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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for arntl1a+arntl1b
Z-value: 2.24
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Transcription factors associated with arntl1a+arntl1b
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000006791 | aryl hydrocarbon receptor nuclear translocator-like 1a | |
| ENSDARG00000035732 | aryl hydrocarbon receptor nuclear translocator-like 1b | |
| ENSDARG00000114562 | aryl hydrocarbon receptor nuclear translocator-like 1b |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| arntl1a | dr11_v1_chr25_-_17910714_17910714 | -0.90 | 4.7e-07 | Click! |
| arntl1b | dr11_v1_chr7_+_66072580_66072580 | -0.57 | 1.3e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of arntl1a+arntl1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 51.2 | GO:0006397 | mRNA processing(GO:0006397) |
| 0.6 | 17.4 | GO:0007286 | spermatid development(GO:0007286) |
| 1.3 | 14.5 | GO:1902299 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
| 0.0 | 7.6 | GO:0043066 | negative regulation of apoptotic process(GO:0043066) |
| 0.3 | 5.6 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 5.3 | GO:0070507 | regulation of microtubule cytoskeleton organization(GO:0070507) |
| 0.2 | 4.6 | GO:0070831 | basement membrane assembly(GO:0070831) |
| 0.6 | 4.2 | GO:0019346 | homoserine metabolic process(GO:0009092) cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344) transsulfuration(GO:0019346) |
| 0.2 | 3.9 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
| 0.1 | 3.8 | GO:0035082 | axoneme assembly(GO:0035082) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 15.4 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.8 | 14.5 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 6.7 | GO:0005929 | cilium(GO:0005929) |
| 0.2 | 4.6 | GO:0043256 | basal lamina(GO:0005605) laminin complex(GO:0043256) |
| 0.3 | 3.9 | GO:1990246 | uniplex complex(GO:1990246) |
| 0.9 | 3.7 | GO:0070195 | growth hormone receptor complex(GO:0070195) |
| 0.0 | 3.7 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 3.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.6 | 2.6 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 0.2 | 2.5 | GO:0097431 | mitotic spindle pole(GO:0097431) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 61.2 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 2.9 | 14.5 | GO:0043140 | ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518) |
| 0.9 | 7.2 | GO:0004067 | asparaginase activity(GO:0004067) |
| 0.5 | 6.4 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 6.2 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 5.1 | GO:0019901 | protein kinase binding(GO:0019901) |
| 0.0 | 4.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 4.2 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.0 | 4.0 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.9 | 3.7 | GO:0004903 | growth hormone receptor activity(GO:0004903) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 3.5 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 3.4 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 2.1 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.2 | 1.8 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 1.6 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.4 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 1.2 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.0 | 1.0 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 0.9 | PID CONE PATHWAY | Visual signal transduction: Cones |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 14.4 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.1 | 6.5 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 4.9 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 3.5 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 3.4 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.2 | 2.7 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.3 | 2.6 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 2.5 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 2.5 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 2.4 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |