ISMARA results: creb1a+creb1b+crema+cremb

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for creb1a+creb1b+crema+cremb

Z-value: 2.06

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Transcription factors associated with creb1a+creb1b+crema+cremb

Gene Symbol	Gene ID	Gene Info
crema NCBI UniProt	ENSDARG00000023217	cAMP responsive element modulator a
creb1a NCBI UniProt	ENSDARG00000053586	cAMP responsive element binding protein 1a
creb1b NCBI UniProt	ENSDARG00000093420	cAMP responsive element binding protein 1b
cremb NCBI UniProt	ENSDARG00000102899	cAMP responsive element modulator b
cremb NCBI UniProt	ENSDARG00000109505	cAMP responsive element modulator b
cremb NCBI UniProt	ENSDARG00000116064	cAMP responsive element modulator b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
crema	dr11_v1_chr2_-_43196595_43196595	-0.90	4.6e-07	Click!
creb1b	dr11_v1_chr9_-_28275600_28275600	-0.64	4.3e-03	Click!
cremb	dr11_v1_chr24_+_31348595_31348735	-0.46	5.4e-02	Click!
creb1a	dr11_v1_chr1_-_33557915_33557915	-0.34	1.7e-01	Click!

Activity profile of creb1a+creb1b+crema+cremb motif

Sorted Z-values of creb1a+creb1b+crema+cremb motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_-_26985231 Show fit	3.41	ENSDART00000050585	znhit2 NCBI UniProt Show fit	zinc finger, HIT-type containing 2
chr4_+_73651053 Show fit	2.98	ENSDART00000150532 ENSDART00000172536	znf989 NCBI UniProt Show fit	zinc finger protein 989
chr11_-_11331052 Show fit	2.96	ENSDART00000081765 ENSDART00000160247	mrpl4 NCBI UniProt Show fit	mitochondrial ribosomal protein L4
chr13_-_36141486 Show fit	2.93	ENSDART00000044115	med6 NCBI UniProt Show fit	mediator complex subunit 6
chr12_-_25201576 Show fit	2.90	ENSDART00000077188	cox7a3 NCBI UniProt Show fit	cytochrome c oxidase subunit VIIa polypeptide 3
chr18_+_5850837 Show fit	2.80	ENSDART00000013150	cog8 NCBI UniProt Show fit	component of oligomeric golgi complex 8
chr17_-_13007484 Show fit	2.62	ENSDART00000156812	si:dkeyp-33b5.4 NCBI UniProt Show fit	si:dkeyp-33b5.4
chr10_-_9346360 Show fit	2.46	ENSDART00000039536	mrrf NCBI UniProt Show fit	mitochondrial ribosome recycling factor
chr1_-_53714885 Show fit	2.41	ENSDART00000026409	cct4 NCBI UniProt Show fit	chaperonin containing TCP1, subunit 4 (delta)
chr1_+_16073887 Show fit	2.38	ENSDART00000160270	tusc3 NCBI UniProt Show fit	tumor suppressor candidate 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of creb1a+creb1b+crema+cremb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.6	GO:0006457	protein folding(GO:0006457)
0.0	6.5	GO:0006364	rRNA processing(GO:0006364)
0.0	6.3	GO:0006412	translation(GO:0006412)
0.3	4.8	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.3	3.0	GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.1	2.9	GO:0008535	respiratory chain complex IV assembly(GO:0008535)
0.1	2.8	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
0.1	2.4	GO:0016926	protein desumoylation(GO:0016926)
0.1	2.4	GO:0015693	magnesium ion transport(GO:0015693)
0.8	2.3	GO:0000472	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)

Showing 1 to 10 of 63 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.2	GO:0005730	nucleolus(GO:0005730)
0.5	5.5	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.1	4.5	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.6	3.0	GO:0055087	Ski complex(GO:0055087)
0.4	2.9	GO:0070847	core mediator complex(GO:0070847)
0.0	2.9	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.2	2.8	GO:0017119	Golgi transport complex(GO:0017119)
0.2	2.4	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.2	2.4	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.1	2.3	GO:0030686	90S preribosome(GO:0030686)

Showing 1 to 10 of 42 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.8	GO:0003735	structural constituent of ribosome(GO:0003735)
1.1	4.5	GO:0034511	U3 snoRNA binding(GO:0034511)
0.0	3.8	GO:0051082	unfolded protein binding(GO:0051082)
0.6	3.6	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.0	2.5	GO:0003713	transcription coactivator activity(GO:0003713)
0.1	2.4	GO:0016929	SUMO-specific protease activity(GO:0016929)
0.0	2.3	GO:0008080	N-acetyltransferase activity(GO:0008080)
0.1	2.2	GO:0009982	pseudouridine synthase activity(GO:0009982)
0.2	2.0	GO:0033170	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	2.0	GO:0043021	ribonucleoprotein complex binding(GO:0043021)

Showing 1 to 10 of 49 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.3	PID ATR PATHWAY	ATR signaling pathway
0.0	1.2	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.0	1.2	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.0	0.8	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	0.4	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	0.3	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network

Showing 1 to 6 of 6 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.8	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1	2.4	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.2	1.8	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1	1.8	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	1.8	REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	Genes involved in Activation of ATR in response to replication stress
0.0	1.7	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.1	1.5	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.1	1.4	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0	1.3	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	1.3	REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C	Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C

Showing 1 to 10 of 19 entries

Results for creb1a+creb1b+crema+cremb

Z-value: 2.06

Motif logo

Transcription factors associated with creb1a+creb1b+crema+cremb

Activity-expression correlation:

Activity profile of creb1a+creb1b+crema+cremb motif

Sorted Z-values of creb1a+creb1b+crema+cremb motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of creb1a+creb1b+crema+cremb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: