0.1 0.7 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.6 GO:0060074 synapse maturation(GO:0060074)
0.1 0.6 GO:0060283 negative regulation of oocyte development(GO:0060283)
0.1 0.6 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.1 0.4 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.1 0.4 GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis.(GO:0002926)
0.1 0.6 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.1 0.4 GO:0071869 response to monoamine(GO:0071867) response to catecholamine(GO:0071869) response to epinephrine(GO:0071871)
0.1 0.3 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.1 1.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.9 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.1 0.6 GO:0032205 negative regulation of telomere maintenance(GO:0032205)
0.1 0.3 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.1 0.2 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 0.2 GO:0045002 double-strand break repair via single-strand annealing(GO:0045002)
0.1 0.3 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.1 0.2 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 0.3 GO:0046485 ether lipid metabolic process(GO:0046485)
0.1 0.4 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 0.3 GO:0000012 single strand break repair(GO:0000012)
0.0 0.3 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143) protein urmylation(GO:0032447)
0.0 0.5 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.1 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0 0.1 GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.0 0.2 GO:0051660 establishment of centrosome localization(GO:0051660)
0.0 0.2 GO:2000389 neutrophil extravasation(GO:0072672) regulation of neutrophil extravasation(GO:2000389) positive regulation of neutrophil extravasation(GO:2000391)
0.0 0.3 GO:0031048 chromatin silencing by small RNA(GO:0031048)
0.0 0.2 GO:0015709 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.0 0.2 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.2 GO:0071800 podosome assembly(GO:0071800)
0.0 0.2 GO:1904356 regulation of telomere maintenance via telomere lengthening(GO:1904356)
0.0 0.2 GO:0051645 Golgi localization(GO:0051645)
0.0 0.2 GO:0060965 negative regulation of posttranscriptional gene silencing(GO:0060149) negative regulation of gene silencing by miRNA(GO:0060965) negative regulation of gene silencing by RNA(GO:0060967)
0.0 0.2 GO:1902024 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.0 0.1 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.2 GO:0006083 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.0 0.2 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.2 GO:0034505 tooth mineralization(GO:0034505)
0.0 0.2 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.2 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.0 0.2 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.0 0.2 GO:2000290 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.0 0.3 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 0.7 GO:0045047 protein targeting to ER(GO:0045047) establishment of protein localization to endoplasmic reticulum(GO:0072599)
0.0 0.2 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0 0.4 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.3 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.2 GO:0021634 optic nerve formation(GO:0021634)
0.0 0.6 GO:0060021 palate development(GO:0060021)
0.0 0.2 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.3 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 0.1 GO:0006004 fucose metabolic process(GO:0006004)
0.0 0.2 GO:1902038 positive regulation of hematopoietic stem cell differentiation(GO:1902038)
0.0 0.1 GO:0018872 arsonoacetate metabolic process(GO:0018872)
0.0 0.5 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.2 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.2 GO:0071479 cellular response to ionizing radiation(GO:0071479)
0.0 0.2 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.2 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.0 0.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.2 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.1 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.0 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.1 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.1 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.0 0.1 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.3 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.5 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.2 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.1 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.0 0.1 GO:0072045 convergent extension involved in nephron morphogenesis(GO:0072045)
0.0 0.3 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 0.1 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.0 0.2 GO:1901663 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.0 0.0 GO:0048785 hatching gland development(GO:0048785)
0.0 0.1 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 0.1 GO:0042723 thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723)
0.0 0.3 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 0.1 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 0.4 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.1 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.0 0.1 GO:0072584 caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 0.3 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0097189 apoptotic body(GO:0097189)
0.1 0.6 GO:0070724 BMP receptor complex(GO:0070724)
0.1 0.5 GO:1990498 mitotic spindle microtubule(GO:1990498)
0.1 0.3 GO:0031310 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.1 0.3 GO:0005880 nuclear microtubule(GO:0005880)
0.1 0.9 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.3 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 0.5 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.5 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.4 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.3 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.4 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.3 GO:0071818 BAT3 complex(GO:0071818)
0.0 0.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.3 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.2 GO:0034448 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.2 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.2 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.5 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.2 GO:0070876 SOSS complex(GO:0070876)
0.0 0.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.2 GO:0016586 RSC complex(GO:0016586)
0.0 0.2 GO:0032021 NELF complex(GO:0032021)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.2 GO:0035060 brahma complex(GO:0035060)
0.0 0.3 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.4 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.2 GO:0002102 podosome(GO:0002102)
0.0 0.9 GO:0016592 mediator complex(GO:0016592)
0.0 0.2 GO:0070187 telosome(GO:0070187)
0.0 0.2 GO:0045180 basal cortex(GO:0045180)
0.0 0.1 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 0.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.9 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.3 GO:0005844 polysome(GO:0005844)
0.0 0.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.6 GO:0032580 Golgi cisterna membrane(GO:0032580)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0009374 biotin binding(GO:0009374)
0.1 0.4 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 0.3 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.1 0.6 GO:0070698 type I activin receptor binding(GO:0070698)
0.1 0.4 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.1 0.2 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 1.0 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 0.2 GO:0015462 protein-transmembrane transporting ATPase activity(GO:0015462) efflux transmembrane transporter activity(GO:0015562)
0.1 0.2 GO:0070336 flap-structured DNA binding(GO:0070336)
0.1 0.3 GO:0034046 poly(G) binding(GO:0034046)
0.1 0.2 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.9 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.2 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 0.2 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.1 0.7 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.8 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.0 0.6 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.6 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.1 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.0 0.2 GO:0050218 propionate-CoA ligase activity(GO:0050218)
0.0 0.6 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.0 0.1 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.4 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.1 GO:0072591 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590) citrate-L-glutamate ligase activity(GO:0072591)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.0 0.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.1 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.3 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.3 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.3 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.1 GO:0050699 WW domain binding(GO:0050699)
0.0 0.4 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175) superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.7 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.4 GO:0034595 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) phosphatidylinositol phosphate 5-phosphatase activity(GO:0034595)
0.0 0.6 GO:0019894 kinesin binding(GO:0019894)
0.0 0.2 GO:0008494 translation activator activity(GO:0008494)
0.0 0.1 GO:0032052 bile acid binding(GO:0032052)
0.0 0.2 GO:0032977 membrane insertase activity(GO:0032977)
0.0 0.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.1 GO:0030792 arsenite methyltransferase activity(GO:0030791) methylarsonite methyltransferase activity(GO:0030792)
0.0 0.2 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.2 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.4 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.1 GO:0050333 thiamin-triphosphatase activity(GO:0050333)
0.0 0.1 GO:0004997 thyrotropin-releasing hormone receptor activity(GO:0004997)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.1 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 0.1 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.2 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.2 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.5 GO:0000049 tRNA binding(GO:0000049)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.0 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.2 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.2 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.4 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.4 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.1 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.2 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.2 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.6 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.6 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.3 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 0.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.1 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.2 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.2 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.1 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion