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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for dlx3b

Z-value: 0.41

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Transcription factors associated with dlx3b

Gene Symbol Gene ID Gene Info
ENSDARG00000014626 distal-less homeobox 3b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
dlx3bdr11_v1_chr12_+_5708400_57084000.663.0e-03Click!

Activity profile of dlx3b motif

Sorted Z-values of dlx3b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_25777425 1.82 ENSDART00000021620
claudin d
chr24_-_17029374 0.90 ENSDART00000039267
prostaglandin D2 synthase b, tandem duplicate 1
chr11_-_44801968 0.85 ENSDART00000161846
microtubule-associated protein 1 light chain 3 gamma
chr4_+_13586689 0.79 ENSDART00000067161
ENSDART00000138201
transportin 3
chr5_+_26213874 0.76 ENSDART00000193816
ENSDART00000098514
occludin b
chr16_+_39159752 0.76 ENSDART00000122081
syntabulin (syntaxin-interacting)
chr24_-_17023392 0.75 ENSDART00000106058
prostaglandin D2 synthase b, tandem duplicate 2
chr3_-_26183699 0.72 ENSDART00000147517
ENSDART00000140731
si:ch211-11k18.4
chr15_-_33172246 0.72 ENSDART00000158666
neurobeachin b
chr12_-_35386910 0.66 ENSDART00000153453
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1
chr11_-_39118882 0.59 ENSDART00000113185
ENSDART00000156526
adaptor-related protein complex 5, beta 1 subunit
chr10_-_21362071 0.54 ENSDART00000125167
avidin
chr19_+_20793237 0.52 ENSDART00000014774
thioredoxin-like 4A
chr17_+_16046314 0.52 ENSDART00000154554
ENSDART00000154338
ENSDART00000155336
si:ch73-204p21.2
chr19_+_20793388 0.50 ENSDART00000142463
thioredoxin-like 4A
chr10_-_21362320 0.50 ENSDART00000189789
avidin
chr6_-_40713183 0.48 ENSDART00000157113
ENSDART00000154810
ENSDART00000153702
si:ch211-157b11.12
chr19_+_46158078 0.47 ENSDART00000183933
ENSDART00000164055
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr17_-_15546862 0.43 ENSDART00000091021
collagen, type X, alpha 1a
chr4_+_13586455 0.43 ENSDART00000187230
transportin 3
chr12_-_18577983 0.41 ENSDART00000193262
zinc finger, DHHC-type containing 4
chr17_+_16046132 0.41 ENSDART00000155005
si:ch73-204p21.2
chr2_-_15324837 0.40 ENSDART00000015655
trans-2,3-enoyl-CoA reductase-like 2b
chr8_-_15129573 0.40 ENSDART00000142358
BCAR3, NSP family adaptor protein
chr8_-_23780334 0.40 ENSDART00000145179
ENSDART00000145894
zgc:195245
chr2_+_2168547 0.38 ENSDART00000029347
HIG1 hypoxia inducible domain family, member 1A
chr5_+_59234421 0.37 ENSDART00000045518
PRKR interacting protein 1
chr4_+_9177997 0.36 ENSDART00000057254
ENSDART00000154614
nuclear transcription factor Y, beta a
chr11_-_40147032 0.35 ENSDART00000052918
si:dkey-264d12.4
chr19_-_19871211 0.35 ENSDART00000170980
even-skipped homeobox 1
chr8_+_28452738 0.35 ENSDART00000062706
transmembrane protein 189
chr13_+_38814521 0.32 ENSDART00000110976
collagen, type XIX, alpha 1
chr22_-_14262115 0.31 ENSDART00000168264
si:ch211-246m6.5
chr11_+_31864921 0.30 ENSDART00000180252
diaphanous-related formin 3
chr11_+_18873619 0.29 ENSDART00000176141
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr8_-_39822917 0.29 ENSDART00000067843
zgc:162025
chr17_+_49500820 0.29 ENSDART00000170306
apoptosis resistant E3 ubiquitin protein ligase 1
chr25_+_28555584 0.29 ENSDART00000157046
si:ch211-190o6.3
chr16_-_13623659 0.29 ENSDART00000168978
si:dkeyp-69b9.6
chr23_-_18130264 0.28 ENSDART00000016976
nuclear casein kinase and cyclin-dependent kinase substrate 1b
chrM_+_9052 0.28 ENSDART00000093612
ATP synthase 6, mitochondrial
chr24_-_25004553 0.27 ENSDART00000080997
ENSDART00000136860
zinc finger, DHHC-type containing 20b
chr19_-_8768564 0.27 ENSDART00000170416
si:ch73-350k19.1
chr6_-_50203682 0.26 ENSDART00000083999
ENSDART00000143050
RALY heterogeneous nuclear ribonucleoprotein
chr3_+_32832538 0.26 ENSDART00000139410
CD2 (cytoplasmic tail) binding protein 2
chr15_-_18115540 0.26 ENSDART00000131639
ENSDART00000047902
archain 1b
chr22_-_3564563 0.26 ENSDART00000145114
protein tyrosine phosphatase, receptor type, s, a
chr2_-_28671139 0.26 ENSDART00000165272
ENSDART00000164657
7-dehydrocholesterol reductase
chr19_-_20403845 0.25 ENSDART00000151265
ENSDART00000147911
ENSDART00000151356
deleted in azoospermia-like
chr15_-_9272328 0.25 ENSDART00000172114
calmodulin 2a (phosphorylase kinase, delta)
chr8_-_23776399 0.25 ENSDART00000114800
si:ch211-163l21.4
chr20_+_28803977 0.25 ENSDART00000153351
ENSDART00000038149
farnesyltransferase, CAAX box, beta
chr3_-_21280373 0.24 ENSDART00000003939
synaptogyrin 1a
chr16_-_21620947 0.24 ENSDART00000115011
ENSDART00000183125
ENSDART00000188856
ENSDART00000189460
discoidin domain receptor tyrosine kinase 1
chr7_-_69298271 0.23 ENSDART00000122935
PH domain and leucine rich repeat protein phosphatase 2
chr8_-_5847533 0.23 ENSDART00000192489

chr13_+_38817871 0.23 ENSDART00000187708
collagen, type XIX, alpha 1
chr1_+_37752171 0.22 ENSDART00000183247
ENSDART00000189756
ENSDART00000139448
si:ch211-15e22.3
chr14_-_32631013 0.22 ENSDART00000176815
ATPase phospholipid transporting 11C
chr18_+_41232719 0.22 ENSDART00000138552
ENSDART00000145863
thyroid hormone receptor interactor 12
chr5_+_22067570 0.22 ENSDART00000045574
shisa family member 2a
chr10_-_2971407 0.21 ENSDART00000132526
MARVEL domain containing 2a
chr23_-_20051369 0.21 ENSDART00000049836
biglycan b
chr4_+_14727018 0.21 ENSDART00000124189
cytidine monophosphate N-acetylneuraminic acid synthetase a
chr16_-_13623928 0.21 ENSDART00000164344
si:dkeyp-69b9.6
chr24_+_1023839 0.20 ENSDART00000082526
zgc:111976
chr14_+_23717165 0.19 ENSDART00000006373
Nedd4 family interacting protein 1
chr10_+_29199172 0.19 ENSDART00000148828
phosphatidylinositol binding clathrin assembly protein a
chr25_+_10410620 0.19 ENSDART00000151886
ets homologous factor
chr2_-_32826108 0.19 ENSDART00000098834
pre-mRNA processing factor 4Ba
chr25_-_32869794 0.19 ENSDART00000162784
transmembrane protein 266
chr21_-_26490186 0.18 ENSDART00000009889
zgc:110540
chr19_-_32914227 0.18 ENSDART00000186115
ENSDART00000124246
metadherin a
chr23_-_7799184 0.18 ENSDART00000190946
ENSDART00000165427
myelin transcription factor 1b
chr4_+_14727212 0.18 ENSDART00000158094
cytidine monophosphate N-acetylneuraminic acid synthetase a
chr8_-_31107537 0.18 ENSDART00000098925
vestigial like 4 like
chr16_-_29194517 0.17 ENSDART00000046114
ENSDART00000148899
myocyte enhancer factor 2d
chr18_+_1837668 0.17 ENSDART00000164210

chr13_+_31205439 0.15 ENSDART00000132326
protein tyrosine phosphatase, non-receptor type 20
chr12_+_22580579 0.15 ENSDART00000171725
ENSDART00000192290
capping protein (actin filament), gelsolin-like b
chr5_+_63857055 0.13 ENSDART00000138950
regulator of G protein signaling 3b
chr11_-_29768054 0.12 ENSDART00000079117
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3
chr5_+_27525477 0.12 ENSDART00000051491
secreted frizzled-related protein 1a
chr11_+_18873113 0.11 ENSDART00000103969
ENSDART00000103968
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr23_+_30835589 0.10 ENSDART00000154145
neuropeptides B/W receptor 2a
chr7_-_12464412 0.09 ENSDART00000178723
ADAMTS-like 3
chr25_+_6471401 0.09 ENSDART00000132927
sorting nexin 33
chr12_+_25432627 0.09 ENSDART00000011662
protein phosphatase, Mg2+/Mn2+ dependent, 1Bb
chr19_-_38830582 0.08 ENSDART00000189966
ENSDART00000183055
adhesion G protein-coupled receptor B2
chr15_-_755023 0.08 ENSDART00000155594
zinc finger protein 1011
chr4_+_3980247 0.08 ENSDART00000049194
G protein-coupled receptor 37b
chr9_-_35633827 0.07 ENSDART00000077745
zona pellucida glycoprotein 2, like 1
chr16_-_22930925 0.07 ENSDART00000133819
si:dkey-246i14.3
chr2_-_26720854 0.07 ENSDART00000148110
si:dkey-181m9.8
chr9_-_3934963 0.06 ENSDART00000062336
ubiquitin protein ligase E3 component n-recognin 3
chr20_+_13783040 0.06 ENSDART00000115329
ENSDART00000152497
lysophosphatidylglycerol acyltransferase 1
chr22_-_24284447 0.06 ENSDART00000149894
si:ch211-117l17.4
chr14_-_7207961 0.06 ENSDART00000167994
ENSDART00000166532
storkhead box 2b
chr19_-_32641725 0.06 ENSDART00000165006
ENSDART00000188185
hippocalcin
chr24_+_36452927 0.05 ENSDART00000168181
zgc:114120
chr18_-_37007294 0.05 ENSDART00000088309
mitogen-activated protein kinase kinase kinase 10
chr18_-_19095141 0.05 ENSDART00000090962
ENSDART00000090922
DENN/MADD domain containing 4A
chr22_+_16308450 0.05 ENSDART00000105678
leucine rich repeat containing 39
chr20_+_23185530 0.05 ENSDART00000142346
leucine rich repeat containing 66
chr16_-_37415797 0.04 ENSDART00000188823
si:ch211-208k15.1
chr12_+_20412564 0.04 ENSDART00000186783
Rho GTPase activating protein 17a
chr9_+_1313418 0.04 ENSDART00000191361
caspase 8, apoptosis-related cysteine peptidase, like 2
chr16_-_30903930 0.04 ENSDART00000143996
DENN/MADD domain containing 3b
chr7_+_30787903 0.03 ENSDART00000174000
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr23_+_26946744 0.03 ENSDART00000115141
calcium channel, voltage-dependent, beta 3b
chr18_-_37007061 0.03 ENSDART00000136432
mitogen-activated protein kinase kinase kinase 10
chr21_-_43949208 0.03 ENSDART00000150983
calcium/calmodulin-dependent protein kinase II alpha
chr2_-_54946834 0.02 ENSDART00000192280

chr11_-_19775182 0.02 ENSDART00000037894
nicotinamide phosphoribosyltransferase b
chr11_-_39105253 0.02 ENSDART00000102827
prolyl 3-hydroxylase 1
chr21_+_11244068 0.02 ENSDART00000163432
AT-rich interaction domain 6
chr21_+_15824182 0.02 ENSDART00000065779
gonadotropin-releasing hormone 2
chr9_-_32730487 0.02 ENSDART00000147795
oligodendrocyte transcription factor 1
chr4_-_11106856 0.02 ENSDART00000150764

chr24_-_29963858 0.02 ENSDART00000183442

chr4_-_75681004 0.02 ENSDART00000186296
si:dkey-71l4.5
chr15_-_37835638 0.02 ENSDART00000128922
si:dkey-238d18.3
chr7_-_54679595 0.02 ENSDART00000165320
cyclin D1
chr22_+_16308806 0.02 ENSDART00000162685
leucine rich repeat containing 39
chr5_-_51619742 0.01 ENSDART00000188537
orthopedia homeobox b
chr17_-_29192987 0.01 ENSDART00000164302
spectrin, beta, non-erythrocytic 5
chr22_-_7129631 0.01 ENSDART00000171359
acid-sensing (proton-gated) ion channel 1b
chr9_+_11034314 0.01 ENSDART00000032695
acid-sensing (proton-gated) ion channel family member 4a
chr9_-_44897553 0.01 ENSDART00000110697
DnaJ (Hsp40) homolog, subfamily C, member 10
chr20_-_27225876 0.00 ENSDART00000149204
ENSDART00000149732
si:dkey-85n7.7
chr7_-_17591007 0.00 ENSDART00000171023

chr11_+_13224281 0.00 ENSDART00000102557
ENSDART00000178706
ATP-binding cassette, sub-family B (MDR/TAP), member 11b

Network of associatons between targets according to the STRING database.

First level regulatory network of dlx3b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.2 0.8 GO:0060074 synapse maturation(GO:0060074)
0.1 0.2 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 0.3 GO:0051645 Golgi localization(GO:0051645)
0.1 0.4 GO:0097250 mitochondrial respiratory chain supercomplex assembly(GO:0097250)
0.1 0.2 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.2 GO:0003322 pancreatic A cell development(GO:0003322)
0.0 0.8 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.3 GO:0060967 negative regulation of posttranscriptional gene silencing(GO:0060149) negative regulation of gene silencing by miRNA(GO:0060965) negative regulation of gene silencing by RNA(GO:0060967)
0.0 0.4 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.2 GO:0033183 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.3 GO:0060573 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 1.2 GO:0030217 T cell differentiation(GO:0030217)
0.0 0.7 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.3 GO:0021772 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988) synaptic membrane adhesion(GO:0099560)
0.0 0.4 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.1 GO:0035627 ceramide transport(GO:0035627)
0.0 0.3 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.5 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.1 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.0 0.6 GO:0072114 pronephros morphogenesis(GO:0072114)
0.0 0.2 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.4 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.0 0.3 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.3 GO:0042446 hormone biosynthetic process(GO:0042446)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 GO:0005682 U5 snRNP(GO:0005682)
0.1 0.2 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.1 0.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 3.0 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.8 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.2 GO:0098888 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.0 0.6 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 0.3 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0009374 biotin binding(GO:0009374)
0.2 0.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.9 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.2 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.0 0.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.2 GO:0050699 WW domain binding(GO:0050699)
0.0 0.2 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.4 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.3 GO:0008494 translation activator activity(GO:0008494)
0.0 0.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.0 0.2 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.6 GO:0019894 kinesin binding(GO:0019894)
0.0 0.1 GO:0035620 ceramide transporter activity(GO:0035620) ceramide 1-phosphate binding(GO:1902387) ceramide 1-phosphate transporter activity(GO:1902388)
0.0 0.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.7 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.4 GO:0004860 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.0 0.2 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.1 GO:0004985 opioid receptor activity(GO:0004985)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis