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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for e2f1_e2f7

Z-value: 0.36

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Transcription factors associated with e2f1_e2f7

Gene Symbol Gene ID Gene Info
e2f1
ENSDARG00000103868 E2F transcription factor 1
e2f7
ENSDARG00000008986 E2F transcription factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e2f7dr11_v1_chr4_-_2545310_2545345-0.542.1e-02Click!
e2f1dr11_v1_chr23_-_43486714_43486714-0.116.6e-01Click!

Activity profile of e2f1_e2f7 motif

Sorted Z-values of e2f1_e2f7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_43086548 0.57 ENSDART00000163579
si:dkey-43p13.5
si:dkey-43p13.5
chr7_+_24814866 0.50 ENSDART00000173581
si:ch211-226l4.6
si:ch211-226l4.6
chr20_-_29498178 0.48 ENSDART00000152986
ENSDART00000027851
ENSDART00000152954
rrm2
ribonucleotide reductase M2 polypeptide
chr15_+_17406920 0.45 ENSDART00000081059
rps6kb1b
ribosomal protein S6 kinase b, polypeptide 1b
chr13_-_35908275 0.40 ENSDART00000013961
mycla
MYCL proto-oncogene, bHLH transcription factor a
chr13_-_35907768 0.40 ENSDART00000147522
mycla
MYCL proto-oncogene, bHLH transcription factor a
chr6_-_33916756 0.38 ENSDART00000137447
ENSDART00000138488
nasp
nuclear autoantigenic sperm protein (histone-binding)
chr21_+_34992550 0.38 ENSDART00000109041
ENSDART00000135400
tmprss15
transmembrane protease, serine 15
chr19_-_47570672 0.37 ENSDART00000112155
rrm2
ribonucleotide reductase M2 polypeptide
chr8_-_1219815 0.37 ENSDART00000016800
ENSDART00000149969
znf367
zinc finger protein 367
chr1_+_27690 0.37 ENSDART00000162928
eed
embryonic ectoderm development
chr16_+_53252951 0.37 ENSDART00000126543
si:ch211-269k10.5
si:ch211-269k10.5
chr18_+_15271993 0.36 ENSDART00000099777
si:dkey-103i16.6
si:dkey-103i16.6
chr7_-_26518086 0.36 ENSDART00000058913
eif4a1a
eukaryotic translation initiation factor 4A1A
chr19_+_41006975 0.36 ENSDART00000138555
ENSDART00000049842
casd1
CAS1 domain containing 1
chr24_+_27548474 0.35 ENSDART00000105774
ENSDART00000123368
ek1
eph-like kinase 1
chr8_+_29636431 0.34 ENSDART00000133047
smarcad1a
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 a
chr4_+_13586455 0.34 ENSDART00000187230
tnpo3
transportin 3
chr7_+_24881680 0.33 ENSDART00000058843
krcp
kelch repeat-containing protein
chr6_-_40071899 0.33 ENSDART00000034730
sec61a1
Sec61 translocon alpha 1 subunit
chr15_-_1485086 0.32 ENSDART00000191651
si:dkeyp-97b10.3
si:dkeyp-97b10.3
chr1_-_38170997 0.32 ENSDART00000142811
hmgb2a
high mobility group box 2a
chr8_+_29635968 0.31 ENSDART00000139029
ENSDART00000091409
smarcad1a
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 a
chr5_+_24047292 0.31 ENSDART00000029889
ctdnep1a
CTD nuclear envelope phosphatase 1a
chr20_+_13141408 0.30 ENSDART00000034098
dtl
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
chr23_+_36306539 0.30 ENSDART00000053267
hnrnpa1b
heterogeneous nuclear ribonucleoprotein A1b
chr13_-_25548733 0.29 ENSDART00000168099
ENSDART00000135788
ENSDART00000077655
mcmbp
minichromosome maintenance complex binding protein
chr3_-_35865040 0.29 ENSDART00000102952
suz12a
SUZ12 polycomb repressive complex 2a subunit
chr25_+_32390794 0.29 ENSDART00000012600
galk2
galactokinase 2
chr2_-_57900430 0.29 ENSDART00000132245
ENSDART00000140060
si:dkeyp-68b7.7
si:dkeyp-68b7.7
chr23_-_18057851 0.28 ENSDART00000173075
ENSDART00000173230
ENSDART00000173135
ENSDART00000173431
ENSDART00000173068
ENSDART00000172987
zgc:92287
zgc:92287
chr18_+_17021391 0.28 ENSDART00000100160
chtf8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr18_+_17020967 0.27 ENSDART00000189168
chtf8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr15_-_1484795 0.27 ENSDART00000129356
si:dkeyp-97b10.3
si:dkeyp-97b10.3
chr2_-_52550135 0.27 ENSDART00000044411
gna11b
guanine nucleotide binding protein (G protein), alpha 11b (Gq class)
chr25_-_36370292 0.26 ENSDART00000152766
CR354435.1
Histone H2B 1/2
chr4_+_13586689 0.26 ENSDART00000067161
ENSDART00000138201
tnpo3
transportin 3
chr23_-_18057553 0.26 ENSDART00000173102
ENSDART00000058742
zgc:92287
zgc:92287
chr22_-_20419660 0.26 ENSDART00000105520
pias4a
protein inhibitor of activated STAT, 4a
chr9_-_746317 0.25 ENSDART00000129632
ENSDART00000130720
usp37
ubiquitin specific peptidase 37
chr21_+_34119759 0.25 ENSDART00000024750
ENSDART00000128242
hmgb3b
high mobility group box 3b
chr15_+_43333121 0.25 ENSDART00000161011
zgc:85932
zgc:85932
chr13_+_8255106 0.24 ENSDART00000080465
hells
helicase, lymphoid specific
chr6_+_33931740 0.24 ENSDART00000130492
ENSDART00000151213
orc1
origin recognition complex, subunit 1
chr24_+_26329018 0.24 ENSDART00000145752
mynn
myoneurin
chr23_+_29358188 0.24 ENSDART00000189242
tardbpl
TAR DNA binding protein, like
chr1_+_49415281 0.24 ENSDART00000015007
taf5
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr18_+_14277003 0.23 ENSDART00000006628
zgc:173742
zgc:173742
chr3_-_49514874 0.23 ENSDART00000167179
asf1ba
anti-silencing function 1Ba histone chaperone
chr6_-_9282080 0.23 ENSDART00000159506
ccdc14
coiled-coil domain containing 14
chr24_+_26328787 0.22 ENSDART00000003884
mynn
myoneurin
chr1_+_10305611 0.22 ENSDART00000043881
zgc:77880
zgc:77880
chr23_-_29357764 0.21 ENSDART00000156512
si:ch211-129o18.4
si:ch211-129o18.4
chr8_-_18211605 0.21 ENSDART00000114177
CT025742.1

chr2_-_45663945 0.21 ENSDART00000075080
prpf38b
pre-mRNA processing factor 38B
chr19_-_2582858 0.20 ENSDART00000113829
cdca7b
cell division cycle associated 7b
chr5_-_23596339 0.20 ENSDART00000024815
fam76b
family with sequence similarity 76, member B
chr22_-_24992532 0.20 ENSDART00000102751
si:dkey-179j5.5
si:dkey-179j5.5
chr2_-_122154 0.20 ENSDART00000156248
ENSDART00000004071
znfl2a
zinc finger-like gene 2a
chr3_-_61377127 0.20 ENSDART00000155932
si:dkey-111k8.2
si:dkey-111k8.2
chr23_-_36305874 0.20 ENSDART00000147598
ENSDART00000146986
ENSDART00000086985
ENSDART00000133259
cbx5
chromobox homolog 5 (HP1 alpha homolog, Drosophila)
chr5_+_51248784 0.19 ENSDART00000159571
ENSDART00000189513
ENSDART00000092285
msh3
mutS homolog 3 (E. coli)
chr23_+_20518504 0.19 ENSDART00000114246
adnpb
activity-dependent neuroprotector homeobox b
chr2_+_23081247 0.19 ENSDART00000099702
ENSDART00000088867
mfsd12a
major facilitator superfamily domain containing 12a
chr23_+_39413163 0.19 ENSDART00000184254
src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr25_-_12824656 0.19 ENSDART00000171801
uba2
ubiquitin-like modifier activating enzyme 2
chr8_+_36509885 0.19 ENSDART00000109530
slc7a4
solute carrier family 7, member 4
chr22_+_24157807 0.19 ENSDART00000159165
b3galt2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr23_-_36306337 0.19 ENSDART00000142760
ENSDART00000136929
ENSDART00000143340
cbx5
chromobox homolog 5 (HP1 alpha homolog, Drosophila)
chr19_+_627899 0.19 ENSDART00000148508
tert
telomerase reverse transcriptase
chr7_+_41812636 0.18 ENSDART00000174333
orc6
origin recognition complex, subunit 6
chr21_-_44731865 0.18 ENSDART00000013814
ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 homolog (human)
chr3_+_25999477 0.18 ENSDART00000024316
mcm5
minichromosome maintenance complex component 5
chr11_+_13176568 0.18 ENSDART00000125371
ENSDART00000123257
mknk1
MAP kinase interacting serine/threonine kinase 1
chr13_-_11378355 0.18 ENSDART00000164566
akt3a
v-akt murine thymoma viral oncogene homolog 3a
chr6_+_60112200 0.18 ENSDART00000008243
prelid3b
PRELI domain containing 3
chr5_+_34549845 0.18 ENSDART00000139317
aif1l
allograft inflammatory factor 1-like
chr8_+_10304981 0.18 ENSDART00000160766
pim1
Pim-1 proto-oncogene, serine/threonine kinase
chr18_-_8380090 0.17 ENSDART00000141581
ENSDART00000081143
sephs1
selenophosphate synthetase 1
chr5_+_22970617 0.17 ENSDART00000192859
hmgn7
high mobility group nucleosomal binding domain 7
chr1_+_31573225 0.17 ENSDART00000075286
slc2a15b
solute carrier family 2 (facilitated glucose transporter), member 15b
chr2_+_23081402 0.17 ENSDART00000183073
mfsd12a
major facilitator superfamily domain containing 12a
chr10_+_21434649 0.17 ENSDART00000193938
ENSDART00000064558
etf1b
eukaryotic translation termination factor 1b
chr21_+_1647990 0.16 ENSDART00000148540
fech
ferrochelatase
chr22_-_21676364 0.16 ENSDART00000183668
tle2b
transducin like enhancer of split 2b
chr23_+_44236855 0.16 ENSDART00000130147
ENSDART00000051907
MEPCE
si:ch1073-157b13.1
chr5_+_31168096 0.16 ENSDART00000086443
ENSDART00000192271
atp2a3
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
chr20_-_37933237 0.16 ENSDART00000142567
ENSDART00000036371
ENSDART00000061445
angel2
angel homolog 2 (Drosophila)
chr24_-_11908115 0.16 ENSDART00000184329
tm9sf1
transmembrane 9 superfamily member 1
chr1_+_44814322 0.16 ENSDART00000059227
ndufs8a
NADH dehydrogenase (ubiquinone) Fe-S protein 8a
chr18_-_7456378 0.16 ENSDART00000081459
pdp2
putative pyruvate dehydrogenase phosphatase isoenzyme 2
chr19_-_34873566 0.16 ENSDART00000016057
ctnnal1
catenin (cadherin-associated protein), alpha-like 1
chr5_+_41477526 0.16 ENSDART00000153567
pias2
protein inhibitor of activated STAT, 2
chr9_+_33788626 0.15 ENSDART00000088469
kdm6a
lysine (K)-specific demethylase 6A
chr17_+_45010230 0.15 ENSDART00000192118
coq6
coenzyme Q6 monooxygenase
chr1_+_58608978 0.15 ENSDART00000152744
si:ch73-236c18.9
si:ch73-236c18.9
chr7_+_55518519 0.15 ENSDART00000098476
ENSDART00000149915
cdt1
chromatin licensing and DNA replication factor 1
chr21_-_28340977 0.15 ENSDART00000141629
nrxn2a
neurexin 2a
chr20_-_38827623 0.15 ENSDART00000153310
cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr23_-_36449111 0.15 ENSDART00000110478
zgc:174906
zgc:174906
chr5_-_67365333 0.15 ENSDART00000133438
unga
uracil DNA glycosylase a
chr13_+_26703922 0.15 ENSDART00000020946
fancl
Fanconi anemia, complementation group L
chr12_+_41420355 0.15 ENSDART00000158811
epc1a
enhancer of polycomb homolog 1 (Drosophila) a
chr5_-_67241633 0.15 ENSDART00000114783
clip1a
CAP-GLY domain containing linker protein 1a
chr11_+_1551603 0.14 ENSDART00000185383
ENSDART00000121489
ENSDART00000040577
mybl2b
v-myb avian myeloblastosis viral oncogene homolog-like 2b
chr7_-_73854476 0.14 ENSDART00000186481
zgc:173552
zgc:173552
chr24_+_26140855 0.14 ENSDART00000139017
tmtopsb
teleost multiple tissue opsin b
chr20_+_33994580 0.14 ENSDART00000061729
si:dkey-97o5.1
si:dkey-97o5.1
chr3_-_12227359 0.14 ENSDART00000167356
tfap4
transcription factor AP-4 (activating enhancer binding protein 4)
chr4_-_2380173 0.14 ENSDART00000177727
nap1l1
nucleosome assembly protein 1-like 1
chr21_+_21743599 0.14 ENSDART00000101700
pold3
polymerase (DNA-directed), delta 3, accessory subunit
chr5_-_7712160 0.14 ENSDART00000168820
bmpr1ba
bone morphogenetic protein receptor, type IBa
chr10_-_38456382 0.14 ENSDART00000182129
gdpd5a
glycerophosphodiester phosphodiesterase domain containing 5a
chr7_+_41812817 0.14 ENSDART00000174165
orc6
origin recognition complex, subunit 6
chr21_+_31150438 0.14 ENSDART00000065366
st6gal1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr7_-_6445129 0.13 ENSDART00000172825
FP325123.2
Histone H3.2
chr18_-_30499489 0.13 ENSDART00000033746
gins2
GINS complex subunit 2
chr7_-_73843720 0.13 ENSDART00000111622
caap1
caspase activity and apoptosis inhibitor 1
chr2_+_32016516 0.13 ENSDART00000135040
mycb
MYC proto-oncogene, bHLH transcription factor b
chr7_+_41812190 0.13 ENSDART00000113732
ENSDART00000174137
orc6
origin recognition complex, subunit 6
chr23_+_29357790 0.13 ENSDART00000139223
ENSDART00000141928
tardbpl
TAR DNA binding protein, like
chr10_+_6010570 0.13 ENSDART00000190025
ENSDART00000163680
hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr5_-_69482891 0.13 ENSDART00000109487
CABZ01032476.1

chr19_-_1947403 0.12 ENSDART00000113951
ENSDART00000151293
ENSDART00000134074
znrf2a
zinc and ring finger 2a
chr10_+_16911951 0.12 ENSDART00000164933
UNC13B (1 of many)
unc-13 homolog B
chr25_+_32496877 0.12 ENSDART00000132698
ctdspl2a
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2a
chr11_-_24063196 0.12 ENSDART00000036513
trib3
tribbles pseudokinase 3
chr8_-_22660678 0.12 ENSDART00000181258
iqsec2a
IQ motif and Sec7 domain 2a
chr3_-_34753605 0.12 ENSDART00000000160
thraa
thyroid hormone receptor alpha a
chr5_+_20453874 0.12 ENSDART00000124545
ENSDART00000008402
sart3
squamous cell carcinoma antigen recognized by T cells 3
chr17_+_45009868 0.12 ENSDART00000085009
coq6
coenzyme Q6 monooxygenase
chr6_+_48720617 0.12 ENSDART00000164142
ENSDART00000167131
si:dkeyp-6a3.1
si:dkeyp-6a3.1
chr20_-_28433990 0.12 ENSDART00000182824
ENSDART00000193381
wdr21
WD repeat domain 21
chr12_+_17603528 0.12 ENSDART00000111565
pms2
PMS1 homolog 2, mismatch repair system component
chr2_-_55797318 0.12 ENSDART00000158147
calr3b
calreticulin 3b
chr8_-_49725430 0.12 ENSDART00000135675
gkap1
G kinase anchoring protein 1
chr20_-_33487729 0.12 ENSDART00000061843
smek1
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr5_+_34549365 0.12 ENSDART00000009500
aif1l
allograft inflammatory factor 1-like
chr7_-_41812015 0.12 ENSDART00000174058
vps35
vacuolar protein sorting 35 homolog (S. cerevisiae)
chr6_-_30689126 0.12 ENSDART00000065211
pars2
prolyl-tRNA synthetase 2, mitochondrial
chr21_-_23017478 0.11 ENSDART00000024309
rb1
retinoblastoma 1
chr20_-_28433616 0.11 ENSDART00000169289
wdr21
WD repeat domain 21
chr7_+_29080684 0.11 ENSDART00000173709
ENSDART00000173576
acd
ACD, shelterin complex subunit and telomerase recruitment factor
chr3_-_18737126 0.11 ENSDART00000055767
e4f1
E4F transcription factor 1
chr8_-_20230559 0.11 ENSDART00000193677
mllt1a
MLLT1, super elongation complex subunit a
chr2_+_48074243 0.11 ENSDART00000056291
klf6b
Kruppel-like factor 6b
chr6_+_12504462 0.11 ENSDART00000171460
stk24b
serine/threonine kinase 24b (STE20 homolog, yeast)
chr8_+_18545933 0.10 ENSDART00000148806
tab3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr24_-_35561672 0.10 ENSDART00000058564
mcm4
minichromosome maintenance complex component 4
chr3_-_31086770 0.10 ENSDART00000103421
zgc:153292
zgc:153292
chr6_-_33931696 0.10 ENSDART00000057290
prpf38a
pre-mRNA processing factor 38A
chr20_-_28698172 0.10 ENSDART00000190635
sipa1l1
signal-induced proliferation-associated 1 like 1
chr6_+_12503849 0.10 ENSDART00000149529
stk24b
serine/threonine kinase 24b (STE20 homolog, yeast)
chr22_+_2100774 0.10 ENSDART00000106436
si:dkey-1b17.9
si:dkey-1b17.9
chr8_+_18545185 0.10 ENSDART00000191398
tab3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr6_-_53334259 0.10 ENSDART00000172465
gnb1b
guanine nucleotide binding protein (G protein), beta polypeptide 1b
chr3_-_60589292 0.10 ENSDART00000157822
jmjd6
jumonji domain containing 6
chr2_+_48073972 0.10 ENSDART00000186442
klf6b
Kruppel-like factor 6b
chr14_-_45558490 0.10 ENSDART00000165060
ints5
integrator complex subunit 5
chr6_+_54496808 0.10 ENSDART00000156263
si:ch211-233f11.5
si:ch211-233f11.5
chr1_-_54972170 0.10 ENSDART00000150548
ENSDART00000038330
khsrp
KH-type splicing regulatory protein
chr11_+_45153104 0.10 ENSDART00000159204
ENSDART00000177585
tk1
thymidine kinase 1, soluble
chr1_+_2260407 0.10 ENSDART00000058876
kpnb3
karyopherin (importin) beta 3
chr16_+_25608778 0.10 ENSDART00000077484
zhx2a
zinc fingers and homeoboxes 2a
chr23_-_29751730 0.10 ENSDART00000056865
ctnnbip1
catenin, beta interacting protein 1
chr14_-_22015232 0.09 ENSDART00000137795
ssrp1a
structure specific recognition protein 1a
chr21_-_25213616 0.09 ENSDART00000122513
rfc2
replication factor C (activator 1) 2
chr14_+_14841685 0.09 ENSDART00000158291
ENSDART00000162039
slbp
stem-loop binding protein
chr8_-_1698155 0.09 ENSDART00000186159
CABZ01065417.1

chr16_+_53603945 0.09 ENSDART00000083513
sacm1lb
SAC1 like phosphatidylinositide phosphatase b
chr25_+_36333993 0.09 ENSDART00000184379
CR354435.2

chr7_-_28568238 0.09 ENSDART00000173927
tmem9b
TMEM9 domain family, member B
chr22_+_2510828 0.09 ENSDART00000115348
ENSDART00000145611
zgc:173726
zgc:173726
chr25_-_10629940 0.09 ENSDART00000154483
ENSDART00000155231
ppp6r3
protein phosphatase 6, regulatory subunit 3
chr6_+_112579 0.09 ENSDART00000034505
ap1m2
adaptor-related protein complex 1, mu 2 subunit
chr22_+_2511045 0.09 ENSDART00000106425
zgc:173726
zgc:173726
chr1_+_59142783 0.09 ENSDART00000152669
gpr108
G protein-coupled receptor 108
chr22_-_23228669 0.09 ENSDART00000079536
nek7
NIMA-related kinase 7
chr3_-_42981739 0.09 ENSDART00000167844
mafk
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
chr17_+_23729717 0.09 ENSDART00000179026
zgc:91976
zgc:91976
chr7_-_41812355 0.09 ENSDART00000016105
vps35
vacuolar protein sorting 35 homolog (S. cerevisiae)
chr19_+_42955280 0.09 ENSDART00000141225
fabp3
fatty acid binding protein 3, muscle and heart
chr18_+_22287084 0.09 ENSDART00000151919
ENSDART00000181644
ctcf
CCCTC-binding factor (zinc finger protein)
chr13_+_6189203 0.08 ENSDART00000109665
ppm1g
protein phosphatase, Mg2+/Mn2+ dependent, 1G
chr13_+_6188759 0.08 ENSDART00000161062
ppm1g
protein phosphatase, Mg2+/Mn2+ dependent, 1G
chr17_+_25833947 0.08 ENSDART00000044328
ENSDART00000154604
acss1
acyl-CoA synthetase short chain family member 1
chr5_-_4297459 0.08 ENSDART00000018895
srrt
serrate RNA effector molecule homolog (Arabidopsis)
chr3_+_34988670 0.08 ENSDART00000011319
smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr24_+_9693951 0.08 ENSDART00000082411
topbp1
DNA topoisomerase II binding protein 1
chr22_+_38914983 0.08 ENSDART00000085701
senp5
SUMO1/sentrin specific peptidase 5
chr23_-_3758637 0.08 ENSDART00000131536
ENSDART00000139408
ENSDART00000137826
hmga1a
high mobility group AT-hook 1a
chr17_+_23730089 0.08 ENSDART00000034913
zgc:91976
zgc:91976
chr9_+_2020667 0.08 ENSDART00000157818
lnpa
limb and neural patterns a
chr20_-_31427390 0.08 ENSDART00000007735
ust
uronyl-2-sulfotransferase
chr9_+_33788389 0.08 ENSDART00000144623
kdm6a
lysine (K)-specific demethylase 6A
chr13_+_48358467 0.08 ENSDART00000171080
ENSDART00000162531
msh6
mutS homolog 6 (E. coli)
chr7_+_38090515 0.08 ENSDART00000131387
cebpg
CCAAT/enhancer binding protein (C/EBP), gamma
chr13_-_11378127 0.08 ENSDART00000158632
akt3a
v-akt murine thymoma viral oncogene homolog 3a
chr8_+_37749263 0.08 ENSDART00000108556
ENSDART00000147942
npm2a
nucleophosmin/nucleoplasmin, 2a
chr1_-_54971968 0.08 ENSDART00000140016
khsrp
KH-type splicing regulatory protein

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f1_e2f7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.9 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.1 0.1 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211) pyrimidine deoxyribonucleotide metabolic process(GO:0009219)
0.1 0.4 GO:0043476 pigment accumulation(GO:0043476)
0.1 0.2 GO:0051095 regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096)
0.1 0.2 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.1 0.3 GO:0010867 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867)
0.1 0.2 GO:0007571 age-dependent general metabolic decline(GO:0007571)
0.1 0.7 GO:0000729 DNA double-strand break processing(GO:0000729)
0.1 0.2 GO:0021563 glossopharyngeal nerve development(GO:0021563)
0.0 0.2 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.0 0.5 GO:0044030 regulation of DNA methylation(GO:0044030)
0.0 0.3 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.0 0.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.3 GO:0007603 phototransduction, visible light(GO:0007603)
0.0 0.3 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.0 0.1 GO:1902767 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.0 0.3 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.2 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.1 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.0 0.2 GO:1904184 regulation of pyruvate dehydrogenase activity(GO:1904182) positive regulation of pyruvate dehydrogenase activity(GO:1904184)
0.0 0.1 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.0 0.2 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.0 0.1 GO:0016446 somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0 0.1 GO:0046125 deoxyribonucleoside metabolic process(GO:0009120) thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.0 0.4 GO:0007045 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041) regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109)
0.0 0.2 GO:0001887 selenium compound metabolic process(GO:0001887)
0.0 0.3 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.1 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371) positive regulation of endoplasmic reticulum tubular network organization(GO:1903373)
0.0 0.1 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.0 0.1 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.0 0.1 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.2 GO:0009217 dGTP catabolic process(GO:0006203) purine nucleoside triphosphate catabolic process(GO:0009146) purine deoxyribonucleoside triphosphate catabolic process(GO:0009217) dGTP metabolic process(GO:0046070)
0.0 0.1 GO:0060945 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.0 0.2 GO:0000076 DNA replication checkpoint(GO:0000076)
0.0 0.1 GO:0031053 primary miRNA processing(GO:0031053)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.1 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.0 0.1 GO:0046929 negative regulation of neurotransmitter secretion(GO:0046929) response to cAMP(GO:0051591) cellular response to cAMP(GO:0071320) negative regulation of synaptic vesicle transport(GO:1902804) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.2 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.2 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.1 GO:0051026 chiasma assembly(GO:0051026)
0.0 0.6 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.1 GO:0071684 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.3 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.4 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.1 GO:0019427 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.0 0.0 GO:0034473 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
0.0 0.2 GO:0006265 DNA topological change(GO:0006265)
0.0 0.3 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.9 GO:1902593 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0 0.2 GO:0030311 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.0 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
0.0 0.0 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 0.3 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.1 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.0 0.1 GO:0000012 single strand break repair(GO:0000012)
0.0 0.1 GO:0097340 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.0 0.1 GO:1901207 regulation of heart looping(GO:1901207)
0.0 0.4 GO:0002183 cytoplasmic translational initiation(GO:0002183)
0.0 0.1 GO:0034447 very-low-density lipoprotein particle clearance(GO:0034447)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 0.3 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 0.6 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 0.2 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 0.3 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.1 0.2 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.1 0.3 GO:0005784 Sec61 translocon complex(GO:0005784)
0.1 0.6 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.2 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.0 0.5 GO:0032300 mismatch repair complex(GO:0032300)
0.0 0.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.2 GO:0018444 translation release factor complex(GO:0018444)
0.0 0.3 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.1 GO:0098826 endoplasmic reticulum tubular network membrane(GO:0098826)
0.0 0.8 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.2 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.1 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.2 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.1 GO:0033503 HULC complex(GO:0033503)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.3 GO:0032135 DNA insertion or deletion binding(GO:0032135)
0.1 0.2 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
0.1 0.3 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 0.2 GO:0003721 telomerase RNA reverse transcriptase activity(GO:0003721)
0.1 0.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 0.2 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0 0.2 GO:0019948 SUMO activating enzyme activity(GO:0019948)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.1 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.0 0.1 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.2 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0 0.5 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.1 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0 0.4 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.1 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.0 0.3 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.2 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.4 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.2 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.2 GO:0016793 dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793)
0.0 0.4 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.4 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.3 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 0.4 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.2 GO:0035925 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.2 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.1 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.1 GO:0070513 death domain binding(GO:0070513)
0.0 0.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.2 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.2 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.2 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.4 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.5 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.4 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.4 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.3 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.2 REACTOME TELOMERE MAINTENANCE Genes involved in Telomere Maintenance
0.0 0.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.1 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.3 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.2 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.1 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.2 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.2 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.2 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway