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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for atf4a+atf4b

Z-value: 0.59

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Transcription factors associated with atf4a+atf4b

Gene Symbol Gene ID Gene Info
atf4b
ENSDARG00000038141 activating transcription factor 4b
atf4a
ENSDARG00000111939 activating transcription factor 4a
atf4b
ENSDARG00000114163 activating transcription factor 4b
atf4b
ENSDARG00000114542 activating transcription factor 4b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
atf4bdr11_v1_chr3_+_24197934_24197934-0.223.8e-01Click!
atf4adr11_v1_chr6_+_269204_2692040.145.8e-01Click!

Activity profile of atf4a+atf4b motif

Sorted Z-values of atf4a+atf4b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr24_-_26854032 1.55 ENSDART00000087991
fndc3bb
fibronectin type III domain containing 3Bb
chr20_+_28266892 1.43 ENSDART00000103330
chac1
ChaC, cation transport regulator homolog 1 (E. coli)
chr7_-_30272871 1.21 ENSDART00000099586
zgc:162945
zgc:162945
chr11_+_45287541 0.88 ENSDART00000165321
ENSDART00000173116
pycr1b
pyrroline-5-carboxylate reductase 1b
chr18_+_17600570 0.88 ENSDART00000175258
ENSDART00000151850
ENSDART00000151934
herpud1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr7_+_38090515 0.88 ENSDART00000131387
cebpg
CCAAT/enhancer binding protein (C/EBP), gamma
chr9_-_48214216 0.88 ENSDART00000012938
phgdh
phosphoglycerate dehydrogenase
chr12_+_30788912 0.84 ENSDART00000160422
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr12_+_17154655 0.79 ENSDART00000028003
ankrd22
ankyrin repeat domain 22
chr12_+_30789611 0.78 ENSDART00000181501
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr12_-_13205572 0.77 ENSDART00000152670
pelo
pelota mRNA surveillance and ribosome rescue factor
chr3_+_13879446 0.74 ENSDART00000164767
farsa
phenylalanyl-tRNA synthetase, alpha subunit
chr3_+_25907266 0.72 ENSDART00000170324
ENSDART00000192633
tom1
target of myb1 membrane trafficking protein
chr18_-_18667416 0.66 ENSDART00000100401
ENSDART00000136544
aars
alanyl-tRNA synthetase
chr5_+_57658898 0.63 ENSDART00000074268
ENSDART00000124568
zgc:153929
zgc:153929
chr12_-_13205854 0.62 ENSDART00000077829
pelo
pelota mRNA surveillance and ribosome rescue factor
chr19_-_8812891 0.61 ENSDART00000151134
ENSDART00000025385
ENSDART00000180291
cers2a
ceramide synthase 2a
chr14_-_38809561 0.59 ENSDART00000159159
sil1
SIL1 nucleotide exchange factor
chr24_+_16983269 0.57 ENSDART00000139176
ENSDART00000023833
eif2s3
eukaryotic translation initiation factor 2, subunit 3 gamma
chr8_-_46386024 0.56 ENSDART00000136602
ENSDART00000060919
ENSDART00000137472
qars
glutaminyl-tRNA synthetase
chr24_-_38644937 0.46 ENSDART00000170194
slc6a16b
solute carrier family 6, member 16b
chr9_+_747612 0.46 ENSDART00000181004
insig2
insulin induced gene 2
chr6_-_26895750 0.45 ENSDART00000011863
hdlbpa
high density lipoprotein binding protein a
chr13_-_9300299 0.45 ENSDART00000144142
HTRA2 (1 of many)
si:dkey-33c12.12
chr13_-_25408387 0.44 ENSDART00000002741
itprip
inositol 1,4,5-trisphosphate receptor interacting protein
chr20_+_37794633 0.43 ENSDART00000022060
atf3
activating transcription factor 3
chr5_-_69499486 0.43 ENSDART00000023983
ENSDART00000180293
psat1
phosphoserine aminotransferase 1
chr2_-_58257624 0.42 ENSDART00000098940
foxl2b
forkhead box L2b
chr24_+_20536056 0.39 ENSDART00000082082
gars
glycyl-tRNA synthetase
chr7_-_16034324 0.39 ENSDART00000002498
ENSDART00000162962
elp4
elongator acetyltransferase complex subunit 4
chr13_-_25548733 0.37 ENSDART00000168099
ENSDART00000135788
ENSDART00000077655
mcmbp
minichromosome maintenance complex binding protein
chr23_-_29394505 0.37 ENSDART00000017728
pgd
phosphogluconate dehydrogenase
chr23_+_35504824 0.36 ENSDART00000082647
ENSDART00000159218
acp1
acid phosphatase 1
chr2_-_32486080 0.36 ENSDART00000110821
ttc19
tetratricopeptide repeat domain 19
chr23_+_43718115 0.35 ENSDART00000149266
ENSDART00000149503
anapc10
anaphase promoting complex subunit 10
chr12_-_35386910 0.35 ENSDART00000153453
camk2g1
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1
chr20_-_14680897 0.34 ENSDART00000063857
ENSDART00000161314
scrn2
secernin 2
chr10_-_8672820 0.32 ENSDART00000080763
si:dkey-27b3.2
si:dkey-27b3.2
chr21_-_36948 0.31 ENSDART00000181230
JMY
junction mediating and regulatory protein, p53 cofactor
chr3_+_33440615 0.30 ENSDART00000146005
gtpbp1
GTP binding protein 1
chr21_-_11646878 0.30 ENSDART00000162426
ENSDART00000135937
ENSDART00000131448
ENSDART00000148097
ENSDART00000133443
cast
calpastatin
chr20_-_19532531 0.30 ENSDART00000125830
ENSDART00000179566
ENSDART00000184193
eif2b4
BX276101.2
eukaryotic translation initiation factor 2B, subunit 4 delta

chr7_+_16033923 0.29 ENSDART00000161669
ENSDART00000114062
immp1l
inner mitochondrial membrane peptidase subunit 1
chr14_+_30557361 0.28 ENSDART00000019898
mrpl11
mitochondrial ribosomal protein L11
chr20_+_18992679 0.28 ENSDART00000147105
ENSDART00000152811
tdh
L-threonine dehydrogenase
chr6_-_9707599 0.27 ENSDART00000039280
fzd7b
frizzled class receptor 7b
chr13_-_25774183 0.27 ENSDART00000046981
pdlim1
PDZ and LIM domain 1 (elfin)
chr3_+_15394428 0.27 ENSDART00000133168
atxn2l
ataxin 2-like
chr23_-_36441693 0.26 ENSDART00000024354
csad
cysteine sulfinic acid decarboxylase
chr3_+_32868092 0.25 ENSDART00000137668
zgc:162613
zgc:162613
chr23_-_43718067 0.24 ENSDART00000015777
abce1
ATP-binding cassette, sub-family E (OABP), member 1
chr3_+_15505275 0.24 ENSDART00000141714
nupr1
nuclear protein 1
chr15_-_2754056 0.24 ENSDART00000129380
ppp5c
protein phosphatase 5, catalytic subunit
chr12_-_17602958 0.23 ENSDART00000134690
ENSDART00000028090
eif2ak1
eukaryotic translation initiation factor 2-alpha kinase 1
chr12_-_48374728 0.23 ENSDART00000153403
ENSDART00000188117
dnajb12b
DnaJ (Hsp40) homolog, subfamily B, member 12b
chr15_-_24960730 0.22 ENSDART00000109990
ENSDART00000186706
abhd15a
abhydrolase domain containing 15a
chr13_+_21600946 0.22 ENSDART00000144045
sh2d4ba
SH2 domain containing 4Ba
chr4_+_25607101 0.22 ENSDART00000133929
acot14
acyl-CoA thioesterase 14
chr15_-_7337148 0.21 ENSDART00000182568
SLC7A1 (1 of many)
high affinity cationic amino acid transporter 1
chr19_+_43341115 0.20 ENSDART00000145846
ENSDART00000102384
sesn2
sestrin 2
chr19_+_43341424 0.20 ENSDART00000134815
sesn2
sestrin 2
chr6_-_34220641 0.20 ENSDART00000102391
dmrt2b
doublesex and mab-3 related transcription factor 2b
chr20_+_28803977 0.20 ENSDART00000153351
ENSDART00000038149
fntb
farnesyltransferase, CAAX box, beta
chr5_-_35200590 0.20 ENSDART00000051271
fcho2
FCH domain only 2
chr16_-_42770064 0.19 ENSDART00000112879
slc4a7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr8_+_42917515 0.19 ENSDART00000021715
slc23a2
solute carrier family 23 (ascorbic acid transporter), member 2
chr6_+_28428329 0.19 ENSDART00000188056
lpp
LIM domain containing preferred translocation partner in lipoma
chr7_-_32981559 0.18 ENSDART00000175614
pkp3b
plakophilin 3b
chr25_-_6049339 0.18 ENSDART00000075184
snx1a
sorting nexin 1a
chr7_-_31830936 0.18 ENSDART00000052514
ENSDART00000129720
cars
cysteinyl-tRNA synthetase
chr9_-_46415847 0.18 ENSDART00000009790
cx43.4
connexin 43.4
chr20_+_21583639 0.18 ENSDART00000131069
esr2a
estrogen receptor 2a
chr8_-_31384607 0.18 ENSDART00000164134
ENSDART00000024872
creb3l3l
cAMP responsive element binding protein 3-like 3 like
chr12_-_32066469 0.17 ENSDART00000140685
ENSDART00000062185
rab40b
RAB40B, member RAS oncogene family
chr4_+_25607743 0.17 ENSDART00000028297
acot14
acyl-CoA thioesterase 14
chr2_+_44348473 0.17 ENSDART00000155166
ENSDART00000098146
zgc:152670
zgc:152670
chr21_+_944715 0.16 ENSDART00000144766
nars
asparaginyl-tRNA synthetase
chr19_+_30885258 0.16 ENSDART00000143394
yars
tyrosyl-tRNA synthetase
chr14_-_7306983 0.16 ENSDART00000158914
si:ch211-51f19.1
si:ch211-51f19.1
chr25_-_21894706 0.16 ENSDART00000189158
fbxo31
F-box protein 31
chr5_-_57528943 0.16 ENSDART00000130320
pisd
phosphatidylserine decarboxylase
chr17_-_50220228 0.15 ENSDART00000058707
jdp2a
Jun dimerization protein 2a
chr17_-_42799104 0.15 ENSDART00000154755
prkd3
protein kinase D3
chr18_-_21047007 0.15 ENSDART00000162702
igf1ra
insulin-like growth factor 1a receptor
chr6_+_23809501 0.15 ENSDART00000168701
glulb
glutamate-ammonia ligase (glutamine synthase) b
chr15_+_20543770 0.14 ENSDART00000092357
sgsm2
small G protein signaling modulator 2
chr9_+_24088062 0.13 ENSDART00000126198
lrrfip1a
leucine rich repeat (in FLII) interacting protein 1a
chr23_+_32101361 0.13 ENSDART00000138849
zgc:56699
zgc:56699
chr19_+_30884960 0.13 ENSDART00000140603
ENSDART00000183224
ENSDART00000135484
ENSDART00000139599
yars
tyrosyl-tRNA synthetase
chr16_+_10429770 0.13 ENSDART00000173132
vars
valyl-tRNA synthetase
chr15_+_45994123 0.13 ENSDART00000124704
lrfn1
leucine rich repeat and fibronectin type III domain containing 1
chr12_+_13205955 0.13 ENSDART00000092906
ppp1cab
protein phosphatase 1, catalytic subunit, alpha isozyme b
chr19_+_30884706 0.12 ENSDART00000052126
yars
tyrosyl-tRNA synthetase
chr15_+_24737599 0.12 ENSDART00000078024
crk
v-crk avian sarcoma virus CT10 oncogene homolog
chr19_-_30447611 0.12 ENSDART00000073705
ENSDART00000048977
ENSDART00000191237
abcf1
ATP-binding cassette, sub-family F (GCN20), member 1
chr2_-_59247811 0.12 ENSDART00000141384
ftr32
finTRIM family, member 32
chr15_-_23908605 0.11 ENSDART00000185578
usp32
ubiquitin specific peptidase 32
chr17_-_45552602 0.11 ENSDART00000154844
ENSDART00000034432
susd4
sushi domain containing 4
chr6_-_58975010 0.11 ENSDART00000144911
ENSDART00000144514
mars
methionyl-tRNA synthetase
chr21_+_21374277 0.11 ENSDART00000079431
rtn2b
reticulon 2b
chr6_+_10871659 0.11 ENSDART00000041858
mtx2
metaxin 2
chr3_-_30152836 0.10 ENSDART00000165920
nucb1
nucleobindin 1
chr24_-_14576812 0.10 ENSDART00000140624
pabpn1
poly(A) binding protein, nuclear 1
chr13_+_21601149 0.10 ENSDART00000179369
sh2d4ba
SH2 domain containing 4Ba
chr16_+_33143503 0.10 ENSDART00000058471
ENSDART00000179385
rhbdl2
rhomboid, veinlet-like 2 (Drosophila)
chr3_-_30153242 0.09 ENSDART00000077089
nucb1
nucleobindin 1
chr5_-_55395384 0.09 ENSDART00000147298
ENSDART00000082577
prune2
prune homolog 2 (Drosophila)
chr18_+_26719787 0.09 ENSDART00000141672
alpk3a
alpha-kinase 3a
chr18_-_16922905 0.09 ENSDART00000187165
wee1
WEE1 G2 checkpoint kinase
chr19_-_3876877 0.09 ENSDART00000163711
thrap3b
thyroid hormone receptor associated protein 3b
chr13_+_4225173 0.09 ENSDART00000058242
ENSDART00000143456
mea1
male-enhanced antigen 1
chr15_-_5780593 0.09 ENSDART00000163555
ENSDART00000082388
chchd2
coiled-coil-helix-coiled-coil-helix domain containing 2
chr8_-_43923788 0.08 ENSDART00000146152
adgrd1
adhesion G protein-coupled receptor D1
chr23_-_9855627 0.08 ENSDART00000180159
prkcbp1l
protein kinase C binding protein 1, like
chr15_-_24869826 0.08 ENSDART00000127047
tusc5a
tumor suppressor candidate 5a
chr2_-_20890429 0.08 ENSDART00000149989
pdca
phosducin a
chr15_-_23908779 0.08 ENSDART00000088808
usp32
ubiquitin specific peptidase 32
chr14_-_26465729 0.08 ENSDART00000143454
syvn1
synovial apoptosis inhibitor 1, synoviolin
chr20_-_38746889 0.08 ENSDART00000140275
trim54
tripartite motif containing 54
chr15_-_42283830 0.07 ENSDART00000015979
farsb
phenylalanyl-tRNA synthetase, beta subunit
chr14_+_7892021 0.07 ENSDART00000161307
ube2d2
ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
chr23_-_20345473 0.07 ENSDART00000140935
si:rp71-17i16.6
si:rp71-17i16.6
chr22_+_25931782 0.07 ENSDART00000157842
dnaja3b
DnaJ (Hsp40) homolog, subfamily A, member 3B
chr5_-_43935119 0.07 ENSDART00000142271
si:ch211-204c21.1
si:ch211-204c21.1
chr15_-_33495048 0.07 ENSDART00000159882
stard13b
StAR-related lipid transfer (START) domain containing 13b
chr8_+_54202554 0.07 ENSDART00000020569
creld1b
cysteine-rich with EGF-like domains 1b
chr2_-_28671139 0.07 ENSDART00000165272
ENSDART00000164657
dhcr7
7-dehydrocholesterol reductase
chr23_-_26227805 0.07 ENSDART00000158082
BX927204.1

chr6_+_39279831 0.06 ENSDART00000155088
ankrd33ab
ankyrin repeat domain 33Ab
chr3_+_25191467 0.06 ENSDART00000156956
ENSDART00000154799
il2rb
interleukin 2 receptor, beta
chr21_-_30467900 0.06 ENSDART00000078949
ENSDART00000078953
afap1l1b
actin filament associated protein 1-like 1b
chr16_-_31351419 0.06 ENSDART00000178298
ENSDART00000018091
mroh1
maestro heat-like repeat family member 1
chr20_-_18915376 0.06 ENSDART00000063725
xkr6b
XK, Kell blood group complex subunit-related family, member 6b
chr7_+_49862837 0.05 ENSDART00000174315
slc1a2a
solute carrier family 1 (glial high affinity glutamate transporter), member 2a
chr11_-_26666501 0.05 ENSDART00000188067
ENSDART00000111539
efcc1
EF-hand and coiled-coil domain containing 1
chr12_+_6065661 0.05 ENSDART00000142418
sgms1
sphingomyelin synthase 1
chr23_-_26228077 0.05 ENSDART00000162423
BX927204.1

chr1_-_11519934 0.05 ENSDART00000162060
sdk1b
sidekick cell adhesion molecule 1b
chr21_-_43949208 0.05 ENSDART00000150983
camk2a
calcium/calmodulin-dependent protein kinase II alpha
chr23_-_12014931 0.05 ENSDART00000134652
si:dkey-178k16.1
si:dkey-178k16.1
chr18_-_2727764 0.04 ENSDART00000160841
ARHGEF17
si:ch211-248g20.5
chr22_-_20720427 0.04 ENSDART00000105532
oaz1a
ornithine decarboxylase antizyme 1a
chr6_-_25201810 0.04 ENSDART00000168683
lrrc8c
leucine rich repeat containing 8 VRAC subunit C
chr24_-_39771667 0.04 ENSDART00000181867
GFOD1
si:ch211-276f18.2
chr22_+_18469004 0.04 ENSDART00000061430
cilp2
cartilage intermediate layer protein 2
chr1_-_19237576 0.03 ENSDART00000143663
ENSDART00000131579
ptprdb
protein tyrosine phosphatase, receptor type, D, b
chr23_-_27345425 0.03 ENSDART00000022042
ENSDART00000191870
scn8aa
sodium channel, voltage gated, type VIII, alpha subunit a
chr3_-_3297913 0.03 ENSDART00000186350
AL953907.2

chr4_+_8797197 0.03 ENSDART00000158671
sult4a1
sulfotransferase family 4A, member 1
chr5_+_13243446 0.03 ENSDART00000186140
CR933528.1

chr3_-_40284744 0.02 ENSDART00000018626
pdap1b
pdgfa associated protein 1b
chr2_+_1001560 0.02 ENSDART00000134656
cacna1eb
calcium channel, voltage-dependent, R type, alpha 1E subunit b
chr2_-_37059966 0.02 ENSDART00000137967
diras1b
DIRAS family, GTP-binding RAS-like 1b
chr5_-_32323136 0.02 ENSDART00000110804
hspb15
heat shock protein, alpha-crystallin-related, b15
chr15_-_31406093 0.02 ENSDART00000123444
or111-8
odorant receptor, family D, subfamily 111, member 8
chr25_+_26923193 0.02 ENSDART00000187364
grm8b
glutamate receptor, metabotropic 8b
chr2_+_21000334 0.02 ENSDART00000062563
ENSDART00000147809
rreb1b
ras responsive element binding protein 1b
chr7_-_52842605 0.02 ENSDART00000083002
map1aa
microtubule-associated protein 1Aa
chr16_+_25245857 0.02 ENSDART00000155220
klhl38b
kelch-like family member 38b
chr4_+_20545448 0.01 ENSDART00000189006
BX248410.3

chr19_-_9712530 0.01 ENSDART00000134816
slc2a3a
solute carrier family 2 (facilitated glucose transporter), member 3a
chr25_+_32473433 0.01 ENSDART00000152326
sqor
sulfide quinone oxidoreductase
chr22_+_30631072 0.01 ENSDART00000059970
zmp:0000000606
zmp:0000000606
chr16_-_20006270 0.01 ENSDART00000079155
hdac9b
histone deacetylase 9b
chr22_-_24284447 0.01 ENSDART00000149894
si:ch211-117l17.4
si:ch211-117l17.4
chr12_-_26423439 0.00 ENSDART00000113978
synpo2lb
synaptopodin 2-like b
chr2_-_36932253 0.00 ENSDART00000124217
map1sb
microtubule-associated protein 1Sb
chr9_+_2574122 0.00 ENSDART00000166326
ENSDART00000191822
CIR1
si:ch73-167c12.2

Network of associatons between targets according to the STRING database.

First level regulatory network of atf4a+atf4b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.3 1.4 GO:0032790 ribosome disassembly(GO:0032790)
0.3 0.9 GO:1903069 regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903069)
0.3 0.8 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.2 1.7 GO:0006561 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.2 1.8 GO:1903318 negative regulation of protein processing(GO:0010955) negative regulation of protein maturation(GO:1903318)
0.2 0.5 GO:0036316 response to sterol(GO:0036314) cellular response to sterol(GO:0036315) SREBP-SCAP complex retention in endoplasmic reticulum(GO:0036316) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 0.6 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.1 0.4 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 0.2 GO:0015882 L-ascorbic acid transport(GO:0015882) L-ascorbic acid metabolic process(GO:0019852)
0.1 0.4 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 0.4 GO:0071233 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.0 0.2 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.3 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.3 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.3 GO:0006567 threonine metabolic process(GO:0006566) threonine catabolic process(GO:0006567)
0.0 0.4 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.0 0.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.1 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.1 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 0.1 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.0 0.2 GO:0030520 intracellular estrogen receptor signaling pathway(GO:0030520) cellular response to estradiol stimulus(GO:0071392)
0.0 0.4 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.2 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.2 GO:0071428 ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753) rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0 0.4 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 0.7 GO:0046513 ceramide biosynthetic process(GO:0046513)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.6 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.3 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.2 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.4 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.4 GO:0042555 MCM complex(GO:0042555)
0.0 0.2 GO:0030904 retromer complex(GO:0030904)
0.0 0.4 GO:0005844 polysome(GO:0005844)
0.0 0.1 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.1 GO:0000835 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.3 1.6 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.2 0.8 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.2 0.9 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 0.4 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 0.3 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.1 0.4 GO:0070728 leucine binding(GO:0070728)
0.1 0.3 GO:0008743 L-threonine 3-dehydrogenase activity(GO:0008743)
0.0 0.2 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.0 0.3 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 0.3 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.6 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.2 GO:0034338 short-chain carboxylesterase activity(GO:0034338)
0.0 0.2 GO:1903924 estradiol binding(GO:1903924)
0.0 0.1 GO:0005009 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.0 0.1 GO:0016880 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.2 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.4 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 0.9 GO:0044325 ion channel binding(GO:0044325)
0.0 0.2 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 0.3 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0 0.6 GO:0000049 tRNA binding(GO:0000049)
0.0 0.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.9 GO:0051287 NAD binding(GO:0051287)
0.0 0.0 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.4 GO:0050661 NADP binding(GO:0050661)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.1 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 3.2 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.1 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.4 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.0 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.1 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex